Peter Valtchev
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Cumulative environmental exposures adversely impact social behaviour and are associated with dysregulation of genes and proteins involved in epigenetic, ribosomal, and immune regulation in male mice Open
Objective This study investigated how cumulative environmental exposures influence offspring behaviour and inflammation-related molecular signatures in the brain and peripheral immune system. Methods A novel "triple-hit" mouse model was de…
Butyrate modifies epigenetic and immune pathways in peripheral mononuclear cells from children with neurodevelopmental disorders associated with chromatin dysregulation Open
Pathogenic DNA variants in chromatin-related genes constitute an important minority of neurodevelopmental disorders (NDDs). Epigenetic mechanisms, including chromatin regulation driven by genetic or environmental factors, are increasingly …
View article: Butyrate modifies epigenetic and immune pathways in peripheral mononuclear cells from children with neurodevelopmental disorders associated with chromatin dysregulation
Butyrate modifies epigenetic and immune pathways in peripheral mononuclear cells from children with neurodevelopmental disorders associated with chromatin dysregulation Open
Pathogenic DNA variants in chromatin-related genes cause an important minority of neurodevelopmental disorders (NDDs). Epigenetic mechanisms, including chromatin regulation, are associated with NDD etiopathogenesis. Therapeutic strategies …
View article: Modification of Faba Bean Protein Gels Using Thermal Treatment and Calcium Sulphate
Modification of Faba Bean Protein Gels Using Thermal Treatment and Calcium Sulphate Open
Faba bean protein concentrate (FPC) offers promising applications in the food industry, particularly in the formulation of plant‐based meat and dairy alternatives, because of its versatile functional characteristics. This study examined th…
View article: Pulse Proteins: Processing, Nutrition, and Functionality in Foods
Pulse Proteins: Processing, Nutrition, and Functionality in Foods Open
Pulses are grown worldwide and provide agronomic benefits that contribute to the sustainability of cropping systems. Pulses are high in protein and provide a good source of carbohydrates, dietary fibre, vitamins, minerals, and bioactive co…
View article: Effect of Dry and Wet Fractionation on Nutritional and Physicochemical Properties of Faba Bean and Yellow Pea Protein
Effect of Dry and Wet Fractionation on Nutritional and Physicochemical Properties of Faba Bean and Yellow Pea Protein Open
Plant‐based proteins continue to gain popularity as a sustainable alternative to animal proteins due to their nutritional, functional and health benefits. Dry and wet fractionation methods are increasingly being used for the production of …
Strategies for senolytic drug discovery Open
Senolytics are a category of drugs that reduce the impact of cellular senescence, an effect associated with a range of chronic and age‐related diseases. Since the discovery of the first senolytics in 2015, the number of known senolytic age…
View article: Solar‐Driven Co‐Production of Hydrogen and Value‐Add Conductive Polyaniline Polymer (Adv. Funct. Mater. 52/2022)
Solar‐Driven Co‐Production of Hydrogen and Value‐Add Conductive Polyaniline Polymer (Adv. Funct. Mater. 52/2022) Open
Solar-Driven Hydrogen Production In article number 2204807, W. Y. Ho-Baillie, Hongjun Chen, and co-workers report a solar-driven hydrogen production with a 98.6% faradaic efficiency and 33% power savings compared to conventional water-spli…
View article: Solar‐Driven Co‐Production of Hydrogen and Value‐Add Conductive Polyaniline Polymer
Solar‐Driven Co‐Production of Hydrogen and Value‐Add Conductive Polyaniline Polymer Open
To reduce the reliance on fossil fuel, H 2 , as a clean fuel, has attracted substantial research and development activities in recent years. The traditional water splitting approach requires an applied bias of more than 1.5 V and the use o…
Identifying HSV-1 Inhibitors from Natural Compounds via Virtual Screening Targeting Surface Glycoprotein D Open
Herpes simplex virus (HSV) infections are a worldwide health problem in need of new effective treatments. Of particular interest is the identification of antiviral agents that act via different mechanisms compared to current drugs, as thes…
