Explanipedia

Author Correction: A consensus immune dysregulation framework for sepsis and critical illnesses Open

A. R. Moore, Hong Zheng, Ananthakrishnan Ganesan, Yehudit Hasin-Brumshtein, Manoj V. Maddali , et al. · 2025

Macrophages Polarization as a Potential Driver and a Therapeutic Target for Sepsis-induced Cognitive Impairment in Older Adults Open

Rola S Zeidan, Susan C. Reinhard, S. R. Sykes, Catherine C. Price, Shannon M. Wallet , et al. · 2025

Sepsis, a dysregulated host response to infection, remains a growing global health concern, particularly in older adults. While much attention focuses on acute survival, an increasing number of sepsis survivors experience persistent neurol…

Age- and Sex- Driven Transcriptional and Metabolic Diversity in Myeloid-Derived Suppressor Cells After Mouse Sepsis Open

Christine Rodhouse, Dayuan Wang, Hua Tang, Valerie E. Polcz, Miguel Hernández-Ríos , et al. · 2025

Summary Sepsis induces profound immune dysregulation, often resulting in chronic critical illness characterized by persistent immunosuppression and poor outcomes. Myeloid-derived suppressor cells (MDSCs) are central mediators of this immun…

A consensus immune dysregulation framework for sepsis and critical illnesses Open

A. R. Moore, Hong Zheng, Ananthakrishnan Ganesan, Yehudit Hasin-Brumshtein, Manoj V. Maddali , et al. · 2025

Critical care syndromes such as sepsis, acute respiratory distress syndrome (ARDS) and trauma continue to have unacceptably high morbidity and mortality, with progress limited by the inherent heterogeneity within syndromic illnesses. Altho…

Home-Based, Remotely-Delivered Exercise Training to Improve Physical Function of Middle-aged and Older Sepsis Survivors – the HEAL Sepsis Trial (Preprint) Open

Yi Lin, Rola S Zeidan, Rezvan Ghaderpanah, Margaret K Ohama, Min-Kyung Jung , et al. · 2025

BACKGROUND Sepsis survivors frequently experience post-discharge physical function decline and encounter logistical barriers to participation in traditional outpatient rehabilitation. OBJECTIVE This pilot study examined the feasibility,…

Monocyte Anisocytosis Can Discriminate Between Sepsis and Sterile Inflammation, but not Mortality, in Critically Ill Surgical/Trauma Patients: A Secondary Prospective Analysis Open

Miguel Hernández-Ríos, Renbiao Wu, Valerie E. Polcz, Rachel D. Burnside, Lael M. Yonker , et al. · 2025

OBJECTIVES (BACKGROUND): Monocyte anisocytosis (monocyte distribution width [MDW]) has been previously validated to predict sepsis and outcome in patients presenting in the emergency department and mixed-population ICUs. Determining sepsis…

Single-cell multiomics identifies both shared and unique features of immune dysfunction in Parkinson’s disease and inflammatory bowel disease colon, plasma and stool Open

MacKenzie L. Bolen, Marie‐Annick Buendia, Ji Shi, Hannah A. Staley, Jennifer M. Kachergus , et al. · 2025

Parkinson’s disease (PD) is the fastest growing neurodegenerative disease in the world1. Gastrointestinal (GI) dysfunction can occur decades before motor impairments and in up to 80% of individuals living with PD2,3,4. We investigated peri…

Language Models for Multilabel Document Classification of Surgical Concepts in Exploratory Laparotomy Operative Notes: Algorithm Development Study Open

Jeremy A. Balch, Sasank Desaraju, Victoria Nolan, Divya Vellanki, Timothy R. Buchanan , et al. · 2025

Background Operative notes are frequently mined for surgical concepts in clinical care, research, quality improvement, and billing, often requiring hours of manual extraction. These notes are typically analyzed at the document level to det…

Microbiome-based therapeutics towards healthier aging and longevity Open

Saurabh Kadyan, Gwoncheol Park, Tejinder Pal Singh, Cole Patoine, Saiful Singar , et al. · 2025

Surgical ICU Admission Criteria: A Scoping Review Open

Kenneth L. Abbott, Philip Hong, Matthew M. Ruppert, Purvi P. Patel, Philip A. Efron , et al. · 2025

OBJECTIVES: The aims of this scoping review were to: 1) explore factors driving surgical ICU (SICU) admission decisions, 2) provide an environmental scan of SICU admission practices, and 3) identify underexamined domains relevant for SICU …

Temporal changes in the protein cargo of extracellular vesicles and resultant immune reprogramming after severe burn injury in humans and mice Open

Micah L. Willis, Roland F. Seim, Laura E. Herring, Angie L. Mordant, Thomas S. Webb , et al. · 2025

Introduction Severe injury, including burn trauma, leads to profound immune dysfunction, yet the mechanisms driving these changes remain incompletely defined. This lack of understanding has hindered efforts to modulate the immune response …

Temporal changes in the protein cargo of extracellular vesicles and resultant immune reprogramming after severe burn injury in humans and mice Open

Thomas S. Webb, Ashish Sharma, Philip A. Efron · 2025

Severe injury, including burn trauma, leads to profound immune dysfunction, yet the mechanisms driving these changes remain incompletely defined. This lack of understanding has hindered efforts to modulate the immune response effectively. …

Sepsis Induces Age- and Sex-Specific Chromatin Remodeling in Myeloid-Derived Suppressor Cells Open

Angel Charles, Dijoia B. Darden, Dijoia B. Darden, Miguel Hernández-Ríos, Mingqi Zhou , et al. · 2025

SUMMARY Sepsis survivors frequently develop long-term immune dysfunction, but the epigenetic mechanisms underlying persistent myeloid suppression remain unclear. Myeloid-derived suppressor cells (MDSCs), whose function is shaped by host ag…

Chromatin Remodeling and Transcriptional Silencing Define the Dynamic Innate Immune Response of Tissue Resident Macrophages After Burn Injury Open

Han Sang Kim, Marie‐Pierre L. Gauthier, Aidan Higgs, Denise A. Hernandez, Mingqi Zhou , et al. · 2025

Summary Severe burn injury induces long-lasting immune dysfunction, but the molecular mechanisms underlying this phenomenon remain unclear. We hypothesized that burn injury leads to epigenetic and transcriptional reprogramming of innate im…

Temporal impact of sepsis on Alzheimer's disease pathology and neuroinflammation Open

Quan Vo, Dina C. Nacionales, Karen N. McFarland, Carmelina Gorski, Evan L. Barrios , et al. · 2025

Epidemiological evidence has revealed an associative link between sepsis survivorship and increased risk of dementia, particularly Alzheimer's disease (AD). Paradoxically, population studies show females are less susceptible to sepsis but …

Single-cell multiomics identifies both shared and unique features of immune dysfunction in Parkinson’s disease and inflammatory bowel disease colon, plasma and stool Open

MacKenzie L. Bolen, Marie‐Annick Buendia, Ji Shi, Hannah A. Staley, Jennifer M. Kachergus , et al. · 2025

Parkinson’s disease (PD) is the fastest growing neurodegenerative disease in the world 1 . Gastrointestinal (GI) dysfunction can occur decades before motor impairments and in up to 80% of individuals living with PD 2,3,4 . We investigated …

Innate immune training in the neonatal response to sepsis Open

Jaimar C. Rincon, Dayuan Wang, Valerie E. Polcz, Evan L. Barrios, Marvin L. Dirain , et al. · 2025

Determining potential immunomodulatory drug efficacy in sepsis using ELISpot Open

Andrew H. Walton, Monty B. Mazer, Kenneth E. Remy, Dale F. Osborne, Ethan Davitt , et al. · 2025

This study evaluated the ability of ELISpot to identify potential immuno-modulatory drug therapies in sepsis. ELISpot was performed ex vivo on whole blood from septic patients and healthy controls. Innate and adaptive immunity were evaluat…

Temporal changes in the protein cargo of extracellular vesicles and resultant immune reprogramming after severe burn injury in humans and mice Open

Micah L. Willis, Roland F. Seim, Laura E. Herring, Angie L. Mordant, Thomas Webb , et al. · 2025

Introduction Severe injury, including burn trauma, leads to profound immune dysfunction, yet the mechanisms driving these changes remain incompletely defined. This lack of understanding has hindered efforts to modulate the immune response …

Corrigendum to “Functional connectivity within sensorimotor cortical and striatal regions is regulated by sepsis in a sex-dependent manner” [NeuroImage 305 (2025) 120995] Open

Quan Vo, Zachary D Simon, Gwoncheol Park, Dina C. Nacionales, Carmelina Gorski , et al. · 2025

Functional connectivity within sensorimotor cortical and striatal regions is regulated by sepsis in a sex-dependent manner Open

