Peter Stenvinkel
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View article: Correlations Between Trimethylamine-N-Oxide, Megalin, Lysine and Markers of Tubular Damage in Chronic Kidney Disease
Correlations Between Trimethylamine-N-Oxide, Megalin, Lysine and Markers of Tubular Damage in Chronic Kidney Disease Open
Trimethylamine-N-oxide (TMAO), a gut microbiota-derived dietary metabolite, is linked to progression of chronic kidney disease (CKD). Megalin, a renal proximal tubule receptor crucial for albumin reabsorption, also plays a role in CKD. How…
View article: Comparative physiology and biomimetics in metabolic and environmental health: what can we learn from extreme animal phenotypes?
Comparative physiology and biomimetics in metabolic and environmental health: what can we learn from extreme animal phenotypes? Open
This review explores the remarkable metabolic adaptations of species that thrive in extreme environments, providing insights into their resilience, flexibility and disease resistance. Species such as hibernating brown bears, migratory bird…
View article: Could Cultured Meat Be a Sustainable and Safe Source of Protein?
Could Cultured Meat Be a Sustainable and Safe Source of Protein? Open
Red and processed meat includes high‐quality proteins and essential sources of micronutrients, such as iron, zinc, and vitamin B12; however, high consumption is linked to an increased risk of chronic disease burden and also harms environme…
View article: Pentosidine and Bone Properties in Autosomal Dominant Polycystic Kidney Disease
Pentosidine and Bone Properties in Autosomal Dominant Polycystic Kidney Disease Open
Background/Objectives: Altered bone metabolism and oxidative stress are features of autosomal dominant polycystic kidney disease (ADPKD). Pentosidine, an advanced glycation end-product and a marker of oxidative stress, has been proposed as…
View article: Ignoring the planet: A critical blind spot for research on ageing
Ignoring the planet: A critical blind spot for research on ageing Open
Although research on ageing has largely concentrated on understanding the fundamental biology of the ageing process and devising pharmaceutical interventions in order to slow it down, increasing evidence has underscored the crucial role of…
View article: #2754 A bleeding concern: incidence of major gastrointestinal bleeding in dialysis
#2754 A bleeding concern: incidence of major gastrointestinal bleeding in dialysis Open
Background and Aims Gastrointestinal bleeding (GIB) is the most common bleeding event in dialysis,1 yet known incidence rates are based on small studies and the influence of patient characteristics is unknown. We used a nationally represen…
View article: Sarcopenia and Its Individual Traits Independently Predict Mortality in Patients on Dialysis: A Systematic Review and Meta‐Analysis
Sarcopenia and Its Individual Traits Independently Predict Mortality in Patients on Dialysis: A Systematic Review and Meta‐Analysis Open
Background Loss of muscle mass, muscle weakness and the combination of the two are commonly observed in patients on dialysis and may have a negative impact on their survival. In this systematic review and meta‐analysis (MA), we evaluated t…
View article: #2123 Impact of a plant-based food basket on uremic toxins, dietary patterns and carbon footprint in patients with chronic kidney disease
#2123 Impact of a plant-based food basket on uremic toxins, dietary patterns and carbon footprint in patients with chronic kidney disease Open
Background and Aims Plant-based diets (PBD) have been recommended to patients with chronic kidney disease (CKD) stages 3 to 5, due their potential metabolic benefits. Among these is the reduction in the production of uremic toxins by the g…
View article: Applicability of the Framingham Risk Score in predicting mortality among kidney failure patients: an international analysis
Applicability of the Framingham Risk Score in predicting mortality among kidney failure patients: an international analysis Open
Background The usefulness of the Framingham Risk Score (FRS) for estimation of mortality risk in kidney failure patients was explored in three cohorts of end-stage renal disease (ESRD) patients. Methods Associations of the FRS with mortali…
View article: Causal assessment of CKD-MBD biomarker alterations on CKD progression through a g-formula analysis in the EQUAL study
Causal assessment of CKD-MBD biomarker alterations on CKD progression through a g-formula analysis in the EQUAL study Open
Among older men and women with advanced CKD not receiving dialysis, the presence of hyperphosphatemia, especially when combined with hypocalcemia and hyperparathyroidism, leads to an increased risk of CKD progression.
