Explanipedia

Fixed low dose versus concentration-controlled initial tacrolimus dosing with reduced target levels in the course after kidney transplantation: results from a prospective randomized controlled non-inferiority trial (Slow & Low study) Open

Julian Stumpf, Klemens Budde, Oliver Witzke, Claudia Sommerer, Thomas Vogel , et al. · 2023

A paired-kidney allocation study found superior survival with HLA-DR compatible kidney transplants in the Eurotransplant Senior Program Open

Johan W. de Fijter, Geertje J. Dreyer, Marko J.K. Mallat, Klemens Budde, Johann Pratschke , et al. · 2023

#4233 FIXED LOW DOSE VERSUS CONCENTRATION-CONTROLLED INITIAL TACROLIMUS DOSING: RESULTS FROM A PROSPECTIVE RANDOMIZED CONTROLLED TRIAL (SLOW&LOW STUDY) Open

Julian Stumpf, Klemens Budde, Oliver Witzke, Claudia Sommerer, Thomas Vogel , et al. · 2023

Background and Aims Optimal initial tacrolimus dosing and early exposure of tacrolimus after renal transplantation is not well studied. Based on the assumption that current treatment protocols using frequent trough level determinations in …

Study design and rationale of the pAtients pResenTing with cOngenital heaRt dIseAse Register (ARTORIA‐R) Open

Christoph Sinning, Elvin Zengin, Gerhard‐Paul Diller, Francesco Onorati, M. Castel , et al. · 2021

Aim Due to improved therapy in childhood, many patients with congenital heart disease reach adulthood and are termed adults with congenital heart disease (ACHD). ACHD often develop heart failure (HF) as a consequence of initial palliative …

Pankreastransplantation – Klinik, Technik und histologische Beurteilung Open

Maike Büttner‐Herold, Kerstin Amann, Frederick Pfister, Andrea Tannapfel, M. V. Maslova , et al. · 2021

Zusammenfassung Hintergrund Die Pankreastransplantation wird in Deutschland nur in wenigen ausgewählten Zentren durchgeführt, üblicherweise in Kombination mit einer Niere. Die Kenntnis von Indikationen und Techniken der Transplantation sel…

Challenges Associated with Pancreas and Kidney Retransplantation—A Retrospective Analysis Open

Nina Pillokeit, Sascha Grzella, Panagiota Zgoura, Timm H. Westhoff, Richard Viebahn , et al. · 2021

Simultaneous pancreas and kidney transplantation (SPK) is an accepted treatment for diabetic patients with renal failure, and is associated with increased survival and quality of life for recipients. There are only a few publications on th…

Corrigendum: The Aquaporin 5 −1364A/C Promoter Polymorphism Is Associated With Cytomegalovirus Infection Risk in Kidney Transplant Recipients Open

Tim Rahmel, Hartmuth Nowak, Sandra Frisenda, Katharina Rump, Björn Koos , et al. · 2021

Sandra Frisenda was not included as an author in the published article. The corrected AuthorContributions Statement appears below. The authors apologize for this error and state that thisdoes not change the scientific conclusions of the ar…

First World Consensus Conference on pancreas transplantation: Part II – recommendations Open

Ugo Boggi, Fabio Vistoli, Axel Andrès, Helmut Arbogast, Lionel Badet , et al. · 2021

Detection of pre-existing SARS-CoV-2-reactive T cells in unexposed renal transplant patients Open

Moritz Anft, Arturo Blazquez‐Navarro, Ulrik Stervbo, Sarah Skrzypczyk, Oliver Witzke , et al. · 2021

Background Recent data demonstrate potentially protective pre-existing T cells reactive against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in samples of healthy blood donors, collected before the SARS-CoV-2 pandemic. …

Biopsy findings after detection of de novo donor-specific antibodies in renal transplant recipients: a single center experience Open

Christoph Waldecker, Panagiota Zgoura, Felix S. Seibert, Sabina Gall, Peter Schenker , et al. · 2021

The Magnitude and Functionality of SARS-CoV-2 Reactive Cellular and Humoral Immunity in Transplant Population Is Similar to the General Population Despite Immunosuppression Open

