Peter Stroeken
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View article: Data from Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors
Data from Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors Open
Cancer therapy frequently fails due to the emergence of resistance. Many tumors include phenotypically immature tumor cells, which have been implicated in therapy resistance. Neuroblastoma cells can adopt a lineage-committed adrenergic (AD…
View article: Supplementary Data from Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors
Supplementary Data from Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors Open
Supplementary Data from Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors
View article: Supplementary Data from Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors
Supplementary Data from Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors Open
Supplementary Data from Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors
View article: Supplementary Data from Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors
Supplementary Data from Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors Open
Supplementary Data from Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors
View article: Supplementary Data from Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors
Supplementary Data from Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors Open
Supplementary Data from Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors
View article: Data from Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors
Data from Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors Open
Cancer therapy frequently fails due to the emergence of resistance. Many tumors include phenotypically immature tumor cells, which have been implicated in therapy resistance. Neuroblastoma cells can adopt a lineage-committed adrenergic (AD…
View article: Supplementary Figures S1-S5 from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma
Supplementary Figures S1-S5 from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma Open
Supplementary Figures S1-S5 PDF file - 807K, Baseline FACS data to Figure 3b (S1); Total FOXO3a and phosphorylated FOXO3a levels correlate with apoptosis across a cell line panel following MK-2206 treatment (S2); Genes regulated by PI3K/AK…
View article: Supplementary Figure and Table Legends from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma
Supplementary Figure and Table Legends from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma Open
Supplementary Figure and Table Legends PDF file - 63K, Legend for Supplementary Figures S1-S5 and Supplementary Table S1
View article: Supplementary Methods from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma
Supplementary Methods from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma Open
Supplementary Methods PDF file - 114K, Includes Lentiviral constructs, Western blotting & Cell fractionation, Luciferase constructs & reporter assay, Cell Viability Assay, Microarray profiling, and TFBS enrichment analysis. Also includes S…
View article: Data from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma
Data from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma Open
Neuroblastoma is a pediatric tumor of the peripheral sympathetic nervous system with a highly variable prognosis. Activation of the phosphoinositide 3-kinase (PI3K)/AKT pathway in neuroblastoma is correlated with poor patient prognosis, bu…
View article: Supplementary Table S1 from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma
Supplementary Table S1 from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma Open
Supplementary Table S1 XLS file - 186K, Genes regulated in the SY5Y microarray experiments
View article: Supplementary Methods from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma
Supplementary Methods from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma Open
Supplementary Methods PDF file - 114K, Includes Lentiviral constructs, Western blotting & Cell fractionation, Luciferase constructs & reporter assay, Cell Viability Assay, Microarray profiling, and TFBS enrichment analysis. Also includes S…
View article: Supplementary Figure and Table Legends from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma
Supplementary Figure and Table Legends from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma Open
Supplementary Figure and Table Legends PDF file - 63K, Legend for Supplementary Figures S1-S5 and Supplementary Table S1
View article: Supplementary Figures S1-S5 from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma
Supplementary Figures S1-S5 from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma Open
Supplementary Figures S1-S5 PDF file - 807K, Baseline FACS data to Figure 3b (S1); Total FOXO3a and phosphorylated FOXO3a levels correlate with apoptosis across a cell line panel following MK-2206 treatment (S2); Genes regulated by PI3K/AK…
View article: Supplementary Table S1 from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma
Supplementary Table S1 from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma Open
Supplementary Table S1 XLS file - 186K, Genes regulated in the SY5Y microarray experiments
View article: Data from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma
Data from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma Open
Neuroblastoma is a pediatric tumor of the peripheral sympathetic nervous system with a highly variable prognosis. Activation of the phosphoinositide 3-kinase (PI3K)/AKT pathway in neuroblastoma is correlated with poor patient prognosis, bu…
View article: <scp>FOXO3A</scp>‐short is a novel regulator of non‐oxidative glucose metabolism associated with human longevity
<span>FOXO3A</span>‐short is a novel regulator of non‐oxidative glucose metabolism associated with human longevity Open
Intronic single‐nucleotide polymorphisms (SNPs) in FOXO3A are associated with human longevity. Currently, it is unclear how these SNPs alter FOXO3A functionality and human physiology, thereby influencing lifespan. Here, we identify a prima…
View article: Correction: Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors
Correction: Mesenchymal-Type Neuroblastoma Cells Escape ALK Inhibitors Open
In the original version of this article (1), there was an issue in Fig. 2B. Specifically, some of the Western blot bands showing expression of DBH, DLK1, PRRX1, SNAI2, and β-actin in the 691-MES/691-ADRN and SH-EP2/SH-SY5Y isogenic neurobl…
View article: An immature subset of neuroblastoma cells synthesizes retinoic acid and depends on this metabolite
An immature subset of neuroblastoma cells synthesizes retinoic acid and depends on this metabolite Open
Neuroblastoma is a pediatric tumor of the adrenergic sympathetic lineage. Most high risk neuroblastoma go in complete clinical remission by chemotherapy, which is subsequently complemented by retinoic acid (RA) maintenance therapy. However…
View article: A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma
A NOTCH feed-forward loop drives reprogramming from adrenergic to mesenchymal state in neuroblastoma Open
Transition between differentiation states in development occurs swift but the mechanisms leading to epigenetic and transcriptional reprogramming are poorly understood. The pediatric cancer neuroblastoma includes adrenergic (ADRN) and mesen…
View article: FOXO3A-Short is a Novel Regulator of Non-Oxidative Glucose Metabolism Associated with Human Longevity
FOXO3A-Short is a Novel Regulator of Non-Oxidative Glucose Metabolism Associated with Human Longevity Open