Peter Thalmann
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View article: 3D X-ray Histology for the Investigation of Temporal Lobe Epilepsy in a Mouse Model
3D X-ray Histology for the Investigation of Temporal Lobe Epilepsy in a Mouse Model Open
The most common form of epilepsy among adults is mesial temporal lobe epilepsy (mTLE), with seizures often originating in the hippocampus due to abnormal electrical activity. The gold standard for the histopathological analysis of mTLE is …
View article: Sensitivity comparison of absorption and grating-based phase tomography of paraffin-embedded human brain tissue
Sensitivity comparison of absorption and grating-based phase tomography of paraffin-embedded human brain tissue Open
Advances in high-resolution hard X-ray computed tomography have led to the field of virtual histology to complement histopathological analyses. Phase-contrast modalities have been favored because, for soft tissues, the real part of the ref…
View article: Hard X-ray Nano-Holotomography of Formalin-Fixated and Paraffin-Embedded Human Brain Tissue
Hard X-ray Nano-Holotomography of Formalin-Fixated and Paraffin-Embedded Human Brain Tissue Open
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View article: Propagation-based X-ray Phase Contrast Microtomography of Zebrafish Embryos to Understand Drug Delivery
Propagation-based X-ray Phase Contrast Microtomography of Zebrafish Embryos to Understand Drug Delivery Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: Volumetric Nanoscale Imaging: Hard X‐Ray Nanoholotomography: Large‐Scale, Label‐Free, 3D Neuroimaging beyond Optical Limit (Adv. Sci. 6/2018)
Volumetric Nanoscale Imaging: Hard X‐Ray Nanoholotomography: Large‐Scale, Label‐Free, 3D Neuroimaging beyond Optical Limit (Adv. Sci. 6/2018) Open
In article number https://doi.org/10.1002/advs.201700694, Bert Müller and co‐workers launch nano‐holotomography for the isotropic 3D imaging of paraffin‐embedded human brain tissues. Nano‐holotomography bridges the spatial resolution gap b…
View article: Hard X‐Ray Nanoholotomography: Large‐Scale, Label‐Free, 3D Neuroimaging beyond Optical Limit
Hard X‐Ray Nanoholotomography: Large‐Scale, Label‐Free, 3D Neuroimaging beyond Optical Limit Open
There have been great efforts on the nanoscale 3D probing of brain tissues to image subcellular morphologies. However, limitations in terms of tissue coverage, anisotropic resolution, stain dependence, and complex sample preparation all hi…
View article: Implementation of a double-grating interferometer for phase-contrast computed tomography in a conventional system nanotom® m
Implementation of a double-grating interferometer for phase-contrast computed tomography in a conventional system nanotom® m Open
Visualizing the internal architecture of large soft tissue specimens within the laboratory environment in a label-free manner is challenging, as the conventional absorption-contrast tomography yields a poor contrast. In this communication,…
View article: Three-dimensional imaging and analysis of entire peripheral nerves after repair and reconstruction
Three-dimensional imaging and analysis of entire peripheral nerves after repair and reconstruction Open
We have presented a potential way for 3D imaging and analysis of entire regenerated nerves non-destructively, paving the way for high-throughput analysis of therapeutic conditions of treating adult nerve injuries.
View article: Three-dimensional and non-destructive characterization of nerves inside conduits using laboratory-based micro computed tomography
Three-dimensional and non-destructive characterization of nerves inside conduits using laboratory-based micro computed tomography Open
We demonstrate the potential of the micro computed tomography for non-destructive monitoring of peripheral nerves inside the conduits.
View article: Removing ring artefacts from synchrotron radiation-based hard x-ray tomography data
Removing ring artefacts from synchrotron radiation-based hard x-ray tomography data Open
In hard X-ray microtomography, ring artefacts regularly originate from improperly functioning pixel elements on the detector or from particles and scratches on the scintillator. We show that due to the high sensitivity of contemporary beam…
View article: Hard X-ray submicrometer tomography of human brain tissue at Diamond Light Source
Hard X-ray submicrometer tomography of human brain tissue at Diamond Light Source Open
There is a lack of the necessary methodology for three-dimensional (3D) investigation of soft tissues with cellular resolution without staining or tissue transformation. Synchrotron radiation based hard X-ray in-line phase contrast tomogra…
View article: Multimodal imaging of the human knee down to the cellular level
Multimodal imaging of the human knee down to the cellular level Open
Computed tomography reaches the best spatial resolution for the three-dimensional visualization of human tissues among the available nondestructive clinical imaging techniques. Nowadays, sub-millimeter voxel sizes are regularly obtained. R…
View article: Hard X-ray phase tomography for brain tissue imaging
Hard X-ray phase tomography for brain tissue imaging Open
Phase tomography based on hard X-ray double-grating interferometry (XDGI) is a well-established imaging technique for the three-dimensional visualization of soft tissues, providing tomograms with superior contrast. The experimental setup c…
View article: Mineralization of Early Stage Carious Lesions In Vitro—A Quantitative Approach
Mineralization of Early Stage Carious Lesions In Vitro—A Quantitative Approach Open
Micro computed tomography has been combined with dedicated data analysis for the in vitro quantification of sub-surface enamel lesion mineralization. Two artificial white spot lesions, generated on a human molar crown in vitro, were examin…