Peter Sasieni
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View article: Self-supervised Text-vision Alignment for Automated Brain MRI Abnormality Detection: A Multicenter Study (ALIGN Study)
Self-supervised Text-vision Alignment for Automated Brain MRI Abnormality Detection: A Multicenter Study (ALIGN Study) Open
Purpose To develop a self-supervised text-vision framework to detect abnormalities on brain MRI scans by leveraging free-text neuroradiology reports, eliminating the need for expertlabeled training datasets. Materials and Methods This retr…
View article: Interventions for patients with prostate cancer on active surveillance: a narrative review
Interventions for patients with prostate cancer on active surveillance: a narrative review Open
Objective To examine contemporary evidence supporting non‐surgical interventions for patients with early prostate cancer (PCa) on active surveillance (AS). Methods A literature search was conducted using the databases PubMed, Medline, and …
View article: Figure S2 from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis
Figure S2 from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis Open
Figure S2 shows The effect of the timing of the reporting of late-stage incidence on the association with the mortality outcome, by cancer (if data were available for at least two time points).
View article: Figure 4 from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis
Figure 4 from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis Open
Exploratory analysis of the effect of the timing of the reporting of late-stage incidence on the association with the mortality outcome. The figure includes trials that reported their late-stage outcomes at least twice [at intervention pha…
View article: Figure S3 from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis
Figure S3 from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis Open
Figure S3 shows he association between the screening effect on the proportion of late-stage cancers (among all cancers diagnosed up to the time of the reporting) and the screening effect on mortality (trial-level surrogacy), by cancer type…
View article: Table 2 from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis
Table 2 from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis Open
Summary of the “primary” late-stage and “main” mortality outcome estimates in the 57 trials.
View article: Figure 3 from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis
Figure 3 from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis Open
Bubble plots to evaluate the strength of association between the trial-level effect of screening on cancer mortality and the effect on either incidence of late-stage cancer or the proportion of cancers that are late stage, separately for b…
View article: Figure 1 from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis
Figure 1 from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis Open
PRISMA flowchart for the systematic search of the literature. The figure describes the process of identifying, screening, and selecting the studies for the systematic review. * As half of the original MEDLINE search results (prior deduplic…
View article: Figure 5 from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis
Figure 5 from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis Open
Exploratory evaluation of the utility of the 95% CI RR for late-stage incidence as a “forecast” of the final trial result for cancer-specific mortality. A, The observed RR for mortality (point estimates) versus the “predicted” 95% C…
View article: Figure S4 from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis
Figure S4 from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis Open
Figure S4 shows the Evaluation of the utility of regarding the 95% CI RR for late-stage incidence as a “forecast” of the final trial result for cancer-specific mortality, only including 15 trial arm comparisons with the late-stage outcome …
View article: Table 1 from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis
Table 1 from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis Open
Summary of the design and other characteristics of the 57 trials included in the systematic review and meta-analysis.
View article: Supplementary Methods (Protocol) from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis
Supplementary Methods (Protocol) from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis Open
Supplementary Methods Preplanned Protocol is the final version of the pre-planned protocol after amendments.
View article: Figure 2 from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis
Figure 2 from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis Open
Bubble plots to evaluate the strength of association between the trial-level effect of screening on cancer mortality and the effect on either incidence of late-stage cancer or the proportion of cancers that are late stage across all trials…
View article: Supplementary Methods and Tables from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis
Supplementary Methods and Tables from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis Open
Supplementary Methods and Tables: includes five sections. Section 1 outlines the comparison with previously published meta-analyses of mortality outcome surrogacy in cancer screening trials (including Table S1 and Table S2, and description…
View article: Figure S1 from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis
Figure S1 from Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis Open
Figure S1 shows the association between the screening effect on the incidence of late-stage cancer and the screening effect on mortality (trial-level surrogacy), by cancer type where at least three trials were available for analysis.
