Explanipedia

Left Atrial Appendage Occlusion Using a Novel System Open

Felix Mahfoud, Christian Ukena, Philip D Adamson, Matthew John O’Connor, Patricia J. Brooks , et al. · 2025

This novel LAA occlusion system demonstrated favorable early safety and performance in both preclinical and FIH evaluation. The novel design features enabled effective LAA sealing and absence of DRT, supporting further investigation in lar…

Machine learning to predict high-risk coronary artery disease on CT in the SCOT-HEART trial Open

Michelle C. Williams, A Guimarães, Muchen Jiang, Jacek Kwieciński, Jonathan Weir‐McCall , et al. · 2025

Background Machine learning based on clinical characteristics has the potential to predict coronary CT angiography (CCTA) findings and help guide resource utilisation. Methods From the SCOT-HEART (Scottish Computed Tomography of the HEART)…

The Asia Pacific Cardiovascular Research (ASPIRE) Network Open

Clement Lau, Philip D Adamson, Nicholas Chew, Gemma A. Figtree, Alan Yean Yip Fong , et al. · 2025

Soluble urokinase plasminogen activator receptor (suPAR) for risk stratification from undifferentiated acute chest pain through to convalescence after acute coronary syndromes Open

Thomas E. Keys, Charlotte Greer, Philip D Adamson, John W. Pickering, Anna P. Pilbrow , et al. · 2025

Aim The performance of plasma soluble urokinase plasminogen activator receptor (suPAR) for prediction of heart failure (HF) readmission or death within 5 years was assessed in patients incurring (i) initially undifferentiated chest pain an…

Fatigue is a key contributor to quality of life in heart valve disease and after valve replacement/repair Open

Ariel Pons, Gillian Whalley, Rosemary Wyber, Paul Bridgman, Ralph Stewart , et al. · 2025

Background Heart valve disease can result in high morbidity and impairment of quality of life (QOL) both before and after intervention. However, there are few descriptions of the QOL of people with heart valve disease across the disease co…

Transcatheter Aortic Valve Implantation (TAVI) Outcomes for the 2022 Cohort at Christchurch Hospital – How are They at 2 Years? Open

J. Liu, J. Blake, S Jones, J. Kim, Airong Hu , et al. · 2025

Permanent Pacemaker (PPM) Insertion Rates for the 2022 Cohort Following Transcatheter Aortic Valvular Implantation (TAVI) at Christchurch Hospital Open

J. Liu, S. Jones, J. Kim, Anming Hu, S. Paintin , et al. · 2025

Insulin-like growth factor binding protein-3 (IGFBP-3): a biomarker of coronary artery disease induced myocardial ischaemia Open

Jacqui A Lee, Jessika Wise, Sara D Raudsepp, Louise N. Paton, Jan Powell , et al. · 2025

Aims Among individuals presenting to the emergency department (ED) with chest pain, clinical uncertainty surrounds the appropriate identification of non-myocardial infarction (MI) individuals who would most benefit from objective functiona…

Impact of diabetes mellitus on coronary artery plaque characteristics and outcomes in the SCOT-HEART trial Open

Zuzanna Malgorzata Gebert, Jacek Kwieciński, Jonathan Weir‐McCall, Philip D Adamson, Nicholas L. Mills , et al. · 2025

Diabetes mellitus was an independent predictor of quantitatively assessed plaque burden, particularly calcified plaque, and was associated with an increased risk of myocardial infarction.

Coronary CT angiography-guided management of patients with stable chest pain: 10-year outcomes from the SCOT-HEART randomised controlled trial in Scotland Open

Michelle C. Williams, Ryan Wereski, Christopher Tuck, Philip D Adamson, Anoop Shah , et al. · 2025

The Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Edinburgh and Lothian's Health Foundation Trust, British Heart Foundation, and Heart Diseases Research Fund.

Characterizing Nonculprit Lesions and Perivascular Adipose Tissue of Patients Following Acute Myocardial Infarction Using Coronary Computed Tomography Angiography: A Comparative Study Open

Xiaomeng Wang, Ching‐Hui Sia, Philip D Adamson, Charlotte Greer, Weimin Huang , et al. · 2024

Background The comparison of coronary computed tomography angiography plaques and perivascular adipose tissue (PVAT) between patients with acute myocardial infarction (AMI) posttreatment and patients with stable coronary artery disease is …

Rationale and Design of SCOT-HEART 2 Trial Open

Michael McDermott, Mohammed N. Meah, Phyo Khaing, Kang-Ling Wang, J. Ramsay , et al. · 2024

Coronary artery disease continues to be the leading cause of death globally. Identifying patients who are at risk of coronary artery disease remains a public health priority. At present, the focus of cardiovascular disease prevention relie…

Sex differences in coronary atherosclerotic plaque activity using 18F-sodium fluoride positron emission tomography Open

Jacek Kwieciński, Kang-Ling Wang, Evangelos Tzolos, Alastair J. Moss, Marwa Daghem , et al. · 2024

Coronary Atherosclerotic Plaque Activity and Risk of Myocardial Infarction Open

Kang-Ling Wang, Craig Balmforth, Mohammed N. Meah, Marwa Daghem, Alastair J. Moss , et al. · 2024

Prognostic performance of soluble urokinase plasminogen activator receptor for heart failure or mortality in Western and Asian patients with acute breathlessness Open

