Explanipedia

International Benchmark Values for Robotic Right Hepatectomy: Multicenter Study From 22 Expert Centers Open

Philip C. Müller, Noa L E Aegerter, Adrian T. Billeter, Janina Eden, Beat Moeckli , et al. · 2025

Objective: This study aimed to identify benchmark values for robotic right hepatectomy (RH) based on a low-risk cohort treated at expert centers. Background: Robotic liver surgery is emerging as a preferred minimally invasive approach to t…

Hypothermic oxygenated perfusion (HOPE) against cancer recurrence after liver transplantation for hepatocellular carcinoma—study protocol for an international multicenter randomized controlled trial (HOPE4Cancer) Open

Janina Eden, Philip C. Müller, Christoph Kuemmerli, Florian Peters, Tanja Litke , et al. · 2025

Reporting of major complications in randomized clinical trials in pancreatic surgery according to Clavien–Dindo classification Open

Amila Cizmic, Laetitia Zoe Hampe, Philipp Anthony Wise, Pascal Probst, Markus K. Müller , et al. · 2025

Key steps of complex robotic liver surgery: an international expert survey Open

Noa L E Aegerter, Christoph Kuemmerli, Felix Nickel, Cristiano Guidetti, Christoph Tschuor , et al. · 2025

Life Expectancy of Transplanted Livers Open

Janina Eden, Philip C. Müller, Christoph Kuemmerli, Noa L E Aegerter, Isabel M.A. Brüggenwirth , et al. · 2025

Objective: To investigate the impact of cumulative liver age on graft survival in liver transplant recipients. Background: Organ shortage has led to increased use of elderly donor livers for an ageing group of recipients, particularly in E…

Conversion of Robotic Distal Pancreatectomy Open

Philip C. Müller, Philipp Sedlaczek, Adrian T. Billeter, Baiyong Shen, Jiabin Jin , et al. · 2025

Objective: The aim of this study was to identify risk factors for conversion and assess its consequences on clinical outcomes after robotic distal pancreatectomy (RPD). Summary of Background Data: RDP has gained popularity due to its lower…

Global and Local Contrastive Learning for Joint Representations from Cardiac MRI and ECG Open

Alexander Selivanov, Philip C. Müller, Özgün Turgut, Nil Stolt-Ansó, Daniel Rückert · 2025

An electrocardiogram (ECG) is a widely used, cost-effective tool for detecting electrical abnormalities in the heart. However, it cannot directly measure functional parameters, such as ventricular volumes and ejection fraction, which are c…

International validation of the distal pancreatectomy fistula risk score: evaluation in minimally invasive and open surgery Open

Philip C. Müller, Suna Erdem, Christoph Kuemmerli, Felix Nickel, O. H. Fiete Gehrisch , et al. · 2025

Quantifying Flavin mononucleotide: an internationally validated methodological approach for enhanced decision making in organ transplantation Open

Keyue Sun, Chunbao Jiao, Rebecca Panconesi, Sangeeta Satish, O Karakaya , et al. · 2025

Training and learning curves in robotic pancreatic surgery Open

Anas Amin Preukschas, Amila Cizmic, Philip C. Müller, Christoph Kuemmerli, Faik G. Uzunoǧlu , et al. · 2025

From Competency to Mastery: Learning Phases in Robotic Liver Surgery in 5 International Expert Centres Open

Gabriel Fridolin Hess, Christoph Kümmerli, Philipp Dutkowski, Adrian T. Billeter, Beat P. Müller‐Stich , et al. · 2025

Background Open liver surgery is increasingly being replaced by minimally invasive surgery, especially using robot-assisted liver resections (RLR). Along the learning phases of a surgical procedure intraoperative, postoperative, and oncolo…

First International Benchmark Values for Robotic Right Hepatectomy: A New Standard of Care? Open

Philip C. Müller, Christoph Kuemmerli, Adrian T. Billeter, P Dutkowksi, Beat P. Müller‐Stich · 2025

