Peter Wenner
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View article: Localization of Fascin to Dendritic Protrusions Regulates Postsynaptic Plasticity
Localization of Fascin to Dendritic Protrusions Regulates Postsynaptic Plasticity Open
The Fascin family of actin-bundling proteins organizes actin filaments (F-actin) into tightly packed bundles that drive dynamic membrane protrusions such as filopodia. In neurons, fascin has been thought to primarily function in axons, as …
View article: Impairment in the homeostatic recruitment of layer 5/6 neurons following whisker stimulation in Fmr1 KO mice
Impairment in the homeostatic recruitment of layer 5/6 neurons following whisker stimulation in Fmr1 KO mice Open
Mouse models of Fragile X Syndrome (FXS) have demonstrated impairments in sensory-evoked neuronal firing of excitatory and inhibitory neurons. Homeostatic plasticity does not compensate for these changes in activity. Previous work has show…
View article: Whisker deprivation triggers a distinct form of cortical homeostatic plasticity that is impaired in the<i>Fmr1</i>KO
Whisker deprivation triggers a distinct form of cortical homeostatic plasticity that is impaired in the<i>Fmr1</i>KO Open
SUMMARY Mouse models of Fragile X Syndrome (FXS) have demonstrated impairments in excitatory and inhibitory sensory-evoked neuronal firing. Homeostatic plasticity, which encompasses a set of mechanisms to stabilize baseline activity levels…
View article: Homeostatic Regulation of Spike Rate within Bursts in Two Distinct Preparations
Homeostatic Regulation of Spike Rate within Bursts in Two Distinct Preparations Open
Homeostatic plasticity represents a set of mechanisms thought to stabilize some function of neural activity. Here, we identified the specific features of cellular or network activity that were maintained after the perturbation of GABAergic…
View article: GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation
GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation Open
Homeostatic plasticity represents a set of mechanisms that are thought to recover some aspect of neural function. One such mechanism called AMPAergic scaling was thought to be a likely candidate to homeostatically control spiking activity.…
View article: Author response: GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation
Author response: GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation Open
View article: GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation
GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation Open
Homeostatic plasticity represents a set of mechanisms that are thought to recover some aspect of neural function. One such mechanism called AMPAergic scaling was thought to be a likely candidate to homeostatically control spiking activity.…
View article: Reviewer #3 (Public Review): GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation
Reviewer #3 (Public Review): GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation Open
Homeostatic plasticity represents a set of mechanisms that are thought to recover some aspect of neural function. One such mechanism called AMPAergic scaling was thought to be a likely candidate to homeostatically control spiking activity.…
View article: Author response: GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation
Author response: GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation Open
Homeostatic plasticity represents a set of mechanisms that are thought to recover some aspect of neural function. One such mechanism called AMPAergic scaling was thought to be a likely candidate to homeostatically control spiking activity.…
View article: Plasticity in Preganglionic and Postganglionic Neurons of the Sympathetic Nervous System during Embryonic Development
Plasticity in Preganglionic and Postganglionic Neurons of the Sympathetic Nervous System during Embryonic Development Open
Sympathetic preganglionic neurons (SPNs) are the final output neurons from the central arm of the autonomic nervous system. Therefore, SPNs represent a crucial component of the sympathetic nervous system for integrating several inputs befo…
View article: GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation
GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation Open
Homeostatic plasticity represents a set of mechanisms that are thought to recover some aspect of neural function. One such mechanism called AMPAergic scaling was thought to be a likely candidate to homeostatically control spiking activity.…
View article: Author Response: GABAergic synaptic scaling is triggered by changes in spiking activity rather than transmitter receptor activation
Author Response: GABAergic synaptic scaling is triggered by changes in spiking activity rather than transmitter receptor activation Open
Homeostatic plasticity represents a set of mechanisms that are thought to recover some aspect of neural function. One such mechanism called AMPAergic scaling was thought to be a likely candidate to homeostatically control spiking activity.…
View article: GABAergic synaptic scaling is triggered by changes in spiking activity rather than transmitter receptor activation
GABAergic synaptic scaling is triggered by changes in spiking activity rather than transmitter receptor activation Open
Homeostatic plasticity represents a set of mechanisms that are thought to recover some aspect of neural function. One such mechanism called AMPAergic scaling was thought to be a likely candidate to homeostatically control spiking activity.…
View article: GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation
GABAergic synaptic scaling is triggered by changes in spiking activity rather than AMPA receptor activation Open
Homeostatic plasticity represents a set of mechanisms that are thought to recover some aspect of neural function. One such mechanism called AMPAergic scaling was thought to be a likely candidate to homeostatically control spiking activity.…
View article: Decision letter: A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up- or downscaling
Decision letter: A bidirectional switch in the Shank3 phosphorylation state biases synapses toward up- or downscaling Open
