Peter Verhamme
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View article: Epidemiology of Venous Thromboembolism in Belgium: A Cohort Study
Epidemiology of Venous Thromboembolism in Belgium: A Cohort Study Open
Venous thromboembolism (VTE) is a significant contributor to global morbidity and mortality. Although management strategies and the distribution of risk factors have evolved, contemporary epidemiologic data are limited and have not been pr…
View article: Sex differences in venous thromboembolism outcomes: findings from the GARFIELD-VTE registry
Sex differences in venous thromboembolism outcomes: findings from the GARFIELD-VTE registry Open
View article: Diagnostic accuracy of CT venography compared to ultrasonography for detection of peripherally inserted central venous catheter-related thrombosis in patients with cancer: the DETECT study
Diagnostic accuracy of CT venography compared to ultrasonography for detection of peripherally inserted central venous catheter-related thrombosis in patients with cancer: the DETECT study Open
Both CT venography and ultrasonography missed VTE at screening. Results indicate that it is unlikely that the sensitivity of CT venography alone exceeds that of ultrasonography in detection of asymptomatic PICC-related VTE.
View article: Acquired von Willebrand syndrome secondary to monoclonal gammopathy: a single-center case series
Acquired von Willebrand syndrome secondary to monoclonal gammopathy: a single-center case series Open
Acquired von Willebrand syndrome (AVWS) is a well-known complication of a monoclonal gammopathy with a potentially severe bleeding tendency. Treatment with von Willebrand factor (VWF)/factor VIII (FVIII) concentrate yields mixed results in…
View article: New horizons in the pharmacological management of venous thromboembolism
New horizons in the pharmacological management of venous thromboembolism Open
Many patients suffer from venous thromboembolism (VTE) and its consequences. Despite substantial advancements with the introduction of direct oral anticoagulants (DOACs), patients and clinicians still encounter challenges in the acute and …
View article: Risk factors associated with gastrointestinal bleeding in patients with cardiovascular disease (INTERBLEED): a case control study
Risk factors associated with gastrointestinal bleeding in patients with cardiovascular disease (INTERBLEED): a case control study Open
Aims This study aimed to identify and quantify the importance of risk factors for gastrointestinal (GI) bleeding in patients with CV disease. Methods and results We conducted a case-control study in 9 countries in Asia, America, Europe, an…
View article: Low-Density Lipoprotein Cholesterol Levels and Bleeding Risk in Venous Thromboembolism
Low-Density Lipoprotein Cholesterol Levels and Bleeding Risk in Venous Thromboembolism Open
This case-control study evaluates low-density lipoprotein cholesterol levels and bleeding risk during anticoagulation in patients with acute venous thromboembolism.
View article: BLOOD PRESSURE TRAJECTORY FROM BIRTH TO PRESCHOOL- AND SCHOOL-AGE: EVIDENCE FROM ENVIRONAGE BIRTH COHORT
BLOOD PRESSURE TRAJECTORY FROM BIRTH TO PRESCHOOL- AND SCHOOL-AGE: EVIDENCE FROM ENVIRONAGE BIRTH COHORT Open
Objective: Blood pressure (BP) is an essential modifiable risk factor and associated with cardiovascular disease in adulthood. The modifiable effect of BP might initiates from birth and operates across the whole life span. We aimed to expl…
View article: Association of Biomarkers With Intracerebral Hematoma Expansion and Arterial Thromboembolic Events in Patients With Acute Intracranial Hemorrhage: The ANNEXA-I Biomarker Substudy
Association of Biomarkers With Intracerebral Hematoma Expansion and Arterial Thromboembolic Events in Patients With Acute Intracranial Hemorrhage: The ANNEXA-I Biomarker Substudy Open
BACKGROUND: ANNEXA-I (Andexanet Alfa, a Novel Antidote to the Anticoagulation Effects of FXA Inhibitors) was a randomized trial that demonstrated that andexanet compared with usual care in patients with intracranial hemorrhage associated w…
View article: Treatment and outcomes after on-treatment recurrent venous thromboembolism in patients with cancer: a post hoc analysis of the Hokusai venous thromboembolism cancer study
Treatment and outcomes after on-treatment recurrent venous thromboembolism in patients with cancer: a post hoc analysis of the Hokusai venous thromboembolism cancer study Open
