Petya Dimitrova
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View article: Genetic and Epigenetic Phenomena in the Neutrophil Developmental Program
Genetic and Epigenetic Phenomena in the Neutrophil Developmental Program Open
Neutrophils are short‐lived innate immune cells, which develop in the bone marrow and replenish daily the circulatory and marginal pools in various organs in the steady state. Recent technological advances have reshaped the traditional par…
View article: New Glass-Ceramics in the System Ca2SiO4-Ca3(PO4)2—Phase Composition, Microstructure, and Effect on the Cell Viability
New Glass-Ceramics in the System Ca2SiO4-Ca3(PO4)2—Phase Composition, Microstructure, and Effect on the Cell Viability Open
The CaO-SiO2-P2O5 system is one of the main systems studied aiming for the synthesis of new bioactive materials for bone regeneration. The interest in materials containing calcium-phosphate-silicate phases is determined by their biocompati…
View article: Neutrophils shape the therapeutic efficacy of sirtuin 1 activity modulators in murine influenza virus infection
Neutrophils shape the therapeutic efficacy of sirtuin 1 activity modulators in murine influenza virus infection Open
Sirtuin 1 (Sirt1), a class III histone deacetylase, is a key regulator of gene expression in various immune cell types, including neutrophils, during infection and acute inflammation. Herein, we studied the effect of the Sirt1 activator (S…
View article: Biological effect of alkaloid enriched fractions and reticuline from the Stephania dielsianaY. C. Wu on promyelocyte HL-60 cell line
Biological effect of alkaloid enriched fractions and reticuline from the Stephania dielsianaY. C. Wu on promyelocyte HL-60 cell line Open
Stephania dielsiana Y. C. Wu is a traditional medicinal plant that, like the other species of the genus Stephania, is used in some Asian countries for the treatment of various conditions and diseases. Phytochemical studies have revealed th…
View article: Gram Negative Biofilms: Structural and Functional Responses to Destruction by Antibiotic-Loaded Mixed Polymeric Micelles
Gram Negative Biofilms: Structural and Functional Responses to Destruction by Antibiotic-Loaded Mixed Polymeric Micelles Open
Biofilms are a well-known multifactorial virulence factor with a pivotal role in chronic bacterial infections. Their pathogenicity is determined by the combination of strain-specific mechanisms of virulence and the biofilm extracellular ma…
View article: Inula salicina L.: Insights into Its Polyphenolic Constituents and Biological Activity
Inula salicina L.: Insights into Its Polyphenolic Constituents and Biological Activity Open
In this study, UHPLC-HRMS analysis of the defatted methanol extract obtained from Inula salicina L. led to the identification of 58 compounds—hydroxycinnamic and hydroxybenzoic acids and their glycosides, acylquinic and caffeoylhexaric aci…
View article: α/β-TCP silicate glass-ceramic obtained by sol–gel: Structure and in vitro bioactivity
α/β-TCP silicate glass-ceramic obtained by sol–gel: Structure and in vitro bioactivity Open
A glass-ceramic in the CaO–P2O5–SiO2 system, which contains two polymorphic modifications of tricalcium phosphate – whitlockite, β-Ca3(PO4)2 and α-Ca3(PO4)2, has been synthesized by the sol–gel method and thermal treatment up to 1200 °C. T…
View article: Infection Meets Inflammation: N6-Methyladenosine, an Internal Messenger RNA Modification as a Tool for Pharmacological Regulation of Host–Pathogen Interactions
Infection Meets Inflammation: N6-Methyladenosine, an Internal Messenger RNA Modification as a Tool for Pharmacological Regulation of Host–Pathogen Interactions Open
The significance of internal mRNA modifications for the modulation of transcript stability, for regulation of nuclear export and translation efficiency, and their role in suppressing innate immunity is well documented. Over the years, the …
View article: The Triterpenoid Nrf2 Activator, CDDO-Me, Decreases Neutrophil Senescence in a Murine Model of Joint Damage
The Triterpenoid Nrf2 Activator, CDDO-Me, Decreases Neutrophil Senescence in a Murine Model of Joint Damage Open
The synthetic 2-cyano-3,12-dioxo-oleana-1,9(11)-dien-28-oic acid methyl ester (CDDO-Me) is a potent activator of the erythroid 2-p45-derived factor 2, Nrf2, a leucine-zipper regulator of the antioxidant response. Herein, we investigated th…
View article: Modulation of Nrf2 expression in human neutrophils by Ballota nigra extract
Modulation of Nrf2 expression in human neutrophils by Ballota nigra extract Open
View article: Human decidual gamma/delta T cells possess unique effector and TCR repertoire profiles during pregnancy
Human decidual gamma/delta T cells possess unique effector and TCR repertoire profiles during pregnancy Open
Human γδ T cells are enriched at the maternal-fetal interface (MFI, decidua basalis) showing a highly differentiated phenotype. However, their functional potential is not well-known and it is not clear whether this decidua-enrichment is as…
View article: Biotechnologically-Produced Myconoside and Calceolarioside E Induce Nrf2 Expression in Neutrophils
Biotechnologically-Produced Myconoside and Calceolarioside E Induce Nrf2 Expression in Neutrophils Open
The pathological manifestation of various diseases can be suppressed by the activation of nuclear factor erythroid 2 p45-related factor 2 (Nrf2), a transcriptional regulator of the cellular redox balance. Haberlea rhodopensis Friv. is a re…
