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150 How Many Urines Had We Been Culturing Way Too Many...... Open

Claudine Jurkovitz, P.H. Holmes, Marci Drees · 2025

Introduction/Objective Urinalyses (UA) are frequently ordered to diagnose urinary tract infections (UTIs), but a positive UA may indicate asymptomatic bacteriuria as well as a true UTI. To help ensure that urine cultures are always complet…

Serial measurement of nitrite and xanthine oxidase (XO) to assess antimicrobial pharmacodynamics (PD) and treatment efficacy in urinary tract infections (UTIs): A proof-of-concept for personalized antimicrobial therapy Open

Marc Stadler, Paul O’Hare, P.H. Holmes, Dr Timothy Rawson · 2025

Medicine Chemistry Biology

Introduction: UTI is a common indication for antimicrobial therapy. Biomarkers specific to the causative organism, such as nitrite, are often employed in UTI diagnosis through qualitative detection methods such as dipsticks. XO was found t…

Dragonfly Molecular Diagnostic Platform: A Rapid Point-of-Care Solution for Monkeypox and Skin Lesion Pathogens Open

Diana D. Cardenas, Dr Matthew Cavuto, David W. Pond, Dr Ivana Pennisi, M. Mirza , et al. · 2025

Biology Computer science Medicine

Introduction: The WHO's declaration of a monkeypox (mpox) clade II outbreak as a Public Health Emergency of International Concern in 2022 underscored the global threat posed by this virus. By February 2024, the outbreak had spread to 117 n…

Guilty by dissociation: Paper-fluidic presumptive testing of the new psychoactive substance, diphenidine Open

P.H. Holmes, Lauren McNeill, Oliver B. Sutcliffe, Kirsty J. Shaw · 2016

Chemistry Engineering Materials science

This paper reports a paper microfluidic device which can presumptively test for the new psychoactive substance (NPS), diphenidine. A simple 'dip-stick' test has been developed in which Scott's and Marquis reagents are stored on the paper-f…

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