Peter Taggart
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Psychological stress, the central nervous system and arrhythmias Open
Summary This review highlights the links between psychological stress and the neurocircuitry of cardiac–brain interactions leading to arrhythmias. The role of efferent and afferent connections in the heart–brain axis is considered, with th…
Time-Averaged Wavefront Analysis Demonstrates Preferential Pathways of Atrial Fibrillation, Predicting Pulmonary Vein Isolation Acute Response Open
Electrical activation during atrial fibrillation (AF) appears chaotic and disorganised, which impedes characterisation of the underlying substrate and treatment planning. While globally chaotic, there may be local preferential activation p…
Emerging evidence for a mechanistic link between low-frequency oscillation of ventricular repolarization measured from the electrocardiogram T-wave vector and arrhythmia Open
Strong recent clinical evidence links the presence of prominent oscillations of ventricular repolarization in the low-frequency range (0.04–0.15 Hz) to the incidence of ventricular arrhythmia and sudden death in post-MI patients and patien…
Editorial: Neurocardiac Oscillation in Repolarization and Cardiac Arrhythmias Open
EDITORIAL article Front. Physiol., 27 October 2020 | https://doi.org/10.3389/fphys.2020.604950
Complex Interaction Between Low-Frequency APD Oscillations and Beat-to-Beat APD Variability in Humans Is Governed by the Sympathetic Nervous System Open
Beta-adrenergic blockade reduces LF oscillatory behavior of APD (ARI) in humans in vivo. Our results support the importance of LF oscillations in modulating the response of BVR to beta-adrenergic blockers, suggesting that LF oscillations m…
View article: Evaluation of the reentry vulnerability index to predict ventricular tachycardia circuits using high-density contact mapping
Evaluation of the reentry vulnerability index to predict ventricular tachycardia circuits using high-density contact mapping Open
RVI identifies vulnerable regions closest to VT sites of origin. Activation-repolarization metrics may improve VT substrate delineation and inform novel ablation strategies.
Cardiac Response to Live Music Performance: Computing Techniques for Feature Extraction and Analysis Open
Strong emotions and mental stress have been linked to potentially deadly arrhythmias. Music evokes strong emotion through the regulation of tension and release and the modulation of changes and transitions. We exploit this in a novel study…
Mechanisms Underlying Interactions Between Low-Frequency Oscillations and Beat-to-Beat Variability of Celullar Ventricular Repolarization in Response to Sympathetic Stimulation: Implications for Arrhythmogenesis Open
Background and Objectives: Enhanced beat-to-beat variability of ventricular repolarization (BVR) has been linked to arrhythmias and sudden cardiac death. Recent experimental studies on human left ventricular epicardial electrograms have sh…
View article: Autonomic modulation of the electrical substrate in mice haploinsufficient for cardiac sodium channels: a model of the Brugada syndrome
Autonomic modulation of the electrical substrate in mice haploinsufficient for cardiac sodium channels: a model of the Brugada syndrome Open
A murine line haploinsufficient in the cardiac sodium channel has been used to model human Brugada syndrome: a disease causing sudden cardiac death due to lethal ventricular arrhythmias. We explored the effects of cholinergic tone on elect…
Early Results on the Utilisation of ECG-Imaging During Catheter Ablation Procedures for Prediction of Sites of Earliest Activation During Re-entrant Ventricular Tachycardia Open
Success rate of ventricular tachycardia (VT) ablation remains sub-optimal.Current technology does not allow fast and accurate delineation of the ablation target.Noninvasive panoramic ECG-imaging (ECGI) offers the possibility of studying th…
Optimization of a Novel Activation-Repolarization Metric to Identify Targets for Catheter Ablation Open
Identification of targets for catheter ablation of arrhythmias remains a significant challenge. Traditional mapping techniques often neglect the tissue repolarization, hampering the detection of pro-arrhythmic regions. We have recently dev…
Evaluation of Multilead ECG Markers to Track Changes in Dispersion of Ventricular Repolarization in the Intact Human Heart Open
Dispersion of ventricular repolarization (DRT) is an important factor contributing to the vulnerability to life-threatening arrhythmias.An accurate non-invasive methodology for its estimation would contribute to improve risk-prediction.We …