Treatment strategies for recurrent VTE in patients with cancer are heterogeneous. The risk of a second recurrence and major bleeding are considerable. More studies are needed to determine the optimal treatment strategy for recurrent cancer…
View article: Clinical utility of panel-based genetic sequencing for von Willebrand disease
Clinical utility of panel-based genetic sequencing for von Willebrand disease Open
Panel-based sequencing for VWD in a well-selected cohort, particularly those with type 2 and type 3 VWD, was clinically relevant in differentiating genocopies, directing therapies, and family planning. Sequencing in those with low VWF and …
View article: Urinary Proteomics and Systems Biology Link Eight Proteins to the Higher Risk of Hypertension and Related Complications in Blacks Versus Whites
Urinary Proteomics and Systems Biology Link Eight Proteins to the Higher Risk of Hypertension and Related Complications in Blacks Versus Whites Open
Blacks are more prone to salt‐sensitive hypertension than Whites. This cross‐sectional analysis of a multi‐ethnic cohort aimed to search for proteins potentially involved in the susceptibility to salt sensitivity, hypertension, and hyperte…
View article: Racial and regional disparities in the risk of noncommunicable disease between sub-Saharan black and European white patients
Racial and regional disparities in the risk of noncommunicable disease between sub-Saharan black and European white patients Open
Objectives: Greater vulnerability of Black vs. White individuals to cardiovascular disease (CVD) and chronic kidney disease (CKD) is well charted in the United States, but studies involving sub-Saharan blacks are scarce. Methods: Baseline …
View article: OSTEO18, a novel urinary proteomic signature, associated with osteoporosis in heart transplant recipients
OSTEO18, a novel urinary proteomic signature, associated with osteoporosis in heart transplant recipients Open
Background Immunosuppressive treatment in heart transplant (HTx) recipient causes osteoporosis. The urinary proteomic profile (UPP) includes peptide fragments derived from the bone extracellular matrix. Purpose Study aims were to develop a…
View article: Corrigendum: Progression of functional and structural glaucomatous damage in relation to diurnal and nocturnal dips in mean arterial pressure
Corrigendum: Progression of functional and structural glaucomatous damage in relation to diurnal and nocturnal dips in mean arterial pressure Open
[This corrects the article DOI: 10.3389/fcvm.2022.1024044.].
View article: Human genetics implicate thromboembolism in the pathogenesis of long COVID in individuals of European ancestry
Human genetics implicate thromboembolism in the pathogenesis of long COVID in individuals of European ancestry Open
SARS-CoV-2 infection can result in long COVID, characterized by post-acute symptoms from multiple organs. Current hypotheses on mechanisms underlying long COVID include persistent inflammation and thromboembolism; however, compelling evide…
View article: Urinary proteomic signature of mineralocorticoid receptor antagonism by spironolactone: evidence from the HOMAGE trial
Urinary proteomic signature of mineralocorticoid receptor antagonism by spironolactone: evidence from the HOMAGE trial Open
Objective Heart failure (HF) is characterised by collagen deposition. Urinary proteomic profiling (UPP) followed by peptide sequencing identifies parental proteins, for over 70% derived from collagens. This study aimed to refine understand…
View article: The current landscape of factor XI inhibitors
The current landscape of factor XI inhibitors Open
Anticoagulant therapy has always been tightly connected with bleeding risk, as two sides of the same coin. New insights in thrombosis and hemostasis prompted the development of intrinsic pathway inhibitors that promise to uncouple thrombos…
View article: Lead-associated mortality in the US 1999–2020: a time-stratified analysis of a national cohort
Lead-associated mortality in the US 1999–2020: a time-stratified analysis of a national cohort Open
Objectives: We undertook time-stratified analyses of the National Health and Nutrition Examination Survey in the US to assess time trends (1999–2020) in the associations of blood lead (BL) with blood pressure, mortality, the BL-associated …
