Peter W. Bircham
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View article: The anti-cancer transition-state inhibitor MTDIA inhibits human MTAP, inducing autophagy in humanized yeast
The anti-cancer transition-state inhibitor MTDIA inhibits human MTAP, inducing autophagy in humanized yeast Open
Methylthioadenosine-DADMe immucillin-A (MTDIA) is a transition-state analog that potently inhibits the human protein 5′-methylthioadenosine phosphorylase (MTAP) at picomolar concentrations and elicits anti-tumor activity against lung, pros…
View article: Combinatorial optimization of gene expression through recombinase-mediated promoter and terminator shuffling in yeast
Combinatorial optimization of gene expression through recombinase-mediated promoter and terminator shuffling in yeast Open
Microbes are increasingly employed as cell factories to produce biomolecules. This often involves the expression of complex heterologous biosynthesis pathways in host strains. Achieving maximal product yields and avoiding build-up of (toxi…
View article: Novel Saccharomyces cerevisiae variants slow down the accumulation of staling aldehydes and improve beer shelf-life
Novel Saccharomyces cerevisiae variants slow down the accumulation of staling aldehydes and improve beer shelf-life Open
Beer quality generally diminishes over time as staling compounds accumulate through various oxidation reactions. Here, we show that refermentation, a traditional practice where Saccharomyces cerevisiae cells are added to beer prior to bott…
View article: Ice2 promotes ER membrane biogenesis in yeast by inhibiting the conserved lipin phosphatase complex
Ice2 promotes ER membrane biogenesis in yeast by inhibiting the conserved lipin phosphatase complex Open
Cells dynamically adapt organelle size to current physiological demand. Organelle growth requires membrane biogenesis and therefore needs to be coordinated with lipid metabolism. The endoplasmic reticulum (ER) can undergo massive expansion…
View article: <scp>ESCRT</scp> machinery mediates selective microautophagy of endoplasmic reticulum in yeast
<span>ESCRT</span> machinery mediates selective microautophagy of endoplasmic reticulum in yeast Open
ER-phagy, the selective autophagy of endoplasmic reticulum (ER), safeguards organelle homeostasis by eliminating misfolded proteins and regulating ER size. ER-phagy can occur by macroautophagic and microautophagic mechanisms. While dedicat…
View article: A Hands‐On Guide to Brewing and Analyzing Beer in the Laboratory
A Hands‐On Guide to Brewing and Analyzing Beer in the Laboratory Open
Beer would not exist without microbes. During fermentation, yeast cells convert cereal‐derived sugars into ethanol and CO 2 . Yeast also produces a wide array of aroma compounds that influence beer taste and aroma. The complex interaction …
View article: ESCRT machinery mediates selective microautophagy of endoplasmic reticulum
ESCRT machinery mediates selective microautophagy of endoplasmic reticulum Open
ER-phagy, the selective autophagy of endoplasmic reticulum (ER), safeguards organelle homeostasis by eliminating misfolded proteins and regulating ER size. ER-phagy can occur by macroautophagic and microautophagic mechanisms. While dedicat…
View article: SHRED is a regulatory cascade that reprograms Ubr1 substrate specificity for enhanced protein quality control during stress. Szoradi et al. 2018
SHRED is a regulatory cascade that reprograms Ubr1 substrate specificity for enhanced protein quality control during stress. Szoradi et al. 2018 Open
This dataset includes raw blot and microscopy images from the manuscript "SHRED is a regulatory cascade that reprograms Ubr1 substrate specificity for enhanced protein quality control during stress" submitted to Molecular Cell. The areas o…