Petr V. Nazarov
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View article: Hub genes in a pan-cancer co-expression network show potential for predicting drug responses
Hub genes in a pan-cancer co-expression network show potential for predicting drug responses Open
Dataset 1. Gene co-expression network data. It contains network nodes, weighted network and list of hubs. Dataset 2. qPCR data from independent validation, including MIQE and additional information.
View article: DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms
DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms Open
View article: P01.18.B MODELING GLIOBLASTOMA TREATMENT RESPONSES: INSIGHTS INTO TUMOR PLASTICITY AND THE ROLE OF THE TUMOR MICROENVIRONMENT
P01.18.B MODELING GLIOBLASTOMA TREATMENT RESPONSES: INSIGHTS INTO TUMOR PLASTICITY AND THE ROLE OF THE TUMOR MICROENVIRONMENT Open
BACKGROUND Glioblastoma relapse remains inevitable, placing these tumors among the most difficult to treat. Treatment challenges include inherent drug resistance, tumour’s plastic nature, and suppressive tumour microenvironment (TME). In o…
View article: OS03.5.A FUNCTIONAL PRECISION MEDICINE SCREENING REVEALS PERSONALIZED THERAPEUTIC VULNERABILITIES IN HIGH-GRADE GLIOMA SUBTYPES
OS03.5.A FUNCTIONAL PRECISION MEDICINE SCREENING REVEALS PERSONALIZED THERAPEUTIC VULNERABILITIES IN HIGH-GRADE GLIOMA SUBTYPES Open
BACKGROUND Precision medicine has transformed cancer treatment by tailoring therapies to the specific molecular aberrations of an individual patient’s tumor. The integration of high-resolution multi-omics with high-throughput functional pr…
View article: Integrative multi-omics combined with functional pharmacological profiling in patient-derived organoids identifies personalized therapeutic vulnerabilities of adult high-grade gliomas
Integrative multi-omics combined with functional pharmacological profiling in patient-derived organoids identifies personalized therapeutic vulnerabilities of adult high-grade gliomas Open
Background: Precision medicine has transformed cancer treatment by tailoring therapies to specific molecular aberrations. Integrating high-resolution multi-omics with high-throughput functional profiling in patient-derived organoids offers…
View article: Stabilization of Stochastic Dynamic Systems with Markov Parameters and Concentration Point
Stabilization of Stochastic Dynamic Systems with Markov Parameters and Concentration Point Open
This paper addresses the problem of optimal stabilization for stochastic dynamical systems characterized by Markov switches and concentration points of jumps, which is a scenario not adequately covered by classical stability conditions. Un…
View article: Estimating sparse regression models in multi-task learning and transfer learning through adaptive penalisation
Estimating sparse regression models in multi-task learning and transfer learning through adaptive penalisation Open
Method Here, we propose a simple two-stage procedure for sharing information between related high-dimensional prediction or classification problems. In both stages, we perform sparse regression separately for each problem. While this is do…
View article: Comprehensive multi-omics profiling of a healthy human cohort
Comprehensive multi-omics profiling of a healthy human cohort Open
Multi-omics investigations hold promise for uncovering biomarker profiles crucial for disease diagnosis, prognosis, and monitoring interventions. However, these profiles are susceptible to technical and biological variation. Capturing biol…
View article: Patient-based multilevel transcriptome exploration highlights relevant chemokines and chemokine receptor axes in glioblastoma
Patient-based multilevel transcriptome exploration highlights relevant chemokines and chemokine receptor axes in glioblastoma Open
View article: Metformin impacts the differentiation of mouse bone marrow cells into macrophages affecting tumour immunity
Metformin impacts the differentiation of mouse bone marrow cells into macrophages affecting tumour immunity Open
View article: PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation
PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation Open
