Peter Vestergaard
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View article: The Symptom Burden of Autonomic Neuropathy Is Associated with Decreased Quality of Life in 6961 People with Diabetes
The Symptom Burden of Autonomic Neuropathy Is Associated with Decreased Quality of Life in 6961 People with Diabetes Open
Background: Diabetes often causes microvascular complications such as neuropathy. Autonomic neuropathy remains under-recognized, and its impact on quality of life (QoL) is unclear. This study investigated associations between symptoms of a…
View article: Development of Machine Learning Models to Predict Hypoglycemia and Hyperglycemia on Days of Hemodialysis in Patients with Diabetes based on Continuous Glucose Monitoring
Development of Machine Learning Models to Predict Hypoglycemia and Hyperglycemia on Days of Hemodialysis in Patients with Diabetes based on Continuous Glucose Monitoring Open
Background/Objectives Patients with diabetes undergoing hemodialysis (HD) are at risk of asymptomatic hypo- and hypergly-cemia within 24 hours of dialysis. Continuous glucose monitoring (CGM) can improve glycemic control, and machine learn…
View article: Early life determinants of skeletal maturation, body composition and endocrine health in young adults (EPIPEAK): protocol for a nationwide birth cohort study
Early life determinants of skeletal maturation, body composition and endocrine health in young adults (EPIPEAK): protocol for a nationwide birth cohort study Open
Introduction Early-life exposures, such as nutritional deficiencies, stress, smoking, toxins, medications, diseases, infections and inflammation may affect multiple physiological and metabolic systems in the offspring, including hormonal r…
View article: Effect of Adherence to Oral Semaglutide on Glycemic Control in People With Type 2 Diabetes Treated With Metformin: Protocol for an Open-Label Clinical Trial
Effect of Adherence to Oral Semaglutide on Glycemic Control in People With Type 2 Diabetes Treated With Metformin: Protocol for an Open-Label Clinical Trial Open
Background Treatment adherence by people with type 2 diabetes (T2D) is overall suboptimal, which can hinder glycemic control. Multiple adherence barriers have been identified, such as the dislike and fear of injections. Several of the reco…
View article: Semaglutide treatment in hypothalamic obesity: Two-Year outcomes on body composition, appetite, and quality of life
Semaglutide treatment in hypothalamic obesity: Two-Year outcomes on body composition, appetite, and quality of life Open
Purpose Hypothalamic obesity is a severe complication of craniopharyngioma, marked by hyperphagia and rapid weight gain. Glucagon-like peptide-1 receptor agonists such as semaglutide have shown promising effects on weight reduction, but lo…
View article: Skin Autofluorescence May Contribute to Prediction of Low Bone Quality in Type 1 Diabetes—A Clinical Cross‐Sectional Study
Skin Autofluorescence May Contribute to Prediction of Low Bone Quality in Type 1 Diabetes—A Clinical Cross‐Sectional Study Open
Introduction People with type 1 diabetes are at risk of complications, including impaired bone health. Hyperglycaemia and accumulation of advanced glycation end products (AGEs) are involved in the development of those. Bone measurements su…
View article: Static and Dynamic Balance Is Impaired in Patients With Long‐Term, Well‐Controlled Acromegaly: A Cross‐Sectional Study
Static and Dynamic Balance Is Impaired in Patients With Long‐Term, Well‐Controlled Acromegaly: A Cross‐Sectional Study Open
Objective Balance impairment is an underrecognized complication of acromegaly with potentially serious consequences for affected patients. In this study, we aimed to assess the balance in patients with long‐term acromegaly compared to non‐…
View article: Trends in anti-hyperglycaemic drug usage among Danish type 2 diabetes patients on second-line treatment and beyond: A nationwide cohort study
Trends in anti-hyperglycaemic drug usage among Danish type 2 diabetes patients on second-line treatment and beyond: A nationwide cohort study Open
2 Abstract OBJECTIVE The paradigm shift introduced by the glucagon-like peptide-1 (GLP1) receptor agonist and sodium-glucose co-transporter-2 (SGLT2) inhibitor classes of drugs has led to changes in treatment practices in Denmark. The aim …
View article: Health economic model assumptions of pharmaceutical treatment paths compared with real-world evidence for patients with type 2 diabetes: A nationwide cohort study
Health economic model assumptions of pharmaceutical treatment paths compared with real-world evidence for patients with type 2 diabetes: A nationwide cohort study Open
2 Abstract OBJECTIVE The glucagon-like peptide-1 (GLP1) and sodium-glucose co-transporter-2 (SGLT2) classes are increasingly being used around the globe to treat type 2 diabetes and its comorbidities. Decision-analytical models (DAMs) are …
