Petru Liuba
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View article: Protein-losing enteropathy following Fontan completion: A 30-year national cohort study in Sweden
Protein-losing enteropathy following Fontan completion: A 30-year national cohort study in Sweden Open
PLE remains a serious complication following Fontan, with notable mortality. Patients with right ventricular morphology of the systemic ventricle had a higher risk of PLE. Previous pulmonary venous congestion was common when PLE was diagno…
View article: Endovascular Repair of Thoracic Aortic Atresia in Adults: A Narrative Review of a Rare Entity and Emerging Technique
Endovascular Repair of Thoracic Aortic Atresia in Adults: A Narrative Review of a Rare Entity and Emerging Technique Open
Thoracic aortic atresia in adults represents a rare and extreme manifestation of aortic coarctation, marked by complete luminal occlusion and frequently compensated by extensive collateral circulation. This narrative review critically eval…
View article: Risk Factors for Reintervention Following Treatment for Aortic Coarctation With or Without Aortic Arch Hypoplasia in Sweden: From Isolated Coarctation to Complex Bi‐ and Univentricular Congenital Heart Disease
Risk Factors for Reintervention Following Treatment for Aortic Coarctation With or Without Aortic Arch Hypoplasia in Sweden: From Isolated Coarctation to Complex Bi‐ and Univentricular Congenital Heart Disease Open
Background Repaired coarctation of the aorta (CoA)—either simple or as part of complex congenital heart disease—can be associated with long‐term sequelae such as recoarctation of the aorta (reCoA) or arterial hypertension. The aim of this …
View article: Sternal opening width is associated with increased risk for capillary leak syndrome and death in neonates and infants after cardiac surgery with delayed sternal closure
Sternal opening width is associated with increased risk for capillary leak syndrome and death in neonates and infants after cardiac surgery with delayed sternal closure Open
Capillary leak syndrome is a serious postoperative complication in neonates and infants after open-heart surgery for CHD. The aim of this study was to investigate the relationship between sternal opening width and the occurrence of capilla…
View article: Prediction of healthy mitral valve hemodynamics in children and adults: validation of fluid-structure interaction simulations against echocardiography and magnetic resonance imaging
Prediction of healthy mitral valve hemodynamics in children and adults: validation of fluid-structure interaction simulations against echocardiography and magnetic resonance imaging Open
A computational framework for clinically feasible patient-specific prediction of mitral valve hemodynamics was developed and validated in vivo in the largest cohort presented to date. Computational time was acceptable for clinical planning…
View article: Prosthetic pulmonary valve infectious endocarditis in paediatric congenital heart disease patients
Prosthetic pulmonary valve infectious endocarditis in paediatric congenital heart disease patients Open
OBJECTIVES Pulmonary valve implantation (PVI) is common in children with congenital heart disease particularly as they get older. While surgical PVI (SPVI) was the mainstay of treatment for years, percutaneous PVI (PPVI) has evolved into a…
View article: Young Healthy Individuals With a First‐Degree Relative With Type 1 Diabetes Displayed Adverse Lipid Changes
Young Healthy Individuals With a First‐Degree Relative With Type 1 Diabetes Displayed Adverse Lipid Changes Open
Aim Timeline of atherosclerosis in children with type 1 diabetes is unknown. We aimed to investigate if familial risk of type 1 diabetes is associated with pro‐atherosclerotic changes. Methods Young first‐degree relatives to patients with …
View article: Three-dimensional aortic arch geometry and blood flow in neonates after surgical repair for aortic coarctation
Three-dimensional aortic arch geometry and blood flow in neonates after surgical repair for aortic coarctation Open
Background Recurrent coarctation of the aorta (re-CoA) is a well-known although not fully understood complication after surgical repair, typically occurring in 10%–20% of cases within months after discharge. Objectives To (1) characterize …
View article: Lymphatic Disorder Management in Pediatric Patients With Congenital Heart Disease in European Pediatric Cardiology Centers: Current Status, Disparities, and Future Considerations
Lymphatic Disorder Management in Pediatric Patients With Congenital Heart Disease in European Pediatric Cardiology Centers: Current Status, Disparities, and Future Considerations Open
Background Lymphatic disorders such as protein‐losing enteropathy, plastic bronchitis, and chylothorax are important complications of the Fontan circulation and ultimately result in an increased risk of early death. Several European center…
View article: Validation of smartwatch electrocardiogram intervals in children compared to standard 12 lead electrocardiograms
Validation of smartwatch electrocardiogram intervals in children compared to standard 12 lead electrocardiograms Open
