Petra Schelstraete
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View article: Charcot-Leyden Crystals drive pathology and inflammation in muco-obstructive lung disease
Charcot-Leyden Crystals drive pathology and inflammation in muco-obstructive lung disease Open
Mucus plugging leading to airway obstruction is a hallmark of chronic respiratory diseases, yet the biology of plugs and their contribution to airway inflammation remain poorly defined. Through guided retrieval and analysis of plugs from p…
View article: Spiroplasma infection as a cause of severe congenital keratouveitis, cataract and glaucoma
Spiroplasma infection as a cause of severe congenital keratouveitis, cataract and glaucoma Open
View article: SARS-CoV-2 Infection in Children Less Than Forty Days Hospitalized in Belgium Between 2020 and 2022
SARS-CoV-2 Infection in Children Less Than Forty Days Hospitalized in Belgium Between 2020 and 2022 Open
Our study aimed to assess the severity of severe acute respiratory syndrome coronavirus 2 infection in hospitalized infants under 40 days old, across 21 Belgian hospitals between 2020 and 2022. Of the 365 infants studied, 14.2% needed resp…
View article: Spiroplasma infection as a cause of severe congenital keratouveitis, cataract and glaucoma
Spiroplasma infection as a cause of severe congenital keratouveitis, cataract and glaucoma Open
Background: Only seven cases of ocular Spiroplasma infection have been reported to date, all presenting as congenital cataracts with concomitant intraocular inflammation. We describe the first case of Spiroplasma infection initially presen…
View article: The use of information technology to improve interdisciplinary communication during infectious diseases ward rounds on the paediatric intensive care unit
The use of information technology to improve interdisciplinary communication during infectious diseases ward rounds on the paediatric intensive care unit Open
Prospective audit with feedback during infectious diseases ward rounds (IDWR) is a common antimicrobial stewardship (AMS) practice on the Paediatric Intensive Care Unit (PICU). These interdisciplinary meetings rely on the quality of handov…
View article: Comparison of SARS-CoV-2 seroconversion in children with chronic diseases with healthy children and adults during the first waves of the COVID-19 pandemic
Comparison of SARS-CoV-2 seroconversion in children with chronic diseases with healthy children and adults during the first waves of the COVID-19 pandemic Open
Background Infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is clinically diverse, and children have a low risk of developing severe coronavirus disease 2019 (COVID-19). However, children with chronic diseases ha…
View article: Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study
Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study Open
View article: The Use of Information Technology to improve Interdisciplinary Communication during Infectious Diseases Ward Rounds on the Paediatric Intensive Care Unit
The Use of Information Technology to improve Interdisciplinary Communication during Infectious Diseases Ward Rounds on the Paediatric Intensive Care Unit Open
Prospective audit with feedback during infectious diseases ward rounds (IDWR) is a common antibiotic stewardship (AS) practice on the Pediatric Intensive Care Unit (PICU). These interdisciplinary meetings rely on the quality of handover, w…
View article: Anterior and posterior tracheopexy for severe tracheomalacia
Anterior and posterior tracheopexy for severe tracheomalacia Open
View article: TIM3+<i> TRBV11-2</i> T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C
TIM3+<i> TRBV11-2</i> T cells and IFNγ signature in patrolling monocytes and CD16+ NK cells delineate MIS-C Open
In rare instances, pediatric SARS-CoV-2 infection results in a novel immunodysregulation syndrome termed multisystem inflammatory syndrome in children (MIS-C). We compared MIS-C immunopathology with severe COVID-19 in adults. MIS-C does no…
View article: Mental Health Outcomes Among Parents of Children With a Chronic Disease During the COVID-19 Pandemic: The Role of Parental Burn-Out
Mental Health Outcomes Among Parents of Children With a Chronic Disease During the COVID-19 Pandemic: The Role of Parental Burn-Out Open
Objective The COVID-19 pandemic and associated quarantine measures highly impacted parental psychological well-being. Parents of children with chronic diseases might be specifically vulnerable as they already face multiple challenges to pr…
View article: The accuracy of saliva versus nasopharyngeal and/or oropharyngeal samples for the detection of SARS-CoV-2 in children – A rapid systematic review and meta-analysis
The accuracy of saliva versus nasopharyngeal and/or oropharyngeal samples for the detection of SARS-CoV-2 in children – A rapid systematic review and meta-analysis Open
Background The comparative performance of saliva and nasopharyngeal samples for the detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by reverse transcriptase polymerase chain reaction (RT-PCR) in children…
View article: SeroCovid19 : prospective seroprevalence monitoring reveals substantially reduced SARS-CoV-2 infection rate among tertiary pediatric patients
SeroCovid19 : prospective seroprevalence monitoring reveals substantially reduced SARS-CoV-2 infection rate among tertiary pediatric patients Open
