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View article: RhCMV Expands CCR5 Memory T Cells and promotes SIV reservoir seeding in the Gut Mucosa
RhCMV Expands CCR5 Memory T Cells and promotes SIV reservoir seeding in the Gut Mucosa Open
Cytomegalovirus (CMV) is a prevalent β-herpesvirus that persists asymptomatically in immunocompetent hosts. In people with HIV-1 (PWH), CMV is associated with HIV-1 persistence and particular inflammatory-related co-morbidities. The true c…
View article: Effect of 3-mercaptopyruvate sulfurtransferase (3-MST) inhibitors on contractile responses in porcine coronary artery.
Effect of 3-mercaptopyruvate sulfurtransferase (3-MST) inhibitors on contractile responses in porcine coronary artery. Open
Inhibition of 3-MST in coronary arteries leads to an inhibition of both calcium-dependent and calcium-independent contractions, whereas CBS/CSE inhibitors had no effect on receptor-mediated contractions. These data suggest that 3-MST, not …
View article: The IUPHAR/BPS Guide to PHARMACOLOGY in 2026
The IUPHAR/BPS Guide to PHARMACOLOGY in 2026 Open
The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb, https://www.guidetopharmacology.org) is an open-access database of expert-curated, high-quality pharmacological data. It provides succinct overviews and key references for pharmacological targe…
View article: Coronavirus (CoV) proteins in GtoPdb v.2025.3
Coronavirus (CoV) proteins in GtoPdb v.2025.3 Open
Coronaviruses are large, often spherical, enveloped, single-stranded positive-sense RNA viruses, ranging in size from 80-220 nm. Their genomes and protein structures are highly conserved. Three coronaviruses have emerged over the last 20 y…
View article: S33: Prolyl aminopeptidase in GtoPdb v.2025.3
S33: Prolyl aminopeptidase in GtoPdb v.2025.3 Open
Peptidase family S33 contains mainly exopeptidases that act at the N-terminus of peptides.
View article: Endocannabinoid turnover in GtoPdb v.2025.3
Endocannabinoid turnover in GtoPdb v.2025.3 Open
The principle endocannabinoids are 2-acylglycerol esters, such as 2-arachidonoylglycerol (2-AG), and N-acylethanolamines, such as anandamide (N-arachidonoylethanolamine, AEA). The glycerol esters and ethanolamides are synthesised and hydro…
View article: Class A Orphans in GtoPdb v.2025.3
Class A Orphans in GtoPdb v.2025.3 Open
Table 1 lists a number of putative GPCRs identified by NC-IUPHAR [206], for which preliminary evidence for an endogenous ligand has been published, or for which there exists a potential link to a disease, or disorder. These GPCRs have rece…
View article: Hydrolases & Lipases in GtoPdb v.2025.3
Hydrolases & Lipases in GtoPdb v.2025.3 Open
Listed in this section are hydrolases not accumulated in other parts of the Concise Guide, such as monoacylglycerol lipase and acetylcholinesterase. Pancreatic lipase is the predominant mechanism of fat digestion in the alimentary system; …
View article: Class A Orphans in GtoPdb v.2025.2
Class A Orphans in GtoPdb v.2025.2 Open
Table 1 lists a number of putative GPCRs identified by NC-IUPHAR [197], for which preliminary evidence for an endogenous ligand has been published, or for which there exists a potential link to a disease, or disorder. These GPCRs have rece…
View article: Hydrolases & Lipases in GtoPdb v.2025.2
Hydrolases & Lipases in GtoPdb v.2025.2 Open
Listed in this section are hydrolases not accumulated in other parts of the Concise Guide, such as monoacylglycerol lipase and acetylcholinesterase. Pancreatic lipase is the predominant mechanism of fat digestion in the alimentary system; …
View article: Reporting innovations in pharmacology and drug development, upholding excellence and improving author experience at the <i>British Journal of Pharmacology</i> in 2024
Reporting innovations in pharmacology and drug development, upholding excellence and improving author experience at the <i>British Journal of Pharmacology</i> in 2024 Open
International audience
View article: Class A Orphans in GtoPdb v.2025.1
Class A Orphans in GtoPdb v.2025.1 Open
Table 1 lists a number of putative GPCRs identified by NC-IUPHAR [164], for which preliminary evidence for an endogenous ligand has been published, or for which there exists a potential link to a disease, or disorder. These GPCRs have rece…
View article: Coronavirus (CoV) proteins in GtoPdb v.2025.1
Coronavirus (CoV) proteins in GtoPdb v.2025.1 Open
Coronaviruses are large, often spherical, enveloped, single-stranded positive-sense RNA viruses, ranging in size from 80-220 nm. Their genomes and protein structures are highly conserved. Three coronaviruses have emerged over the last 20 y…
View article: Cannabinoid receptors in GtoPdb v.2025.1
Cannabinoid receptors in GtoPdb v.2025.1 Open
Cannabinoid receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Cannabinoid Receptors [127]) are activated by endogenous ligands that include N-arachidonoylethanolamine (anandamide), N-homo-γ-linolenoylethanolamine, N-docosa…
View article: Novel drugs approved by the EMA, the FDA and the MHRA in 2024: A year in review
Novel drugs approved by the EMA, the FDA and the MHRA in 2024: A year in review Open
In the past year, the European Medicines Agency (EMA), the Food and Drug Administration (FDA) and the Medicines and Healthcare Products Regulatory Agency (MHRA) authorised 53 novel drugs. While the 2024 harvest is not as rich as in 2023, w…
View article: Hydrolases &amp; Lipases in GtoPdb v.2024.4
Hydrolases & Lipases in GtoPdb v.2024.4 Open
Listed in this section are hydrolases not accumulated in other parts of the Concise Guide, such as monoacylglycerol lipase and acetylcholinesterase. Pancreatic lipase is the predominant mechanism of fat digestion in the alimentary system; …
View article: Distribution of two notodendrodid foraminiferal congeners in McMurdo Sound, Antarctica: an example of extreme regional endemism?
