Peter Sieger
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View article: Miniaturized screening and performance prediction of tailored subcutaneous extended-release formulations for preclinical in vivo studies
Miniaturized screening and performance prediction of tailored subcutaneous extended-release formulations for preclinical in vivo studies Open
Microencapsulation of active pharmaceutical ingredients (APIs) for preparation of long acting injectable (LAI) formulations is an auspicious technique to enable preclinical characterization of a broad variety of APIs, ideally independent o…
View article: CCDC 2267021: Experimental Crystal Structure Determination
CCDC 2267021: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Discovery and development of BI 1265162, an ENaC inhibitor for the treatment of cystic fibrosis
Discovery and development of BI 1265162, an ENaC inhibitor for the treatment of cystic fibrosis Open
Lung selective inhibition of the endothelial sodium channel (ENaC) is a potential mutation agnostic treatment of Cystic Fibrosis (CF). We describe the discovery and development of BI 1265162, the first ENaC inhibitor devoid of the amilorid…
View article: CCDC 2232043: Experimental Crystal Structure Determination
CCDC 2232043: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2232042: Experimental Crystal Structure Determination
CCDC 2232042: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2232044: Experimental Crystal Structure Determination
CCDC 2232044: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: The polymorph landscape of dabigatran etexilate mesylate: Taking the challenge to bring a metastable polymorph to market
The polymorph landscape of dabigatran etexilate mesylate: Taking the challenge to bring a metastable polymorph to market Open
Dabigatran etexilate mesylate is polymorphic and can exist in different crystalline forms. Two polymorphs have been encountered during the development of this drug substance, namely anhydrous form I and anhydrous form II. Additionally, a h…
View article: BIreactive: Expanding the Scope of Reactivity Predictions to Propynamides
BIreactive: Expanding the Scope of Reactivity Predictions to Propynamides Open
We present the first comprehensive study on the prediction of reactivity for propynamides. Covalent inhibitors like propynamides often show improved potency, selectivity, and unique pharmacologic properties compared to their non-covalent c…
View article: A Bidirectional Permeability Assay for beyond Rule of 5 Compounds
A Bidirectional Permeability Assay for beyond Rule of 5 Compounds Open
Bidirectional permeability measurement with cellular models grown on Transwell inserts is widely used in pharmaceutical research since it not only provides information about the passive permeability of a drug, but also about transport prot…
View article: CCDC 1578256: Experimental Crystal Structure Determination
CCDC 1578256: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …