Peter W. Andrews
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View article: Childhood outcomes in children with Hirschsprung disease: a population-based data linkage study in England
Childhood outcomes in children with Hirschsprung disease: a population-based data linkage study in England Open
Objective Hirschsprung disease (HSCR) is a rare congenital intestinal condition that, despite lifesaving surgery, can result in increased hospitalisations and a lower quality of life throughout childhood and into adulthood. There is a lack…
View article: Functional and molecular rescue of aganglionic colon by human enteric nervous system progenitor transplantation in Hirschsprung disease
Functional and molecular rescue of aganglionic colon by human enteric nervous system progenitor transplantation in Hirschsprung disease Open
Hirschsprung disease (HSCR) is a devastating congenital disorder characterised by absence of the enteric nervous system (ENS) in the distal gut. Cell therapy, using human pluripotent stem cell-derived ENS progenitors, offers an attractive …
View article: Stem cell fate decisions: Substates and attractors
Stem cell fate decisions: Substates and attractors Open
View article: Author response: Changes in local mineral homeostasis facilitate the formation of benign and malignant testicular microcalcifications
Author response: Changes in local mineral homeostasis facilitate the formation of benign and malignant testicular microcalcifications Open
View article: Changes in local mineral homeostasis facilitate the formation of benign and malignant testicular microcalcifications
Changes in local mineral homeostasis facilitate the formation of benign and malignant testicular microcalcifications Open
Testicular microcalcifications consist of hydroxyapatite and have been associated with an increased risk of testicular germ cell tumors (TGCTs) but are also found in benign cases such as loss-of-function variants in the phosphate transport…
View article: Changes in local mineral homeostasis facilitate the formation of benign and malignant testicular microcalcifications
Changes in local mineral homeostasis facilitate the formation of benign and malignant testicular microcalcifications Open
Testicular microcalcifications consist of hydroxyapatite and have been associated with an increased risk of testicular germ cell tumors (TGCTs) but are also found in benign cases such as loss-of-function variants in the phosphate-transport…
View article: Author response: Changes in local mineral homeostasis facilitate the formation of benign and malignant testicular microcalcifications
Author response: Changes in local mineral homeostasis facilitate the formation of benign and malignant testicular microcalcifications Open
View article: From cancer to pluripotent stem cells–A long and winding road
From cancer to pluripotent stem cells–A long and winding road Open
View article: Germ cell tumors, cell surface markers, and the early search for human pluripotent stem cells
Germ cell tumors, cell surface markers, and the early search for human pluripotent stem cells Open
Many strands of research by different groups, starting from teratocarcinomas in the laboratory mouse, later moving the corresponding human tumors, contributed to the isolation and description of human pluripotent stem cells (PSCs). In this…
View article: Changes in local mineral homeostasis facilitate the formation of benign and malignant testicular microcalcifications
Changes in local mineral homeostasis facilitate the formation of benign and malignant testicular microcalcifications Open
Testicular microcalcifications consist of hydroxyapatite and have been associated with an increased risk of testicular germ cell tumors (TGCTs) but are also found in benign cases such as loss-of-function variants in the phosphate transport…
View article: Changes in local mineral homeostasis facilitate the formation of benign and malignant testicular microcalcifications
Changes in local mineral homeostasis facilitate the formation of benign and malignant testicular microcalcifications Open
Testicular microcalcifications consist of hydroxyapatite and have been associated with an increased risk of testicular germ cell tumors (TGCTs) but may also be the result of benign causes such as loss-of-function variants in the phosphate-…
View article: Human enteric nervous system progenitor transplantation improves functional responses in Hirschsprung disease patient-derived tissue
Human enteric nervous system progenitor transplantation improves functional responses in Hirschsprung disease patient-derived tissue Open
Objective Hirschsprung disease (HSCR) is a severe congenital disorder affecting 1:5000 live births. HSCR results from the failure of enteric nervous system (ENS) progenitors to fully colonise the gastrointestinal tract during embryonic dev…
View article: A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations
A human neural crest model reveals the developmental impact of neuroblastoma-associated chromosomal aberrations Open
View article: The origins of human pluripotent stem cells: the road from a cancer to regenerative medicine
The origins of human pluripotent stem cells: the road from a cancer to regenerative medicine Open
The notion of using pluripotent stem cells (PSCs) as a source of differentiated cell types for replacement of disease or damaged tissues in regenerative medicine is now an active area of research, with approaches to treating eye diseases s…
View article: A short history of pluripotent stem cells markers
A short history of pluripotent stem cells markers Open
