Peter J. Wild
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View article: ERBB2 Mutation Testing in NSCLC: A Pan-European Real-World Evaluation of the Oncomine Precision Assay
ERBB2 Mutation Testing in NSCLC: A Pan-European Real-World Evaluation of the Oncomine Precision Assay Open
Background/Objectives: The non-small-cell lung cancer (NSCLC) therapeutic landscape has undergone a profound transformation with the introduction of multiple personalized treatment options. Mutations in ERBB2 (HER2) have recently emerged a…
View article: Exosomal cargo genes as biomarkers and potential mediators of exosome-driven cell communication in Pleural Mesothelioma
Exosomal cargo genes as biomarkers and potential mediators of exosome-driven cell communication in Pleural Mesothelioma Open
Pleural mesothelioma (PM) is a rare yet aggressive and heterogeneous cancer type with very poor survival rates. Due to its long latency period and nonspecific symptoms, the disease is usually detected at advanced stages, limiting available…
View article: Head and neck tumor organoid biobank for modelling individual responses to radiation therapy according to the TP53/HPV status
Head and neck tumor organoid biobank for modelling individual responses to radiation therapy according to the TP53/HPV status Open
Background Head and neck cancers (HNC) represent an extremely heterogeneous group of diseases with a poorly predictable therapy outcome. Patient-derived tumor organoids (PDTO) offer enormous potential for individualized therapy testing and…
View article: Evaluation of an IDH1/2 Mutation FastTrack Assay for Patients with Cholangiocarcinoma
Evaluation of an IDH1/2 Mutation FastTrack Assay for Patients with Cholangiocarcinoma Open
Background: Cholangiocarcinoma, a malignancy originating from the bile ducts, poses significant treatment challenges due to its typically late diagnosis and limited therapeutic options. However, recent advances in molecular genetics enable…
View article: Implementation of Valid HPV Diagnostics for the Early Detection of Cervical Cancer in Molecular Pathology: HPV 3.5 LCD-Array (Chipron GmbH) vs. PapilloCheck® (Greiner Bio-One GmbH) vs. VisionArray® (ZytoVision GmbH)
Implementation of Valid HPV Diagnostics for the Early Detection of Cervical Cancer in Molecular Pathology: HPV 3.5 LCD-Array (Chipron GmbH) vs. PapilloCheck® (Greiner Bio-One GmbH) vs. VisionArray® (ZytoVision GmbH) Open
The occurrence of cervical cancer is often linked to a previous infection with a human papillomavirus (HPV). In order to detect HPV infections in cervical smears, a broad range of tests can be used. This study compares the two hybridisatio…
View article: Expression of claudin‐18.2 in cholangiocarcinoma: a comprehensive immunohistochemical analysis from a German tertiary centre
Expression of claudin‐18.2 in cholangiocarcinoma: a comprehensive immunohistochemical analysis from a German tertiary centre Open
Aims Anti‐claudin‐18.2 (CLDN18.2) therapy was recently approved for the treatment of gastric or gastro‐oesophageal junction adenocarcinoma. The aim of the present study was to investigate the expression of CLDN18.2 in cholangiocarcinoma (C…
View article: Upregulation of mitochondrial function is associated with advanced prostate cancer
Upregulation of mitochondrial function is associated with advanced prostate cancer Open
1 Abstract: Background: The mitochondrial metabolism in prostate cancer (PCa) is of great importance due the unique metabolic shift from glycolysis to oxidative phosphorylation. In this study, we aimed to analyze the expression level of mi…
View article: Fresh Hemorrhages in Intestinal Resection Margins Are Associated with Unfavorable Clinical Outcomes in Preterm Infants with Necrotizing Enterocolitis with Surgical Intervention
Fresh Hemorrhages in Intestinal Resection Margins Are Associated with Unfavorable Clinical Outcomes in Preterm Infants with Necrotizing Enterocolitis with Surgical Intervention Open
Background: Necrotizing enterocolitis (NEC) is a common disease in premature infants. If conservative treatment does not respond, surgical removal of the necrotic section of bowel is common practice. This study investigates whether there i…
View article: Detection of diagnostic somatic copy number alterations from cerebrospinal fluid cell-free DNA in brain tumor patients
Detection of diagnostic somatic copy number alterations from cerebrospinal fluid cell-free DNA in brain tumor patients Open
The gold standard for precise diagnostic classification of brain tumors requires tissue sampling, which carries relevant procedural risks. Brain biopsies often have limited sensitivity and fail to address tumor heterogeneity, because small…
View article: Gene Expression Profiling of the Peritumoral Immune Cell Infiltrate of Penile Squamous Cell Carcinomas
Gene Expression Profiling of the Peritumoral Immune Cell Infiltrate of Penile Squamous Cell Carcinomas Open
