Peter T. Tsai
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View article: Cerebellar contributions to tau-mediated cognitive and behavioral dysfunction
Cerebellar contributions to tau-mediated cognitive and behavioral dysfunction Open
Dementia is characterized by loss of cognitive function, social deficits, and emotional impairment and is prevalent in tau-mediated disorders. However, the mechanisms underlying this cognitive and behavioral dysfunction remain uncertain, a…
View article: Neuronal cell type specific roles for Nprl2 in neurodevelopmental disorder-relevant behaviors
Neuronal cell type specific roles for Nprl2 in neurodevelopmental disorder-relevant behaviors Open
Loss of function in the subunits of the GTPase-activating protein (GAP) activity toward Rags-1 (GATOR1) complex, an amino-acid sensitive negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), is implicated in both ge…
View article: Cerebellar contribution to autism-relevant behaviors in fragile X syndrome models
Cerebellar contribution to autism-relevant behaviors in fragile X syndrome models Open
Cerebellar dysfunction has been linked to autism spectrum disorders (ASDs). Although cerebellar pathology has been observed in individuals with fragile X syndrome (FXS) and in mouse models of the disorder, a cerebellar functional contribut…
View article: Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity
Synaptic BMAL1 phosphorylation controls circadian hippocampal plasticity Open
The time of day strongly influences adaptive behaviors like long-term memory, but the correlating synaptic and molecular mechanisms remain unclear. The circadian clock comprises a canonical transcription-translation feedback loop (TTFL) st…
View article: Electroencephalographic (EEG) Biomarkers in Genetic Neurodevelopmental Disorders
Electroencephalographic (EEG) Biomarkers in Genetic Neurodevelopmental Disorders Open
Collectively, neurodevelopmental disorders are highly prevalent, but more than a third of neurodevelopmental disorders have an identifiable genetic etiology, each of which is individually rare. The genes associated with neurodevelopmental …
View article: Increased glycine contributes to synaptic dysfunction and early mortality in Nprl2 seizure model
Increased glycine contributes to synaptic dysfunction and early mortality in Nprl2 seizure model Open
View article: Adaptive Prediction for Social Contexts: The Cerebellar Contribution to Typical and Atypical Social Behaviors
Adaptive Prediction for Social Contexts: The Cerebellar Contribution to Typical and Atypical Social Behaviors Open
Social interactions involve processes ranging from face recognition to understanding others’ intentions. To guide appropriate behavior in a given context, social interactions rely on accurately predicting the outcomes of one's actions and …
View article: Cerebellar Dysfunction in Autism Spectrum Disorders: Deriving Mechanistic Insights from an Internal Model Framework
Cerebellar Dysfunction in Autism Spectrum Disorders: Deriving Mechanistic Insights from an Internal Model Framework Open
View article: Regulation of autism-relevant behaviors by cerebellar–prefrontal cortical circuits
Regulation of autism-relevant behaviors by cerebellar–prefrontal cortical circuits Open
View article: <scp>TLR</scp>3 agonism re‐establishes <scp>CNS</scp> immune competence during <i>α</i>4‐integrin deficiency
<span>TLR</span>3 agonism re‐establishes <span>CNS</span> immune competence during <i>α</i>4‐integrin deficiency Open
Objective Natalizumab blocks α 4‐integrin‐mediated leukocyte migration into the central nervous system ( CNS ). It diminishes disease activity in multiple sclerosis ( MS ), but carries a high risk of progressive multifocal encephalopathy (…
View article: Sensitive Periods for Cerebellar-Mediated Autistic-like Behaviors
Sensitive Periods for Cerebellar-Mediated Autistic-like Behaviors Open
Despite a prevalence exceeding 1%, mechanisms underlying autism spectrum disorders (ASDs) are poorly understood, and targeted therapies and guiding parameters are urgently needed. We recently demonstrated that cerebellar dysfunction is suf…
View article: Aberrant Proteostasis of BMAL1 Underlies Circadian Abnormalities in a Paradigmatic mTOR-opathy
Aberrant Proteostasis of BMAL1 Underlies Circadian Abnormalities in a Paradigmatic mTOR-opathy Open
View article: Prostate Bed Stereotactic Body Radiation Therapy (PB-SBRT) for Postprostatectomy Biochemical Recurrence: First Toxicity Results of a Phase 1 Dose-Escalation Trial
Prostate Bed Stereotactic Body Radiation Therapy (PB-SBRT) for Postprostatectomy Biochemical Recurrence: First Toxicity Results of a Phase 1 Dose-Escalation Trial Open
View article: Reversal of neurobehavioral social deficits in dystrophic mice using inhibitors of phosphodiesterases PDE5A and PDE9A
Reversal of neurobehavioral social deficits in dystrophic mice using inhibitors of phosphodiesterases PDE5A and PDE9A Open
View article: The Role of the Pediatric Cerebellum in Motor Functions, Cognition, and Behavior
The Role of the Pediatric Cerebellum in Motor Functions, Cognition, and Behavior Open
View article: The role of cerebellar circuitry alterations in the pathophysiology of autism spectrum disorders
The role of cerebellar circuitry alterations in the pathophysiology of autism spectrum disorders Open
The cerebellum has been repeatedly implicated in gene expression, rodent model and post-mortem studies of autism spectrum disorder (ASD). How cellular and molecular anomalies of the cerebellum relate to clinical manifestations of ASD remai…
View article: Cerebellar associative sensory learning defects in five mouse autism models
Cerebellar associative sensory learning defects in five mouse autism models Open
Sensory integration difficulties have been reported in autism, but their underlying brain-circuit mechanisms are underexplored. Using five autism-related mouse models, Shank3+/ΔC, Mecp2R308/Y, Cntnap2−/−, L7-Tsc1 (L7/Pcp2Cre::Tsc1flox/+), …
View article: Author response: Cerebellar associative sensory learning defects in five mouse autism models
Author response: Cerebellar associative sensory learning defects in five mouse autism models Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract Sensory integration difficulties have been repo…