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View article: Comprehensive Genomic Profiling of Small-Cell Lung Cancer Reveals Frequent Potentially Targetable Alterations
Comprehensive Genomic Profiling of Small-Cell Lung Cancer Reveals Frequent Potentially Targetable Alterations Open
Small-cell lung carcinoma (SCLC) remains one of the most aggressive lung cancers and continues to pose a major challenge for precision oncology. Despite its morphological uniformity, SCLC exhibits marked molecular heterogeneity with recurr…
View article: TRPA1 ion channel activation context‐dependently regulates gene expression in normal and psoriatic human skin
TRPA1 ion channel activation context‐dependently regulates gene expression in normal and psoriatic human skin Open
Background and Purpose Psoriasis is a chronic, relapsing, immune‐mediated inflammatory skin disease. The transient receptor potential ankyrin 1 (TRPA1) ion channel plays a protective role in the formation of psoriasiform skin reactions. He…
View article: Hypervirulent <i>Klebsiella pneumoniae</i> causing bloodstream infections in Hungary
Hypervirulent <i>Klebsiella pneumoniae</i> causing bloodstream infections in Hungary Open
Hypervirulent Klebsiella pneumoniae (hvKP) can cause severe infections even in healthy individuals. Currently, no data are available on the frequency of hvKP-induced bloodstream infections (BSI) in Hungary. Our investigation revealed that …
View article: Genomic Characterization and Molecular Epidemiology of Tusaviruses and Related Novel Protoparvoviruses (Family Parvoviridae) from Ruminant Species (Bovine, Ovine and Caprine) in Hungary
Genomic Characterization and Molecular Epidemiology of Tusaviruses and Related Novel Protoparvoviruses (Family Parvoviridae) from Ruminant Species (Bovine, Ovine and Caprine) in Hungary Open
Tusavirus 1 of species Protoparvovirus incertum 1 (family Parvoviridae) was first identified in humans and later in small ruminants (caprine and ovine). This study reports the full-length coding sequences (~4400–4600 nt) of three novel tus…
View article: Drought and Salt Stressors Alter NAC and WRKY Gene Expression Profiles in Grafted Citrullus lanatus
Drought and Salt Stressors Alter NAC and WRKY Gene Expression Profiles in Grafted Citrullus lanatus Open
Increasing drought and soil salinity pose significant threats to crop production around the world. One potential strategy to mitigate the impacts of these environmental changes is grafting, a horticultural technique that joins tissues from…
View article: Morphogenesis, starvation, and light responses in a mushroom-forming fungus revealed by long-read sequencing and extensive expression profiling
Morphogenesis, starvation, and light responses in a mushroom-forming fungus revealed by long-read sequencing and extensive expression profiling Open
Mushroom-forming fungi (Agaricomycetes) are emerging as pivotal players in several fields of science and industry. Genomic data for Agaricomycetes are accumulating rapidly; however, this is not paralleled by improvements of gene annotation…
View article: Identification of a potential interspecies reassortant rotavirus G and avastrovirus 2 co-infection from black-headed gull (Chroicocephalus ridibundus) in Hungary
Identification of a potential interspecies reassortant rotavirus G and avastrovirus 2 co-infection from black-headed gull (Chroicocephalus ridibundus) in Hungary Open
The black-headed gull is the most common nesting gull species in Hungary. Based on the lifestyle and feeding habits of the black-headed gull, which is highly adapted to the human environment, they can be carriers and spreaders of potential…
View article: Real-world experience with continuous subcutaneous foslevodopa/foscarbidopa infusion: insights and recommendations
Real-world experience with continuous subcutaneous foslevodopa/foscarbidopa infusion: insights and recommendations Open
Traditional advanced therapies in Parkinson’s disease (PD) with motor fluctuations and dyskinesias like continuous apomorphine infusion (CSAI), levodopa-carbidopa intestinal gel (LCIG), levodopa-carbidopa entacapone intestinal gel (LECIG),…
View article: Multiparameter flow cytometric and transcriptional analyis of CD20 positive T-cells in bone marrow in patients of multiple myeloma and monoclonal gammopathy of undetermined significance
Multiparameter flow cytometric and transcriptional analyis of CD20 positive T-cells in bone marrow in patients of multiple myeloma and monoclonal gammopathy of undetermined significance Open
Introduction CD20+ T-cells were described firstly in peripheral blood and later in bone marrow in patients with hematological tumors, and certain immune-mediated diseases. During our hematological diagnostic work, this peculiar subgroup of…