Penile carcinomas are rare tumors in Europe and need further investigations due to their inferior prognosis in late tumor stages. The presence of disparate immune cell infiltrates was observed in these tumors, which were subsequently demon…
View article: Supplementary Tables 1-12 from Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses
Supplementary Tables 1-12 from Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses Open
Supplementary Table S1 shows the clinical data of the CRC organoid-stroma cohort. Supplementary Table S2 shows the inventory of available materials and molecular analyses. Supplementary Table S3 shows the selected variant types for whole e…
View article: Supplementary Figures 1-12 from Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses
Supplementary Figures 1-12 from Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses Open
Supplementary Figure S1 shows light microscopic images of CRC organoids and CAFs. Supplementary Figure S2 shows immunostaining and RNA sequencing analysis of cultured CAFs. Supplementary Figure S3 shows chromosomal copy number changes in t…
View article: Data from Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses
Data from Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses Open
In colorectal cancers (CRC) the tumor microenvironment plays a key role for prognosis and therapy efficacy. Patient-derived tumor organoids (PDTOs) show enormous potential for preclinical testing, however, cultured tumor cells lose importa…
View article: Supplementary Figures 1-12 from Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses
Supplementary Figures 1-12 from Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses Open
Supplementary Figure S1 shows light microscopic images of CRC organoids and CAFs. Supplementary Figure S2 shows immunostaining and RNA sequencing analysis of cultured CAFs. Supplementary Figure S3 shows chromosomal copy number changes in t…
View article: Supplementary Tables 1-12 from Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses
Supplementary Tables 1-12 from Colorectal cancer organoid-stroma biobank allows subtype-specific assessment of individualized therapy responses Open
Supplementary Table S1 shows the clinical data of the CRC organoid-stroma cohort. Supplementary Table S2 shows the inventory of available materials and molecular analyses. Supplementary Table S3 shows the selected variant types for whole e…
View article: Single Center Characterization of a Cohort of Salivary Gland Carcinomas
Single Center Characterization of a Cohort of Salivary Gland Carcinomas Open
Salivary gland cancer (SGC) is a rare cancer that can present a diagnostic challenge to pathologists, with emerging, but still limited options for the treatment of recurrent/metastatic disease. We aimed to characterize the cohort of saliva…
View article: Single-cell integration and multi-modal profiling reveals phenotypes and spatial organization of neutrophils in colorectal cancer
Single-cell integration and multi-modal profiling reveals phenotypes and spatial organization of neutrophils in colorectal cancer Open
SUMMARY The immune composition of the tumor microenvironment (TME) has a major impact on the therapeutic response and clinical outcome in patients with colorectal cancer (CRC). Here, we comprehensively characterize the TME at the single-ce…
View article: Biomechanical Assessment of Liver Integrity: Prospective Evaluation of Mechanical Versus Acoustic <scp>MR</scp> Elastography
Biomechanical Assessment of Liver Integrity: Prospective Evaluation of Mechanical Versus Acoustic <span>MR</span> Elastography Open
Background Magnetic resonance elastography (MRE) can quantify tissue biomechanics noninvasively, including pathological hepatic states like metabolic dysfunction‐associated steatohepatitis. Purpose To compare the performance of 2D/3D‐MRE u…
View article: Impact of homologous recombination repair/BReast CAncer ( <scp> <i>BRCA</i> ) </scp> gene alterations on survival in a real‐world setting of metastatic prostate cancer
Impact of homologous recombination repair/BReast CAncer ( <span> <i>BRCA</i> ) </span> gene alterations on survival in a real‐world setting of metastatic prostate cancer Open
Objective To investigate alterations of homologous recombination repair (HRR) and especially BReast CAncer 1/2 ( BRCA 1/2) gene on overall survival (OS). Moreover, to explore the effect of inhibition of poly(ADP‐ribose)‐polymerase (PARPi) …
View article: Fluorescence confocal microscopy for evaluation of fresh surgical specimens and consecutive tumor cell isolation in rare pediatric tumors
Fluorescence confocal microscopy for evaluation of fresh surgical specimens and consecutive tumor cell isolation in rare pediatric tumors Open
Fluorescence confocal microscopy (FCM) is an optical technique that uses laser light sources of different wavelengths to generate real-time images of fresh, unfixed tissue specimens. FCM allows histological evaluation of fresh tissue sampl…