Peter Van Eyken
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View article: BIOM-07. A NOVEL MONOCLONAL ANTI-HERV-K113 POLYMERASE ANTIBODY TO PREDICT THE SURVIVAL OF GLIOBLASTOMA PATIENTS
BIOM-07. A NOVEL MONOCLONAL ANTI-HERV-K113 POLYMERASE ANTIBODY TO PREDICT THE SURVIVAL OF GLIOBLASTOMA PATIENTS Open
Glioblastoma (GBM) is the most frequent and lethal subtype of high-grade glioma, constituting about 48% of all malignant brain and central nervous system (CNS) tumors. The median survival is 12–15 months despite multimodal treatment plans,…
View article: TMIC-55. CHARACTERIZATION OF THERAPEUTICS EFFECTS IN GLIOBLASTOMA THROUGH INTEGRATED SPATIAL SINGLE-CELL MULTIOME PROFILING OF LONGITUDINAL SAMPLES: UNVEILING CLINICALLY RELEVANT SUBTYPES OF PATHOLOGICAL CHANGES
TMIC-55. CHARACTERIZATION OF THERAPEUTICS EFFECTS IN GLIOBLASTOMA THROUGH INTEGRATED SPATIAL SINGLE-CELL MULTIOME PROFILING OF LONGITUDINAL SAMPLES: UNVEILING CLINICALLY RELEVANT SUBTYPES OF PATHOLOGICAL CHANGES Open
Glioblastoma (GBM) remains a highly malignant, intrinsically resistant and inevitably recurring brain tumor with dismal prognosis. The aggressiveness and lack of effective GBM treatments can be attributed to the highly heterogeneous and pl…
View article: Artificial Intelligence Models for the Detection of Microsatellite Instability from Whole-Slide Imaging of Colorectal Cancer
Artificial Intelligence Models for the Detection of Microsatellite Instability from Whole-Slide Imaging of Colorectal Cancer Open
With the advent of whole-slide imaging (WSI), a technology that can digitally scan whole slides in high resolution, pathology is undergoing a digital revolution. Detecting microsatellite instability (MSI) in colorectal cancer is crucial fo…
View article: RETRACTED: Characterization of therapeutic effects in Glioblastoma through integrated spatial single-cell multiome profiling of longitudinal samples: unveiling clinically relevant subtypes of pathological changes
RETRACTED: Characterization of therapeutic effects in Glioblastoma through integrated spatial single-cell multiome profiling of longitudinal samples: unveiling clinically relevant subtypes of pathological changes Open
The authors have requested that this preprint be removed from Research Square.
View article: Lessons from autopsy: Topographical variability of atherosclerosis plaques
Lessons from autopsy: Topographical variability of atherosclerosis plaques Open
Atherosclerosis is a complex disease characterized by the accumulation of plaques in arterial walls. Understanding its pathogenesis remains incomplete, with factors like inflammation, oxidative stress, and hypertension playing critical rol…
View article: Autoimmune liver disease triggered by SARS-CoV-2: a case report and review of the literature.
Autoimmune liver disease triggered by SARS-CoV-2: a case report and review of the literature. Open
Probably triggered by the SARS-CoV-2-induced cytokine storm, the association between COVID-19 and autoimmune-related inflammatory injury may display a particular paradigm of AILD pathogenesis.
View article: The fascinating theory of fetal programming of adult diseases: A review of the fundamentals of the Barker hypothesis
The fascinating theory of fetal programming of adult diseases: A review of the fundamentals of the Barker hypothesis Open
The theory of fetal programming of adult diseases was first proposed by David J.P. Barker in the eighties of the previous century, to explain the higher susceptibility of some people toward the development of ischemic heart disease. Accord…
View article: High-grade HER2-positive mucoepidermoid carcinoma of the breast: a case report and review of the literature
High-grade HER2-positive mucoepidermoid carcinoma of the breast: a case report and review of the literature Open
Background Mucoepidermoid carcinoma of the breast is a rare special type of salivary gland-like tumor of the breast, usually displaying triple-negative phenotype. To date, only 64 cases have been reported in the English literature. Herein,…
View article: L1CAM EXPRESSION IN THE PERITUMORAL STROMAL CELLS OF THE MICROENVIRONMENT OF COLORECTAL CANCER: A NEW TARGET FOR ONCOLOGISTS?
