Petr Jabandžiev
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View article: Tissue MicroRNA Expression Signatures as Diagnostic Biomarkers and Predictors of Residual Disease Activity and Relapse in Treatment-Naïve Pediatric Inflammatory Bowel Disease
Tissue MicroRNA Expression Signatures as Diagnostic Biomarkers and Predictors of Residual Disease Activity and Relapse in Treatment-Naïve Pediatric Inflammatory Bowel Disease Open
Background Identifying novel diagnostic and prognostic biomarkers for pediatric inflammatory bowel diseases (PIBD), including Crohn’s disease (pCD) and ulcerative colitis (pUC), is essential for enhancing treatment outcomes. MicroRNAs (miR…
View article: Dysregulated microRNA expression in neonatal sepsis: validation study of potential novel biomarkers
Dysregulated microRNA expression in neonatal sepsis: validation study of potential novel biomarkers Open
Background Neonatal sepsis remains, to this day, a significant problem in perinatal care for term and preterm infants. Incidence and mortality are staggeringly high, as 4 in 10 infants with sepsis die or experience a significant disability…
View article: Aseptic abscess syndrome as first manifestation of Crohn’s disease – a case report
Aseptic abscess syndrome as first manifestation of Crohn’s disease – a case report Open
In cases of lymphadenitis that does not respond to standard antibiotic treatment, diagnosis of aseptic abscess syndrome should be considered as a potential etiology and, subsequently, inflammatory bowel disease should be investigated, give…
View article: Wide-spread brain alterations early after the onset of Crohn’s disease in children in remission—a pilot study
Wide-spread brain alterations early after the onset of Crohn’s disease in children in remission—a pilot study Open
Background The research on possible cerebral involvement in Crohn’s disease (CD) has been largely marginalized and failed to capitalize on recent developments in magnetic resonance imaging (MRI). Objective This cross-sectional pilot study …
View article: A tagging polymorphism in fat mass and obesity-associated (<i>FTO</i>) gene is associated with sepsis status in children
A tagging polymorphism in fat mass and obesity-associated (<i>FTO</i>) gene is associated with sepsis status in children Open
Introduction Sepsis is one of the most common causes of death in patients admitted to intensive care units (ICUs). The development of sepsis is significantly influenced by genetic predisposition. In this study, we highlight a potential ass…
View article: IL-6 as potential predictive biomarker of febrile seizures
IL-6 as potential predictive biomarker of febrile seizures Open
Background Febrile seizures are the most common type of convulsions in children. Fever is induced by cytokines release during infection. Recent studies focusing on the identification of a possible role of cytokines in pathogenesis of febri…
View article: Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children
Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children Open
We found that 19 (10.4%) of 183 unvaccinated children hospitalized for COVID-19 pneumonia had autoantibodies (auto-Abs) neutralizing type I IFNs (IFN-α2 in 10 patients: IFN-α2 only in three, IFN-α2 plus IFN-ω in five, and IFN-α2, IFN-ω plu…
View article: Celiac Disease: Promising Biomarkers for Follow-Up
Celiac Disease: Promising Biomarkers for Follow-Up Open
Celiac disease is a common gastroenterological illness. Current diagnostics of the disease are based on serological markers and histology of duodenal biopsies. Hitherto, a strict gluten-free diet is the only effective treatment and is nece…
View article: Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates
Role of the microbiome in pathophysiology of necrotising enterocolitis in preterm neonates Open
Although necrotising enterocolitis (NEC) is a serious, life-threatening disease, improved neonatal care is increasing the number of survivors with NEC among extremely preterm neonates. Therapy is nevertheless mostly symptomatic and the mor…
View article: Hydrocolpos causing bowel obstruction in a preterm newborn: A case report
Hydrocolpos causing bowel obstruction in a preterm newborn: A case report Open
Background:Hymenal atresia is the most common congenital defect of the female urogenital tract. The spectrum of clinical manifestations is broad, ranging from mild cases undiagnosed until adolescence to severe cases of giant intraabdominal…
View article: Multivariate linear mixture models for the prediction of febrile seizure risk and recurrence: a prospective case–control study
Multivariate linear mixture models for the prediction of febrile seizure risk and recurrence: a prospective case–control study Open
Our goal was to identify highly accurate empirical models for the prediction of the risk of febrile seizure (FS) and FS recurrence. In a prospective, three-arm, case–control study, we enrolled 162 children (age 25.8 ± 17.1 months old, 71 f…
View article: Targeted treatment of severe vascular malformations harboring PIK3CA and TEK mutations with alpelisib is highly effective with limited toxicity
Targeted treatment of severe vascular malformations harboring PIK3CA and TEK mutations with alpelisib is highly effective with limited toxicity Open
This was a prospective cohort study of eighteen patients with large and debilitating vascular malformations with one or more major systemic complications. In all patients, we discovered activating alterations in either TEK or PIK3CA . Base…
View article: Ventilation efficacy during Paediatric Cardiopulmonary Resuscitation (PEDIVENT): Simulation-based Comparative Study
Ventilation efficacy during Paediatric Cardiopulmonary Resuscitation (PEDIVENT): Simulation-based Comparative Study Open
Background: To our knowledge, this is the first study concerning the effectiveness of 5 initial breaths and subsequent ventilation during paediatric resuscitation. The recommendations on initial resuscitation in unresponsive non-breathing …
View article: Multivariate models for the prediction of febrile seizure risk and recurrence: a prospective case-control study
Multivariate models for the prediction of febrile seizure risk and recurrence: a prospective case-control study Open
Our goal was to identify highly accurate empirical models for the prediction of the risk of febrile seizure (FS) and FS recurrence. In a prospective, three-arm, case-control study, we enrolled 162 children (age 25.8±17.1 months old, 71 fem…
View article: IL-17-driven induction of Paneth cell antimicrobial functions protects the host from microbiota dysbiosis and inflammation in the ileum
IL-17-driven induction of Paneth cell antimicrobial functions protects the host from microbiota dysbiosis and inflammation in the ileum Open
Interleukin (IL)-17 protects epithelial barriers by inducing the secretion of antimicrobial peptides. However, the effect of IL-17 on Paneth cells (PCs), the major producers of antimicrobial peptides in the small intestine, is unclear. Her…
View article: Two sisters with cardiac‐urogenital syndrome secondary to pathogenic splicing variant in the <i>MYRF</i> gene with unaffected parents: A case of gonadal mosaicism?
