Luu V. Pham
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View article: Evaluation of the Effect of Ticagrelor Dose Interruption and Treatment Resumption with or without Bolus Doses Through Population PK/PD Simulation
Evaluation of the Effect of Ticagrelor Dose Interruption and Treatment Resumption with or without Bolus Doses Through Population PK/PD Simulation Open
Our results suggest the need for individualizing duration of dose interruption prior to surgery and its resumption afterwards.
View article: Optimization of Distributed Generation Planning to Maximize the Absorption Rate of Renewable Energy in Distribution Networks
Optimization of Distributed Generation Planning to Maximize the Absorption Rate of Renewable Energy in Distribution Networks Open
This paper presents a multi-objective optimization approach for optimal Distributed Generation (DG) placement and sizing, optimizing power loss reduction, cost efficiency, voltage stability, and Renewable Energy Source (RES) absorption. Th…
View article: 0007 Comparing Post-prandial Glycemia After Late Eating vs Late Sleep: Preliminary Results from a Randomized Crossover Study
0007 Comparing Post-prandial Glycemia After Late Eating vs Late Sleep: Preliminary Results from a Randomized Crossover Study Open
Introduction Our previous work showed that a late dinner (22:00) compared to routine dinner (18:00) in healthy volunteers increased postprandial glucose and reduced dietary fat oxidation. However, it remains unclear whether these adverse m…
View article: 1509 Sleep and Exercise as Exacerbators of Hypoxemia and Their Responses to Supplemental Oxygen at High Altitude
1509 Sleep and Exercise as Exacerbators of Hypoxemia and Their Responses to Supplemental Oxygen at High Altitude Open
Introduction Acute mountain sickness, a potentially life-threatening condition consisting of sleep disturbances, headache, cerebral edema and pulmonary edema, is a complication of travel to high altitude. These complications stem from hypo…
View article: 0577 Cognitive Behavioral Therapy for Insomnia Improves Pain Sequelae in Traumatic Brain Injury: Preliminary Subgroup Analyses
0577 Cognitive Behavioral Therapy for Insomnia Improves Pain Sequelae in Traumatic Brain Injury: Preliminary Subgroup Analyses Open
Introduction Persistent pain is a prevalent consequence of traumatic brain injury (TBI), with an estimated 51.5% of civilian populations experiencing chronic pain comorbidly. Sleep disturbance and pain are interrelated and share cognitive-…
View article: 0597 Rates of Comorbid Insomnia and Sleep Apnea (COMISA) in Two Different Traumatic Brain Injury Populations: Military and Civilian
0597 Rates of Comorbid Insomnia and Sleep Apnea (COMISA) in Two Different Traumatic Brain Injury Populations: Military and Civilian Open
Introduction Insomnia and sleep apnea (SA) are common sleep disorders, with approximately 11-13% of the global population experiencing comorbid insomnia and sleep apnea (COMISA). COMISA substantially increases risk for both medical and psy…
View article: 0050 Acutely Delaying Sleep Onset Causes Dynamic Changes in Sleep Architecture: Insights from a Randomized Crossover Study
0050 Acutely Delaying Sleep Onset Causes Dynamic Changes in Sleep Architecture: Insights from a Randomized Crossover Study Open
Introduction The timing of meals may influence weight control and cardiovascular health. In a previous randomized crossover study (“Dinner Time”), we found that a late dinner (22:00) compared to a routine dinner (18:00) increased post pran…
View article: 1231 Sleep Measures Before and After Treatment in Psychiatric Populations
1231 Sleep Measures Before and After Treatment in Psychiatric Populations Open
Introduction Sleep problems are prevalent in psychiatric populations, and may serve as a marker or mediator of disease severity. However, systematic measurements of subjective and objective sleep parameters are lacking in this population. …
View article: Effects of time-restricted eating on actigraphy-derived sleep parameters: post hoc analysis of a randomized, isocaloric feeding study
Effects of time-restricted eating on actigraphy-derived sleep parameters: post hoc analysis of a randomized, isocaloric feeding study Open
Study Objectives Time-restricted eating (TRE) is a novel dietary intervention targeting weight loss and cardiometabolic risk factors. The impact of TRE on sleep patterns remains under-explored. Methods This was a post hoc analysis of a par…
View article: Polysomnographic features of hypoglossal nerve stimulation efficacy: Looking deeper than the apnea‐hypopnea index
Polysomnographic features of hypoglossal nerve stimulation efficacy: Looking deeper than the apnea‐hypopnea index Open
Objectives Hypoglossal nerve stimulation (HGNS) is a promising surgical option for patients with obstructive sleep apnea (OSA) who are intolerant of continuous positive airway pressure therapy (CPAP). Efficacy studies for HGNS stimulation …
View article: Novel application of orange marigold flower petal (Tagetes erecta L.) as a dietary supplement to improve skin redness of Koi carps (Cyprinus carpio L.)