Background Robotic liver surgery is rapidly emerging as the preferred surgical approach to the liver. Novel benchmark values in robotic surgery are urgently needed to enable conclusive comparisons with the standard open or laparoscopic app…

Defining Global Benchmarks for Total Pancreatectomy: A Multicenter Study from 22 International Expert Centers Open

Christoph Kuemmerli, Philip C. Müller, A Billetter, Beat P. Müller‐Stich · 2025

Background Total pancreatectomy (TP) is the preferred treatment for patients with advanced pancreatic cancer or multifocal pancreatic tumors. Furthermore, in patients with concomitant vascular resections, TP may be performed to avoid the r…

International Validation of the Distal Pancreatectomy Fistula Risk Score – More Than a Throw of the Dice? Open

S. Erdem-Sanchez, Philip C. Müller, Christoph Kümmerli, Amelie Hannoschöck, Adrian T. Billeter , et al. · 2025

Background Postoperative pancreatic fistula (POPF) remains the most severe complication following distal pancreatectomy (DP). The preoperative distal fistula risk score (D-FRS) was recently introduced to predict the POPF risk. Aims The aim…

Single versus dual hypothermic oxygenated perfusion in liver transplantation: a call for risk-matched outcome analyses Open

O Karakaya, Sangeeta Satish, Philip C. Müller, Philipp Dutkowski, Andrea Schlegel · 2025

Artificial intelligence and image guidance in minimally invasive pancreatic surgery: current status and future challenges Open

Philip C. Müller, Suna Erdem, Christoph Kuemmerli, Joël L. Lavanchy, Marko Kraljević , et al. · 2025

Artificial intelligence (AI), machine learning (ML), and image guidance are increasingly being used to support surgeons in preoperative, intraoperative, and postoperative decision making and optimized patient care. Surgery is the cornersto…

Digital standardization in liver surgery through a surgical workflow management system: A pilot randomized controlled trial Open

Fabian Haak, Philip C. Müller, Otto Kollmar, Adrian T. Billeter, Joël L. Lavanchy , et al. · 2025

Competency, Proficiency, and Mastery Open

Philip C. Müller, Christoph Kuemmerli, Adrian T. Billeter, Baiyong Shen, Jiabin Jin , et al. · 2024

Objective: The aim of this study was to evaluate the different phases of the learning curve for robotic distal pancreatectomy (RDP) in international expert centers. Summary Background Data: RDP is an emerging minimally invasive approach; h…

Matching the opposites: liver transplantation from a situs viscerum inversus totalis donor Open

Cristiano Guidetti, Roberta Odorizzi, Barbara Catellani, Philip C. Müller, Paolo Magistri , et al. · 2024

Situs viscerum inversus totalis (SIT) is a rare congenital anomaly. Deceased donors with this condition are often declined because of the technical issues in both the organ’s procurement and its transplant. Only eight cases of deceased don…

Intraoperative Allogeneic Blood Transfusion Has No Impact on Postoperative Short-Term Outcomes After Pancreatoduodenectomy for Periampullary Malignancies: A Propensity Score Matching Analysis and Mediation Analysis Open

Kristjan Ukegjini, René Warschkow, Henrik Petrowsky, Philip C. Müller, José Oberholzer , et al. · 2024

Background/Objectives: The aim of this study was to investigate the association between intraoperative blood transfusion (BT) and the short-term outcomes of pancreatoduodenectomy (PD) for patients with periampullary malignancies. Methods: …

Extent of resection and underlying liver disease influence the accuracy of the preoperative risk assessment with the American College of Surgeons Risk Calculator Open

Noa L E Aegerter, Christoph Kümmerli, Anouk Just, Thierry Girard, Oliver Bandschapp , et al. · 2024

The ACS-RC is a reliable tool for estimating 30-day postoperative morbidity, particularly for patients with healthy liver parenchyma undergoing partial liver resection. However, accurate perioperative risk prediction should be adjusted for…