Background Specific microglia responses are thought to contribute to the development and progression of neurodegenerative diseases, including Parkinson’s disease (PD). However, the phenotypic acquisition of microglial cells and their role …
View article: Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts
Glioblastoma-instructed microglia transition to heterogeneous phenotypic states with phagocytic and dendritic cell-like features in patient tumors and patient-derived orthotopic xenografts Open
View article: Early-life influenza A (H1N1) infection independently programs brain connectivity, HPA AXIS and tissue-specific gene expression profiles
Early-life influenza A (H1N1) infection independently programs brain connectivity, HPA AXIS and tissue-specific gene expression profiles Open
View article: Glioma subtype classification from histopathological images using in-domain and out-of-domain transfer learning: An experimental study
Glioma subtype classification from histopathological images using in-domain and out-of-domain transfer learning: An experimental study Open
View article: PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation
PARK7/DJ-1 deficiency impairs microglial activation in response to LPS-induced inflammation Open
Background Specific microglia responses are thought to contribute to the development and progression of neurodegenerative diseases, including Parkinson’s disease (PD). However, the phenotypic acquisition of microglial cells and their role …
View article: <scp>AllergoOncology</scp>: Biomarkers and refined classification for research in the allergy and glioma nexus—A joint <scp>EAACI‐EANO</scp> position paper
<span>AllergoOncology</span>: Biomarkers and refined classification for research in the allergy and glioma nexus—A joint <span>EAACI‐EANO</span> position paper Open
Epidemiological studies have explored the relationship between allergic diseases and cancer risk or prognosis in AllergoOncology. Some studies suggest an inverse association, but uncertainties remain, including in IgE‐mediated diseases and…
View article: Metformin Impacts the Differentiation of Bone Marrow Cells into Macrophages Affecting Tumour Immunity
Metformin Impacts the Differentiation of Bone Marrow Cells into Macrophages Affecting Tumour Immunity Open
View article: consICA: an R package for robust reference-free deconvolution of multi-omics data
consICA: an R package for robust reference-free deconvolution of multi-omics data Open
Motivation Deciphering molecular signals from omics data helps understanding cellular processes and disease progression. Effective algorithms for extracting these signals are essential, with a strong emphasis on robustness and reproducibil…
View article: Digital Voice-Based Biomarker for Monitoring Respiratory Quality of Life: Findings from the Colive Voice Study
Digital Voice-Based Biomarker for Monitoring Respiratory Quality of Life: Findings from the Colive Voice Study Open
Regular monitoring of respiratory quality of life (RQoL) is essential in respiratory healthcare, facilitating prompt diagnosis and tailored treatment for chronic respiratory diseases. Voice alterations resulting from respiratory conditions…
View article: AllergoOncology: Biomarkers and Refined Classification for Research in the Allergy and Glioma Nexus - a Joint EAACI-EANO Position Paper
AllergoOncology: Biomarkers and Refined Classification for Research in the Allergy and Glioma Nexus - a Joint EAACI-EANO Position Paper Open
Epidemiological studies have explored the relationship between allergic diseases and cancer risk or prognosis in AllergoOncology. Some studies suggest an inverse association, but uncertainties remain, including in IgE-mediated diseases and…
View article: DNAR-13. TARGETING THE DNA DAMAGE RESPONSE IN GLIOBLASTOMA PROPAGATING CELLS: FROM MOLECULAR MECHANISMS TO PRECISION MEDICINE
DNAR-13. TARGETING THE DNA DAMAGE RESPONSE IN GLIOBLASTOMA PROPAGATING CELLS: FROM MOLECULAR MECHANISMS TO PRECISION MEDICINE Open
Glioblastoma (GBM) is the most aggressive and lethal primary tumor of the central nervous system (CNS). Despite surgical resection and a combination of radiotherapy and alkylation chemotherapy, the median survival for patients with newly d…
View article: TMIC-47. INHIBITION OF MIR-146A-5P DECREASES PROGRESSION OF MELANOMA BRAIN METASTASIS VIA NOTCH PATHWAY DYSREGULATION IN ASTROCYTES