Constantin J. Thieme, Moritz Anft, Krystallenia Paniskaki, Arturo Blazquez‐Navarro, Adrian Doevelaar , et al. · 2021

Background. The ability of transplant (Tx) patients to generate a protective antiviral response under immunosuppression is pivotal in COVID-19 infection. However, analysis of immunity against SARS-CoV-2 is currently lacking. Methods. Here,…

Renal Function and Patient-Reported Outcomes in Stable Kidney Transplant Patients Following Conversion From Twice-Daily Immediate-Release Tacrolimus to Once-Daily Prolonged-Release Tacrolimus: A 12-Month Observational Study in Routine Clinical Practice in Germany (ADAGIO) Open

Christian Hugo, H. Weihprecht, Bernhard Banas, Bernd Schröppel, Sabine Jank , et al. · 2021

The NFKB1 Promoter Polymorphism (-94ins/delATTG) Is Associated with Susceptibility to Cytomegalovirus Infection after Kidney Transplantation and Should Have Implications on CMV Prophylaxis Regimens Open

Hartmuth Nowak, Svenja Vornweg, Katharina Rump, Tim Rahmel, Matthias Unterberg , et al. · 2021

Infections with cytomegalovirus (CMV) are one of the most frequent opportunistic infections in kidney transplant recipients. Current risk-adapted CMV chemoprophylaxis regimens are based almost solely on the donor and recipient CMV serostat…

Impact of SARS-CoV-2 on pancreas transplant activity: survey of international surgeons Open

Sivesh K. Kamarajah, Helmut Arbogast, Thierry Berney, Ugo Boggi, J. Branchereau , et al. · 2020

This study has identified the need for clear and consistent national or international guidelines to be in place in the event of future pandemics to ensure a standardised level of care for all pancreas transplant patients.

Lessons for the clinical nephrologist: recurrence of nephrotic syndrome induced by SARS-CoV-2 Open

Adrian Doevelaar, Bodo Hölzer, Felix S. Seibert, Frederic Bauer, Ulrik Stervbo , et al. · 2020

Psychological Responses to the Coronavirus Disease 2019 Pandemic in Renal Transplant Recipients Open

Panagiota Zgoura, Felix S. Seibert, Christoph Waldecker, Adrian Doevelaar, Frederic Bauer , et al. · 2020

Immune monitoring facilitates the clinical decision in multifocal COVID-19 of a pancreas-kidney transplant patient Open

Nina Babel, Moritz Anft, Arturo Blazquez‐Navarro, Adrian Doevelaar, Felix S. Seibert , et al. · 2020

Allograft infiltration and meningoencephalitis by SARS-CoV-2 in a pancreas-kidney transplant recipient Open

Timm H. Westhoff, Felix S. Seibert, Frederic Bauer, Ulrik Stervbo, Moritz Anft , et al. · 2020

Clinical characteristics and outcomes of patients with adult congenital heart disease listed for heart and heart‒lung transplantation in the Eurotransplant region Open

Peter Moritz Becher, Benedikt Schrage, Jessica Weimann, Jacqueline M. Smits, Christina Magnussen , et al. · 2020

The Aquaporin 3 Promoter Polymorphism −1431 A/G is Associated with Acute Graft Rejection and Cytomegalovirus Infection in Kidney Recipients Due to Altered Immune Cell Migration Open

Katharina Rump, Tim Rahmel, Anna-Maria Rustige, Matthias Unterberg, Hartmuth Nowak , et al. · 2020

Major complications after kidney transplantation are graft rejection and cytomegalovirus (CMV) infection, which are related to T-cell function, which depends on aquaporin 3 (AQP3) expression. The impact of the AQP3 A(−1431)G promoter polym…

Impact of donor cardiopulmonary resuscitation on the outcome of simultaneous pancreas–kidney transplantation—a retrospective study Open

Jannik Hinzmann, Sascha Grzella, Thorsten Lengenfeld, Nina Pillokeit, Marielle Hummels , et al. · 2020