Lay people are now able to obtain one-lead electrocardiograms (ECG) using smartwatches, which facilitates documentation of arrhythmias. The accuracy of smartwatch derived ECG intervals has not been validated in children though. Home-based …
View article: Newborn Screening for High-Risk Congenital Heart Disease by Dried Blood Spot Biomarker Analysis
Newborn Screening for High-Risk Congenital Heart Disease by Dried Blood Spot Biomarker Analysis Open
Importance Congenital heart disease (CHD) is the most common human organ malformation, affecting approximately 1 of 125 newborns globally. Objectives Assessing the performance of 2 diagnostic tests using minimal amounts of dried blood spot…
View article: Validation of smartwatch electrocardiogram intervals in children compared to standard 12 lead electrocardiograms
Validation of smartwatch electrocardiogram intervals in children compared to standard 12 lead electrocardiograms Open
Background/Aim: Lay people are now able to obtain one-lead electrocardiograms (ECG) using smartwatches, which facilitates documentation of arrhythmias. The accuracy of smartwatch derived ECG intervals has not been validated in children tho…
View article: Biomarkers and Proteomics in Sarcomeric Hypertrophic Cardiomyopathy in the Young—FGF-21 Highly Associated with Overt Disease
Biomarkers and Proteomics in Sarcomeric Hypertrophic Cardiomyopathy in the Young—FGF-21 Highly Associated with Overt Disease Open
Background: Any difference in biomarkers between genotype-positive individuals with overt hypertrophic cardiomyopathy (HCM), and genotype-positive but phenotype-negative individuals (G+P-) in HCM-associated pathways might shed light on pat…
View article: Longitudinal ECG changes in tetralogy of Fallot and association with surgical repair
Longitudinal ECG changes in tetralogy of Fallot and association with surgical repair Open
Background ECG abnormalities have been linked to adverse changes in right ventricular (RV) morphology and poor clinical outcomes in repaired Tetralogy of Fallot (rTOF). Our aim was to describe how ECG changes progress in early and intermed…
View article: Impact of Underweight, Overweight, and Obesity on Health-Related Quality of Life in Children with Tetralogy of Fallot Variants
Impact of Underweight, Overweight, and Obesity on Health-Related Quality of Life in Children with Tetralogy of Fallot Variants Open
Traditional cardiovascular risk factors put patients with congenital heart disease (CHD) at increased risk for cardiovascular morbidity and mortality. The aim of this study was to evaluate whether body mass index (BMI) is associated with h…
View article: Long‐Term Survival After Single‐Ventricle Palliation: A Swedish Nationwide Cohort Study
Long‐Term Survival After Single‐Ventricle Palliation: A Swedish Nationwide Cohort Study Open
Background Long‐term survival after single‐ventricle palliation and the effect of dominant ventricle morphology in large, unselected series of patients are scarcely reported. Methods and Results This nationwide cohort study included all ch…
View article: Ceramides: a potential cardiovascular biomarker in young adult childhood cancer survivors?
Ceramides: a potential cardiovascular biomarker in young adult childhood cancer survivors? Open
Aims The aim of this study was to investigate circulating ceramides involved in cardiovascular disease (CVD) in young adult childhood cancer survivors (CCS) and their correlations to previously reported adverse cardiovascular changes in th…
View article: Multi-modal Phantom Experiments, mimicking Flow through the Mitral Heart Valve
Multi-modal Phantom Experiments, mimicking Flow through the Mitral Heart Valve Open
Purpose Fluid-structure interaction (FSI) models are more commonly applied in medical research as computational power is increasing. However, understanding the accuracy of FSI models is crucial, especially in the context of heart valve dis…
View article: Validation of fluid-structure interaction simulations of the opening phase of phantom mitral heart valves under physiologically inspired conditions
Validation of fluid-structure interaction simulations of the opening phase of phantom mitral heart valves under physiologically inspired conditions Open
Parameters relevant to the diagnosis of heart valve disease estimated by FSI simulations showed good agreement when compared to in vitro benchmarking data, with differences small enough not to affect the grading of heart valve disease. The…
View article: Circulating leptin is associated with adverse vascular changes in young adult survivors of childhood cancer
Circulating leptin is associated with adverse vascular changes in young adult survivors of childhood cancer Open
Introduction: Proteomics may help discover novel biomarkers and underlying mechanisms for cardiovascular disease. This could be useful for childhood cancer survivors as they show an increased risk of cardiovascular disease. The aim of this…
View article: Atrial septal defect closure in children at young age is beneficial for left ventricular function
Atrial septal defect closure in children at young age is beneficial for left ventricular function Open
Aims Atrial septal defects (ASDs) lead to volume-loaded right ventricles (RVs). ASD closure does not always alleviate symptoms or improve exercise capacity, which is possibly explained by impaired left ventricular (LV) haemodynamics. This …