Biopolymer‐Based Multilayer Microparticles for Probiotic Delivery to Colon Open
The potential health benefits of probiotics may not be realized because of the substantial reduction in their viability during food storage and gastrointestinal transit. Microencapsulation has been successfully utilized to improve the resi…
Lipoprotein-induced cell growth and hemocyanin biosynthesis in rhogocytes Open
Rhogocyte is a unique molluscan cell that synthesises a supramolecular respiratory protein known as hemocyanin. Its ability to synthesise the protein has eluded the scientists despite hemocyanin’s importance as a carrier protein and comple…
Dynamic flow and shear stress as key parameters for intestinal cells morphology and polarization in an organ-on-a-chip model Open
Gut-on-a-chip microfluidic devices have emerged as versatile and practical systems for modeling the human intestine in vitro . Cells cultured under microfluidic conditions experience the effect of shear stress, used as a biomechanical cue …
The Effects of Thermal Pasteurisation, Freeze-Drying, and Gamma-Irradiation on the Antibacterial Properties of Donor Human Milk Open
The most common pasteurisation method used by human milk banks is Holder pasteurisation. This involves thermal processing, which can denature important proteins and can potentially reduce the natural antimicrobial properties found in human…
Synthesis and Characterization of Bone Binding Antibiotic-1 (BBA-1), a Novel Antimicrobial for Orthopedic Applications Open
Osteomyelitis and orthopedic infections are major clinical problems, limited by a lack of antibiotics specialized for such applications. In this paper, we describe the design and synthesis of a novel bone-binding antibiotic (BBA-1) and its…
Pharmacokinetic profile of injectable tramadol in the koala (Phascolarctos cinereus) and prediction of its analgesic efficacy Open
Tramadol is used as an analgesic in humans and some animal species. When tramadol is administered to most species it undergoes metabolism to its main metabolites M1 or O-desmethyltramadol, and M2 or N-desmethyltramadol, and many other meta…
The risk of infectious pathogens in breast-feeding, donated human milk and breast milk substitutes Open
Objective: This review collates the published reports that focus on microbial and viral illnesses that can be transmitted by breast milk, donor milk and powdered infant formula (PIF). In this context, we attempt to define a risk framework …
Citrus Peel Flavonoids as Potential Cancer Prevention Agents Open
Citrus fruit and in particular flavonoid compounds from citrus peel have been identified as agents with utility in the treatment of cancer. This review provides a background and overview regarding the compounds found within citrus peel wit…
View article: A Bioactive Coating Enhances Bone Allografts in Rat Models of Bone Formation and Critical Defect Repair
A Bioactive Coating Enhances Bone Allografts in Rat Models of Bone Formation and Critical Defect Repair Open
Bone allografts are inferior to autografts for the repair of critical‐sized defects. Prior studies have suggested that bone morphogenetic protein‐2 (BMP‐2) can be combined with allografts to produce superior healing. We created a bioactive…
A benign process for the recovery of solanesol from tomato leaf waste Open
Solanesol, the precursor for the synthesis of coenzyme Q10, is currently recovered from tobacco leaves by conventional extraction techniques that require multiple purification steps and a large amount of organic solvents. We recently ident…
Simulating Inflammation in a Wound Microenvironment Using a Dermal Wound‐on‐a‐Chip Model Open
Considerable progress has been made in the field of microfluidics to develop complex systems for modeling human skin and dermal wound healing processes. While microfluidic models have attempted to integrate multiple cell types and/or 3D cu…
Study on novel antibacterial and antiviral compounds from abalone as an important marine mollusc Open
Infectious diseases caused by bacteria and viruses are the most common cause of death in developing countries.The acquisition of antibiotic resistance and emergence of new pathogens require the development of new antibacterial and antivira…