Quan Vo, Zachary D Simon, Gwoncheol Park, Dina C. Nacionales, Carmelina Gorski , et al. · 2025

Sepsis is a state of systemic immune dysregulation and organ failure that is frequently associated with severe brain disability. Epidemiological studies have indicated that younger females have better prognosis and clinical outcomes relati…

Investigating Sepsis-Associated Delirium Through Optical Neuroimaging: A New Frontier in Critical Care Research Open

Shixie Jiang, Matthew Gunther, José R. Maldonado, Philip A. Efron, Steven T. DeKosky , et al. · 2024

Sepsis is a life-threatening syndrome consisting of physiological, pathological, and biochemical abnormalities induced by infection which continues to be a major public health burden. It remains one of the most common reasons for intensive…

Unique lymphocyte transcriptomic profiles in septic patients with chronic critical illness Open

Evan L. Barrios, Leandro Balzano‐Nogueira, Valerie E. Polcz, Christine Rodhouse, Jack R. Leary , et al. · 2024

Introduction Despite continued improvement in post-sepsis survival, long term morbidity and mortality remain high. Chronic critical illness (CCI), defined as persistent inflammation and organ injury requiring prolonged intensive care, is a…

International multi-cohort analysis identifies novel framework for quantifying immune dysregulation in critical illness: results of the SUBSPACE consortium Open

A. R. Moore, Hong Zheng, Ananthakrishnan Ganesan, Yehudit Hasin-Brumshtein, Manoj V. Maddali , et al. · 2024

Progress in the management of critical care syndromes such as sepsis, Acute Respiratory Distress Syndrome (ARDS), and trauma has slowed over the last two decades, limited by the inherent heterogeneity within syndromic illnesses. Numerous i…

Home-Based Digital Exercise Training Program to Improve Physical Function of Older Sepsis Survivors: Protocol of the HEAL Sepsis Randomized Clinical Trial Open

Rola S Zeidan, Margaret K Ohama, Natalia Evripidou, Stephen D. Anton, Lamia Hamed , et al. · 2024

Background While sepsis, an exaggerated response to infection, can affect people of all age groups, it is more prevalent in middle-aged and older adults. Older adults suffer worse short-term and long-term outcomes than younger patients. Ol…

Surviving septic patients endotyped with a functional assay demonstrate active immune responses Open

Adam D Price, Ellen R Becker, Evan L. Barrios, Monty B. Mazer, Patrick W. McGonagill , et al. · 2024

Introduction Sepsis is a complex clinical syndrome characterized by a heterogenous host immune response. Historically, static protein and transcriptomic metrics have been employed to describe the underlying biology. Here, we tested the hyp…

Community-engaged artificial intelligence research: A scoping review Open

Tyler J. Loftus, Jeremy A. Balch, Kenneth L. Abbott, Die Hu, Matthew M. Ruppert , et al. · 2024

The degree to which artificial intelligence healthcare research is informed by data and stakeholders from community settings has not been previously described. As communities are the principal location of healthcare delivery, engaging them…

MerTK-dependent efferocytosis by monocytic-MDSCs mediates resolution of ischemia/reperfusion injury after lung transplant Open

Victoria Leroy, Denny Joseph Manual Kollareth, Zhenxiao Tu, Jeff Arni C. Valisno, Makena Woolet-Stockton , et al. · 2024

Lung transplantation (LTx) outcomes are impeded by ischemia/reperfusion injury (IRI) and subsequent chronic lung allograft dysfunction (CLAD). We examined the undefined role of receptor Mer tyrosine kinase (MerTK) on monocytic myeloid-deri…

Development and optimization of a diluted whole blood ELISpot assay to test immune function Open

Ricardo Ungaro, Julie Xu, Tamara A. Kucaba, Mahil Rao, Christian B. Bergmann , et al. · 2024

Sepsis remains a leading cause of death worldwide with no proven immunomodulatory therapies. Stratifying Patient Immune Endotypes in Sepsis ('SPIES') is a prospective, multicenter observational study testing the utility of ELISpot as a fun…

Incorporating Patient Values in Large Language Model Recommendations for Surrogate and Proxy Decisions Open

Victoria Nolan, Jeremy A. Balch, Naveen Baskaran, Benjamin Shickel, Philip A. Efron , et al. · 2024

Background: Surrogates, proxies, and clinicians making shared treatment decisions for patients who have lost decision-making capacity often fail to honor patients’ wishes, due to stress, time pressures, misunderstanding patient values, and…

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