Novel application of orange marigold flower petal (Tagetes erecta L.) as a dietary supplement to improve skin redness of Koi carps (Cyprinus carpio L.) Open
In this study, orange marigold (Tagetes erecta L.) petal was used as a direct lutein-containing resource for the Koi carps (Cyprinus carpio L.) with aim to enhance redness of specific area on their skin. The petals were collected from fres…
View article: The efficacy of intranasal leptin for opioid-induced respiratory depression depends on sex and obesity state
The efficacy of intranasal leptin for opioid-induced respiratory depression depends on sex and obesity state Open
Introduction: Opioid-induced respiratory depression (OIRD) is the primary cause of death associated with opioids and individuals with obesity are particularly susceptible due to comorbid obstructive sleep apnea (OSA). Repeated exposure to …
View article: Effects of sex, age, and body mass index on serum bicarbonate
Effects of sex, age, and body mass index on serum bicarbonate Open
Rationale Obesity hypoventilation syndrome (OHS) is often underdiagnosed, with significant morbidity and mortality. Bicarbonate, as a surrogate of arterial carbon dioxide, has been proposed as a screening tool for OHS. Understanding the pr…
View article: The effect of diet-induced obesity on sleep and breathing in female mice
The effect of diet-induced obesity on sleep and breathing in female mice Open
Obesity and male sex are main risk factors for sleep-disordered breathing (SDB). We have shown that male diet-induced obesity (DIO) mice develop hypoventilation, sleep apnea, and sleep fragmentation. The effects of DIO on breathing and sle…
View article: 0001 Effect of Time-Restricted Eating on Actigraphy-Derived Sleep Parameters
0001 Effect of Time-Restricted Eating on Actigraphy-Derived Sleep Parameters Open
Introduction Time-restricted eating (TRE) is an emerging dietary intervention for weight loss. Sleep can be influenced by timing of food intake. Nevertheless, the impact of TRE on sleep patterns remains under-explored. The Time-Restricted …
View article: 0255 Female Mice Are Less Susceptible to the Effects of Diet-Induced Obesity on Sleep and Sleep-Disordered Breathing
0255 Female Mice Are Less Susceptible to the Effects of Diet-Induced Obesity on Sleep and Sleep-Disordered Breathing Open
Introduction Diet-induced obesity (DIO) in male mice is a well-established model of sleep-disordered breathing (SDB). Male DIO mice manifest hypoventilation, increased apnea severity, and sleep fragmentation. The effects of DIO on breathin…
View article: Targeted Hypoglossal Nerve Stimulation for Patients With Obstructive Sleep Apnea
Targeted Hypoglossal Nerve Stimulation for Patients With Obstructive Sleep Apnea Open
Importance Evidence is lacking from randomized clinical trials of hypoglossal nerve stimulation in obstructive sleep apnea (OSA). Objective To evaluate the safety and effectiveness of targeted hypoglossal nerve stimulation (THN) of the pro…
View article: PSUN111 Rationale and Design of the Dinner Time 2 Trial: A Randomized, Crossover Trial to Compare the Effects of Delayed Eating vs Delayed Sleeping on Overnight Metabolism in Healthy Volunteers
PSUN111 Rationale and Design of the Dinner Time 2 Trial: A Randomized, Crossover Trial to Compare the Effects of Delayed Eating vs Delayed Sleeping on Overnight Metabolism in Healthy Volunteers Open
Background Obesity and its associated metabolic complications are leading causes of morbidity and mortality worldwide. Recent studies suggest that the timing of meals may be critically important for weight control and metabolic health. Con…
View article: TRPM7 channels regulate breathing during sleep in obesity by acting peripherally in the carotid bodies
TRPM7 channels regulate breathing during sleep in obesity by acting peripherally in the carotid bodies Open
Sleep‐disordered breathing (SDB) affects over 50% of obese individuals. Exaggerated hypoxic chemoreflex is a cardinal trait of SDB in obesity. We have shown that leptin acts in the carotid bodies (CB) to augment chemoreflex and that leptin…
View article: Diet-induced obesity leads to sleep fragmentation independently of the severity of sleep-disordered breathing
Diet-induced obesity leads to sleep fragmentation independently of the severity of sleep-disordered breathing Open
Our diet-induced obesity (DIO) model reproduces sleep features of human obesity, including sleep fragmentation, increased apnea frequency, and larger breathing variability. DIO induces sleep fragmentation independently of apnea severity. S…
View article: Isocapnic CO2 administration stabilizes breathing and eliminates apneas during sleep in obese mice exposed to hypoxia
Isocapnic CO2 administration stabilizes breathing and eliminates apneas during sleep in obese mice exposed to hypoxia Open
We hypothesized that exposure to hypoxia will destabilize breathing during sleep in our mouse model of sleep-disordered breathing (SDB), and the isocapnic administration of CO2 during severe hypoxia will improve SDB.
View article: Time Domains of Hypoxia Responses and -Omics Insights
Time Domains of Hypoxia Responses and -Omics Insights Open
The ability to respond rapidly to changes in oxygen tension is critical for many forms of life. Challenges to oxygen homeostasis, specifically in the contexts of evolutionary biology and biomedicine, provide important insights into mechani…
View article: Reversing coronary vascular sequelae of intermittent hypoxia: what is the window of opportunity?
Reversing coronary vascular sequelae of intermittent hypoxia: what is the window of opportunity? Open
Journal Article Reversing coronary vascular sequelae of intermittent hypoxia: what is the window of opportunity? Get access Luu V Pham, Luu V Pham Division of Pulmonary and Critical Care Medicine, Johns Hopkins University School of Medicin…
View article: Acute OSA Impacts Diurnal Alzheimer’s Biomarkers through Nocturnal Hypoxemia and State Transitions
Acute OSA Impacts Diurnal Alzheimer’s Biomarkers through Nocturnal Hypoxemia and State Transitions Open
"Acute OSA Impacts Diurnal Alzheimer's Biomarkers through Nocturnal Hypoxemia and State Transitions." American Journal of Respiratory and Critical Care Medicine, 206(8), pp. 1039–1042