Philip E. Empey
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View article: Understanding clinician support preferences related to the use of pharmacogenomic results in electronic health records: A qualitative study in an academic health system
Understanding clinician support preferences related to the use of pharmacogenomic results in electronic health records: A qualitative study in an academic health system Open
Clinician-preferred strategies, including intuitive clinical decision support tools, modular education resources, and streamlined communication pathways, are critical to successful PGx implementation. These findings offer a practical bluep…
View article: <i>CYP2D6</i> Phenotypes and Emergency Department Visits Among Patients Receiving Opioid Treatment
<i>CYP2D6</i> Phenotypes and Emergency Department Visits Among Patients Receiving Opioid Treatment Open
Importance Cytochrome P450 2D6 ( CYP2D6 ) bioactivates hydrocodone, tramadol, codeine, and oxycodone to active metabolites that primarily provide analgesic activity. Reduced CYP2D6 activity may be associated with poor pain control. Objecti…
View article: Pharmacokinetic analysis of morphine-3-glucuronide after acute morphine intravenous bolus administration to rats with traumatic brain injury
Pharmacokinetic analysis of morphine-3-glucuronide after acute morphine intravenous bolus administration to rats with traumatic brain injury Open
View article: Progress in Pharmacogenomics Implementation in the United States: Barrier Erosion and Remaining Challenges
Progress in Pharmacogenomics Implementation in the United States: Barrier Erosion and Remaining Challenges Open
Barriers to incorporating pharmacogenetics into routine clinical practice in the United States are well documented. Initial surveys by the Clinical Pharmacogenetics Implementation Consortium (CPIC) in 2009 and 2010 identified barriers acro…
View article: Sustained metabolic reduction and hypothermia in humans
Sustained metabolic reduction and hypothermia in humans Open
Metabolic reduction is an adaptation employed by animals encountering environmental stressors or scarce resources. Lowering metabolism in humans may be useful to reduce consumables, oxygen utilization and carbon dioxide excretion. This is …
View article: Pharmacogenetics: Opportunities for the All of Us Research Program and Other Large Data Sets to Advance the Field
Pharmacogenetics: Opportunities for the All of Us Research Program and Other Large Data Sets to Advance the Field Open
Pharmacogenetic variation is common and an established driver of response for many drugs. There has been tremendous progress in pharmacogenetics knowledge over the last 30 years and in clinical implementation of that knowledge over the las…
View article: Integrating Pharmacogenomics into the Broader Construct of Genomic Medicine: Efforts by the ClinGen Pharmacogenomics Working Group (PGxWG)
Integrating Pharmacogenomics into the Broader Construct of Genomic Medicine: Efforts by the ClinGen Pharmacogenomics Working Group (PGxWG) Open
Pharmacogenomics (PGx) is focused on the relationship between an individual's genetic makeup and their response to medications, with the overarching aim of guiding prescribing decisions to improve drug efficacy and reduce adverse events. T…
View article: Quasi-torpor for long-duration space missions
Quasi-torpor for long-duration space missions Open
Innovative solutions are required to make long-duration space missions feasible. Crew performance and health is paramount to the success of anticipated Moon and Mars missions. Metabolic reduction via a quasi-torpor state is a possible miti…
View article: A common flanking variant is associated with enhanced stability of the FGF14-SCA27B repeat locus
A common flanking variant is associated with enhanced stability of the FGF14-SCA27B repeat locus Open
View article: Towards consensus recommendations for pharmacogenetics testing
Towards consensus recommendations for pharmacogenetics testing Open
In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting a…
View article: Frequency of pharmacogenomic variation and medication exposures among All of Us Participants
Frequency of pharmacogenomic variation and medication exposures among All of Us Participants Open
Pharmacogenomics promises improved outcomes through individualized prescribing. However, the lack of diversity in studies impedes clinical translation and equitable application of precision medicine. We evaluated the frequencies of PGx var…
View article: Author Correction: The frequency of pathogenic variation in the All of Us cohort reveals ancestry-driven disparities
Author Correction: The frequency of pathogenic variation in the All of Us cohort reveals ancestry-driven disparities Open
View article: Alpha-2-adrenergic agonists reduce resting energy expenditure in humans during external cooling
Alpha-2-adrenergic agonists reduce resting energy expenditure in humans during external cooling Open
Intravenous alpha-2-adrenergic receptor agonists reduce energy expenditure and lower the temperature when shivering begins in humans, allowing a decrease in core body temperature. Because there are few data about similar effects from oral …
View article: Response to “<i>DPYD</i> genotyping panels: Impact of population diversity”
Response to “<i>DPYD</i> genotyping panels: Impact of population diversity” Open
We thank Dr. Suarez-Kurtz for his Letter to the Editor on our publication "DPYD HapB3 haplotype structure and implications for pharmacogenomic testing".1 In response to our findings, the Clinical Pharmacogenetics Implementation Consortium …
View article: Empowering Personalized Pharmacogenomics with Generative AI Solutions
Empowering Personalized Pharmacogenomics with Generative AI Solutions Open
Objective This study evaluates an AI assistant developed using OpenAI’s GPT-4 for interpreting pharmacogenomic (PGx) testing results, aiming to improve decision-making and knowledge sharing in clinical genetics, and to enhance patient care…
