Douglas P. Dyer
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View article: Airway macrophage specific expression of a dense glycocalyx and its remodelling following viral infection
Airway macrophage specific expression of a dense glycocalyx and its remodelling following viral infection Open
The glycocalyx is best studied for its regulation of immune cell trafficking from the vasculature into inflamed tissues. The glycocalyx is composed of a range of glycans and glyco-proteins that form a peri-cellular matrix and its shedding …
View article: The chemokines CCL22 and CCL17 are a defining feature of type 2 stimulated human lung macrophages and exhibit different metabolic dependencies
The chemokines CCL22 and CCL17 are a defining feature of type 2 stimulated human lung macrophages and exhibit different metabolic dependencies Open
Introduction Although human lung macrophages are heterogenous and play key roles during health and disease, the mechanisms that govern their activation and function are unclear, particularly in type 2 settings. Our understanding of how hum…
View article: CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity
CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity Open
Radiotherapy (RT) is essential in treating abdominal and pelvic cancers but often damages the healthy tissues, particularly the intestines, leading to radiation-induced toxicities with limited treatment options. While the immune system is …
View article: Rules of engagement: Determinants of chemokine receptor activation and selectivity by CCL27 and CCL28
Rules of engagement: Determinants of chemokine receptor activation and selectivity by CCL27 and CCL28 Open
The distinct functional roles of chemokines CCL27 and CCL28 in epithelial immunity of skin and mucosal tissues, respectively, are coordinated by their shared receptor, CCR10, and the CCL28-specific receptor, CCR3. To identify determinants …
View article: Rules of engagement: determinants of chemokine receptor activation and selectivity by CCL27 and CCL28
Rules of engagement: determinants of chemokine receptor activation and selectivity by CCL27 and CCL28 Open
The distinct functional roles of chemokines CCL27 and CCL28 in epithelial immunity of skin and mucosal tissues, respectively, are coordinated by their shared receptor, CCR10 and the CCL28-specific receptor, CCR3. In this study, we conducte…
View article: Heparan sulfate glycosaminoglycans mediate CXCL4 (PF4) transport across the blood-brain barrier and effects on neurogenesis
Heparan sulfate glycosaminoglycans mediate CXCL4 (PF4) transport across the blood-brain barrier and effects on neurogenesis Open
CXCL4 (PF4) is a chemokine stored in platelets that has pleiotropic effects across biological settings. These effects include driving of inflammation and fibrosis as well as reversal of the effects of ageing. We have recently demonstrated …
View article: Hallmarks and metabolic regulation of type 2 activated human lung macrophages
Hallmarks and metabolic regulation of type 2 activated human lung macrophages Open
Although human lung macrophages are heterogenous and play key roles during health and disease, the mechanisms that govern their activation and function are unclear, particularly in type 2 settings. Our understanding of how human lung macro…
View article: CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity
CCR2-driven monocyte recruitment is protective against radiotherapy-induced intestinal toxicity Open
Radiotherapy (RT) is essential in treating abdominal and pelvic cancers but often damages the healthy tissues, particularly the intestines, leading to radiation-induced toxicities with limited treatment options. While the immune system is …
View article: Chemokine Oligomers and the Impact of Fondaparinux Binding
Chemokine Oligomers and the Impact of Fondaparinux Binding Open
Heparin, a widely used clinical anticoagulant, is generally well-tolerated; however, approximately 1% of patients develop heparin-induced thrombocytopenia (HIT), a serious side effect. While efforts to understand the role of chemokines in …
View article: Leukocytes have a heparan sulfate glycocalyx that regulates recruitment during inflammation
Leukocytes have a heparan sulfate glycocalyx that regulates recruitment during inflammation Open
The glycocalyx is a proteoglycan-rich layer present on the surface of all mammalian cells that is particularly prevalent on endothelial cells lining the vasculature. It has been hypothesized that the glycocalyx mediates leukocyte migration…
View article: A systematic review of normal tissue neurovascular unit damage following brain irradiation—Factors affecting damage severity and timing of effects
A systematic review of normal tissue neurovascular unit damage following brain irradiation—Factors affecting damage severity and timing of effects Open
Background Radiotherapy is key in the treatment of primary and secondary brain tumors. However, normal tissue is inevitably irradiated, causing toxicity and contributing to cognitive dysfunction. The relative importance of vascular damage …
View article: Chronic cranial window implantation for high-resolution intravital imaging of the endothelial glycocalyx in mouse cortex
Chronic cranial window implantation for high-resolution intravital imaging of the endothelial glycocalyx in mouse cortex Open
View article: Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans
Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans Open
Chemokine-driven leukocyte recruitment is a key component of the immune response and of various diseases. Therapeutically targeting the chemokine system in inflammatory disease has been unsuccessful, which has been attributed to redundancy…
View article: CXCL17 binds efficaciously to glycosaminoglycans with the potential to modulate chemokine signaling
CXCL17 binds efficaciously to glycosaminoglycans with the potential to modulate chemokine signaling Open
Introduction CXCL17 is a mucosally secreted protein, and the most recently identified human chemokine, an assignment based on protein fold prediction and chemotactic activity for leukocytes. However, these credentials have been the subject…
View article: CXCL17 binds efficaciously to glycosaminoglycans with the potential to modulate chemokine signalling
CXCL17 binds efficaciously to glycosaminoglycans with the potential to modulate chemokine signalling Open
CXCL17 is a mucosally secreted protein, and the most recently identified human chemokine, an assignment based on protein fold prediction and chemotactic activity for leukocytes. However, these credentials have been the subject of much rece…
View article: The recombinant Link module of human TSG-6 suppresses cartilage damage in models of osteoarthritis: A potential disease-modifying OA drug
The recombinant Link module of human TSG-6 suppresses cartilage damage in models of osteoarthritis: A potential disease-modifying OA drug Open
Link_TSG6 has enhanced chondroprotective activity compared to the full-length TSG-6 protein and shows potential as a disease modifying OA drug via its inhibition of aggrecanase and collagenase activity.