Two sisters with cardiac‐urogenital syndrome secondary to pathogenic splicing variant in the <i>MYRF</i> gene with unaffected parents: A case of gonadal mosaicism? Open
Background Cardiac‐urogenital syndrome [MIM # 618280] is a newly described very rare syndrome associated with pathogenic variants in the myelin regulatory factor ( MYRF ) gene that leads to loss of protein function. MYRF is a transcription…
View article: Epidemiological and clinical characteristics of paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the Czech Republic
Epidemiological and clinical characteristics of paediatric inflammatory multisystem syndrome temporally associated with SARS-CoV-2 (PIMS-TS) in the Czech Republic Open
Cíl: Cílem studie bylo analyzovat epidemiologii a klinický průběh syndromu multisystémové zánětlivé odpovědi spojeného s infekcí SARS-CoV-2 u dětí a mladistvých (paediatric inflammatory multisystem syndrome temporally associated with SARS-…
View article: Inflammatory cloacogenic polyp in an adolescent – case report and review of the literature
Inflammatory cloacogenic polyp in an adolescent – case report and review of the literature Open
Inflammatory cloacogenic polyp is a rare lesion arising in the anal transitional zone. It is usually benign, but rare cases of malignant transformation are known. It is most commonly seen in the adult population from the fourth to the sixt…
View article: Impact of <scp>SARS‐CoV</scp>‐2 variants on the incidence of paediatric inflammatory multisystem syndrome (<scp>PIMS‐TS</scp>)
Impact of <span>SARS‐CoV</span>‐2 variants on the incidence of paediatric inflammatory multisystem syndrome (<span>PIMS‐TS</span>) Open
In Spring 2020, following temporary success during the first wave of the world-wide pandemic of the novel 2019 coronavirus disease (COVID-19) with very few positive cases, the Czech Republic (CZ) subsequently suffered from one of the highe…
View article: DYRK1A-related intellectual disability syndrome
DYRK1A-related intellectual disability syndrome Open
Syndrom intelektuálního postižení související s DYRK1A (DYRK1A-related intellectual disability syndrome) je autozomálně dominantní onemocnění charakterizované středním až těžkým intelektuálním postižením, zpožděním vývoje řeči, poruchou au…
View article: Long-Term Device Satisfaction and Safety after Cochlear Implantation in Children
Long-Term Device Satisfaction and Safety after Cochlear Implantation in Children Open
(1) Objectives: For full benefit in children implanted with a cochlear implant (CI), wearing the device all waking hours is necessary. This study focuses on the relationship between daily use and audiological outcomes, with the hypothesis …
View article: Skin manifestations of pancreatic diseases
Skin manifestations of pancreatic diseases Open
Although symptoms of pancreatic diseases such as pancreatitis, acute and chronic and, carcinoma of the pancreas are mainly gastrointestinal in nature, the extra-pancreatic symptoms are also important. These include skin symptoms, such as p…
View article: The Use of Confocal Laser Endomicroscopy in Diagnosing Barrett’s Esophagus and Esophageal Adenocarcinoma
The Use of Confocal Laser Endomicroscopy in Diagnosing Barrett’s Esophagus and Esophageal Adenocarcinoma Open
Confocal laser endomicroscopy (CLE) is a diagnostic technique that enables real-time microscopic imaging during microscopic examination and evaluation of epithelial structures with 1000-fold magnification. CLE can be used in the diagnosis …
View article: Fourth branchial cleft anomaly in a 7-month-old infant: A case report and literature review
Fourth branchial cleft anomaly in a 7-month-old infant: A case report and literature review Open
Fourth branchial cleft anomalies are rare head and neck congenital lesions seen in children. They present as a neck inflammatory mass and arise essentially on the left side of the neck. We report the case of a 7-month-old female with a mas…