View article: Daily Rhythms in Blood Glucose: Time-of-Day Forecasts in Type 2 Diabetes
Daily Rhythms in Blood Glucose: Time-of-Day Forecasts in Type 2 Diabetes Open
Background Accurate and interpretable forecasting of blood glucose levels is critical for effective manage- ment of Type 2 diabetes. While complex machine learning models offer high predictive accuracy, their opacity often limits clinical …
View article: Bone turnover markers and mineral density in type 1 diabetes — A cross-sectional study: DIAFALL
Bone turnover markers and mineral density in type 1 diabetes — A cross-sectional study: DIAFALL Open
View article: Educational inequalities in clinical presentation and pharmacological treatment of early type 2 diabetes: A Danish prevalence study
Educational inequalities in clinical presentation and pharmacological treatment of early type 2 diabetes: A Danish prevalence study Open
View article: Direct Healthcare Cost of Fractures in Patients With Type 1 Diabetes: A Population-Based Cohort Study in Denmark
Direct Healthcare Cost of Fractures in Patients With Type 1 Diabetes: A Population-Based Cohort Study in Denmark Open
Context Patients with type 1 diabetes (T1D) have increased risk of post-fracture complications, such as impaired healing and surgical complications compared to patients without diabetes. However, it is not known if this translates to highe…
View article: Dialysis Nurses’ Experiences with Continuous Glucose Monitoring in Hemodialysis Patients Treated with Insulin
Dialysis Nurses’ Experiences with Continuous Glucose Monitoring in Hemodialysis Patients Treated with Insulin Open
This study examines dialysis nurses’ perspectives on the use of continuous glucose monitoring (CGM) in hemodialysis (HD) patients with insulin-treated diabetes. Through eight semi-structured interviews, nurses highlighted how CGM improved …
View article: YKL-40 and risk of incident cancer in early type 2 diabetes: a Danish cohort study
YKL-40 and risk of incident cancer in early type 2 diabetes: a Danish cohort study Open
Background We examined the association of serum YKL-40, an inflammatory biomarker, with incident cancer risk in early type 2 diabetes. Methods A cohort of 11,346 individuals newly diagnosed with type 2 diabetes was followed for up to 14 ye…
View article: A continuous glucose monitoring device as a valuable tool for supporting diabetes care in haemodialysis patients: A qualitative interview study
A continuous glucose monitoring device as a valuable tool for supporting diabetes care in haemodialysis patients: A qualitative interview study Open
Continuous glucose monitoring (CGM) potentially supports diabetes care in dialysis patients. This qualitative study explores the use of CGM in individuals with type 1 diabetes and those with insulin-treated type 2 diabetes undergoing haemo…
View article: Efficacy and safety of continuous glucose monitoring on glycaemic control in patients with chronic pancreatitis and insulin‐treated diabetes: A randomised, open‐label, crossover trial
Efficacy and safety of continuous glucose monitoring on glycaemic control in patients with chronic pancreatitis and insulin‐treated diabetes: A randomised, open‐label, crossover trial Open
Aims Continuous glucose monitoring (CGM) improves glycaemic control and reduces hypoglycaemia in type 1 and 2 diabetes, but its role in managing diabetes in chronic pancreatitis is unknown. We aimed to investigate the effect of CGM compare…
View article: Psychiatric morbidity in acromegaly: a cohort study and meta-analysis of the literature
Psychiatric morbidity in acromegaly: a cohort study and meta-analysis of the literature Open
Purpose We aimed to evaluate the risk of psychiatric disorders through a retrospective cohort study comparing acromegaly and non-functioning pituitary adenomas (NFPAs) and a meta-analysis of existing literature. Methods The cohort study in…
View article: Understanding the impact of diabetic peripheral neuropathy and neuropathic pain on quality of life and mental health in 6,960 people with diabetes
Understanding the impact of diabetic peripheral neuropathy and neuropathic pain on quality of life and mental health in 6,960 people with diabetes Open
Objectives: Diabetic peripheral neuropathy (DPN) and neuropathic pain impacts Quality of Life (QoL) and mental health negatively. This cross-sectional survey study aimed to 1) elucidate the associations between painful and painless DPN and…
View article: Understanding the impact of diabetic peripheral neuropathy and neuropathic pain on quality of life and mental health in 6,960 people with diabetes
Understanding the impact of diabetic peripheral neuropathy and neuropathic pain on quality of life and mental health in 6,960 people with diabetes Open