View article: The Type 2 Diabetes Factor Methylglyoxal Mediates Axon Initial Segment Shortening and Alters Neuronal Function at the Cellular and Network Levels
The Type 2 Diabetes Factor Methylglyoxal Mediates Axon Initial Segment Shortening and Alters Neuronal Function at the Cellular and Network Levels Open
Recent evidence suggests that alteration of axon initial segment (AIS) geometry (i.e., length or location along the axon) contributes to CNS dysfunction in neurological diseases. For example, AIS length is shorter in the prefrontal cortex …
View article: Mitochondrial Structure and Polarity in Dendrites and the Axon Initial Segment Are Regulated by Homeostatic Plasticity and Dysregulated in Fragile X Syndrome
Mitochondrial Structure and Polarity in Dendrites and the Axon Initial Segment Are Regulated by Homeostatic Plasticity and Dysregulated in Fragile X Syndrome Open
Mitochondrial dysfunction has long been overlooked in neurodevelopmental disorders, but recent studies have provided new links to genetic forms of autism, including Rett syndrome and fragile X syndrome (FXS). Mitochondria show plasticity i…
View article: The type 2 diabetes factor methylglyoxal mediates axon initial segment shortening and neuronal network activity changes
The type 2 diabetes factor methylglyoxal mediates axon initial segment shortening and neuronal network activity changes Open
Recent evidence suggests that alteration of axon initial segment (AIS) geometry (i.e., length or position along the axon) contributes to CNS dysfunction in neurological diseases. For example, AIS length is shorter in the prefrontal cortex …
View article: FMRP attenuates activity dependent modifications in the mitochondrial proteome
FMRP attenuates activity dependent modifications in the mitochondrial proteome Open
View article: Mitochondrial Structure and Polarity in Dendrites and the Axon Initial Segment are Regulated by Homeostatic Plasticity and Dysregulated in Fragile X Syndrome
Mitochondrial Structure and Polarity in Dendrites and the Axon Initial Segment are Regulated by Homeostatic Plasticity and Dysregulated in Fragile X Syndrome Open
Mitochondrial dysfunction has long been overlooked in neurodevelopmental disorders, but recent studies have provided new links to genetic forms of autism, including Rett syndrome and Fragile X Syndrome (FXS). In parallel, recent studies ha…
View article: FMRP Attenuates Activity Dependent Modifications in the Mitochondrial Proteome
FMRP Attenuates Activity Dependent Modifications in the Mitochondrial Proteome Open
Homeostatic plasticity is necessary for the construction and maintenance of functional neuronal networks, but principal molecular mechanisms required for or modified by homeostatic plasticity are not well understood. We recently reported t…
View article: Additional file 1 of FMRP attenuates activity dependent modifications in the mitochondrial proteome
Additional file 1 of FMRP attenuates activity dependent modifications in the mitochondrial proteome Open
Additional file 1: Table S1. Proteome hits sensitive to activity deprivation and Fmr1−/y quantified by TMT mass spectrometry.
View article: Isolation and Electrophysiology of Murine Sympathetic Postganglionic Neurons in the Thoracic Paravertebral Ganglia
Isolation and Electrophysiology of Murine Sympathetic Postganglionic Neurons in the Thoracic Paravertebral Ganglia Open
The thoracic paravertebral sympathetic chain postganglionic neurons (tSPNs) represent the predominant sympathetic control of vascular function in the trunk and upper extremities. tSPNs cluster to form ganglia linked by an interganglionic n…
View article: Additional file 2 of FMRP attenuates activity dependent modifications in the mitochondrial proteome
Additional file 2 of FMRP attenuates activity dependent modifications in the mitochondrial proteome Open
Additional file 2: Table S2. Ontological analyses of the proteome sensitive to activity deprivation and Fmr1−/y.
View article: Homeostatic Recovery of Embryonic Spinal Activity Initiated by Compensatory Changes in Resting Membrane Potential
Homeostatic Recovery of Embryonic Spinal Activity Initiated by Compensatory Changes in Resting Membrane Potential Open
When baseline activity in a neuronal network is modified by external challenges, a set of mechanisms is prompted to homeostatically restore activity levels. These homeostatic mechanisms are thought to be profoundly important in the maturat…
View article: Divergent Synaptic Scaling of Miniature EPSCs following Activity Blockade in Dissociated Neuronal Cultures
Divergent Synaptic Scaling of Miniature EPSCs following Activity Blockade in Dissociated Neuronal Cultures Open
Neurons can respond to decreased network activity with a homeostatic increase in the amplitudes of miniature EPSCs (mEPSCs). The prevailing view is that mEPSC amplitudes are uniformly multiplied by a single factor, termed “synaptic scaling…
View article: Activity-Dependent Mitochondrial Plasticity and Mitoproteome are Dysregulated in Fragile X Syndrome
Activity-Dependent Mitochondrial Plasticity and Mitoproteome are Dysregulated in Fragile X Syndrome Open
View article: Homeostatic recovery of embryonic spinal activity initiated by compensatory changes in resting membrane potential
Homeostatic recovery of embryonic spinal activity initiated by compensatory changes in resting membrane potential Open
When baseline activity in a neuronal network is modified by external challenges, a set of mechanisms is prompted to homeostatically restore activity levels. These homeostatic mechanisms are thought to be profoundly important in the maturat…
View article: Homeostatic Intrinsic Plasticity Is Functionally Altered in Fmr1 KO Cortical Neurons
Homeostatic Intrinsic Plasticity Is Functionally Altered in Fmr1 KO Cortical Neurons Open
View article: Regulation of synaptic scaling by action potential–independent miniature neurotransmission
Regulation of synaptic scaling by action potential–independent miniature neurotransmission Open
Synaptic scaling represents a homeostatic adjustment in synaptic strength that was first identified as a cell‐wide mechanism to achieve firing rate homeostasis after perturbations to spiking activity levels. In this review, we consider a f…