Phil Tittensor
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View article: The current clinical practice and experiences in buccal midazolam prescribing in community for status epilepticus termination in the United Kingdom: The Rescue Epilepsy Medication and Training (REMIT) study
The current clinical practice and experiences in buccal midazolam prescribing in community for status epilepticus termination in the United Kingdom: The Rescue Epilepsy Medication and Training (REMIT) study Open
This is the first study to give insights to community management of SE using rescue therapies particularly BM. Further evidence-based guidelines are needed for BM use in multimorbid patients and for its deprescribing. Robust safeguarding p…
View article: Updating Beliefs using New Evidence from a Diagnostic Decision-Support Aid in a Nurse-Led First-Seizure Clinic
Updating Beliefs using New Evidence from a Diagnostic Decision-Support Aid in a Nurse-Led First-Seizure Clinic Open
Summary Recent studies using computational and mathematical interrogation of background EEG have revealed eight biomarkers that inform a diagnostic decision-support tool called BioEP. To assess the utility of BioEP for aiding clinical deci…
View article: Evidencing the challenges of care delivery for people with intellectual disability and epilepsy in England by using the Step Together toolkit
Evidencing the challenges of care delivery for people with intellectual disability and epilepsy in England by using the Step Together toolkit Open
Background People with intellectual disability (PwID) and epilepsy have increased premature and potentially preventable mortality. This is related to a lack of equitable access to appropriate care. The Step Together guidance and toolkit, d…
View article: A Digital Intervention for Capturing the Real-Time Health Data Needed for Epilepsy Seizure Forecasting: Protocol for a Formative Co-Design and Usability Study (The ATMOSPHERE Study)
A Digital Intervention for Capturing the Real-Time Health Data Needed for Epilepsy Seizure Forecasting: Protocol for a Formative Co-Design and Usability Study (The ATMOSPHERE Study) Open
Background Epilepsy is a chronic neurological disorder affecting individuals globally, marked by recurrent and apparently unpredictable seizures that pose significant challenges, including increased mortality, injuries, and diminished qual…
View article: Efficacy and tolerability of Brivaracetam in people with intellectual disability compared to those without intellectual disability
Efficacy and tolerability of Brivaracetam in people with intellectual disability compared to those without intellectual disability Open
This is the first study on BRV, which compares ID cohorts with differing severity and non-ID. Efficacy, tolerability and side-effects reported are similar across differing ID severity to those with no ID.
View article: Estimating the likelihood of epilepsy from clinically noncontributory electroencephalograms using computational analysis: A retrospective, multisite case–control study
Estimating the likelihood of epilepsy from clinically noncontributory electroencephalograms using computational analysis: A retrospective, multisite case–control study Open
Objective This study was undertaken to validate a set of candidate biomarkers of seizure susceptibility in a retrospective, multisite case–control study, and to determine the robustness of these biomarkers derived from routinely collected …
View article: Awareness of social care needs in people with epilepsy and intellectual disability
Awareness of social care needs in people with epilepsy and intellectual disability Open
A gap exists between health and social care professionals in awareness of epilepsy needs for people with ID, requiring essential training and national pathways.
View article: Estimating the likelihood of epilepsy from clinically non-contributory EEG using computational analysis: A retrospective, multi-site case-control study
Estimating the likelihood of epilepsy from clinically non-contributory EEG using computational analysis: A retrospective, multi-site case-control study Open
Summary Background A retrospective, multi-site case control study was carried out to validate a set of candidate biomarkers of seizure susceptibility. The objective was to determine the robustness of these biomarkers derived from routinely…
View article: National compliance with UK wide guidelines for usage of valproate in women of childbearing potential
National compliance with UK wide guidelines for usage of valproate in women of childbearing potential Open
Valproate (VPA) is an effective treatment for epilepsy and also used in bipolar disorder. However, VPA is associated with a significant risk of birth defects and developmental disorders if used during pregnancy. This has led to the introdu…
View article: The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial
The SANAD II study of the effectiveness and cost-effectiveness of valproate versus levetiracetam for newly diagnosed generalised and unclassifiable epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial Open
National Institute for Health Research Health Technology Assessment Programme.
View article: The SANAD II study of the effectiveness and cost-effectiveness of levetiracetam, zonisamide, or lamotrigine for newly diagnosed focal epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial
The SANAD II study of the effectiveness and cost-effectiveness of levetiracetam, zonisamide, or lamotrigine for newly diagnosed focal epilepsy: an open-label, non-inferiority, multicentre, phase 4, randomised controlled trial Open
National Institute for Health Research Health Technology Assessment programme.
View article: Eslicarbazepine acetate response in intellectual disability population versus general population
Eslicarbazepine acetate response in intellectual disability population versus general population Open
Tolerance and Efficacy for ID and 'no ID' people in our data set were similar. Seizure improvement and retention rates were slightly lower than that found in other European data sets, but findings strengthen the evidence for the use of ESL…
View article: Lacosamide in the general population and in people with intellectual disability: Similar responses?
Lacosamide in the general population and in people with intellectual disability: Similar responses? Open
There were no differences for LCM outcomes between general and ID groups. Slower LCM titration in ID populations in the first 3 months was associated with higher retention and lower behavioural side effects as compared to similar European …
View article: Eslicarbazepine acetate as a replacement for levetiracetam in people with epilepsy developing behavioral adverse events
Eslicarbazepine acetate as a replacement for levetiracetam in people with epilepsy developing behavioral adverse events Open
The ESL was well tolerated and did not produce significant PBSEs in those who had PBSEs with LEV leading to withdrawal of the drug. Though numbers were small, the findings suggest that ESL could be a treatment option in those who develop P…