Explanipedia

Assessing differential application of thromboprophylaxis regimes related to risk of pulmonary embolism and mortality in COVID-19 patients through instrumental variable analysis Open

Linda Nab, Chantal Visser, Bas C. T. van Bussel, Albertus Beishuizen, Remy H.H. Bemelmans , et al. · 2025

Thrombotic complications are common in Coronavirus disease 2019 (COVID-19) patients, with pulmonary embolism (PE) being the most frequent. Randomised trials have provided inconclusive results on the optimal dosage of thromboprophylaxis in …

A Kinase Interacting Protein 1 (AKIP1) promotes cardiomyocyte elongation and physiological cardiac remodelling Open

Kirsten T. Nijholt, Pablo Sánchez-Aguilera, Harmen G. Booij, Silke U. Oberdorf‐Maass, Martin M. Dokter , et al. · 2023

Galectin-3 and Blood Group: Binding Properties, Effects on Plasma Levels, and Consequences for Prognostic Performance Open

Carolin Pozder, Elles M. Screever, A. Rogier van der Velde, Herman H.W. Silljé, Janne Suwijn , et al. · 2023

Previous studies have reported an association between ABO type blood group and cardiovascular (CV) events and outcomes. The precise mechanisms underpinning this striking observation remain unknown, although differences in von Willebrand fa…

Transitions across Kidney Disease Stages and Association with New-onset Heart Failure: a Population-Based study of 8569 Individuals and 12.6 Years of Follow-up Open

Yuntao Chen, Stephan J. L. Bakker, Navin Suthahar, Laura M.G. Meems, Dion Groothof , et al. · 2023

Background Limited data exist on transitions across Kidney Disease Improving Global Outcomes (KDIGO) risk stages and association with new-onset heart failure (HF) in the general population. Methods Data were extacted from the first four cl…

Fibroblast Growth Factor 23 and Risk of New Onset Heart Failure With Preserved or Reduced Ejection Fraction: The PREVEND Study Open

S. Heleen Binnenmars, Georgette E. Hoogslag, Stanley M.H. Yeung, Frank P. Brouwers, Stephan J. L. Bakker , et al. · 2022

Background The role of fibroblast growth factor 23 (FGF23) in the development of new‐onset heart failure (HF) with reduced (HFrEF) or preserved ejection fraction (HFpEF) in the general population is unknown. Therefore, we set out to invest…

Blood pressure-lowering treatment for prevention of major cardiovascular diseases in people with and without type 2 diabetes: an individual participant-level data meta-analysis Open

Milad Nazarzadeh, Zeinab Bidel, Dexter Canoy, Emma Copland, Derrick Bennett , et al. · 2022

Unravelling the Difference Between Men and Women in Post-CABG Survival Open

Amand F. Schmidt, Saskia Haitjema, Ulrik Sartipy, Martin J. Holzmann, David J. Malenka , et al. · 2022

Objectives Women have a worse prognosis after coronary artery bypass grafting (CABG) surgery compared to men. We sought to quantify to what extent this difference in post-CABG survival could be attributed to sex itself, or whether this was…

Age is the main determinant of COVID-19 related in-hospital mortality with minimal impact of pre-existing comorbidities, a retrospective cohort study Open

M T H M Henkens, AG Raafs, Job A.J. Verdonschot, Marijke Linschoten, Maarten van Smeden , et al. · 2022

Background Age and comorbidities increase COVID-19 related in-hospital mortality risk, but the extent by which comorbidities mediate the impact of age remains unknown. Methods In this multicenter retrospective cohort study with data from 4…

Pectins from various sources inhibit galectin-3-related cardiac fibrosis Open

Carolin Gehlken, A. Rogier van der Velde, Wouter C. Meijers, Herman H.W. Silljé, Pieter Muntendam , et al. · 2021