View article: Empowering personalized pharmacogenomics with generative AI solutions
Empowering personalized pharmacogenomics with generative AI solutions Open
Objective This study evaluates an AI assistant developed using OpenAI’s GPT-4 for interpreting pharmacogenomic (PGx) testing results, aiming to improve decision-making and knowledge sharing in clinical genetics and to enhance patient care …
View article: The frequency of pathogenic variation in the All of Us cohort reveals ancestry-driven disparities
The frequency of pathogenic variation in the All of Us cohort reveals ancestry-driven disparities Open
View article: Updated <i>DPYD</i><scp>HapB3</scp> haplotype structure and implications for pharmacogenomic testing
Updated <i>DPYD</i><span>HapB3</span> haplotype structure and implications for pharmacogenomic testing Open
The DPYD gene encodes dihydropyrimidine dehydrogenase, the rate‐limiting enzyme for the metabolism of fluoropyrimidines 5‐fluorouracil and capecitabine. Genetic variants in DPYD have been associated with altered enzyme activity, therefore …
View article: N-Acetylcysteine and Probenecid Adjuvant Therapy for Traumatic Brain Injury
N-Acetylcysteine and Probenecid Adjuvant Therapy for Traumatic Brain Injury Open
View article: Pharmacogenomics in the Management of Pulmonary Arterial Hypertension: Current Perspectives
Pharmacogenomics in the Management of Pulmonary Arterial Hypertension: Current Perspectives Open
Pulmonary arterial hypertension (PAH) is a rare disease with heterogeneous causes that can lead to right ventricular (RV) failure and death if left untreated. There are currently 10 medications representative of five unique pharmacologic c…
View article: Development of Competency-based Online Genomic Medicine Training (COGENT)
Development of Competency-based Online Genomic Medicine Training (COGENT) Open
The fields of genetics and genomics have greatly expanded across medicine through the development of new technologies that have revealed genetic contributions to a wide array of traits and diseases. Thus, the development of widely availabl…
View article: Evaluation of Potential Racial Disparities in<i>CYP2C19</i>‐Guided P2Y<sub>12</sub>Inhibitor Prescribing After Percutaneous Coronary Intervention
Evaluation of Potential Racial Disparities in<i>CYP2C19</i>‐Guided P2Y<sub>12</sub>Inhibitor Prescribing After Percutaneous Coronary Intervention Open
Black patients suffer worse outcomes after percutaneous coronary intervention (PCI) than White patients. Inequities in antiplatelet prescribing may contribute to this health disparity. We compared P2Y 12 inhibitor prescribing by race follo…
View article: Transport and Permeation Properties of Dapivirine: Understanding Potential Drug-Drug Interactions
Transport and Permeation Properties of Dapivirine: Understanding Potential Drug-Drug Interactions Open
The dapivirine (DPV) vaginal ring was developed by the nonprofit International Partnership for Microbicides (IPM) for reducing the risk of HIV infection. A clinical study (IPM 028) showed that concomitant use of the DPV ring and miconazole…
View article: Patient-Specific Factors Associated with Dexmedetomidine Dose Requirements in Critically Ill Children
Patient-Specific Factors Associated with Dexmedetomidine Dose Requirements in Critically Ill Children Open
The objective of this study was to evaluate patient-specific factors associated with dexmedetomidine dose requirements during continuous infusion. A retrospective cross-sectional analysis of electronic health record-derived data spanning 1…
View article: <scp>PharmVar GeneFocus</scp>: <scp><i>SLCO1B1</i></scp>
<span>PharmVar GeneFocus</span>: <span><i>SLCO1B1</i></span> Open
The Pharmacogene Variation Consortium (PharmVar) is now providing star (*) allele nomenclature for the highly polymorphic human SLCO1B1 gene encoding the organic anion transporting polypeptide 1B1 (OATP1B1) drug transporter. Genetic variat…
View article: Simultaneous detection of a panel of nine sedatives and metabolites in plasma from critically ill pediatric patients via UPLC-MS/MS
Simultaneous detection of a panel of nine sedatives and metabolites in plasma from critically ill pediatric patients via UPLC-MS/MS Open
View article: Best–worst scaling methodology to evaluate constructs of the Consolidated Framework for Implementation Research: application to the implementation of pharmacogenetic testing for antidepressant therapy
Best–worst scaling methodology to evaluate constructs of the Consolidated Framework for Implementation Research: application to the implementation of pharmacogenetic testing for antidepressant therapy Open
Background Despite the increased demand for pharmacogenetic (PGx) testing to guide antidepressant use, little is known about how to implement testing in clinical practice. Best–worst scaling (BWS) is a stated preferences technique for dete…
View article: A Multidisciplinary Precision Medicine Service in Primary Care
A Multidisciplinary Precision Medicine Service in Primary Care Open
A need for accessible genomic services is growing with the rise of commercial genetic testing. Because of this, primary care clinicians may increasingly encounter genetic cancer risk assessment, pharmacogenomics, and direct-to-consumer gen…
View article: Antiplatelet Therapy and Bleeding Outcomes With CYP2C19 Genotyping
Antiplatelet Therapy and Bleeding Outcomes With CYP2C19 Genotyping Open
Purpose: The impact of antiplatelet therapy with availability of CYP2C19 genotyping on bleeding in a real-world setting has not been extensively studied. Methods: Prospective, single-center, cohort study conducted between December 2015 and…
View article: Fetal Pharmacogenomics: A Promising New Addition to the Care of Medically Complex Neonates
Fetal Pharmacogenomics: A Promising New Addition to the Care of Medically Complex Neonates Open