L1CAM EXPRESSION IN THE PERITUMORAL STROMAL CELLS OF THE MICROENVIRONMENT OF COLORECTAL CANCER: A NEW TARGET FOR ONCOLOGISTS? Open
According to the seed and soil theory, also known as the Paget's hypothesis, the tumor microenvironment (TME) plays a key role in promoting the onset and progression of cancer.In particular, fibroblasts and macrophages of the TME have been…
View article: L1CAM EXPRESSION IDENTIFIES DIFFERENT COLORECTAL TUMOR SUBGROUPS
L1CAM EXPRESSION IDENTIFIES DIFFERENT COLORECTAL TUMOR SUBGROUPS Open
Impact statement: This work highlights different expressions of L1CAM and their relative frequencies in colorectal cancer and provides new data regarding the interindividual variability in L1CAM expression in this tumor.L1CAM is here indic…
View article: Clinicopathological characteristics and disease chronicity in native kidney biopsies in Flanders
Clinicopathological characteristics and disease chronicity in native kidney biopsies in Flanders Open
Background The Flemish Collaborative Glomerulonephritis Group (FCGG) registry provides complete population data on kidney disease epidemiology in the region of Flanders (Belgium), as it captures all native kidney biopsies performed in its …
View article: Epidemiology of native kidney disease in Flanders: results from the FCGG kidney biopsy registry
Epidemiology of native kidney disease in Flanders: results from the FCGG kidney biopsy registry Open
Background The Flemish Collaborative Glomerulonephritis Group (FCGG) registry is the first population-based native kidney biopsy registry in Flanders, Belgium. In this first analysis, we report on patient demographics, frequency distributi…
View article: Ultrastructural findings of lung injury due to Vaccine-induced Immune Thrombotic Thrombo- cytopenia (VITT) following COVID-19 vaccination: a scanning electron microscopic study.
Ultrastructural findings of lung injury due to Vaccine-induced Immune Thrombotic Thrombo- cytopenia (VITT) following COVID-19 vaccination: a scanning electron microscopic study. Open
Vaccine-induced immune thrombotic thrombocytopenia (VITT) is a rare new syndrome occurring after the ChAdOx1 nCoV-19 vaccine immunization. Patients with VITT are characterized by a variable clinical presentation, likewise also the outcome …
View article: PATH-20. SPATIAL MAPPING OF THERAPY-INDUCED, PATHOLOGICAL CHANGES IN GLIOBLASTOMA AT SINGLE-CELL RESOLUTION
PATH-20. SPATIAL MAPPING OF THERAPY-INDUCED, PATHOLOGICAL CHANGES IN GLIOBLASTOMA AT SINGLE-CELL RESOLUTION Open
Glioblastoma (GBM) remains a highly malignant, intrinsically resistant and inevitably recurring brain tumor with dismal prognosis. The aggressiveness and lack of effective GBM treatments can be attributed to the highly heterogeneous and pl…
View article: Zinc as a Drug for Wilson’s Disease, Non-Alcoholic Liver Disease and COVID-19-Related Liver Injury
Zinc as a Drug for Wilson’s Disease, Non-Alcoholic Liver Disease and COVID-19-Related Liver Injury Open
Zinc is the second most abundant trace element in the human body, and it plays a fundamental role in human physiology, being an integral component of hundreds of enzymes and transcription factors. The discovery that zinc atoms may compete …
View article: Erythema multiforme in the esophagus
Erythema multiforme in the esophagus Open
Erythema multiforme is an immune-mediated mucocutaneous disorder. Mucosal involvement usually affects the oral region, the genitals or the eyes. We report a case of esophagitis caused by erythema multiforme in a patient diagnosed with lung…
View article: Vaccine-induced severe thrombotic thrombocytopenia following COVID-19 vaccination: a report of an autoptic case and review of the literature.
