Peter Tyrer
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View article: Trajectory of severe COVID anxiety and predictors for recovery in an 18-month UK cohort
Trajectory of severe COVID anxiety and predictors for recovery in an 18-month UK cohort Open
Background People with severe COVID anxiety have significant fears of contagion, physiological symptoms of anxiety in response to a COVID stimulus and employ often disproportionate safety behaviours at the expense of other life priorities.…
View article: Colin Godber, MD, FRCPsych, FRCP, OBE
Colin Godber, MD, FRCPsych, FRCP, OBE Open
View article: A systematic environmental intervention, nidotherapy, given to whole communities: protocol for a randomised stepped-wedge trial
A systematic environmental intervention, nidotherapy, given to whole communities: protocol for a randomised stepped-wedge trial Open
Background Environmental changes can be positive in mental illness. Systematic, planned and guided environmental change in all its aspects is called nidotherapy. It has shown some benefit but has not been extended to whole communities. Aim…
View article: Factors Predisposing to the Onset of Bipolar Disorder: A 30‐Year Longitudinal Study
Factors Predisposing to the Onset of Bipolar Disorder: A 30‐Year Longitudinal Study Open
Objective To examine the factors that predict the development of bipolar disorder in a population presenting with anxiety and depressive disorders. Method In a 30‐year study, the Nottingham Study of Neurotic Disorder, the personality statu…
View article: Personality in the spotlight: activities of the <scp>WPA</scp> Section on Personality Disorders
Personality in the spotlight: activities of the <span>WPA</span> Section on Personality Disorders Open
View article: Sleep Disturbance in People <scp>w</scp> ith Anxiety or Depressive Disorders <scp>o</scp> ver 30 Years, and the Influence <scp>o</scp> f Personality Disorder
Sleep Disturbance in People <span>w</span> ith Anxiety or Depressive Disorders <span>o</span> ver 30 Years, and the Influence <span>o</span> f Personality Disorder Open
This study demonstrates the complex interplay between anxiety, depressive, and personality disorders and sleep disturbance over a long follow-up period. Future research might look to examine the relationship between personality disorder an…
View article: Establishing the relationship between history of childhood trauma and personality disorder using the ICD‐11 classification system
Establishing the relationship between history of childhood trauma and personality disorder using the ICD‐11 classification system Open
The temporal relationship between childhood trauma and personality status using the ICD‐11 classification was examined in 75 adults (65%F) aged between 19 and 72 selected by constrained procedure to ensure the full range of personality dis…
View article: Eugene (Gene) Stern Paykel, MD, FRCPsych, FAcadMedSci
Eugene (Gene) Stern Paykel, MD, FRCPsych, FAcadMedSci Open
View article: The problem with borderline personality disorder
The problem with borderline personality disorder Open
View article: The benefits and hazards of psychodrama in the management of mental illness: qualitative study linked to nidotherapy
The benefits and hazards of psychodrama in the management of mental illness: qualitative study linked to nidotherapy Open
Drama therapy is a popular form of management in mental illness, as it reaches out beyond many other therapies. Few studies have examined both the advantages and disadvantages of this medium. This qualitative study examines both, and finds…
View article: Sleep disturbance in people with anxiety or depressive disorders over 30 years, and the influence of personality disorder
Sleep disturbance in people with anxiety or depressive disorders over 30 years, and the influence of personality disorder Open
Objectives Sleep disturbance is commonly reported by people with anxiety, depressive and personality disorders, but longitudinal studies exploring the interplay of the three with disturbed sleep have not previously been described. Methods …
View article: Effect of drama training on self-esteem and personality strengths: A feasibility case control study of nidotherapy
Effect of drama training on self-esteem and personality strengths: A feasibility case control study of nidotherapy Open
Background: Although there are many case reports and qualitative studies on the likely positive effects of drama on mental health there have been few quantitative studies with mentally ill patients. Aims: To assess the effect of drama trai…
View article: Review of: "Reasons for diagnostic delays in Bipolar Disorder: Systematic review and narrative synthesis"
Review of: "Reasons for diagnostic delays in Bipolar Disorder: Systematic review and narrative synthesis" Open
Potential competing interests: No competing
View article: Severe COVID anxiety among adults in the United Kingdom: cohort study and nested feasibility trial
Severe COVID anxiety among adults in the United Kingdom: cohort study and nested feasibility trial Open
View article: DSM-5 conduct disorder and symptoms in youths at high risk of psychosis in Kenya with DSM-5 mental disorders and substance use: towards integrated management
DSM-5 conduct disorder and symptoms in youths at high risk of psychosis in Kenya with DSM-5 mental disorders and substance use: towards integrated management Open
Little is known about the prevalence of Conduct Disorder (CD) and symptoms of CD in high risk psychosis persons at both clinical and community populations in LMICs and in particular Kenya. This study aimed to document (1) the prevalence of…
View article: Making Sense of the ICD-11
Making Sense of the ICD-11 Open
The 11th revision of the International Classification of Diseases (ICD-11) is now published and all countries of the world will be asked to implement it in practice. The ICD-11 has made significant revisions to the classification of mental…