View article: Thrombophilia Testing: from Genetic Predisposition to Discrimination
Thrombophilia Testing: from Genetic Predisposition to Discrimination Open
Received: 21 December 2023 Accepted after revision: 05 March 2024 Accepted Manuscript online:09 March 2024
View article: Mortality and Cardiovascular End Points In Relation to the Aortic Pulse Wave Components: An Individual-Participant Meta-Analysis
Mortality and Cardiovascular End Points In Relation to the Aortic Pulse Wave Components: An Individual-Participant Meta-Analysis Open
BACKGROUND: Wave separation analysis enables individualized evaluation of the aortic pulse wave components. Previous studies focused on the pressure height with overall positive but differing results. In the present analysis, we assessed t…
View article: Endovascular Management of Thrombosed Cavoportal Anastomosis after Liver Transplantation Using Catheter Directed Thrombolysis and Stent Placement: A Case Report
Endovascular Management of Thrombosed Cavoportal Anastomosis after Liver Transplantation Using Catheter Directed Thrombolysis and Stent Placement: A Case Report Open
View article: OSTEO18, a novel urinary proteomic signature, associated with osteoporosis in heart transplant recipients
OSTEO18, a novel urinary proteomic signature, associated with osteoporosis in heart transplant recipients Open
View article: Osteoporosis in Relation to a Bone-Related Aging Biomarker Derived from the Urinary Proteomic Profile: A Population Study
Osteoporosis in Relation to a Bone-Related Aging Biomarker Derived from the Urinary Proteomic Profile: A Population Study Open
Screening for and prevention of osteoporosis and osteoporotic fractures is imperative, given the high burden on individuals and society. This study constructed and validated an aging-related biomarker derived from the urinary proteomic pro…
View article: Blood pressure and renal function responses in workers exposed to lead for up to six years
Blood pressure and renal function responses in workers exposed to lead for up to six years Open
The Study for Promotion of Health in Recycling Lead (SPHERL) assessed the blood pressure (BP) and renal function (RF) responses for up to 6 years in the workers without previous occupational lead exposure. BP was the average of five consec…
View article: Incidence and predictors of post-thrombotic syndrome in patients with proximal DVT in a real-world setting: findings from the GARFIELD-VTE registry
Incidence and predictors of post-thrombotic syndrome in patients with proximal DVT in a real-world setting: findings from the GARFIELD-VTE registry Open
View article: Urinary proteomics signature of malignancy post heart transplantation is associated with mortality risk
Urinary proteomics signature of malignancy post heart transplantation is associated with mortality risk Open
Background Heart transplant recipients are at an increased risk of malignancy that has an adverse impact on outcomes. The surveillance of malignancy after heart transplantation is cumbersome and involves multidisciplinary efforts. Purpose …
View article: Percutaneous embolization of pulmonary arteriovenous malformations in adult patient with Rendu–Osler–Weber: a case report
Percutaneous embolization of pulmonary arteriovenous malformations in adult patient with Rendu–Osler–Weber: a case report Open
Background Hereditary haemorrhagic telangiectasia (HHT), or Rendu–Osler–Weber syndrome, is a rare genetic disorder characterized by the development of telangiectasias and arteriovenous malformations (AVMs) throughout the body. We present a…
View article: Enoxaparin for Long-Term Therapy of Venous Thromboembolism in Patients with Cancer and Renal Insufficiency
Enoxaparin for Long-Term Therapy of Venous Thromboembolism in Patients with Cancer and Renal Insufficiency Open
Background The optimal therapy of venous thromboembolism (VTE) in cancer patients with renal insufficiency (RI) is unknown. Current guidelines recommend to use low-molecular-weight heparin over direct oral anticoagulants to treat VTE in ca…
View article: A prognostic score to identify women at increased risk for abnormal uterine bleeding during anticoagulation for venous thromboembolism
A prognostic score to identify women at increased risk for abnormal uterine bleeding during anticoagulation for venous thromboembolism Open