Peter D. Sun
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Vaccination protects against COVID-associated pulmonary fibrin deposition Open
Understanding the protective mechanism of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines against severe COVID is important for therapeutic development to mitigate disease-associated lung pathologies. Here, we investi…
Identification and structural characterization of a mutant KRAS‐G12V specific TCR restricted by HLA‐A3 Open
Mutations in KRAS are some of the most common across multiple cancer types and are thus attractive targets for therapy. Recent studies demonstrated that mutant KRAS generates immunogenic neoantigens that are targetable by adoptive T‐cell t…
View article: Inhibition of HIV-1 release by ADAM metalloproteinase inhibitors
Inhibition of HIV-1 release by ADAM metalloproteinase inhibitors Open
HIV-1 gp120 glycan binding to C-type lectin adhesion receptor L-selectin/CD62L on CD4 T cells facilitates viral attachment and entry. Paradoxically, the adhesion receptor impedes HIV-1 budding from infected T cells and the viral release re…
Identification and Structural Characterization of a mutant KRAS-G12V specific TCR restricted by HLA-A3 Open
Summary Mutations in KRAS are some of the most common across multiple cancer types and are thus attractive targets for therapy. Recent studies demonstrated that mutant KRAS generates immunogenic neoantigens that can be targeted in adoptive…
The solution structure of the unbound IgG Fc receptor CD64 resembles its crystal structure: Implications for function Open
FcγRI (CD64) is the only high-affinity Fcγ receptor found on monocytes, macrophages, eosinophils, neutrophils and dendritic cells. It binds immunoglobulin G (IgG) antibody-antigen complexes at its Fc region to trigger key immune responses.…
306 Long-Term Appearance and Outcomes after Strip Craniectomy Compared with Open Cranial Vault Reconstruction for Sagittal Craniosynostosis Open
OBJECTIVES/GOALS: Strip craniectomy with orthotic helmet therapy (SCOT) and open cranial vault reconstruction (OCVR) are mainstay surgical treatments for sagittal craniosynostosis. The purpose of this study is to compare long-term morpholo…
HIV-1 release requires Nef-induced caspase activation Open
HIV infection remains incurable to date and there are no compounds targeted at the viral release. We show here HIV viral release is not spontaneous, rather requires caspases activation and shedding of its adhesion receptor, CD62L. Blocking…
FcγRI FG-loop functions as a pH sensitive switch for IgG binding and release Open
Understanding the molecular mechanism underlying the hierarchic binding between FcγRs and IgG antibodies is critical for therapeutic antibody engineering and FcγR functions. The recent determination of crystal structures of FcγRI-Fc comple…
Innate receptors with high specificity for HLA class I–peptide complexes Open
Summary Genetic studies associate killer-cell immunoglobulin-like receptors (KIR) and their HLA class I ligands with a variety of human diseases. The basis for these associations, and the relative contribution of inhibitory and activating …
MHC-independent αβT cells: Lessons learned about thymic selection and MHC-restriction Open
Understanding the generation of an MHC-restricted T cell repertoire is the cornerstone of modern T cell immunology. The unique ability of αβT cells to only recognize peptide antigens presented by MHC molecules but not conformational antige…
T cells discriminate between groups C1 and C2 HLA-C Open
Dimorphic amino acids at positions 77 and 80 delineate HLA-C allotypes into two groups, C1 and C2, which associate with disease through interactions with C1 and C2-specific natural killer cell receptors. How the C1/C2 dimorphism affects T …
Analyzing Impact of Dependency Injection on Software Maintainability Open
Dependency injection (DI) is generally known to improve maintainability by keeping application classes separate from the library. Particularly within the Java environment, there are many applications using the principles of DI with the aim…
Author response: T cells discriminate between groups C1 and C2 HLA-C Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Dimorphic amino acids …
T Cell Recognition of Tumor Neoantigens and Insights Into T Cell Immunotherapy Open
