Peter YF. Zeng
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View article: Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer
Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer Open
Over 70% of oropharyngeal head and neck squamous cell carcinoma (HNSC) cases in the United States are positive for human papillomavirus (HPV) yet biomarkers for stratifying oropharyngeal head and neck squamous cell carcinoma (HNSC) patient…
View article: NOVEL INSIGHTS IN ADVANCED THYROID CARCINOMA: FROM MECHANISMS TO TREATMENTS: Molecular insights into the origin, biology, and treatment of anaplastic thyroid carcinoma
NOVEL INSIGHTS IN ADVANCED THYROID CARCINOMA: FROM MECHANISMS TO TREATMENTS: Molecular insights into the origin, biology, and treatment of anaplastic thyroid carcinoma Open
Anaplastic thyroid carcinoma (ATC) is among the most daunting entities in clinical oncology. Large-scale genomic studies of thyroid cancer within the last decade have uncovered a distinct set of recurrent somatic alterations implicated in …
View article: Transcriptomic Features of Recurrence Rates in Idiopathic Subglottic Stenosis
Transcriptomic Features of Recurrence Rates in Idiopathic Subglottic Stenosis Open
Objective Idiopathic subglottic stenosis (iSGS) is a rare disease characterized by narrowing of the upper airway and affects near‐exclusively females. Patients often experience recurrent disease and require repeated surgical dilations. The…
View article: Effect of Serial Intralesional Steroid Injections on Risk of Recurrence in Idiopathic Subglottic Stenosis
Effect of Serial Intralesional Steroid Injections on Risk of Recurrence in Idiopathic Subglottic Stenosis Open
Background Serial intralesional steroid injections (ILSIs) have been suggested to be an effective adjunct treatment for idiopathic subglottic stenosis (iSGS) by maintaining airway patency and extending inter‐surgical intervals. However, ev…
View article: Molecular features of T and N stage progression in laryngeal cancer
Molecular features of T and N stage progression in laryngeal cancer Open
Laryngeal squamous cell cancer (LSCC) is a common type of head and neck cancer that is typically unrelated to human papilloma virus (HPV) infection. Late-stage laryngeal cancers are associated with greater morbidity due to obstructive symp…
View article: Cellular blueprint of healthy and diseased human epiglottis and subglottis—a study of the Canadian Airways Research (CARE) group
Cellular blueprint of healthy and diseased human epiglottis and subglottis—a study of the Canadian Airways Research (CARE) group Open
View article: Cohort-level clinical trajectory and molecular landscape of idiopathic subglottic stenosis for precision laryngology—a study of the Canadian Airways Research (CARE) group
Cohort-level clinical trajectory and molecular landscape of idiopathic subglottic stenosis for precision laryngology—a study of the Canadian Airways Research (CARE) group Open
This study was funded by a grant from the American Laryngology Association (#1082), an Academic Medical Organization of Southwestern Ontario innovation fund grant (INN21-016), grant support from the Departments of Otolaryngology-Head and N…
View article: Understanding and overcoming innate and acquired MAPK-inhibition resistance in anaplastic thyroid cancer
Understanding and overcoming innate and acquired MAPK-inhibition resistance in anaplastic thyroid cancer Open
Anaplastic thyroid cancer (ATC) is one of the most lethal human cancers, with some patients succumbing to the disease within weeks of diagnosis. Although a subset of patients with ATC with BRAF V600E mutation respond to the monomeric type …
View article: A toothpaste efficacy of Dentine Hypersensitivity in Chinese population
A toothpaste efficacy of Dentine Hypersensitivity in Chinese population Open
View article: Metabolic pathway-based subtypes associate glycan biosynthesis and treatment response in head and neck cancer
Metabolic pathway-based subtypes associate glycan biosynthesis and treatment response in head and neck cancer Open
View article: Efficacy of a stannous fluoride dentifrice for relieving dentinal hypersensitivity in Chinese population: an 8-week randomized clinical trial
Efficacy of a stannous fluoride dentifrice for relieving dentinal hypersensitivity in Chinese population: an 8-week randomized clinical trial Open
View article: The genomic and evolutionary landscapes of anaplastic thyroid carcinoma
The genomic and evolutionary landscapes of anaplastic thyroid carcinoma Open
Anaplastic thyroid carcinoma is arguably the most lethal human malignancy. It often co-occurs with differentiated thyroid cancers, yet the molecular origins of its aggressivity are unknown. We sequenced tumor DNA from 329 regions of thyroi…
View article: A comparison of timing and patterns of treatment failure, and survival outcomes after progression between <scp>HPV</scp>+ and <scp>HPV</scp>− patients undergoing chemoradiation for oropharyngeal squamous cell carcinomas
A comparison of timing and patterns of treatment failure, and survival outcomes after progression between <span>HPV</span>+ and <span>HPV</span>− patients undergoing chemoradiation for oropharyngeal squamous cell carcinomas Open
