Peter T. C. So
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View article: QuATON: quantization aware training of optical neurons
QuATON: quantization aware training of optical neurons Open
Optical processors, built with “optical neurons,” can perform large-scale high-dimensional linear operations at the speed of light. With the current advances in micro-fabrication, such optical processors can now be 3D-fabricated, but at li…
Band-Pass Raman Spectroscopy Unlocks Compact Point-of-Care Noninvasive Continuous Glucose Monitoring Open
Noninvasive blood glucose monitoring with precision comparable to standard invasive or minimally invasive methods has been a long-sought goal, especially as diabetes rates soar, with 592 million cases worldwide expected by 2035. Various op…
Multi-photon, label-free photoacoustic and optical imaging of NADH in brain cells Open
Label-free detection of biological events at single-cell resolution in the brain can non-invasively capture brain status for medical diagnosis and basic neuroscience research. NADH is an universal coenzyme that not only plays a central rol…
View article: Workshop on Noninvasive Glucose Monitoring 2024
Workshop on Noninvasive Glucose Monitoring 2024 Open
This first workshop on noninvasive glucose monitoring (NIGM) was held at the Massachusetts Institute of Technology (MIT) on October 30, 2024. Six invited speakers, representing industry, academia, and clinics, gave presentations that cover…
Label-Free Detection of Biochemical Changes during Cortical Organoid Maturation via Raman Spectroscopy and Machine Learning Open
Human cerebral organoids have become valuable tools in neurodevelopment research, holding promise for investigating neurological diseases and reducing drug development costs. However, clinical translation and large-scale production of brai…
In Vivo Optical Clearing of Mammalian Brain Open
Established methods for imaging the living mammalian brain have, to date, taken the brain’s optical properties as fixed; we here demonstrate that it is possible to modify the optical properties of the brain itself to significantly enhance …
High-Throughput Raman Spectroscopy by Horizontally Shifted Collection Fibers Open
Optical fiber probe-based Raman spectroscopy systems are widely used for in situ measurements ranging from material characterization to biomedical applications. However, small Raman cross sections necessitate the use of high-power lasers o…
View article: Cell membrane buckling governs early-stage ridge formation in butterfly wing scales: data
Cell membrane buckling governs early-stage ridge formation in butterfly wing scales: data Open
This repository contains the raw data for: JF Totz, AD McDougal, L Wagner, S Kang, PTC So, J Dunkel, BD Wilts, and M Kolle, Cell membrane buckling governs early-stage ridge formation in butterfly wing scales, (forthcoming). The raw data is…
View article: Cell membrane buckling governs early-stage ridge formation in butterfly wing scales: data
Cell membrane buckling governs early-stage ridge formation in butterfly wing scales: data Open
This repository contains the raw data for: JF Totz, AD McDougal, L Wagner, S Kang, PTC So, J Dunkel, BD Wilts, and M Kolle, Cell membrane buckling governs early-stage ridge formation in butterfly wing scales, (forthcoming). The raw data is…
Two-site microendoscopic imaging probe for simultaneous three-dimensional imaging at two anatomic locations in tissues Open
Systems that can image in three dimensions at cellular resolution and across different locations within an organism may enable insights into complex biological processes, such as immune responses, for which a single location measurement ma…
Swept-source Raman spectroscopy of chemical and biological materials Open
We demonstrate the capabilities of the proposed compact SS-Raman spectroscopy system by obtaining Raman spectra of chemical and biological materials, utilizing straightforward signal processing. We anticipate that the SS-Raman spectroscopy…
Optical diffraction tomography for assessing single cell models in angular light scattering Open
Angularly resolved light scattering (ALS) has become a useful tool for assessing the size and refractive index of biological scatterers at cellular and organelle length scales. Sizing organelle populations with ALS relies on Mie scattering…
Close the Design-to-Manufacturing Gap in Computational Optics with a 'Real2Sim' Learned Two-Photon Neural Lithography Simulator Open
We introduce neural lithography to address the 'design-to-manufacturing' gap in computational optics. Computational optics with large design degrees of freedom enable advanced functionalities and performance beyond traditional optics. Howe…
Optical diffraction tomography for assessing single cell models in angular light scattering Open
Angularly resolved light scattering (ALS) has become a useful tool for assessing size and refractive index of biological scatterers at cellular and organelle length scales. Sizing organelle populations with ALS relies on Mie scattering the…
Multiline Orthogonal Scanning Temporal Focusing (mosTF) Microscopy for Scattering Reduction in High-speed in vivo Brain Imaging Open
Temporal focusing two-photon microscopy enables high resolution imaging of fine structures in vivo over a large volume. A limitation of temporal focusing is that signal-to-background ratio and resolution degrade rapidly with increasing ima…
Optical Diffraction Tomography and Raman Confocal Microscopy for the Investigation of Vacuoles Associated with Cancer Senescent Engulfing Cells Open
Wild-type p53 cancer therapy-induced senescent cells frequently engulf and degrade neighboring ones inside a massive vacuole in their cytoplasm. After clearance of the internalized cell, the vacuole persists, seemingly empty, for several h…
Optical Diffraction Tomography and Raman Confocal Microscopy for the Investigation of Vacuoles Associated with Cancer Senescent Engulfing Cells Open
Wild-type p53 cancer therapy-induced senescent cells frequently engulf and degrade neighboring ones inside a massive vacuole in their cytoplasm. After clearance of the internalized cell, the vacuole persists, seemingly empty, for several h…
Neural Lithography: Close the Design-to-Manufacturing Gap in Computational Optics with a 'Real2Sim' Learned Photolithography Simulator Open
We introduce neural lithography to address the 'design-to-manufacturing' gap in computational optics. Computational optics with large design degrees of freedom enable advanced functionalities and performance beyond traditional optics. Howe…
Supplementary material - Optical Diffraction Tomography and Raman Confocal Microscopy for the Investigation of Vacuoles Associated with Cancer Senescent Engulfing Cells Open
Supplementary material containing the data used in the manuscript "Optical Diffraction Tomography and Raman Confocal Microscopy for the Investigation of Vacuoles Associated with Cancer Senescent Engulfing Cells"
Supplementary material - Optical Diffraction Tomography and Raman Confocal Microscopy for the Investigation of Vacuoles Associated with Cancer Senescent Engulfing Cells Open
Supplementary material containing the data used in the manuscript "Optical Diffraction Tomography and Raman Confocal Microscopy for the Investigation of Vacuoles Associated with Cancer Senescent Engulfing Cells"
DEEP-squared: deep learning powered De-scattering with Excitation Patterning Open
Limited throughput is a key challenge in in vivo deep tissue imaging using nonlinear optical microscopy. Point scanning multiphoton microscopy, the current gold standard, is slow especially compared to the widefield imaging modalities used…
Multiphoton imaging of the monosachharide induced formation of fluorescent advanced glycation end products in tissues Open
We studied the in vitro rate of fluorescent advanced glycation end products (fAGEs) formation with multiphoton microscopy in different porcine tissues (aorta, cornea, kidney, dermis, and tendon). These tissues were treated with d ‐glucose,…
Contributions of individual satellite cells to muscle regeneration assessed using a confetti mouse model Open
Summary Insufficient regeneration is implicated in muscle pathologies, but much remains unknown about the regenerative output of individual muscle stem cells, called satellite cells (SCs). Prior work showed that individual SCs contribute t…