Estimating Neural Orientation Distribution Fields on High Resolution Diffusion MRI Scans Open

Mohammed Munzer Dwedari, William Consagra, Philip C. Müller, Özgün Turgut, Daniel Rueckert , et al. · 2024

The Orientation Distribution Function (ODF) characterizes key brain microstructural properties and plays an important role in understanding brain structural connectivity. Recent works introduced Implicit Neural Representation (INR) based a…

Impact of Positive Lymph Nodes after Systematic Perihilar Lymphadenectomy in Colorectal Liver Metastases Open

Gabriel Fridolin Hess, Noa L E Aegerter, Jasmin Zeindler, Jürg Vosbeck, Kerstin Neuschütz , et al. · 2024

Background: 25 to 50% of patients suffering from colorectal cancer develop liver metastases. The incidence of regional lymph node (LN) metastases within the liver is up to 14%. The need for perihilar lymph node dissection (LND) is still a …

Specialized curricula for training vision-language models in retinal image analysis Open

Robbie Holland, Thomas R. Taylor, Chris Holmes, Sophie Riedl, Julia Mai , et al. · 2024

Clinicians spend a significant amount of time reviewing medical images and transcribing their findings regarding patient diagnosis, referral and treatment in text form. Vision-language models (VLMs), which automatically interpret images an…

Toward a Standardization of Learning Curve Assessment in Minimally Invasive Liver Surgery Open

Christoph Kuemmerli, Johannes M.A. Toti, Fabian Haak, Adrian T. Billeter, Felix Nickel , et al. · 2024

Objective: The aim was to analyze the learning curves of minimal invasive liver surgery (MILS) and propose standardized reporting. Background: MILS offers benefits compared with open resections. For a safe introduction along the learning c…

Evaluation of Language Models in the Medical Context Under Resource-Constrained Settings Open

Andrea Posada, Daniel Rueckert, Felix Meissen, Philip C. Müller · 2024

Since the Transformer architecture emerged, language model development has grown, driven by their promising potential. Releasing these models into production requires properly understanding their behavior, particularly in sensitive domains…

Organspende und Organassessment nach primärem Herz-Kreislauf-Stillstand und sekundärem Hirntod Open

Philip C. Müller, Beat P. Müller‐Stich, Philipp Dutkowski · 2024

Zusammenfassung Hintergrund Der weltweite Organmangel ist das größte Hindernis, um die dringend notwendigen Lebertransplantationsaktivitäten auszuweiten. Um die Anzahl gespendeter Organe zu erhöhen, wurde in vielen europäischen Ländern neb…

Full robotic versus open ALPPS: a bi-institutional comparison of perioperative outcomes Open

Cristiano Guidetti, Philip C. Müller, Paolo Magistri, Jan Philipp Jonas, Roberta Odorizzi , et al. · 2024

Full Robotic Versus Open ALPPS: A Bi-Institutional Comparison of Perioperative Outcomes Open

Philip C. Müller, Cristiano Guidetti, Paolo Magistri, Jan Philipp Jonas, Roberta Odorizzi , et al. · 2024

Background In primarily unresectable liver tumors, ALPPS (Associating Liver Partition and Portal Vein Ligation for Staged hepatectomy) may offer curative two stage hepatectomy trough a fast and extensive hypertrophy. However, concerns have…

The PAncreatic Surgery Composite Endpoint PACE – Development and Validation of a Clinically Relevant Endpoint Requiring Lower Sample Sizes Open

Christoph Kümmerli, Felix Nickel, Philip C. Müller, Mona Wanda Schmidt, L P Schmidt , et al. · 2024

Background Single endpoints in prospective and randomized studies have become impractical due to their low frequency and the marginal benefit of new interventions. Aims To provide a composite endpoint in pancreatic surgery. Methods Data fr…

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