TMIC-47. INHIBITION OF MIR-146A-5P DECREASES PROGRESSION OF MELANOMA BRAIN METASTASIS VIA NOTCH PATHWAY DYSREGULATION IN ASTROCYTES Open
Melanoma has a high propensity for brain metastasis, occurring in 40% of late-stage patients. The progression of secondary tumors in the brain depends on the support of the surrounding microenvironment, emphasizing the importance of modula…
View article: Glioma subtype classification from histopathological images using in-domain and out-of-domain transfer learning: An experimental study
Glioma subtype classification from histopathological images using in-domain and out-of-domain transfer learning: An experimental study Open
We provide in this paper a comprehensive comparison of various transfer learning strategies and deep learning architectures for computer-aided classification of adult-type diffuse gliomas. We evaluate the generalizability of out-of-domain …
View article: Inhibition of extracellular vesicle‐derived miR‐146a‐5p decreases progression of melanoma brain metastasis via Notch pathway dysregulation in astrocytes
Inhibition of extracellular vesicle‐derived miR‐146a‐5p decreases progression of melanoma brain metastasis via Notch pathway dysregulation in astrocytes Open
Melanoma has the highest propensity of all cancers to metastasize to the brain with a large percentage of late‐stage patients developing metastases in the central nervous system (CNS). It is well known that metastasis establishment, cell s…
View article: P02.18.B INTEGRATIVE OMICS ANALYSIS OF IDH1 MUTANT GLIOMA PATIENTS REVEALS ALTERATIONS IN BUTYRATE METABOLISM
P02.18.B INTEGRATIVE OMICS ANALYSIS OF IDH1 MUTANT GLIOMA PATIENTS REVEALS ALTERATIONS IN BUTYRATE METABOLISM Open
BACKGROUND Mutations in isocitrate dehydrogenase (IDH) 1 or 2 define glioma classification and determine the biology of these tumors. Although IDH is an essential enzyme in the cellular metabolism, powerful genome-wide analyses focus mostl…
View article: S141: INHIBITION OF MYC TRANSLATION THROUGH TARGETING OF THE NEWLY IDENTIFIED PHB-EIF4F COMPLEX AS THERAPEUTIC STRATEGY INCHRONIC LYMPHOCYTIC LEUKEMIA (CLL)
S141: INHIBITION OF MYC TRANSLATION THROUGH TARGETING OF THE NEWLY IDENTIFIED PHB-EIF4F COMPLEX AS THERAPEUTIC STRATEGY INCHRONIC LYMPHOCYTIC LEUKEMIA (CLL) Open
Background: CLL is the most common type of leukemia in adult, and despite great advance in the standard of care in the last decades, there is still no cure available. CLL cells are dependent on their microenvironment for proliferation and …
View article: Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response
Single-cell transcriptomics of NRAS-mutated melanoma transitioning to drug resistance reveals P2RX7 as an indicator of early drug response Open
Treatment options for patients with NRAS-mutant melanoma are limited and lack an efficient targeted drug combination that significantly increases overall and progression-free survival. In addition, targeted therapy success is hampered by t…
View article: Impact of IDH Mutations, the 1p/19q Co-Deletion and the G-CIMP Status on Alternative Splicing in Diffuse Gliomas
Impact of IDH Mutations, the 1p/19q Co-Deletion and the G-CIMP Status on Alternative Splicing in Diffuse Gliomas Open
By generating protein diversity, alternative splicing provides an important oncogenic pathway. Isocitrate dehydrogenase (IDH) 1 and 2 mutations and 1p/19q co-deletion have become crucial for the novel molecular classification of diffuse gl…
View article: Stability of stochastic dynamic systems of a random structure with Markov switchings in the presence of concentration points
Stability of stochastic dynamic systems of a random structure with Markov switchings in the presence of concentration points Open
This article aims to investigate sufficient conditions for the stability of stochastic differential equations with a random structure, particularly in contexts involving the presence of concentration points. The proof of asymptotic stabili…
View article: DeepHisto: Dataset for glioma subtype classification from Whole Slide Images
DeepHisto: Dataset for glioma subtype classification from Whole Slide Images Open
DeepHisto dataset contains tiles (patches) of hematoxylin and eosin stained Whole Slide Images (WSI) of 28 adult-type diffuse glioma cases collected at the National Center of Pathology (NCP), Luxembourg National Health Laboratory (Laborato…