View article: BJB volume 47 issue 4 Cover and Front matter
BJB volume 47 issue 4 Cover and Front matter Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: The effect of environmental change, planned and unplanned life events on the long-term outcome of common mental disorders
The effect of environmental change, planned and unplanned life events on the long-term outcome of common mental disorders Open
View article: BJB volume 47 issue 3 Cover and Front matter
BJB volume 47 issue 3 Cover and Front matter Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: Data from Preclinical Development of ADCT-601, a Novel Pyrrolobenzodiazepine Dimer-based Antibody–drug Conjugate Targeting AXL-expressing Cancers
Data from Preclinical Development of ADCT-601, a Novel Pyrrolobenzodiazepine Dimer-based Antibody–drug Conjugate Targeting AXL-expressing Cancers Open
AXL, a tyrosine kinase receptor that is overexpressed in many solid and hematologic malignancies, facilitates cancer progression and is associated with poor clinical outcomes. Importantly, drug-induced expression of AXL results in resistan…
View article: Supplementary Data from Preclinical Development of ADCT-601, a Novel Pyrrolobenzodiazepine Dimer-based Antibody–drug Conjugate Targeting AXL-expressing Cancers
Supplementary Data from Preclinical Development of ADCT-601, a Novel Pyrrolobenzodiazepine Dimer-based Antibody–drug Conjugate Targeting AXL-expressing Cancers Open
Supplementary Data from Preclinical Development of ADCT-601, a Novel Pyrrolobenzodiazepine Dimer-based Antibody–drug Conjugate Targeting AXL-expressing Cancers
View article: Supplementary Methods from Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody–Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer
Supplementary Methods from Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody–Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer Open
Supplementary Methods
View article: Supplementary Data from Preclinical Development of ADCT-601, a Novel Pyrrolobenzodiazepine Dimer-based Antibody–drug Conjugate Targeting AXL-expressing Cancers
Supplementary Data from Preclinical Development of ADCT-601, a Novel Pyrrolobenzodiazepine Dimer-based Antibody–drug Conjugate Targeting AXL-expressing Cancers Open
Supplementary Data from Preclinical Development of ADCT-601, a Novel Pyrrolobenzodiazepine Dimer-based Antibody–drug Conjugate Targeting AXL-expressing Cancers
View article: Supplementary Tables S1 to S4 from Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody–Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer
Supplementary Tables S1 to S4 from Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody–Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer Open
Table S1. P values of comparing time to endpoint survival among all treatment groups in the LNCaP xenograft study Table S2. Summary of PSMA IHC in xenograft tumors Table S3. P values of comparing time to endpoint survival among all treatme…
View article: Supplementary Tables S1 to S4 from Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody–Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer
Supplementary Tables S1 to S4 from Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody–Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer Open
Table S1. P values of comparing time to endpoint survival among all treatment groups in the LNCaP xenograft study Table S2. Summary of PSMA IHC in xenograft tumors Table S3. P values of comparing time to endpoint survival among all treatme…
View article: Data from Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody–Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer
Data from Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody–Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer Open
Prostate-specific membrane antigen (PSMA) is a membrane-bound glutamate carboxypeptidase that is highly expressed in nearly all prostate cancers with the highest expression in metastatic castration-resistant prostate cancer (mCRPC). The pr…
View article: Supplementary Methods from Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody–Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer
Supplementary Methods from Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody–Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer Open
Supplementary Methods
View article: Supplementary Figures S1-S7 from Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody–Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer
Supplementary Figures S1-S7 from Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody–Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer Open
Supplementary Figure S1. Retention of MEDI3726 activity in human, cynomolgus monkey plasma or PBS for up to 7 days. Supplementary Figure S2. Kaplan-Meier analysis of the Time-to-Endpoint Survival in the (A) LNCaP, (B) CWR22Rv1, and (C) PC-…
View article: Data from Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody–Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer
Data from Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody–Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer Open
Prostate-specific membrane antigen (PSMA) is a membrane-bound glutamate carboxypeptidase that is highly expressed in nearly all prostate cancers with the highest expression in metastatic castration-resistant prostate cancer (mCRPC). The pr…
View article: Supplementary Figures S1-S7 from Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody–Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer
Supplementary Figures S1-S7 from Antitumor Activity of MEDI3726 (ADCT-401), a Pyrrolobenzodiazepine Antibody–Drug Conjugate Targeting PSMA, in Preclinical Models of Prostate Cancer Open
Supplementary Figure S1. Retention of MEDI3726 activity in human, cynomolgus monkey plasma or PBS for up to 7 days. Supplementary Figure S2. Kaplan-Meier analysis of the Time-to-Endpoint Survival in the (A) LNCaP, (B) CWR22Rv1, and (C) PC-…