Background We aimed to analyze and compare the timing and patterns of treatment failure, and survival after progression between HPV‐positive (HPV+) and HPV‐negative (HPV−) patients undergoing chemoradiation for oropharyngeal squamous cell …
View article: HPV16 Intratypic Variants in Head and Neck Cancers: A North American Perspective
HPV16 Intratypic Variants in Head and Neck Cancers: A North American Perspective Open
Human papillomavirus (HPV) is the major causative agent for cervical and many head and neck cancers (HNCs). HPVs randomly acquire single nucleotide polymorphisms (SNPs) that may become established via positive selection. Within an HPV type…
View article: Clinical Presentation and Genomic Analysis of HPV-Related Squamous Cell Carcinoma of the Larynx in Two Young Female Patients
Clinical Presentation and Genomic Analysis of HPV-Related Squamous Cell Carcinoma of the Larynx in Two Young Female Patients Open
Laryngeal cancer most frequently develops in males aged 60-70 years with a history of tobacco and/or alcohol use, while fewer cases occur in young patients in which tobacco and alcohol are often absent or less significant, highlighting the…
View article: The genomic and evolutionary landscapes of anaplastic thyroid carcinoma
The genomic and evolutionary landscapes of anaplastic thyroid carcinoma Open
Anaplastic thyroid carcinoma is arguably the most lethal human malignancy. It often co-occurs with differentiated thyroid cancers, yet the molecular origins of its aggressivity are unknown. We sequenced tumor DNA from 329 regions of thyroi…
View article: Supplementary Table ST1 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer
Supplementary Table ST1 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer Open
List of Primers.
View article: Supplementary Table ST4 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer
Supplementary Table ST4 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer Open
Differentially expressed genes from the TCGA Cervical Squamous Cell Carcinoma (CESC).
View article: Supplementary Table ST2 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer
Supplementary Table ST2 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer Open
Demographic and clinical characteristics of the study cases.
View article: Supplementary Table ST5 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer
Supplementary Table ST5 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer Open
Descriptive statistics for HNSC patients from the CHANCE study by p16 cytoplasmic/nuclear status.
View article: Figure S3 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer
Figure S3 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer Open
Additional multiplex staining coexpression and ROI quantification.
View article: Data from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer
Data from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer Open
Over 70% of oropharyngeal head and neck squamous cell carcinoma (HNSC) cases in the United States are positive for human papillomavirus (HPV) yet biomarkers for stratifying oropharyngeal HNSC patient risk are limited. We used immunogenomic…
View article: Figure S1 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer
Figure S1 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer Open
HPV(+) and HPV(-) HNSC are characterized by distinct immunogenomic signatures.
View article: Supplementary Table ST2 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer
Supplementary Table ST2 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer Open
Demographic and clinical characteristics of the study cases.
View article: Supplementary Table ST6 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer
Supplementary Table ST6 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer Open
Crude 5- and 10-year survival rates by p16 cytoplasmic/nuclear status.
View article: Supplementary Table ST4 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer
Supplementary Table ST4 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer Open
Differentially expressed genes from the TCGA Cervical Squamous Cell Carcinoma (CESC).
View article: Supplementary Table ST3 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer
Supplementary Table ST3 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer Open
Differentially expressed genes from the TCGA Head and Neck Squamous Cell Carcinoma (HNSC).
View article: Figure S1 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer
Figure S1 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer Open
HPV(+) and HPV(-) HNSC are characterized by distinct immunogenomic signatures.
View article: Figure S4 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer
Figure S4 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer Open
Association of SYNGR3 expression patient survival.
View article: Supplementary Table ST3 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer
Supplementary Table ST3 from Tumor Cell Extrinsic Synaptogyrin 3 Expression as a Diagnostic and Prognostic Biomarker in Head and Neck Cancer Open
Differentially expressed genes from the TCGA Head and Neck Squamous Cell Carcinoma (HNSC).