View article: Multiple Co-Infecting Caliciviruses in Oral Fluid and Enteric Samples of Swine Detected by a Novel RT-qPCR Assay and a 3′RACE-PCR-NGS Method
Multiple Co-Infecting Caliciviruses in Oral Fluid and Enteric Samples of Swine Detected by a Novel RT-qPCR Assay and a 3′RACE-PCR-NGS Method Open
Caliciviruses including noro- and sapoviruses of family Caliciviridae are important enteric human and swine pathogens, while others, like valoviruses, are less known. In this study, we developed a detection and typing pipeline for the most…
View article: Prohibited Olympic Medalist with PIEZO1 VUS Who Claims Innocence
Prohibited Olympic Medalist with PIEZO1 VUS Who Claims Innocence Open
Competitive athletes are often exposed to extreme physiological loading, resulting in over excessive mechanotransduction during their acute intensive training sessions and competitions. Individual differences in their genetics often affect…
View article: On the Boundary of Exploratory Genomics and Translation in Sequential Glioblastoma
On the Boundary of Exploratory Genomics and Translation in Sequential Glioblastoma Open
OMICS methods brought significant advancements to the understanding of tumor cell biology, which transformed the treatment and prognosis of several cancers. Clinical practice and outcomes, however, changed significantly less in the case of…
View article: Same same, but different: exploring the enigmatic role of the pituitary adenylate cyclase-activating polypeptide (PACAP) in invertebrate physiology
Same same, but different: exploring the enigmatic role of the pituitary adenylate cyclase-activating polypeptide (PACAP) in invertebrate physiology Open
View article: Antibacterial efficacy interference of the photocatalytic TiO2 nanoparticle and the lytic bacteriophage vb_EcoS_bov25_1D on the Enterohaemorragic Escherichia coli strain Sakai
Antibacterial efficacy interference of the photocatalytic TiO2 nanoparticle and the lytic bacteriophage vb_EcoS_bov25_1D on the Enterohaemorragic Escherichia coli strain Sakai Open
View article: Energy-Efficient Production of Microchloropsis salina Biomass with High CO2 Fixation Yield in Open Thin-Layer Cascade Photobioreactors
Energy-Efficient Production of Microchloropsis salina Biomass with High CO2 Fixation Yield in Open Thin-Layer Cascade Photobioreactors Open
Lipid production using microalgae is challenging for producing low-value-added products. Harnessing microalgae for their fast and efficient CO2 fixation capabilities may be more reasonable since algal biomass can be utilized as a precursor…
View article: Unraveling Morphogenesis, Starvation, and Light Responses in a Mushroom-Forming Fungus,<i>Coprinopsis cinerea</i>, Using Long Read Sequencing and Extensive Expression Profiling
Unraveling Morphogenesis, Starvation, and Light Responses in a Mushroom-Forming Fungus,<i>Coprinopsis cinerea</i>, Using Long Read Sequencing and Extensive Expression Profiling Open
Mushroom-forming fungi (Agaricomycetes) are emerging as pivotal players in several fields, as drivers of nutrient cycling, sources of novel applications, and the group includes some of the most morphologically complex multicellular fungi. …
View article: Molecular Responses of the Eukaryotic Cell Line INT407 on the Internalized Campylobacter jejuni—The Other Side of the Coin
Molecular Responses of the Eukaryotic Cell Line INT407 on the Internalized Campylobacter jejuni—The Other Side of the Coin Open
Campylobacter jejuni is a zoonotic bacterium with the capacity to invade the epithelial cells during the pathogenic process. Several bacterial factors have been identified to contribute to this process, but our knowledge is still very limi…
View article: Detection and complete genome characterization of a genogroup X (GX) sapovirus (family Caliciviridae) from a golden jackal (Canis aureus) in Hungary
Detection and complete genome characterization of a genogroup X (GX) sapovirus (family Caliciviridae) from a golden jackal (Canis aureus) in Hungary Open
View article: Co-infecting viruses of species Bovine rhinitis B virus (Picornaviridae) and Bovine nidovirus 1 (Tobaniviridae) identified for the first time from a post-mortem respiratory sample of a sheep (Ovis aries) in Hungary
Co-infecting viruses of species Bovine rhinitis B virus (Picornaviridae) and Bovine nidovirus 1 (Tobaniviridae) identified for the first time from a post-mortem respiratory sample of a sheep (Ovis aries) in Hungary Open
In this study, a picornavirus and a nidovirus were identified from a single available nasopharyngeal swab (NPS) sample of a freshly deceased sheep, as the only vertebrate viruses found with viral metagenomics and next-generation sequencing…
View article: Missing Heritability in Albinism: Deep Characterization of a Hungarian Albinism Cohort Raises the Possibility of the Digenic Genetic Background of the Disease
