Phidéline Gérard
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View article: Copper-catalyzed direct α-peroxidation of nitrogen heterocycles
Copper-catalyzed direct α-peroxidation of nitrogen heterocycles Open
Functionalized, saturated nitrogen heterocycles form the core structures of many molecules that have an impact on our daily lives, including natural products and pharmaceuticals. An efficient and general method for the direct alpha-peroxid…
View article: Total Synthesis of Conulothiazole A
Total Synthesis of Conulothiazole A Open
An efficient total synthesis of the chlorinated thiazole-containing natural product conulothiazole A is reported. Key features of this synthesis include a novel rhodium-catalyzed enantioselective hydrogenation of a 2-enamido-thiazole and a…
View article: Copper-Mediated N-Arylations of Hydantoins
Copper-Mediated N-Arylations of Hydantoins Open
A set of two broadly applicable procedures for the N-arylation of hydantoins is reported. The first one relies on the use of stoichiometric copper(I) oxide under ligand- and base-free conditions and enables a clean regioselective arylation…
View article: Copper-Catalyzed Direct Oxidative α-Arylation of Pyrrolidine with Phenols and Naphtols
Copper-Catalyzed Direct Oxidative α-Arylation of Pyrrolidine with Phenols and Naphtols Open
An efficient procedure for the direct arylation of pyrrolidine with phenols and naphtols is reported. Upon reaction with catalytic amounts of a binuclear copper(II)-7-azaindole complex under an atmosphere of oxygen, pyrrolidine is smoothly…
View article: Room‐Temperature Alkynylation of Phosphine Oxides with Copper Acetylides: Practical Synthesis of Alkynylphosphine Oxides (Eur. J. Org. Chem. 4/2016)
Room‐Temperature Alkynylation of Phosphine Oxides with Copper Acetylides: Practical Synthesis of Alkynylphosphine Oxides (Eur. J. Org. Chem. 4/2016) Open
The cover picture shows the alkynylation of phosphine oxides with copper acetylides. These polymeric, rock-stable and unreactive reagents can be readily activated by coordination with simple ligands and oxidation with molecular oxygen. Thi…