Dr. Meijers is supported by the Mandema-Stipendium of the Junior Scientific Masterclass 2020-10, University Medical Center Groningen and by the Netherlands Heart Foundation (Dekkerbeurs 2021)Dr. de Boer is supported by the Netherlands Hear…

Clinical presentation, disease course, and outcome of COVID-19 in hospitalized patients with and without pre-existing cardiac disease: a cohort study across 18 countries Open

Marijke Linschoten, Alicia Uijl, Astrid Schut, C E M Jakob, L R Romão , et al. · 2021

Aims Patients with cardiac disease are considered high risk for poor outcomes following hospitalization with COVID-19. The primary aim of this study was to evaluate heterogeneity in associations between various heart disease subtypes and i…

Age-stratified and blood-pressure-stratified effects of blood-pressure-lowering pharmacotherapy for the prevention of cardiovascular disease and death: an individual participant-level data meta-analysis Open

Kazem Rahimi, Zeinab Bidel, Milad Nazarzadeh, Emma Copland, Dexter Canoy , et al. · 2021

The erythropoietin receptor expressed in skeletal muscle is essential for mitochondrial biogenesis and physiological exercise Open

Kirsten T. Nijholt, Laura M.G. Meems, Willem P.T. Ruifrok, Alexander H. Maass, Salva R. Yurista , et al. · 2021

Pharmacological blood pressure lowering for primary and secondary prevention of cardiovascular disease across different levels of blood pressure: an individual participant-level data meta-analysis Open

Kazem Rahimi, Zeinab Bidel, Milad Nazarzadeh, Emma Copland, Dexter Canoy , et al. · 2021

British Heart Foundation, UK National Institute for Health Research, and Oxford Martin School.

Antihypertensive treatment and risk of cancer: an individual participant data meta-analysis Open

Emma Copland, Dexter Canoy, Milad Nazarzadeh, Zeinab Bidel, Rema Ramakrishnan , et al. · 2021

HisGIS Kustzone Noord-Holland met Haarlem, Alkmaar en Medemblik Open

J.A. Mol, J.J. Feikens, Thomas Vermaut, Wiek H. van Gilst · 2021

Age dependent associations of risk factors with heart failure: pooled population based cohort study Open

Jasper Tromp, Samantha M. Paniagua, Emily S. Lau, Norrina B. Allen, Michael J. Blaha , et al. · 2021

Objective To assess age differences in risk factors for incident heart failure in the general population. Design Pooled population based cohort study. Setting Framingham Heart Study, Prevention of Renal and Vascular End-stage Disease Study…

Cardiac complications in patients hospitalised with COVID-19 Open

Marijke Linschoten, Sanne A. E. Peters, Maarten van Smeden, Lucia S.D. Jewbali, Jeroen Schaap , et al. · 2020

Aims: To determine the frequency and pattern of cardiac complications in patients hospitalised with coronavirus disease (COVID-19). Methods and results: CAPACITY-COVID is an international patient registry established to determine the role …

Association Between Chromosome 9p21 Variants and the Ankle-Brachial Index Identified by a Meta-Analysis of 21 Genome-Wide Association Studies Open

Joanne M. Murabito, Charles C. White, Maryam Kavousi, Yan V. Sun, Mary F. Feitosa , et al. · 2020

Genetic determinants of peripheral arterial disease (PAD) remain largely unknown. To identify genetic variants associated with the ankle-brachial index (ABI), a noninvasive measure of PAD, we conducted a meta-analysis of genome-wide associ…

Carotid Intima-Media Thickness Progression as Surrogate Marker for Cardiovascular Risk Open

Peter Willeit, Lena Tschiderer, Elias Allara, Kathrin Reuber, Lisa Seekircher , et al. · 2020

Background: To quantify the association between effects of interventions on carotid intima-media thickness (cIMT) progression and their effects on cardiovascular disease (CVD) risk. Methods: We systematically collated data from randomized,…