View article: Human enteric nervous system progenitor transplantation restores functional responses in Hirschsprung Disease patient-derived tissue
Human enteric nervous system progenitor transplantation restores functional responses in Hirschsprung Disease patient-derived tissue Open
Objective Hirschsprung disease (HSCR) is a severe congenital disorder affecting 1:5000 live births. HSCR results from failure of enteric nervous system (ENS) progenitors to fully colonise the gastrointestinal tract during embryonic develop…
View article: ISSCR standards for the use of human stem cells in basic research
ISSCR standards for the use of human stem cells in basic research Open
View article: In Vivo Tumorigenicity of the 20q11.21 Amplicon in an Engraftment Model of hPSCs and Differentiated Liver Cells
In Vivo Tumorigenicity of the 20q11.21 Amplicon in an Engraftment Model of hPSCs and Differentiated Liver Cells Open
Human pluripotent stem cells (hPSCs) are a promising source of somatic cells for clinical applications and disease modelling. However, during culture they accumulate genetic aberrations such as amplification of 20q11.21 which occurs in app…
View article: Supplementary Data from Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics
Supplementary Data from Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics Open
Supplementary Data from Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics
View article: Supplementary Data from Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics
Supplementary Data from Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics Open
Supplementary Data from Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics
View article: Supplementary Data from Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics
Supplementary Data from Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics Open
Supplementary Data from Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics
View article: Supplementary Data from Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics
Supplementary Data from Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics Open
Supplementary Data from Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics
View article: Data from Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics
Data from Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics Open
Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer with poor patient outcomes, highlighting the unmet clinical need for targeted therapies and better model systems. Here, we developed and comprehensively characteri…
View article: Supplementary Data from Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics
Supplementary Data from Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics Open
Supplementary Data from Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics
View article: Data from Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics
Data from Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics Open
Triple-negative breast cancer (TNBC) is an aggressive form of breast cancer with poor patient outcomes, highlighting the unmet clinical need for targeted therapies and better model systems. Here, we developed and comprehensively characteri…
View article: Supplementary Data from Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics
Supplementary Data from Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics Open
Supplementary Data from Patient-Derived Triple-Negative Breast Cancer Organoids Provide Robust Model Systems That Recapitulate Tumor Intrinsic Characteristics
View article: Supplementary Tables 1 through 4 and Supplementary Figures 1 and 2 from Identification of Novel Fusion Genes in Testicular Germ Cell Tumors
Supplementary Tables 1 through 4 and Supplementary Figures 1 and 2 from Identification of Novel Fusion Genes in Testicular Germ Cell Tumors Open
Supplementary Table S1: primers used in RT-PCR and qRT-PCR validation and quantification of fusion genes and transcripts. Supplementary Table S2: Primers and probes for assays used in ddPCR linkage experiments. Supplementary Table S3: Pair…
View article: Supplementary Table 3 from Differentiation of Human Embryonal Carcinomas <i>In vitro</i> and <i>In vivo</i> Reveals Expression Profiles Relevant to Normal Development
Supplementary Table 3 from Differentiation of Human Embryonal Carcinomas <i>In vitro</i> and <i>In vivo</i> Reveals Expression Profiles Relevant to Normal Development Open
Supplementary Table 3 from Differentiation of Human Embryonal Carcinomas In vitro and In vivo Reveals Expression Profiles Relevant to Normal Development
View article: Supplementary Figure 2 from Analysis of Gene Expression Profiles of Microdissected Cell Populations Indicates that Testicular Carcinoma <i>In situ</i> Is an Arrested Gonocyte
Supplementary Figure 2 from Analysis of Gene Expression Profiles of Microdissected Cell Populations Indicates that Testicular Carcinoma <i>In situ</i> Is an Arrested Gonocyte Open
Supplementary Figure 2 from Analysis of Gene Expression Profiles of Microdissected Cell Populations Indicates that Testicular Carcinoma In situ Is an Arrested Gonocyte
View article: Data from Analysis of Gene Expression Profiles of Microdissected Cell Populations Indicates that Testicular Carcinoma <i>In situ</i> Is an Arrested Gonocyte
Data from Analysis of Gene Expression Profiles of Microdissected Cell Populations Indicates that Testicular Carcinoma <i>In situ</i> Is an Arrested Gonocyte Open
Testicular germ cell cancers in young adult men derive from a precursor lesion called carcinoma in situ (CIS) of the testis. CIS cells were suggested to arise from primordial germ cells or gonocytes. However, direct studies on purif…