Missing Heritability in Albinism: Deep Characterization of a Hungarian Albinism Cohort Raises the Possibility of the Digenic Genetic Background of the Disease Open
Albinism is characterized by a variable degree of hypopigmentation affecting the skin and the hair, and causing ophthalmologic abnormalities. Its oculocutaneous, ocular and syndromic forms follow an autosomal or X-linked recessive mode of …
View article: Molecular Responses of The Eukaryotic Cell Line INT407 on the Internalised <em>C. jejuni</em> - the other Side of the Coin
Molecular Responses of The Eukaryotic Cell Line INT407 on the Internalised <em>C. jejuni</em> - the other Side of the Coin Open
Campylobacter jejuni is a zoonotic bacterium, causing intestinal infection in humans. One characteristic feature of the pathogenicity process is the ability of this bacterium invading the epithelial cells. Several factors have been identif…
View article: Novel IR Laser Debonding for Heterogeneous and 3D Integration
Novel IR Laser Debonding for Heterogeneous and 3D Integration Open
Wafer carrier and thin wafer support during processing is key in 3D integration and advanced packaging processes. Today carrier technology can be divided based on the application and carrier wafer material. While for DRAM and other stacked…
View article: Hemokinin-1 induces transcriptomic alterations in pain-related signaling processes in rat primary sensory neurons independent of NK1 tachykinin receptor activation
Hemokinin-1 induces transcriptomic alterations in pain-related signaling processes in rat primary sensory neurons independent of NK1 tachykinin receptor activation Open
The tachykinin hemokinin-1 (HK-1) is involved in immunological processes, inflammation, and pain. Although the neurokinin 1 receptor (NK1R) is described as its main target, several effects are mediated by currently unidentified receptor(s)…
View article: The genomic and epidemiological investigations of enteric viruses of domestic caprine ( <i>Capra hircus</i> ) revealed the presence of multiple novel viruses related to known strains of humans and ruminant livestock species
The genomic and epidemiological investigations of enteric viruses of domestic caprine ( <i>Capra hircus</i> ) revealed the presence of multiple novel viruses related to known strains of humans and ruminant livestock species Open
In this study, the enteric virome of diarrheic caprine was investigated using next-generation sequencing, reverse transcription PCR methods, and bioinformatics analyses. The complete or nearly complete genomes of seven novel viruses includ…
View article: Biofilm formation initiating rotifer-specific biopolymer and its predicted components
Biofilm formation initiating rotifer-specific biopolymer and its predicted components Open
View article: Identification of an NF1 Microdeletion with Optical Genome Mapping
Identification of an NF1 Microdeletion with Optical Genome Mapping Open
Neurofibromatosis type 1 (NF1) is a clinically heterogeneous neurocutaneous disorder inherited in autosomal dominant manner. Approximately 5–10% of the cases are caused by NF1 microdeletions involving the NF1 gene and its flanking regions.…
View article: miRNA Profiling of Developing Rat Retina in the First Three Postnatal Weeks
miRNA Profiling of Developing Rat Retina in the First Three Postnatal Weeks Open
The morphogenesis of the mammalian retina depends on the precise control of gene expression during development. Small non-coding RNAs, including microRNAs play profound roles in various physiological and pathological processes via gene exp…
View article: Same same, but different: exploring the enigmatic role of the pituitary adenylate cyclase- activating polypeptide (PACAP) in invertebrate physiology
Same same, but different: exploring the enigmatic role of the pituitary adenylate cyclase- activating polypeptide (PACAP) in invertebrate physiology Open
There is a long-standing debate about the presence and functionality of the pituitary adenylate cyclase-activating polypeptide (PACAP) in non-bilaterians, protostomes, and invertebrate deuterostomes. Evidence has been accumulating that hom…
View article: Characterization of antibiotic resistomes by reprogrammed bacteriophage-enabled functional metagenomics in clinical strains
Characterization of antibiotic resistomes by reprogrammed bacteriophage-enabled functional metagenomics in clinical strains Open
View article: ATTR- and AFib amyloid - two different types of amyloid in the annular ligament of trigger finger
ATTR- and AFib amyloid - two different types of amyloid in the annular ligament of trigger finger Open
Histological examination of tissue specimens obtained during surgical treatment of trigger finger frequently encountered unclassifiable amyloid deposits in the annular ligament. We systematically explored this unknown type by a comprehensi…