Rationale and design of the PRAETORIAN-COVID trial: A double-blind, placebo-controlled randomized clinical trial with valsartan for PRevention of Acute rEspiraTORy dIstress syndrome in hospitAlized patieNts with SARS-COV-2 Infection Disease Open

D.H. Frank Gommans, Joris Nas, S. J. Pinto-Sietsma, Yvonne Koop, Regina E. Konst , et al. · 2020

Digital arterial pressure pulse wave analysis and cardiovascular events in the general population: the Prevention of Renal and Vascular End-stage Disease study Open

Maarten A. de Jong, Arie M. van Roon, Jens T. Bakker, Hendrik T.J. Bijen, Douwe J. Mulder , et al. · 2020

Background: Arterial stiffness influences the contour of the digital pressure pulse wave. Method: Here, we investigated whether the digital pulse propagation index (DPPI), based on the digital pressure pulse wave, DPPI is associated with c…

De onbesliste rol van digoxine bij stabiel hartfalen en atriumfibrilleren Open

Eva M. Boorsma, Dirk J. van Veldhuisen, Wiek H. van Gilst, Michiel Rienstra · 2020

HisGIS 1832 Kustzone Zuid-Holland Open

J.J. Feikens, Thomas Vermaut, Wiek H. van Gilst · 2020

Progression of conventional cardiovascular risk factors and vascular disease risk in individuals: insights from the PROG-IMT consortium Open

Martin Bahls, Matthias Lorenz, Marcus Dörr, Lu Gao, Kazuo Kitagawa , et al. · 2019

Aims Averaged measurements, but not the progression based on multiple assessments of carotid intima-media thickness, (cIMT) are predictive of cardiovascular disease (CVD) events in individuals. Whether this is true for conventional risk fa…

The Cardiovascular Research community calls for action to address the growing burden of cardiovascular disease Open

Jeremy D. Pearson, Karin R. Sipido, Piotr Musiałek, Wiek H. van Gilst · 2019

Treating oxidative stress in heart failure: past, present and future Open

Atze van der Pol, Wiek H. van Gilst, Adriaan A. Voors, Peter van der Meer · 2018

Advances in cardiovascular research have identified oxidative stress as an important pathophysiological pathway in the development and progression of heart failure. Oxidative stress is defined as the imbalance between the production of rea…

The Association of Obesity and Cardiometabolic Traits With Incident HFpEF and HFrEF Open

Nazir Savji, Wouter C. Meijers, Traci M. Bartz, Vijeta Bhambhani, Mary Cushman , et al. · 2018

Association of Cardiovascular Biomarkers With Incident Heart Failure With Preserved and Reduced Ejection Fraction Open

Rudolf A. de Boer, Matthew Nayor, Christopher R. deFilippi, Danielle Enserro, Vijeta Bhambhani , et al. · 2018

Biomarkers of renal dysfunction, endothelial dysfunction, and inflammation were associated with incident HFrEF. By contrast, only natriuretic peptides and UACR were associated with HFpEF. These findings highlight the need for future studie…

Predictors and outcomes of heart failure with mid‐range ejection fraction Open

Vijeta Bhambhani, Jorge R. Kizer, João A.C. Lima, Pim van der Harst, Hossein Bahrami , et al. · 2017

Aims While heart failure with preserved (HFpEF) and reduced ejection fraction (HFrEF) are well described, determinants and outcomes of heart failure with mid‐range ejection fraction (HFmrEF) remain unclear. We sought to examine clinical an…

Statin Effects on Metabolic Profiles Open

Daniel Kofink, Ruben N. Eppinga, Wiek H. van Gilst, Stephan J. L. Bakker, Robin P.F. Dullaart , et al. · 2017

Background— Statins lower cholesterol by inhibiting HMG-CoA reductase, the rate-limiting enzyme of the metabolic pathway that produces cholesterol and other isoprenoids. Little is known about their effects on metabolite and lipoprotein sub…

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