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View article: Diffusion tensor imaging with free‐water correction reveals distinctions between severe and attenuated subtypes in Mucopolysaccharidosis type I
Diffusion tensor imaging with free‐water correction reveals distinctions between severe and attenuated subtypes in Mucopolysaccharidosis type I Open
Mucopolysaccharidosis type I (MPS I) is an inherited lysosomal storage disorder leading to deleterious brain effects. While animal models suggested that MPS I severely affects white matter (WM), whole‐brain diffusion tensor imaging (DTI) a…
View article: Evidence-based commentary on the diagnosis, management, and further research of degenerative cervical spinal cord compression in the absence of clinical symptoms of myelopathy
Evidence-based commentary on the diagnosis, management, and further research of degenerative cervical spinal cord compression in the absence of clinical symptoms of myelopathy Open
Degenerative cervical myelopathy (DCM) represents the final consequence of a series of degenerative changes in the cervical spine, resulting in cervical spinal canal stenosis and mechanical stress on the cervical spinal cord. This process …
View article: 1H magnetic resonance spectroscopic imaging of deuterated glucose and of neurotransmitter metabolism at 7 T in the human brain
1H magnetic resonance spectroscopic imaging of deuterated glucose and of neurotransmitter metabolism at 7 T in the human brain Open
View article: Noninvasive 3-Dimensional 1H-Magnetic Resonance Spectroscopic Imaging of Human Brain Glucose and Neurotransmitter Metabolism Using Deuterium Labeling at 3T
Noninvasive 3-Dimensional 1H-Magnetic Resonance Spectroscopic Imaging of Human Brain Glucose and Neurotransmitter Metabolism Using Deuterium Labeling at 3T Open
Objectives Noninvasive, affordable, and reliable mapping of brain glucose metabolism is of critical interest for clinical research and routine application as metabolic impairment is linked to numerous pathologies, for example, cancer, deme…
View article: Non-invasive three-dimensional 1H-MR Spectroscopic Imaging of human brain glucose and neurotransmitter metabolism using deuterium labeling at 3T
Non-invasive three-dimensional 1H-MR Spectroscopic Imaging of human brain glucose and neurotransmitter metabolism using deuterium labeling at 3T Open
Objectives Non-invasive, affordable, and reliable mapping of brain glucose metabolism is of critical interest for clinical research and routine application as metabolic impairment is linked to numerous pathologies e.g., cancer, dementia an…
View article: Quantitative MR Markers in Non-Myelopathic Spinal Cord Compression: A Narrative Review
Quantitative MR Markers in Non-Myelopathic Spinal Cord Compression: A Narrative Review Open
Degenerative spinal cord compression is a frequent pathological condition with increasing prevalence throughout aging. Initial non-myelopathic cervical spinal cord compression (NMDC) might progress over time into potentially irreversible d…
View article: Quantitative MR Markers in Non-Myelopathic Spinal Cord Compression: A Narrative Review
Quantitative MR Markers in Non-Myelopathic Spinal Cord Compression: A Narrative Review Open
Degenerative spinal cord (SC) compression is a frequent pathological condition with increasing prevalence throughout aging. Initial non-myelopathic cervical SC compression (NMDC) might progress over time into potentially irreversible degen…
View article: Semi-automated detection of cervical spinal cord compression with the Spinal Cord Toolbox
Semi-automated detection of cervical spinal cord compression with the Spinal Cord Toolbox Open
This study demonstrates successful semi-automated compression detection based on four parameters. The inter-trial variability of parameters established through two MRI examinations was conclusively better for Spinal Cord Toolbox compared w…
View article: Different FreeSurfer versions might generate different statistical outcomes in case–control comparison studies
Different FreeSurfer versions might generate different statistical outcomes in case–control comparison studies Open
View article: Deuterium labeling enables non-invasive 3D proton MR imaging of glucose and neurotransmitter metabolism in the human brain
Deuterium labeling enables non-invasive 3D proton MR imaging of glucose and neurotransmitter metabolism in the human brain Open
Impaired brain glucose metabolism characterizes most severe brain diseases. Recent studies have proposed deuterium (2H)-Magnetic Resonance Spectroscopic Imaging (MRSI) as a reliable, non-invasive, and safe method to quantify the human meta…