Sequential Electro-Anatomical Mapping Methodology and Preliminary Results for Reentry Vulnerability Index Estimation Open
Ventricular tachycardia (VT) recurrence after catheter ablation remains frequent and improved ablation strategies are needed. The re-entry vulnerability index (RVI) is an activation-repolarization marker to localize critical sites for VT i…
Unraveling the Underlying Arrhythmia Mechanism in Persistent Atrial Fibrillation Open
Background: The mechanisms that initiate and sustain persistent atrial fibrillation are not well characterized. Ablation results remain significantly worse than in paroxysmal atrial fibrillation in which the mechanism is better understood …
Assessment of a conduction-repolarisation metric to predict Arrhythmogenesis in right ventricular disorders Open
RVI reliably identifies the earliest RV endocardial activation site of VT in BrS and ARVC but not focal ventricular arrhythmias and predicts the incidence of haemodynamically significant arrhythmias. Therefore, RVI may be of value in predi…
<i>In vivo</i> human sock‐mapping validation of a simple model that explains unipolar electrogram morphology in relation to conduction‐repolarization dynamics Open
Introduction The unipolar electrogram (UEG) provides local measures of cardiac activation and repolarization and is an important translational link between patient and laboratory. A simple theoretical model of the UEG was previously propos…
View article: Beat-to-Beat Variability of Ventricular Action Potential Duration Oscillates at Low Frequency During Sympathetic Provocation in Humans
Beat-to-Beat Variability of Ventricular Action Potential Duration Oscillates at Low Frequency During Sympathetic Provocation in Humans Open
Background: The temporal pattern of ventricular repolarization is of critical importance in arrhythmogenesis. Enhanced beat-to-beat variability (BBV) of ventricular action potential duration (APD) is pro-arrhythmic and is increased during …
Spatio-temporal Organization During Ventricular Fibrillation in the Human Heart Open
In this paper, we present a novel approach to quantify the spatio-temporal organization of electrical activation during human ventricular fibrillation (VF). We propose three different methods based on correlation analysis, graph theoretica…
Optimisation of the Global Re-entry Vulnerability Index to Minimise Cycle Length Dependency and Prediction of Ventricular Arrhythmias During Human Epicardial Sock Mapping Open
The re-entry vulnerability index (RVI) is an activationrepolarization marker recently proposed to predict sites of ventricular tachycardia (VT) initiation.RVI is inversely related to the probability of establishing a re-entry.The aim of th…
P268Novel repolarisation metric predicts arrhythmia origin and clinical events in ARVC and Brugada Syndrome Open
Background: Excessive supraventricular ectopic activity (ESEA) can represent a focus which is able to fire and initiate paroxysms of atrial fibrillation (AF).Therefore, early recognition of ESEA can be useful to prevent stroke and transien…
32 Global high density mapping of re-entry vulnerability index aids risk stratification and identifies sites of arrhythmia initiation in brugada syndrome and arvc Open
Introduction Initiation of reentrant ventricular tachycardia (VT) involves complex interactions between activation (AT) and repolarization times (RT). Recently, an algorithm has been developed to generate a spatial map (designated the re-e…
Autonomic Modulation in Patients with Heart Failure Increases Beat-to-Beat Variability of Ventricular Action Potential Duration Open
Background: Exaggerated beat-to-beat variability of ventricular action potential duration (APD) is linked to arrhythmogenesis. Sympathetic stimulation has been shown to increase QT interval variability, but its effect on ventricular APD in…
Novel Repolarisation Metric Predicts Arrhythmia Origin And Clinical Events In ARVC And Brugada Syndrome Open
Background: Initiation of re-entrant ventricular tachycardia (VT) involves complex interactions between activation (AT) and repolarization times (RT). The re-entry vulnerability index (RVI) is a recently proposed activation-repolarization …
Spatiotemporal characterization of the transition from sinus rhythm to ventricular fibrillation during an acute ischemic event in the intact human heart by whole-heart sock-mapping Open
The accurate characterization of the spatiotemporal pattern of electrical activation and repolarization during ischemia is relevant for diagnosis and sudden cardiac death prediction. Although several animal studies have comprehensively des…