Peter Schlattmann
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View article: Long-term outcomes after intensive care unit-treated COVID-19, influenza and respiratory sepsis in 2020 – a comparative, population-based cohort study
Long-term outcomes after intensive care unit-treated COVID-19, influenza and respiratory sepsis in 2020 – a comparative, population-based cohort study Open
Background Sepsis survivors are affected by a broad spectrum of long-term impairments, which overlap with Long-Covid and sequelae after influenza in their clinical presentation. However, we lack comparative assessments on the burden of lon…
View article: Obstructive Coronary Artery Disease Improved Prediction by the COME-CCT Pretest Probability Calculator With Cardiac CT
Obstructive Coronary Artery Disease Improved Prediction by the COME-CCT Pretest Probability Calculator With Cardiac CT Open
View article: Rehospitalizations for ambulatory care sensitive conditions in sepsis survivors– a nationwide cohort study using health claims data 2016–2019
Rehospitalizations for ambulatory care sensitive conditions in sepsis survivors– a nationwide cohort study using health claims data 2016–2019 Open
Purpose Sepsis survivors suffer from frequent rehospitalizations, of which a certain proportion is considered preventable by timely and adequate management in the outpatient setting (= ambulatory care sensitive conditions, ACSC). We aimed …
View article: Transitional care after hospitalization for sepsis in Germany– results from the population-based AVENIR cohort study
Transitional care after hospitalization for sepsis in Germany– results from the population-based AVENIR cohort study Open
Purpose Sepsis survivorship is associated with significant long-term morbidity, mortality and health care utilization. Transitional care between inpatient and follow-up care is crucial, but insufficiently understood. We investigated health…
View article: Modulation of cardiac fatty acid or glucose oxidation to treat heart failure in preclinical models: a systematic review and meta-analysis
Modulation of cardiac fatty acid or glucose oxidation to treat heart failure in preclinical models: a systematic review and meta-analysis Open
View article: Reduction of cardiovascular risk factors by the diet – Evaluation of the MoKaRi concept by a parallel-designed randomized study
Reduction of cardiovascular risk factors by the diet – Evaluation of the MoKaRi concept by a parallel-designed randomized study Open
View article: Polygenic contributions to lithium augmentation outcomes in antidepressant non-responders with unipolar depression
Polygenic contributions to lithium augmentation outcomes in antidepressant non-responders with unipolar depression Open
Objective Lithium augmentation (LA) is an effective treatment for patients with major depression after inadequate antidepressant response, but therapeutic outcomes vary considerably between individuals. Molecular studies could yield novel …
View article: Systematic review and meta-analysis of pain management after tonsillectomy
Systematic review and meta-analysis of pain management after tonsillectomy Open
View article: Gute Praxis arbeitsepidemiologische systematische Reviews (GPAR)
Gute Praxis arbeitsepidemiologische systematische Reviews (GPAR) Open
View article: Cost-effectiveness-analysis of oral health remotivation and reinstruction in nursing homes in a cluster-randomized controlled trial
Cost-effectiveness-analysis of oral health remotivation and reinstruction in nursing homes in a cluster-randomized controlled trial Open
ClinicalTrials.gov (Trial registration number NCT04140929).
View article: Multi-cancer early detection: searching for evidence
Multi-cancer early detection: searching for evidence Open
View article: The effectiveness of coronary computed tomography angiography and functional testing for the diagnosis of obstructive coronary artery disease: results from the individual patient data Collaborative Meta-Analysis of Cardiac CT (COME-CCT)
The effectiveness of coronary computed tomography angiography and functional testing for the diagnosis of obstructive coronary artery disease: results from the individual patient data Collaborative Meta-Analysis of Cardiac CT (COME-CCT) Open
Aim To determine the effectiveness of functional stress testing and computed tomography angiography (CTA) for diagnosis of obstructive coronary artery disease (CAD). Methods and results Two-thousand nine-hundred twenty symptomatic stable c…
View article: Facial nerve reconstruction for flaccid facial paralysis: a systematic review and meta-analysis
Facial nerve reconstruction for flaccid facial paralysis: a systematic review and meta-analysis Open
Objectives To determine the functional outcome after facial nerve reconstruction surgery in patients with flaccid facial paralysis. Methods A systematic review and meta-analysis was performed on studies reporting outcomes after direct faci…
View article: Improving prevention and early detection of sepsis among patient groups at risk: Introducing a model for a multimodal information campaign—The SepWiss study protocol
Improving prevention and early detection of sepsis among patient groups at risk: Introducing a model for a multimodal information campaign—The SepWiss study protocol Open
Background Sepsis is a life-threatening organ dysfunction due to a dysregulated host response to infection. Annually, sepsis leads to approx. 90.000 deaths in Germany. Risk factors include amongst others older age (>60), innate or acquired…
View article: Validation of Nutritional Approaches to Modulate Cardiovascular and Diabetic Risk Factors in Patients with Hypertriglyceridemia or Prediabetes—The MoKaRi II Randomized Controlled Study
Validation of Nutritional Approaches to Modulate Cardiovascular and Diabetic Risk Factors in Patients with Hypertriglyceridemia or Prediabetes—The MoKaRi II Randomized Controlled Study Open
Hypertriglyceridemia and diabetes mellitus type 2 are among the most important metabolic diseases globally. Diet plays a vital role in the development and progression of both clinical pictures. For the 10-week randomized, controlled, inter…
View article: Epirubicin for the Treatment of Sepsis and Septic Shock (EPOS-1): study protocol for a randomised, placebo-controlled phase IIa dose-escalation trial