View article: Estimands for Clinical Effectiveness of Risk-Reducing Early Salpingectomy in Women With High Risk of Ovarian Cancer
Estimands for Clinical Effectiveness of Risk-Reducing Early Salpingectomy in Women With High Risk of Ovarian Cancer Open
Importance Risk-reducing early-salpingectomy (RRES) and delayed oophorectomy (DO) is a novel 2-stage alternative prevention strategy to risk-reducing salpingo-oophorectomy (RRSO) that avoids detrimental consequences of premature menopause.…
View article: Urine human papillomavirus testing for cervical screening in a UK general screening population: a diagnostic test accuracy study
Urine human papillomavirus testing for cervical screening in a UK general screening population: a diagnostic test accuracy study Open
Background Cervical screening uptake is decreasing in the UK, with only 67.5% of those eligible under 50 years old attending in 2022. Barriers include restricted access to screening appointments and poor acceptability of the speculum exami…
View article: Noncancer-Related Mortality in Randomized Clinical Trials
Noncancer-Related Mortality in Randomized Clinical Trials Open
Importance Cancer screening is a critical tool in cancer control, reducing cancer-specific mortality. However, it also has potential harms, including overdiagnosis and overtreatment. Measuring the effect of screening based on all-cause mor…
View article: The National Health Service-Galleri multi-cancer screening trial: explanation and justification of unique and important design issues
The National Health Service-Galleri multi-cancer screening trial: explanation and justification of unique and important design issues Open
Despite there being a plethora of multi-cancer early-detection tests, NHS-Galleri (ISRCTN91431511) is the only randomized controlled trial (RCT) of a multi-cancer liquid biopsy in a screening setting thus far. The NHS-Galleri trial has gen…
View article: Impact of mode of offer of self-sampling to people overdue cervical screening on screening participation: a randomised controlled trial
Impact of mode of offer of self-sampling to people overdue cervical screening on screening participation: a randomised controlled trial Open
View article: Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis
Late-Stage Outcomes as Surrogates for Mortality in Cancer Screening Trials: A Systematic Review and Meta-analysis Open
Late-stage cancer incidence has been proposed as a surrogate outcome for cancer-specific mortality in future screening trials. Two previous meta-analyses with 33 and 39 trials assessed trial-level surrogacy but provided inconsistent conclu…
View article: Biomarker risk stratification with capsule sponge in the surveillance of Barrett's oesophagus: prospective evaluation of UK real-world implementation
Biomarker risk stratification with capsule sponge in the surveillance of Barrett's oesophagus: prospective evaluation of UK real-world implementation Open
Innovate UK, Cancer Research UK, National Health Service England Cancer Alliance.
View article: Impact of human papillomavirus vaccines in the reduction of infection, precursor lesions, and cervical cancer: A systematic literature review
Impact of human papillomavirus vaccines in the reduction of infection, precursor lesions, and cervical cancer: A systematic literature review Open
Cervical cancer is a preventable disease for which vaccines are available to provide long-term protection against human papillomavirus (HPV) infection. This systematic literature review (SLR) was performed to summarize the efficacy, effect…
View article: Assessment of the impact of multi-cancer early detection test screening intervals on late-stage cancer at diagnosis and mortality using a state-transition model
Assessment of the impact of multi-cancer early detection test screening intervals on late-stage cancer at diagnosis and mortality using a state-transition model Open
Objective Multi-cancer early detection (MCED) tests are novel technologies that detect cancer signals from a broad set of cancer types using a single blood sample. The objective of this study was to estimate the effect of screening with an…
View article: Evaluation of user experiences, perceptions and attitudes towards faecal immunochemical testing (FIT) for risk-stratified colonoscopy in people with Lynch syndrome
Evaluation of user experiences, perceptions and attitudes towards faecal immunochemical testing (FIT) for risk-stratified colonoscopy in people with Lynch syndrome Open
Objective This study evaluates the experiences, perceptions, and attitudes of people with Lynch syndrome (LS) towards faecal immunochemical testing (FIT) as an adjunct to colonoscopy for colorectal cancer surveillance. Methods A mixed-meth…
View article: Technical, legal and ethical framework of cancer audit in cervical screening – Summary of best practices for organised programmes delineated through an expert group consultation
Technical, legal and ethical framework of cancer audit in cervical screening – Summary of best practices for organised programmes delineated through an expert group consultation Open
Efficient and well‐organised cervical screening programmes have significantly reduced both the incidence and mortality rates of cervical cancer in the population. For optimal performance, such programmes need to incorporate essential quali…
View article: Impact of hospital-specific domain adaptation on BERT-based models to classify neuroradiology reports
Impact of hospital-specific domain adaptation on BERT-based models to classify neuroradiology reports Open
Objectives To determine the effectiveness of hospital-specific domain adaptation through masked language modelling (MLM) on BERT-based models’ performance in classifying neuroradiology reports, and to compare these models with open-source …
View article: Protocol for a randomised phase 3 trial evaluating the role of Finasteride in Active Surveillance for men with low and intermediate-risk prostate cancer: the FINESSE Study
Protocol for a randomised phase 3 trial evaluating the role of Finasteride in Active Surveillance for men with low and intermediate-risk prostate cancer: the FINESSE Study Open
Background Prostate cancer (PCa) is the most common male malignancy in the western world. Many men (40%) are diagnosed with localised low or intermediate-risk PCa, which is suitable for active surveillance (AS). AS affords careful monitori…
View article: NHS-Galleri trial: Enriched enrolment approaches and sociodemographic characteristics of enrolled participants
NHS-Galleri trial: Enriched enrolment approaches and sociodemographic characteristics of enrolled participants Open
Background/aims: Certain sociodemographic groups are routinely underrepresented in clinical trials, limiting generalisability. Here, we describe the extent to which enriched enrolment approaches yielded a diverse trial population enriched …
View article: Study protocol: multi-centre, randomised controlled clinical trial exploring stromal targeting in locally advanced pancreatic cancer; STARPAC2
Study protocol: multi-centre, randomised controlled clinical trial exploring stromal targeting in locally advanced pancreatic cancer; STARPAC2 Open