Background\nCoronavirus disease 2019 (COVID-19) is a clinically heterogeneous entity with several host,\nenvironmental, and viral risk factors identified to date. COVID-19 in children generally manifests\nasymptomatic or mild. Pediatric pa…
View article: Sensitivity and specificity of 14 SARS-CoV-2 serological assays and their diagnostic potential in RT-PCR negative COVID-19 infections
Sensitivity and specificity of 14 SARS-CoV-2 serological assays and their diagnostic potential in RT-PCR negative COVID-19 infections Open
Sensitivity of COVID-19 serological diagnosis was variable but consistently increased at >7 days after symptom onset. Specificity was high. Our data suggest that serology can complement molecular testing for diagnosis of COVID-19, especial…
View article: Optimizing the Use of Antibiotic Agents in the Pediatric Intensive Care Unit: A Narrative Review
Optimizing the Use of Antibiotic Agents in the Pediatric Intensive Care Unit: A Narrative Review Open
View article: Plasma C3d levels as a diagnostic marker for complete complement factor I deficiency
Plasma C3d levels as a diagnostic marker for complete complement factor I deficiency Open
View article: COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study
COVID-19 in children and adolescents in Europe: a multinational, multicentre cohort study Open
View article: Author Correction: A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation
Author Correction: A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation Open
View article: A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation
A human immune dysregulation syndrome characterized by severe hyperinflammation with a homozygous nonsense Roquin-1 mutation Open
View article: Contribution of QuantiFERON-TB Gold-in-Tube to the Diagnosis of Mycobacterium tuberculosis Infection in Young Children in a Low TB Prevalence Country
Contribution of QuantiFERON-TB Gold-in-Tube to the Diagnosis of Mycobacterium tuberculosis Infection in Young Children in a Low TB Prevalence Country Open
Introduction: Interferon Gamma Release Assay (IGRA) has proven to be a useful test to evaluate the immune response to Mycobacterium tuberculosis antigens in children over the age of 5 years as an alternative to tuberculin ski…
View article: Appropriateness of vancomycin dosing and therapeutic drug monitoring practices in a Belgian tertiary hospital
Appropriateness of vancomycin dosing and therapeutic drug monitoring practices in a Belgian tertiary hospital Open
View article: Emergence of livestock-associated MRSA isolated from cystic fibrosis patients: Result of a Belgian national survey
Emergence of livestock-associated MRSA isolated from cystic fibrosis patients: Result of a Belgian national survey Open
View article: Pulmonary interstitial glycogenosis – A systematic analysis of new cases
Pulmonary interstitial glycogenosis – A systematic analysis of new cases Open
View article: Establishing the diagnosis of chronic colonization with Pseudomonas aeruginosa of cystic fibrosis patients: Comparison of the European consensus criteria with genotyping of P. aeruginosa isolates
Establishing the diagnosis of chronic colonization with Pseudomonas aeruginosa of cystic fibrosis patients: Comparison of the European consensus criteria with genotyping of P. aeruginosa isolates Open
Genotyping of P. aeruginosa isolates confirmed CC for 25 out of 27 ECC-positive patients (92.6% specificity) and predicted CC 9.3 months earlier than the ECC.
View article: Development and validation of an LC tandem MS assay for the quantification of β-lactam antibiotics in the sputum of cystic fibrosis patients
Development and validation of an LC tandem MS assay for the quantification of β-lactam antibiotics in the sputum of cystic fibrosis patients Open
The method allows a reliable measurement of the selected antibiotics, if precautions are taken regarding the limited stability of piperacillin at room temperature. Due to freeze-thaw instability, piperacillin should always be analysed on t…
View article: Acute hemorrhagic edema of infancy : a dramatic presentation with a benign course
Acute hemorrhagic edema of infancy : a dramatic presentation with a benign course Open
View article: Epidemic Achromobacter xylosoxidans strain among Belgian cystic fibrosis patients and review of literature
Epidemic Achromobacter xylosoxidans strain among Belgian cystic fibrosis patients and review of literature Open
View article: 81 Evaluation of the European Consensus Criteria for chronic colonization of CF patients with Pseudomonas aeruginosa by means of genotyping of consequent isolates
81 Evaluation of the European Consensus Criteria for chronic colonization of CF patients with Pseudomonas aeruginosa by means of genotyping of consequent isolates Open
View article: WS20.4 Allergic bronchopulmonary aspergillosis syndrome (ABPAs) in Pseudomonas (Pa) naïve patients is facilitated by lung damage and the use of inhaled corticosteroids
WS20.4 Allergic bronchopulmonary aspergillosis syndrome (ABPAs) in Pseudomonas (Pa) naïve patients is facilitated by lung damage and the use of inhaled corticosteroids Open
View article: Pseudomonas aeruginosa in cystic fibrosis patients : acquisition, early diagnosis and efficacy of eradication treatment
Pseudomonas aeruginosa in cystic fibrosis patients : acquisition, early diagnosis and efficacy of eradication treatment Open