View article: Veronica austriaca L. Extract and Arbutin Expand Mature Double TNF-α/IFN-γ Neutrophils in Murine Bone Marrow Pool
Veronica austriaca L. Extract and Arbutin Expand Mature Double TNF-α/IFN-γ Neutrophils in Murine Bone Marrow Pool Open
Plants from the Veronica genus are used across the world as traditional remedies. In the present study, extracts from the aerial part of the scarcely investigated Veronica austriaca L., collected from two habitats in Bulgaria—the Balkan Mo…
View article: AB0044 PHARMACOLOGICAL MANIPULATION OF SIRTUIN 1 ACTIVITY IN EXPERIMENTALLY INDUCED ARTHRITIS
AB0044 PHARMACOLOGICAL MANIPULATION OF SIRTUIN 1 ACTIVITY IN EXPERIMENTALLY INDUCED ARTHRITIS Open
View article: Early Pregnancy Human Decidua is Enriched with Activated, Fully Differentiated and Pro-Inflammatory Gamma/Delta T Cells with Diverse TCR Repertoires
Early Pregnancy Human Decidua is Enriched with Activated, Fully Differentiated and Pro-Inflammatory Gamma/Delta T Cells with Diverse TCR Repertoires Open
Pregnancy is a state where high and stage-dependent plasticity of the maternal immune system is necessary in order to equilibrate between immunosuppression of harmful responses towards the fetus and ability to fight infections. TCR γδ cell…
View article: <i>Chlorella vulgaris</i>H1993 and<i>Desmodesmus communis</i>H522 for low-cost production of high-value microalgal products
<i>Chlorella vulgaris</i>H1993 and<i>Desmodesmus communis</i>H522 for low-cost production of high-value microalgal products Open
Recently, scientists are focused on the discovery of alternative sources of high-value products such as proteins, lipids and carbohydrates. Microalgal cells have great potential for accumulation of bioactive components important in food, f…
View article: Clinopodium vulgare L. (wild basil) extract and its active constituents modulate cyclooxygenase-2 expression in neutrophils
Clinopodium vulgare L. (wild basil) extract and its active constituents modulate cyclooxygenase-2 expression in neutrophils Open
Clinopodium vulgare L. (wild basil) has a wide range of ethnopharmacological applications and accumulates a broad spectrum of phenolic compounds, recognized for their anti-inflammatory and anticancer properties. The triggered cyclooxygenas…
View article: Clinopodium vulgare L. (wild basil) extract and its active constituents modulate cyclooxygenase-2 expression in neutrophils
Clinopodium vulgare L. (wild basil) extract and its active constituents modulate cyclooxygenase-2 expression in neutrophils Open
View article: ANTIOXIDANT ACTIVITY AND MINERAL CONTENT OF ROCKET (ERUCA SATIVA) PLANT FROM ITALIAN AND BULGARIAN ORIGINS
ANTIOXIDANT ACTIVITY AND MINERAL CONTENT OF ROCKET (ERUCA SATIVA) PLANT FROM ITALIAN AND BULGARIAN ORIGINS Open
Rocket plant (Eruca sativa) is a green leafy vegetable with significant levels of bioactive active components. Although, this plant is known in Bulgaria, scanty data concerning chemical composition of representatives with Bulgarian origin …
View article: Pilot assessment of cyanotoxins as potential risk factors for cancer in Bulgaria
Pilot assessment of cyanotoxins as potential risk factors for cancer in Bulgaria Open
<p>Cyanoprokaryotes (=cyanobacteria, blue-green algae) are the most ancient oxygen-producing phototrophic microorganisms, spread all over the Globe, which form the important basis of different food chains in aquatic and terrestrial h…
View article: IVIG regulates the survival of human but not mouse neutrophils
IVIG regulates the survival of human but not mouse neutrophils Open
Intravenous immunoglobulin (IVIG) are purified IgG preparations made from the pooled plasma from thousands of healthy donors and are being tested in preclinical mouse models. Inherent challenges, however, are the pluripotency of IVIG and i…
View article: Faculty Opinions recommendation of MicroRNA-29b mediates altered innate immune development in acute leukemia.
Faculty Opinions recommendation of MicroRNA-29b mediates altered innate immune development in acute leukemia. Open
View article: Faculty Opinions recommendation of UNG protects B cells from AID-induced telomere loss.
Faculty Opinions recommendation of UNG protects B cells from AID-induced telomere loss. Open
View article: Faculty Opinions recommendation of Multisystem Anomalies in Severe Combined Immunodeficiency with Mutant BCL11B.
Faculty Opinions recommendation of Multisystem Anomalies in Severe Combined Immunodeficiency with Mutant BCL11B. Open
View article: Faculty Opinions recommendation of Widespread seasonal gene expression reveals annual differences in human immunity and physiology.
Faculty Opinions recommendation of Widespread seasonal gene expression reveals annual differences in human immunity and physiology. Open
View article: Intravenous Immunoglobulin with Enhanced Polyspecificity Improves Survival in Experimental Sepsis and Aseptic Systemic Inflammatory Response Syndromes
Intravenous Immunoglobulin with Enhanced Polyspecificity Improves Survival in Experimental Sepsis and Aseptic Systemic Inflammatory Response Syndromes Open
Sepsis is a major cause for death worldwide. Numerous interventional trials with agents neutralizing single proinflammatory mediators have failed to improve survival in sepsis and aseptic systemic inflammatory response syndromes. This fail…