Objectives: Diabetic peripheral neuropathy (DPN) and neuropathic pain impacts Quality of Life (QoL) and mental health negatively. This cross-sectional survey study aimed to 1) elucidate the associations between painful and painless DPN and…
View article: Birthweight and risk of chronic kidney disease after a type 2 diabetes diagnosis in the DD2 cohort
Birthweight and risk of chronic kidney disease after a type 2 diabetes diagnosis in the DD2 cohort Open
Aims/hypothesis Low birthweight (LBW) is associated with younger age, less obesity and more hypertension among people recently diagnosed with type 2 diabetes, as well as increased cardiovascular morbidity and mortality risk. It is not know…
View article: RET C611Y Germline Variant in Multiple Endocrine Neoplasia Type 2A in Denmark 1930–2021: A Nationwide Study
RET C611Y Germline Variant in Multiple Endocrine Neoplasia Type 2A in Denmark 1930–2021: A Nationwide Study Open
Background: Multiple endocrine neoplasia type 2A (MEN 2A) is a rare hereditary cancer syndrome caused by pathogenic variants in the rearranged during transfection (RET) gene and is characterized by medullary thyroid carcinoma (MTC), pheoch…
View article: Impact of <i>TCF7L2</i> rs7903146 on clinical presentation and risk of complications in patients with type 2 diabetes
Impact of <i>TCF7L2</i> rs7903146 on clinical presentation and risk of complications in patients with type 2 diabetes Open
Aims TCF7L2 rs7903146 is the most impactful single genetic risk variant for type 2 diabetes. However, its role on disease progression, complications and mortality among people with type 2 diabetes at diagnosis remains unclear. Materials an…
View article: Additive Prognostic Importance of Low-Grade Inflammation for Major Cardiovascular Events and Mortality in Recently Diagnosed Type 2 Diabetes without Prevalent Cardiovascular Disease: A Nationwide Danish Cohort Study
Additive Prognostic Importance of Low-Grade Inflammation for Major Cardiovascular Events and Mortality in Recently Diagnosed Type 2 Diabetes without Prevalent Cardiovascular Disease: A Nationwide Danish Cohort Study Open
View article: Developing an AI-Based clinical decision support system for basal insulin titration in type 2 diabetes in primary Care: A Mixed-Methods evaluation using heuristic Analysis, user Feedback, and eye tracking
Developing an AI-Based clinical decision support system for basal insulin titration in type 2 diabetes in primary Care: A Mixed-Methods evaluation using heuristic Analysis, user Feedback, and eye tracking Open
The AI-based Clinical Decision Support System shows promise in managing basal insulin titration for people with type 2 diabetes, addressing clinical inertia, and providing a user-friendly, efficient tool to improve glycemic control during …
View article: YKL-40, cardiovascular events, and mortality in individuals recently diagnosed with type 2 diabetes: A Danish cohort study
YKL-40, cardiovascular events, and mortality in individuals recently diagnosed with type 2 diabetes: A Danish cohort study Open
View article: Modeling the fasting blood glucose response to basal insulin adjustment in type 2 diabetes: An explainable machine learning approach on real-world data
Modeling the fasting blood glucose response to basal insulin adjustment in type 2 diabetes: An explainable machine learning approach on real-world data Open
Developing explainable machine learning models using real-world data is possible for basal insulin titration. However, model performance is influenced by data's ability to capture everyday behavior, underscoring the need for incorporating …
View article: The intelligent diabetes telemonitoring using decision support to treat patients on insulin therapy (DiaTRUST) trial: study protocol for a randomized controlled trial
The intelligent diabetes telemonitoring using decision support to treat patients on insulin therapy (DiaTRUST) trial: study protocol for a randomized controlled trial Open
View article: Prevalence of self-reported symptoms of diabetic autonomic dysfunction in the North Denmark Region: a population-based survey
Prevalence of self-reported symptoms of diabetic autonomic dysfunction in the North Denmark Region: a population-based survey Open
View article: Prediction of People With Type 2 Diabetes Not Achieving HbA1c Target After Initiation of Fast-Acting Insulin Therapy: Using Machine Learning Framework on Clinical Trial Data
Prediction of People With Type 2 Diabetes Not Achieving HbA1c Target After Initiation of Fast-Acting Insulin Therapy: Using Machine Learning Framework on Clinical Trial Data Open
Background and Aims: Glycemic control is crucial for people with type 2 diabetes. However, only about half achieve the advocated HbA1c target of ≤7%. Identifying those who will probably struggle to reach this target may be valuable as they…