Distribution of two notodendrodid foraminiferal congeners in McMurdo Sound, Antarctica: an example of extreme regional endemism? Open
We used morphological and molecular surveys to determine the presence or absence of Notodendrodes antarctikos and its congener, Notodendrodes hyalinosphaira, at diverse sites within McMurdo Sound, Antarctica. Morphological surveys were per…
View article: Natural product pharmacology: the British Journal of Pharmacology perspective
Natural product pharmacology: the British Journal of Pharmacology perspective Open
Natural products (NPs) have long been used as a rich source of bioactive compounds for drug development. Recent technological advancements have revitalised natural products research as evidenced by increased publications in this field. In …
View article: Coronavirus (CoV) proteins in GtoPdb v.2024.2
Coronavirus (CoV) proteins in GtoPdb v.2024.2 Open
Coronaviruses are large, often spherical, enveloped, single-stranded positive-sense RNA viruses, ranging in size from 80-220 nm. Their genomes and protein structures are highly conserved. Three coronaviruses have emerged over the last 20 y…
View article: Hydrolases & Lipases in GtoPdb v.2024.2
Hydrolases & Lipases in GtoPdb v.2024.2 Open
Listed in this section are hydrolases not accumulated in other parts of the Concise Guide, such as monoacylglycerol lipase and acetylcholinesterase. Pancreatic lipase is the predominant mechanism of fat digestion in the alimentary system; …
View article: Novel drugs approved by the EMA, the FDA, and the MHRA in 2023: A year in review
Novel drugs approved by the EMA, the FDA, and the MHRA in 2023: A year in review Open
In 2023, seventy novel drugs received market authorization for the first time in either Europe (by the EMA and the MHRA) or in the United States (by the FDA). Confirming a steady recent trend, more than half of these drugs target rare dise…
View article: Hydrolases & Lipases in GtoPdb v.2023.3
Hydrolases & Lipases in GtoPdb v.2023.3 Open
Listed in this section are hydrolases not accumulated in other parts of the Concise Guide, such as monoacylglycerol lipase and acetylcholinesterase. Pancreatic lipase is the predominant mechanism of fat digestion in the alimentary system; …
View article: Coronavirus (CoV) proteins in GtoPdb v.2023.3
Coronavirus (CoV) proteins in GtoPdb v.2023.3 Open
Coronaviruses are large, often spherical, enveloped, single-stranded positive-sense RNA viruses, ranging in size from 80-220 nm. Their genomes and protein structures are highly conserved. Three coronaviruses have emerged over the last 20 y…
View article: The IUPHAR/BPS Guide to PHARMACOLOGY in 2024
The IUPHAR/BPS Guide to PHARMACOLOGY in 2024 Open
The IUPHAR/BPS Guide to PHARMACOLOGY (GtoPdb; https://www.guidetopharmacology.org) is an open-access, expert-curated, online database that provides succinct overviews and key references for pharmacological targets and their recommended exp…
View article: The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors
The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors Open
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and nearly 60…
View article: The Concise Guide to PHARMACOLOGY 2023/24: Transporters
The Concise Guide to PHARMACOLOGY 2023/24: Transporters Open
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000…
View article: The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets
The Concise Guide to PHARMACOLOGY 2023/24: Introduction and Other Protein Targets Open
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 600…
View article: The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors
The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors Open
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 600…
View article: The Concise Guide to PHARMACOLOGY 2023/24: Nuclear hormone receptors
The Concise Guide to PHARMACOLOGY 2023/24: Nuclear hormone receptors Open
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and nearly 60…