View article: Emerging methods and applications of ultra-high field MR spectroscopic imaging in the human brain
Emerging methods and applications of ultra-high field MR spectroscopic imaging in the human brain Open
Magnetic Resonance Spectroscopic Imaging (MRSI) of the brain enables insights into the metabolic changes and fluxes in diseases such as tumors, multiple sclerosis, epilepsy, or hepatic encephalopathy, as well as insights into general brain…
View article: <i>In vivo</i> Molecular Signatures of Cervical Spinal Cord Pathology in Degenerative Compression
<i>In vivo</i> Molecular Signatures of Cervical Spinal Cord Pathology in Degenerative Compression Open
Degenerative cervical myelopathy (DCM) is a severe consequence of degenerative cervical spinal cord (CSC) compression. The non-myelopathic stage of compression (NMDC) is highly prevalent and often progresses to disabling DCM. This study ai…
View article: Diffusion magnetic resonance imaging reveals tract‐specific microstructural correlates of electrophysiological impairments in non‐myelopathic and myelopathic spinal cord compression
Diffusion magnetic resonance imaging reveals tract‐specific microstructural correlates of electrophysiological impairments in non‐myelopathic and myelopathic spinal cord compression Open
Background and purpose Non‐myelopathic degenerative cervical spinal cord compression (NMDC) frequently occurs throughout aging and may progress to potentially irreversible degenerative cervical myelopathy (DCM). Whereas standard clinical m…
View article: Effect of Ketamine on Human Neurochemistry in Posterior Cingulate Cortex: A Pilot Magnetic Resonance Spectroscopy Study at 3 Tesla
Effect of Ketamine on Human Neurochemistry in Posterior Cingulate Cortex: A Pilot Magnetic Resonance Spectroscopy Study at 3 Tesla Open
Ketamine is a powerful glutamatergic long-lasting antidepressant, efficient in intractable major depression. Whereas ketamine’s immediate psychomimetic side-effects were linked to glutamate changes, proton MRS ( 1 H-MRS) showed an associat…
View article: HARDI-ZOOMit protocol improves specificity to microstructural changes in presymptomatic myelopathy
HARDI-ZOOMit protocol improves specificity to microstructural changes in presymptomatic myelopathy Open
Diffusion magnetic resonance imaging (dMRI) proved promising in patients with non-myelopathic degenerative cervical cord compression (NMDCCC), i.e., without clinically manifested myelopathy. Aim of the study is to present a fast multi-shel…
View article: Effect of Ketamine on Limbic GABA and Glutamate: A Human In Vivo Multivoxel Magnetic Resonance Spectroscopy Study
Effect of Ketamine on Limbic GABA and Glutamate: A Human In Vivo Multivoxel Magnetic Resonance Spectroscopy Study Open
This study provides evidence for decreased hippocampal GABA+/tCr ratio 2 h following ketamine administration. As MRS methodology measures total levels of intra- and extracellular GABA, results might indicate drug induced alterations in GAB…
View article: Structural Alterations in Deep Brain Structures in Type 1 Diabetes
Structural Alterations in Deep Brain Structures in Type 1 Diabetes Open
Even though well known in type 2 diabetes, the existence of brain changes in type 1 diabetes (T1D) and both their neuroanatomical and clinical features are less well characterized. To fill the void in the current understanding of this dise…
View article: Structural alterations in deep brain structures in type 1 diabetes
Structural alterations in deep brain structures in type 1 diabetes Open
Even though well known in type 2 diabetes, the existence of brain changes in type 1 diabetes (T1D) and both their neuroanatomical and clinical features are less well characterized. To fill the void in the current understanding of this dise…
View article: Structural alterations in deep brain structures in type 1 diabetes
Structural alterations in deep brain structures in type 1 diabetes Open
Even though well known in type 2 diabetes, the existence of brain changes in type 1 diabetes (T1D) and both their neuroanatomical and clinical features are less well characterized. To fill the void in the current understanding of this dise…
View article: Influence of Repetitive Transcranial Magnetic Stimulation on Human Neurochemistry and Functional Connectivity: A Pilot MRI/MRS Study at 7 T
Influence of Repetitive Transcranial Magnetic Stimulation on Human Neurochemistry and Functional Connectivity: A Pilot MRI/MRS Study at 7 T Open
Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation method commonly used in the disciplines of neuroscience, neurology, and neuropsychiatry to examine or modulate brain function. Low frequency rTMS (e.g.…
View article: Influence of Repetitive Transcranial Magnetic Stimulation on Human Neurochemistry and Functional Connectivity: A Pilot MRI/MRS Study at 7 T
Influence of Repetitive Transcranial Magnetic Stimulation on Human Neurochemistry and Functional Connectivity: A Pilot MRI/MRS Study at 7 T Open
Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive brain stimulation method commonly used in the disciplines of neuroscience, neurology, and neuropsychiatry to examine or modulate brain function. Low frequency rTMS (e.g.…
View article: Hippocampal Neurochemical Profile and Glucose Transport Kinetics in Patients With Type 1 Diabetes
Hippocampal Neurochemical Profile and Glucose Transport Kinetics in Patients With Type 1 Diabetes Open
Context Longstanding type 1 diabetes (T1D) may lead to alterations in hippocampal neurochemical profile. Upregulation of hippocampal glucose transport as a result of recurrent exposure to hypoglycemia may preserve cognitive function during…
View article: 7 T Magnetic Resonance Spectroscopic Imaging in Multiple Sclerosis
7 T Magnetic Resonance Spectroscopic Imaging in Multiple Sclerosis Open
Objectives The aim of this study was to assess the utility of increased spatial resolution of magnetic resonance spectroscopic imaging (MRSI) at 7 T for the detection of neurochemical changes in multiple sclerosis (MS)–related brain lesion…
View article: White matter measures correlate with essential tremor severity—A pilot diffusion tensor imaging study
White matter measures correlate with essential tremor severity—A pilot diffusion tensor imaging study Open
Background An evolving pathophysiological concept of essential tremor ( ET ) points to diffuse brain network involvement, which emphasizes the need to investigate white matter ( WM ) changes associated with motor symptoms of ET . Objective…
View article: Corrigendum: Multi-modal Brain MRI in Subjects with PD and iRBD
Corrigendum: Multi-modal Brain MRI in Subjects with PD and iRBD Open
[This corrects the article on p. 709 in vol. 11, PMID: 29311789.].
View article: Multi-modal Brain MRI in Subjects with PD and iRBD
Multi-modal Brain MRI in Subjects with PD and iRBD Open
Idiopathic rapid eye movement sleep behavior disorder (iRBD) is a condition that often evolves into Parkinson's disease (PD). Therefore, by monitoring iRBD it is possible to track the neurodegeneration of individuals who may progress to PD…
View article: Type 1 Diabetes and Impaired Awareness of Hypoglycemia Are Associated with Reduced Brain Gray Matter Volumes
Type 1 Diabetes and Impaired Awareness of Hypoglycemia Are Associated with Reduced Brain Gray Matter Volumes Open
In this study, we retrospectively analyzed the anatomical MRI data acquired from 52 subjects with type 1 diabetes (26M/26F, 36 ± 11 years old, A1C = 7.2 ± 0.9%) and 50 age, sex and BMI frequency-matched non-diabetic controls (25M/25F, 36 ±…
View article: Neurochemical responses to chromatic and achromatic stimuli in the human visual cortex
Neurochemical responses to chromatic and achromatic stimuli in the human visual cortex Open
In the present study, we aimed at determining the metabolic responses of the human visual cortex during the presentation of chromatic and achromatic stimuli, known to preferentially activate two separate clusters of neuronal populations (c…
View article: Test‐retest reproducibility of neurochemical profiles with short‐echo, single‐voxel MR spectroscopy at 3T and 7T
Test‐retest reproducibility of neurochemical profiles with short‐echo, single‐voxel MR spectroscopy at 3T and 7T Open
Purpose To determine the test‐retest reproducibility of neurochemical concentrations obtained with a highly optimized, short‐echo, single‐voxel proton MR spectroscopy (MRS) pulse sequence at 3T and 7T using state‐of‐the‐art hardware. Metho…
View article: Feasibility and reproducibility of neurochemical profile quantification in the human hippocampus at 3 T
Feasibility and reproducibility of neurochemical profile quantification in the human hippocampus at 3 T Open
Hippocampal dysfunction is known to be associated with several neurological and neuropsychiatric disorders such as Alzheimer's disease, epilepsy, schizophrenia and depression; therefore, there has been significant clinical interest in stud…