In cancer, non-synonymous DNA base changes alter protein sequence and produce neoantigens that are detected by the immune system. For immune detection, neoantigens must first be presented on class I or II human leukocyte antigens (HLA) fol…
T cells discriminate between groups C1 and C2 HLA-C Open
Dimorphic residues at positions 77 and 80 delineate HLA-C allotypes into two groups, C1 and C2, which associate with disease through interactions with C1 and C2-specific natural killer cell receptors. How the C1/C2 dimorphism affects T cel…
The Role of L-Selectin in HIV Infection Open
HIV envelope glycoprotein is the most heavily glycosylated viral protein complex identified with over 20 glycans on its surface. This glycan canopy is thought to primarily shield the virus from host immune recognition as glycans are poor i…
<i>Plasmodium falciparum</i> –specific IgM B cells dominate in children, expand with malaria, and produce functional IgM Open
IgG antibodies play a role in malaria immunity, but whether and how IgM protects from malaria and the biology of Plasmodium falciparum (Pf)–specific IgM B cells is unclear. In a Mali cohort spanning infants to adults, we conducted longitud…
High affinity binding of SARS-CoV-2 spike protein enhances ACE2 carboxypeptidase activity Open
The novel severe acute respiratory syndrome coronavirus (SARS-CoV-2) has emerged to a pandemic and caused global public health crisis. Human angiotensin-converting enzyme 2(ACE2) was identified as the entry receptor for SARS-CoV-2. As a ca…
High affinity binding of SARS-CoV-2 spike protein enhances ACE2 carboxypeptidase activity Open
A novel coronavirus (SARS-CoV-2) has emerged to a global pandemic and caused significant damages to public health. Human angiotensin-converting enzyme 2(ACE2) was identified as the entry receptor for SARS-CoV-2. As a carboxypeptidase, ACE2…
Novel MHC-Independent αβTCRs Specific for CD48, CD102, and CD155 Self-Proteins and Their Selection in the Thymus Open
MHC-independent αβTCRs (TCRs) recognize conformational epitopes on native self-proteins and arise in mice lacking both MHC and CD4/CD8 coreceptor proteins. Although naturally generated in the thymus, these TCRs resemble re-engineered thera…
High-affinity oligoclonal TCRs define effective adoptive T cell therapy targeting mutant KRAS-G12D Open
Complete cancer regression occurs in a subset of patients following adoptive T cell therapy (ACT) of ex vivo expanded tumor-infiltrating lymphocytes (TILs). However, the low success rate presents a great challenge to broader clinical appli…
Structure of MHC-Independent TCRs and Their Recognition of Native Antigen CD155 Open
During normal T cell development in the thymus, αβ TCRs signal immature thymocytes to differentiate into mature T cells by binding to peptide–MHC ligands together with CD4/CD8 coreceptors. Conversely, in MHC and CD4/CD8 coreceptor-deficien…
Human NK cell receptor KIR2DS4 detects a conserved bacterial epitope presented by HLA-C Open
Significance Natural killer (NK) cells are known for their role in defense against viruses and cancer. Their activity is regulated, in part, by killer cell immunoglobulin-like receptors (KIRs) that bind to polymorphic human leukocyte antig…
HLA-C-restricted presentation of a conserved bacterial epitope to an innate NK cell receptor Open
The killer-cell Ig-like receptor (KIR) family, expressed mainly in natural killer (NK) cells, includes an activation receptor of unknown function, KIR2DS4. Here we show that KIR2DS4 is restricted by HLA-C*05:01 with a strong preference for…
Helios <sup>+</sup> and Helios <sup>−</sup> Treg subpopulations are phenotypically and functionally distinct and express dissimilar TCR repertoires Open
The transcription factor Helios is expressed in a large subset of Foxp3 + Tregs. We previously proposed that Helios is a marker of thymic derived Treg (tTreg), while Helios − Treg were induced from Foxp3 − T conventional (Tconv) cells in t…
Pentraxins and Fc Receptor-Mediated Immune Responses Open
C-reactive protein (CRP) is a member of the pentraxin family of proteins. These proteins are highly conserved over the course of evolution being present as far back as 250 million years ago. Mammalian pentraxins are characterized by the pr…