Janice Chew‐Harris, Chris Frampton, Charlotte Greer, Sarah Appleby, John W. Pickering , et al. · 2024

suPAR is a strong independent predictor of HF and/or death at 1 year in acutely breathless patients, in both Asian and Western cohorts, and in HF. suPAR may improve stratification of acutely breathless patients, and in acute HF, for risk o…

Convalescent Growth Differentiation Factor-15 and Long-Term Outcomes after an Acute Coronary Syndrome Open

Charlotte Greer, Janice Chew‐Harris, Philip D Adamson, Chris Frampton, John W. Pickering , et al. · 2024

Background Growth differentiation factor-15 (GDF-15) has been shown to be associated with adverse clinical outcomes in patients after an acute coronary syndrome when measured soon after an event. Although dynamic in the acute phase after m…

Isolated Traumatic Membranous Interventricular Septal Rupture: A Rare Complication Following a Motor Vehicle Accident Open

Aashna Deep, Christina Chan, Philip D Adamson, Richard W. Troughton, Ellen Woodcock · 2024

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Computed tomography plaque analysis identifies residual inflammation in recent acute myocardial infarction patients Open

Xiaodong Wang, Min Sen Yew, Philip D Adamson, Mark Y. Chan, N A S Raffiee , et al. · 2023

Introduction Residual inflammatory risk (RIR) following acute myocardial infarction (AMI) patients is associated with recurrent major adverse cardiovascular events. Atherosclerotic plaque quantification using computed tomographic coronary …

Association of left ventricular geometry early after an acute coronary syndrome to long-term mortality Open

Catherine E. Greer, Philip D Adamson, Chris Frampton, John W. Pickering, Anna P. Pilbrow , et al. · 2023

Background Markers of adverse left ventricular remodelling following myocardial infarction are associated with an increased risk of adverse events. Remodelling patterns can be classified using left ventricular mass index (LVMI) and relativ…

Asynchronous communication for medical journal editorial teams in a diverse global research community Open

Catherine M Otto, Philip D Adamson, Isabelle C. Van Gelder, Ganesan Karthikeyan, David E. Newby , et al. · 2023

Temporal Changes in Coronary<sup>18</sup>F-Fluoride Plaque Uptake in Patients with Coronary Atherosclerosis Open

Marwa Daghem, Philip D Adamson, Kang-Ling Wang, Mhairi Doris, Rong Bing , et al. · 2023

Coronary ¹⁸F-sodium fluoride (¹⁸F-fluoride) uptake is a marker of both atherosclerotic disease activity and disease progression. It is currently unknown whether there are rapid temporal changes in coronary ¹⁸

Paired risk scores to predict ischaemic and bleeding risk twenty-eight days to one year after an acute coronary syndrome Open

Andrew Kerr, Yeunhyang Choi, Michael Williams, Ralph Stewart, Harvey D. White , et al. · 2023

Objective The recommended duration of dual anti-platelet therapy (DAPT) following acute coronary syndrome (ACS) varies from 1 month to 1 year depending on the balance of risks of ischaemia and major bleeding. We designed paired ischaemic a…

High-Sensitivity Cardiac Troponin for Risk Assessment in Patients With Chronic Coronary Artery Disease Open

Ryan Wereski, Philip D Adamson, Nur Shazlin Shek Daud, Michael McDermott, Caelan Taggart , et al. · 2023

Echocardiography Impact Factor at Te Whatu Ora Waitaha/Canterbury Open

J. Liu, Richard W. Troughton, Philip D Adamson, Paul Bridgman, Christina Chan , et al. · 2023

Time to Imaging for Echocardiography Among General Medicine Inpatients at Te Whatu Ora Waitaha/Canterbury Open

Jin Liu, Richard W. Troughton, Philip D Adamson, Paul Bridgman, Christina Chan , et al. · 2023

Predictors of Conduction Abnormalities Post Transcatheter Aortic Valve Implantation (TAVI) –A Single-Centre 10-Year Retrospective Analysis Open

Avani Kolla, David Smyth, James Blake, Cameron McAlister, Robert J. Downey , et al. · 2023

Coronary Atherosclerotic Plaque Activity and Future Coronary Events Open

Alastair J. Moss, Marwa Daghem, Evangelos Tzolos, Mohammed N. Meah, Kang-Ling Wang , et al. · 2023

Importance Recurrent coronary events in patients with recent myocardial infarction remain a major clinical problem. Noninvasive measures of coronary atherosclerotic disease activity have the potential to identify individuals at greatest ri…

Troponin in early presenters to rule out myocardial infarction Open

Matthew T.H. Lowry, Dimitrios Doudesis, Jasper Boeddinghaus, Dorien M. Kimenai, Anda Bularga , et al. · 2023

Aims Whether a single cardiac troponin measurement can safely rule out myocardial infarction in patients presenting within a few hours of symptom onset is uncertain. The study aim was to assess the performance of troponin in early presente…

Incidence of Myocarditis Before and After SARS-CoV-2 Vaccination and Infection in Canterbury, 2016–2022 Open

Charlotte Greer, Matthew Daly, Richard W. Troughton, Philip D Adamson · 2023

Latent Coronary Plaque Morphology From Computed Tomography Angiography, Molecular Disease Activity on Positron Emission Tomography, and Clinical Outcomes Open

Jacek Kwieciński, Márton Kolossváry, Evangelos Tzolos, Mohammed N. Meah, Philip D Adamson , et al. · 2023

Background: Assessments of coronary disease activity with 18 F-sodium fluoride positron emission tomography and radiomics-based precision coronary plaque phenotyping derived from coronary computed tomography angiography may enhance risk st…

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