View article: The extracellular matrix and the immune system: A mutually dependent relationship
The extracellular matrix and the immune system: A mutually dependent relationship Open
For decades, immunologists have studied the role of circulating immune cells in host protection, with a more recent appreciation of immune cells resident within the tissue microenvironment and the intercommunication between nonhematopoieti…
View article: Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors
Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate widespread immune cell recruitment independent of chemokine receptors Open
View article: Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans
Chemokines form complex signals during inflammation and disease that can be decoded by extracellular matrix proteoglycans Open
Chemokine driven leukocyte recruitment is a key component of the immune response and is central to a wide range of diseases. However, there has yet to be a clinically successful therapeutic approach that targets the chemokine system during…
View article: Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate wide-spread non-receptor mediated immune cell recruitment
Chemokine CXCL4 interactions with extracellular matrix proteoglycans mediate wide-spread non-receptor mediated immune cell recruitment Open
Leukocyte recruitment from the vasculature into tissues is a crucial component of the immune system, but is also key to inflammatory disease. Chemokines are central to this process but have yet to be therapeutically targeted during inflamm…
View article: Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice
Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice Open
Inflammatory chemokines and their receptors are central to the development of inflammatory/immune pathologies. The apparent complexity of this system, coupled with lack of appropriate in vivo models, has limited our understanding of how ch…
View article: Chemokine redundancy <i>versus</i> specificity in the context of CXCR3 and its ligands
Chemokine redundancy <i>versus</i> specificity in the context of CXCR3 and its ligands Open
In a recent article published in Immunology & Cell Biology, Dalit et al. describe how correcting mutations in the C57BL/6 mouse strain can restore production of the chemokine CXCL11, although surprisingly, this expression of CXCL11 had lit…
View article: Author response: Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice
Author response: Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice Open
Article Figures and data Abstract Editor's evaluation Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Inflammatory chemokine…
View article: <scp>LRRC8A</scp>is dispensable for a variety of microglial functions and response to acute stroke
<span>LRRC8A</span>is dispensable for a variety of microglial functions and response to acute stroke Open
Microglia, resident brain immune cells, are critical in orchestrating responses to central nervous system (CNS) injury. Many microglial functions, such as phagocytosis, motility and chemotaxis, are suggested to rely on chloride channels, i…
View article: Role of extracellular matrix proteoglycans in immune cell recruitment
Role of extracellular matrix proteoglycans in immune cell recruitment Open
Leucocyte recruitment is a critical component of the immune response and is central to our ability to fight infection. Paradoxically, leucocyte recruitment is also a central component of inflammatory‐based diseases such as rheumatoid arthr…
View article: Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates
Dissecting structure-function of 3-O-sulfated heparin and engineered heparan sulfates Open
This study provides proof of concept for cell-based heparin without heparin-induced thrombocytopenia side effects.
View article: Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice
Analysis of combinatorial chemokine receptor expression dynamics using multi-receptor reporter mice Open
Summary Inflammatory chemokines and their receptors are central to the development of inflammatory/immune pathologies. The apparent complexity of this system, coupled with lack of appropriate in vivo models, has limited our understanding o…
View article: Immunomodulation by radiotherapy in tumour control and normal tissue toxicity
Immunomodulation by radiotherapy in tumour control and normal tissue toxicity Open
View article: The recombinant Link module of human TSG-6 suppresses cartilage damage in models of osteoarthritis: a potential disease-modifying OA drug
The recombinant Link module of human TSG-6 suppresses cartilage damage in models of osteoarthritis: a potential disease-modifying OA drug Open
Objectives To investigate the role of endogenous TSG-6 in human osteoarthritis (OA) and assess the disease-modifying potential of a TSG-6-based biological treatment in cell, explant and animal models of OA. Methods Knee articular cartilage…
View article: Perspectives on the Biological Role of Chemokine:Glycosaminoglycan Interactions
Perspectives on the Biological Role of Chemokine:Glycosaminoglycan Interactions Open
Chemokines (chemotactic cytokines) are a family of proteins that mediate recruitment and precise positioning of leukocytes in different anatomical locations, and as such are central to the immune response. Despite their importance, there a…