View article: Water scarcity and conservation and their role in obesity in nature and in humans
Water scarcity and conservation and their role in obesity in nature and in humans Open
Increasing temperatures and water scarcity pose threats to animals living in the wild and humans. Here, we review biological mechanisms animals use to prevent dehydration. Fat and glycogen generate water during metabolism that can be used …
View article: Optimizing Mitochondrial Targeting With Bioactive Compounds: Dietary Pattern Considerations for Patients With Chronic Kidney Disease
Optimizing Mitochondrial Targeting With Bioactive Compounds: Dietary Pattern Considerations for Patients With Chronic Kidney Disease Open
Mitochondrial dysfunction plays a central role in chronic kidney disease (CKD) pathogenesis and progression. It is associated with inflammation, oxidative stress, and cellular senescence. In this regard, targeting the restoration of mitoch…
View article: Reduced mtDNA Copy Number Links to Vascular Calcification and Restores After Transplantation
Reduced mtDNA Copy Number Links to Vascular Calcification and Restores After Transplantation Open
Patients with chronic kidney disease (CKD) face an increased risk of early vascular aging, progressive vascular calcification, and premature death. With increasing age, mitochondrial function and mitochondrial DNA copy number (mtDNA-cn) de…
View article: Recurrent somatic mutation and progerin expression in early vascular aging of chronic kidney disease
Recurrent somatic mutation and progerin expression in early vascular aging of chronic kidney disease Open
Early vascular aging plays a central role in chronic kidney disease (CKD), but its molecular causes remain unclear. Somatic mutations accumulate in various cells with age, yet their functional contribution to aging tissues is not well unde…
View article: Leveraging pulse wave signal properties for coronary artery calcification screening in CKD patients
Leveraging pulse wave signal properties for coronary artery calcification screening in CKD patients Open
Pulse wave analysis combined with machine learning offers a promising, non-invasive method for preliminary CAC screening in CKD patients. This approach could enhance early risk identification and improve clinical management, although furth…
View article: The Exposome and the Kidney: A Silent Dialogue Shaping Chronic Kidney Disease
The Exposome and the Kidney: A Silent Dialogue Shaping Chronic Kidney Disease Open
Genetic predisposition accounts for less than 20% of the global disease burden, highlighting the substantial role of environmental factors in health outcomes. In chronic kidney disease (CKD), a growing global prevalence, understanding the …
View article: Trimethylamine N-Oxide (TMAO) Plasma Levels in Patients with Different Stages of Chronic Kidney Disease
Trimethylamine N-Oxide (TMAO) Plasma Levels in Patients with Different Stages of Chronic Kidney Disease Open
Background: In patients with chronic kidney disease (CKD), trimethylamine n-oxide (TMAO) accumulation exacerbates inflammation and contributes to oxidative stress. These complications are putatively linked to the development of cardiovascu…
View article: International Nephrology Masterclass in Chronic Kidney Disease: Rationale, Summary, and Future Perspectives
International Nephrology Masterclass in Chronic Kidney Disease: Rationale, Summary, and Future Perspectives Open
Chronic kidney disease (CKD) is a progressive condition that affects more than 10% of the population worldwide, accounting for more than 843 million (M) individuals. The prevalence of CKD (844 M patients) is higher than that of diabetes me…
View article: Vascular endothelial growth factor B-mediated fatty acid flux in the adipose-kidney axis contributes to lipotoxicity in diabetic kidney disease
Vascular endothelial growth factor B-mediated fatty acid flux in the adipose-kidney axis contributes to lipotoxicity in diabetic kidney disease Open
A common observation in diabetic kidney disease is lipid accumulation, but the mechanism(s) underlying this pathology is unknown. Inhibition of Vascular endothelial growth factor B (VEGF-B) signaling was shown to prevent glomerular lipid a…
View article: The Janus-faced nature of complement in hemodialysis: interplay between complement, inflammation, and bioincompatibility unveiling a self-amplifying loop contributing to organ damage
The Janus-faced nature of complement in hemodialysis: interplay between complement, inflammation, and bioincompatibility unveiling a self-amplifying loop contributing to organ damage Open
In hemodialysis (HD), complement activation, bioincompatibility, and inflammation are intricately intertwined. In the 1970s, as HD became a routine therapy, the observation of complement pathway activation and transient leukopenia by cellu…
View article: Early vascular aging in chronic kidney disease: focus on microvascular maintenance, senescence signature and potential therapeutics
Early vascular aging in chronic kidney disease: focus on microvascular maintenance, senescence signature and potential therapeutics Open
Chronic kidney disease (CKD) is a strong risk factor for cardiovascular mortality and morbidity. We hypothesized that a senescent phenotype instigated by uremic toxins could account for early vascular aging (EVA) and vascular dysfunctions …
View article: Prediction of gastrointestinal bleeding hospitalization risk in hemodialysis using machine learning
Prediction of gastrointestinal bleeding hospitalization risk in hemodialysis using machine learning Open
Background Gastrointestinal bleeding (GIB) is a clinical challenge in kidney failure. INSPIRE group assessed if machine learning could determine a hemodialysis (HD) patient’s 180-day GIB hospitalization risk. Methods An eXtreme Gradient Bo…
View article: Proceedings of a membrane update symposium: advancements, scientific insights, and future trends for dialysis membranes for enhanced clinical outcomes in end stage kidney disease patients
Proceedings of a membrane update symposium: advancements, scientific insights, and future trends for dialysis membranes for enhanced clinical outcomes in end stage kidney disease patients Open
Purpose of symposium From September 6 – 8 2022, the Life/2022 Membrane Symposium was held in Frankfurt, Germany, and transmitted live to a worldwide internet audience. The event was part of the Life/Nephrology Campus initiative, a continuo…
View article: Effects of Propolis Supplementation on Gut Microbiota and Uremic Toxin Profiles of Patients Undergoing Hemodialysis
Effects of Propolis Supplementation on Gut Microbiota and Uremic Toxin Profiles of Patients Undergoing Hemodialysis Open
Background: Propolis possesses many bioactive compounds that could modulate the gut microbiota and reduce the production of uremic toxins in patients with chronic kidney disease (CKD) undergoing hemodialysis (HD). This clinical trial aimed…
View article: Protein Intake and Mortality in Older Adults With Chronic Kidney Disease
Protein Intake and Mortality in Older Adults With Chronic Kidney Disease Open
Importance Avoiding high protein intake in older adults with chronic kidney disease (CKD) may reduce the risk of kidney function decline, but whether it can be suboptimal for survival is not well known. Objective To estimate the associatio…
View article: ERA 2024 Interview: Peter Stenvinkel
ERA 2024 Interview: Peter Stenvinkel Open
recognised you as the world's 13 th most influential nephrologist.Following your initial medical training, what led you to pursue a career in nephrology?To be honest, it was the only place I got a job.But when I started to work in nephrolo…