Epirubicin for the Treatment of Sepsis and Septic Shock (EPOS-1): study protocol for a randomised, placebo-controlled phase IIa dose-escalation trial Open
Introduction Sepsis remains the major cause of death among hospitalised patients in intensive care. While targeting sepsis-causing pathogens with source control or antimicrobials has had a dramatic impact on morbidity and mortality of seps…
View article: Die adaptive Messung des Freiburger Einsilbertests im Störschall mit einer verringerten Anzahl an Testlisten
Die adaptive Messung des Freiburger Einsilbertests im Störschall mit einer verringerten Anzahl an Testlisten Open
Zusammenfassung Hintergrund Berücksichtigt man die unterschiedliche Kalibrierung und Verdeckung des Störschalls, waren der adaptive Freiburger Einsilbertest im Störschall (aFBE-S) und der Oldenburger Satztest im Störschall (OLSA-S) bezügli…
View article: Understanding health care pathways of patients with sepsis: protocol of a mixed-methods analysis of health care utilization, experiences, and needs of patients with and after sepsis
Understanding health care pathways of patients with sepsis: protocol of a mixed-methods analysis of health care utilization, experiences, and needs of patients with and after sepsis Open
View article: Metabolic Profiling Identifies 1-MetHis and 3-IPA as Potential Diagnostic Biomarkers for Patients With Acute and Chronic Heart Failure With Reduced Ejection Fraction
Metabolic Profiling Identifies 1-MetHis and 3-IPA as Potential Diagnostic Biomarkers for Patients With Acute and Chronic Heart Failure With Reduced Ejection Fraction Open
BACKGROUND: Metabolomics has become a valuable tool for identifying potential new biomarkers and metabolic profiles. It has the potential to improve the diagnosis and prognosis of different phenotypes of heart failure. To generate a distin…
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Frontmatter Open
View article: Association between hospital onset of infection and outcomes in sepsis patients – A propensity score matched cohort study based on health claims data in Germany
Association between hospital onset of infection and outcomes in sepsis patients – A propensity score matched cohort study based on health claims data in Germany Open
HAI sepsis patients face an increased risk of adverse outcomes both during the acute sepsis episode and in the long-term. Measures to prevent HAI and its progression into sepsis may be an opportunity to mitigate the burden of long-term imp…
View article: Evaluation of Influencing Factors on Metabolism of Land-Based n-3 Poly Unsaturated Fatty Acids—The KoALA Study
Evaluation of Influencing Factors on Metabolism of Land-Based n-3 Poly Unsaturated Fatty Acids—The KoALA Study Open
This study aimed to investigate the impact of influencing factors (sex, eicosapentaenoic acid (EPA) status at baseline, linoleic acid (LA) intake, milk fat intake) on the conversion of α-linolenic acid (ALA) obtained from linseed oil into …
View article: Combination of computed tomography angiography with coronary artery calcium score for improved diagnosis of coronary artery disease: a collaborative meta-analysis of stable chest pain patients referred for invasive coronary angiography
Combination of computed tomography angiography with coronary artery calcium score for improved diagnosis of coronary artery disease: a collaborative meta-analysis of stable chest pain patients referred for invasive coronary angiography Open
View article: Surgery for patients with facial palsy in Germany: a diagnosis-related-groups-based nationwide analysis, 2005–2019
Surgery for patients with facial palsy in Germany: a diagnosis-related-groups-based nationwide analysis, 2005–2019 Open
Purpose Chronic flaccid paralysis of the facial nerve leads to permanent dysfunction of eye closure, problems with drinking and eating, and lack of emotional expression. Modern facial surgery can help those affected. An analysis of the dev…
View article: Understanding the biases to sepsis surveillance and quality assurance caused by inaccurate coding in administrative health data
Understanding the biases to sepsis surveillance and quality assurance caused by inaccurate coding in administrative health data Open
View article: Recommendations for Performing Meta-Analyses in Occupational Epidemiological Systematic Reviews
Recommendations for Performing Meta-Analyses in Occupational Epidemiological Systematic Reviews Open
Introduction Performing meta-analyses is a relevant component of systematic reviews, but currently there are no recommendations available for performing meta-analyses tailored to the context of occupational epidemiology. We present guidanc…
View article: SLC4A10 mutation causes a neurological disorder associated with impaired GABAergic transmission
SLC4A10 mutation causes a neurological disorder associated with impaired GABAergic transmission Open
SLC4A10 is a plasma-membrane bound transporter that utilizes the Na+ gradient to drive cellular HCO3− uptake, thus mediating acid extrusion. In the mammalian brain, SLC4A10 is expressed in principal neurons and interneurons, as well as in …
View article: Return to work after sepsis—a German population-based health claims study
Return to work after sepsis—a German population-based health claims study Open
Background Long-term impairments after sepsis can impede the return to work in survivors. We aimed to describe rates of return to work 6 and 12 months postsepsis. Methods This retrospective, population-based cohort study was based on healt…
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Frontmatter Open
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View article: The Association between Patient’s Age and Head and Neck Cancer Treatment Decision—A Population-Based Diagnoses-Related Group-Based Nationwide Study in Germany
The Association between Patient’s Age and Head and Neck Cancer Treatment Decision—A Population-Based Diagnoses-Related Group-Based Nationwide Study in Germany Open
Investigations on the association between patient’s age and head and neck cancer (HNC) treatment decision are sparse. Nationwide diagnoses-related group-based data of 1,226,357 cases hospitalized with primary HNC in Germany from 2005 to 20…