Vaccine-induced severe thrombotic thrombocytopenia following COVID-19 vaccination: a report of an autoptic case and review of the literature. Open
In our patient, the majority of data necessary for a VITT final diagnosis were present: thrombocytopenia and thrombosis in pulmonary, portal, hepatic, renal and mesenteric veins, associated with a marked increase of D-dimer serum levels. T…
View article: Liver changes in Wilson's disease: the full spectrum. A report of 127 biopsies from 43 patients.
Liver changes in Wilson's disease: the full spectrum. A report of 127 biopsies from 43 patients. Open
Our data confirm the variability of the histological pattern in WD. However, the preferential localization of steatosis and balloon cells in periportal zone can be a useful clue for the diagnosis of WD.
View article: Liver changes in Wilson’s disease: the full spectrum. A report of 127 biopsies from 43 patients
Liver changes in Wilson’s disease: the full spectrum. A report of 127 biopsies from 43 patients Open
OBJECTIVE: Wilson’s Disease (WD) is an autosomal recessive copper overload. Several mutations of the copper pump named ATP7B have been involved. WD is difficult to diagnose mainly because of its heterogeneity of presentation. The histologi…
View article: MO249SINGLE-CELL TRANSCRIPTOME OF COVID19 ASSOCIATED IGA NEPHROPATHY*
MO249SINGLE-CELL TRANSCRIPTOME OF COVID19 ASSOCIATED IGA NEPHROPATHY* Open
Background and Aims Acute kidney injury is common in patients infected with the novel coronavirus SARS-CoV-2. Predominant findings in case series of kidney biopsies include acute tubular injury and collapsing podocytopathy. We performed si…
View article: Trace elements and the carotid plaque: the GOOD (Mg, Zn, Se), the UGLY (Fe, Cu), and the BAD (P, Ca)?
Trace elements and the carotid plaque: the GOOD (Mg, Zn, Se), the UGLY (Fe, Cu), and the BAD (P, Ca)? Open
Multiple epidemiological studies have suggested that industrialization and progressive urbanization should be considered one of the main factors responsible for the rising of atherosclerosis in the developing world. In this scenario, the r…
View article: The Role of Magnesium in Pregnancy and in Fetal Programming of Adult Diseases
The Role of Magnesium in Pregnancy and in Fetal Programming of Adult Diseases Open
Magnesium is an essential trace metal and a necessary factor for multiple biochemical functions in humans. Its role in biology is fundamental in over 600 enzymatic reactions implicated in protein synthesis, mitochondrial functions, neuromu…
View article: Gold Nanoparticles: A New Golden Era in Oncology?
Gold Nanoparticles: A New Golden Era in Oncology? Open
In recent years, the spectrum of possible applications of gold in diagnostics and therapeutic approaches in clinical practice has changed significantly, becoming surprisingly broad. Nowadays, gold-based therapeutic agents are used in the t…
View article: Ambient black carbon particles reach the fetal side of human placenta
Ambient black carbon particles reach the fetal side of human placenta Open
Particle transfer across the placenta has been suggested but to date, no direct evidence in real-life, human context exists. Here we report the presence of black carbon (BC) particles as part of combustion-derived particulate matter in hum…
View article: Body surface area-based versus concentration-based intraperitoneal perioperative chemotherapy in a rat model of colorectal peritoneal surface malignancy: pharmacologic guidance towards standardization
Body surface area-based versus concentration-based intraperitoneal perioperative chemotherapy in a rat model of colorectal peritoneal surface malignancy: pharmacologic guidance towards standardization Open
Worldwide, cytoreductive surgery (CRS) and hyperthermic intraperitoneal perioperative chemotherapy (HIPEC) are used in current clinical practice for colorectal peritoneal surface malignancy (PSM) treatment. Although, there is an acknowledg…
View article: The small intestinal mucosa and its stem cells
The small intestinal mucosa and its stem cells Open
In the first part of this review a brief summary of the embryology and histology of the gastrointestinal tract is provided. In the second part intestinal stem cells (ISCs) are discussed. Several signaling pathways play a crucial role in th…