Previous cardiac arrest in brain-dead donors has been discussed as a potential risk factor in pancreas transplantation (PT), leading to a higher rate of organ refusal. This study aimed to assess the impact of cardiopulmonary resuscitation …

The Aquaporin 5 −1364A/C Promoter Polymorphism Is Associated With Cytomegalovirus Infection Risk in Kidney Transplant Recipients Open

Tim Rahmel, Hartmuth Nowak, Sandra Frisenda, Katharina Rump, Björn Koos , et al. · 2019

Background: The aquaporin 5 ( AQP5) −1364A/C promoter single nucleotide polymorphism affects key mechanisms of inflammation and immune cell migration. Thus, it could be involved in the pathogenesis of cytomegalovirus infection. Accordingly…

Intensive blood pressure control is associated with improved patient and graft survival after renal transplantation Open

Nikolaos Pagonas, Frederic Bauer, Felix S. Seibert, Maximilian Seidel, Peter Schenker , et al. · 2019

Based on data of the SPRINT trial, American hypertension guidelines recently reduced the blood pressure goal from 140/90 mmHg to 130/80 mmHg for subjects with chronic kidney disease (CKD), whereas European guidelines recommend a systolic b…

An open-label, randomized trial indicates that everolimus with tacrolimus or cyclosporine is comparable to standard immunosuppression in de novo kidney transplant patients Open

Claudia Sommerer, Barbara Suwelack, Duska Dragun, Peter Schenker, Ingeborg A. Hauser , et al. · 2019

Success of kidney transplantations from deceased donors with acute kidney injury Open

J. D. Bauer, Sascha Grzella, Malwina Bialobrzecka, Lea Berger, Timm H. Westhoff , et al. · 2018

BACKGROUND The acceptance of organs from deceased donors with acute kidney injury (AKI) varies considerably, with uncertain outcomes. The current organ shortage has led to increased use of marginal donor organs. MATERIAL AND METHODS This r…

A Valine Mismatch at Position 129 of MICA Is an Independent Predictor of Cytomegalovirus Infection and Acute Kidney Rejection in Simultaneous Pancreas–Kidney Transplantation Recipients Open

Rafael Tomoya Michita, José Artur Bogo Chies, Sabine Schramm, Peter A. Horn, Falko M. Heinemann , et al. · 2018

The polymorphic major histocompatibility complex class I chain-related molecule A (MICA) and its soluble form (sMICA) interact with activating receptor natural-killer group 2 member D (NKG2D) on natural-killer (NK) and T cells, thereby mod…

Duodenocolostomy as Treatment of Ileus in Short Bowel Syndrome: A Case Report Open

Paraskevas Stamopoulos, Richard Viebahn, Peter Schenker · 2018

BACKGROUND Short bowel syndrome (SBS) is a malabsorption syndrome that results from an extensive intestinal resection or repeated small bowel resections. Postoperative small bowel obstruction is a well-known complication of abdominal surge…

Pancreas Donor Risk Index but Not Pre-Procurement Pancreas Allocation Suitability Score Predicts Pancreas Graft Survival: A Cohort Study from a Large German Pancreas Transplantation Center Open

Mohamad Samim Ayami, Sascha Grzella, Stylianos Kykalos, Richard Viebahn, Peter Schenker · 2018

BACKGROUND The pre-procurement pancreas allocation suitability score (P-PASS) was introduced to support clinical decision-making and ultimately expand the currently insufficient pancreas donor pool. The pancreas donor risk index (PDRI) can…

Effects of Dopamine Donor Pretreatment on Graft Survival after Kidney Transplantation: A Randomized Trial Open

Peter Schnuelle, Wilhelm H. Schmitt, Christel Weiß, Antje Habicht, Lutz Renders , et al. · 2017

Background and objectives Donor dopamine improves initial graft function after kidney transplantation due to antioxidant properties. We investigated if a 4 µ g/kg per minute continuous dopamine infusion administered after brain-death confi…

Issue Information Open

Kerstin Poeschl, Vienna Schalleck, D. Abendroth, Ulm Adey, Francisco Al-Aly , et al. · 2016

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