Philip E. LeBoit
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View article: An evolving supraclavicular plaque: diagnostic challenges in dermatofibrosarcoma protuberans with atrophic and myxoid features
An evolving supraclavicular plaque: diagnostic challenges in dermatofibrosarcoma protuberans with atrophic and myxoid features Open
Dermatofibrosarcoma protuberans is an uncommon locally aggressive mesenchymal neoplasm that classically presents with a proliferation of monomorphic spindled cells with thin nuclei and scant cytoplasm. We report a man in his twenties who p…
View article: Artificial Intelligence-based Diagnosis of Kaposi Sarcoma using Photographs in Dark-skinned Patients
Artificial Intelligence-based Diagnosis of Kaposi Sarcoma using Photographs in Dark-skinned Patients Open
Importance Advanced-stage disease at the time of diagnosis, with resultant high mortality, is among the most urgent issues for HIV-related Kaposi sarcoma (KS) in sub-Saharan Africa. Lack of access to skilled clinical personnel and histopat…
View article: Differences in clinical phenotype between childhood-onset and adult-onset atopic dermatitis: a cross-sectional study
Differences in clinical phenotype between childhood-onset and adult-onset atopic dermatitis: a cross-sectional study Open
Introduction: Atopic dermatitis (AD) is the most common and burdensome inflammatory skin disease worldwide1. AD is heterogeneous both in its clinical presentation and response to treatment, and it is important to understand how adult-onset…
View article: Spitz melanoma
Spitz melanoma Open
It has long been recognized that the histopathologic differential diagnosis between Spitz nevus and melanoma is sometimes extraordinarily difficult. Both can be composed of large oval to spindled melanocytes with abundant cytoplasm and lar…
View article: Dermal cutaneous clear cell sarcoma defined by novel EWSR1-CREM fusion
Dermal cutaneous clear cell sarcoma defined by novel EWSR1-CREM fusion Open
View article: Atypical Spitz tumor with <i>SQSTM1::NTRK2</i> fusion: Report of a case with unique spindled cell features
Atypical Spitz tumor with <i>SQSTM1::NTRK2</i> fusion: Report of a case with unique spindled cell features Open
A host of signature genetic alterations have been demonstrated in Spitz neoplasms, most notably fusions of kinase genes (including BRAF , ALK , ROS1 , NTRK1 , NTRK3 , RET , MET , MAP3K8 ) or variants in HRAS . While there are multiple repo…
View article: PATH-02. NOVEL <i>SOX10</i> INDEL MUTATIONS DRIVE SCHWANNOMAS THROUGH IMPAIRED TRANSACTIVATION OF MYELINATION GENE PROGRAMS
PATH-02. NOVEL <i>SOX10</i> INDEL MUTATIONS DRIVE SCHWANNOMAS THROUGH IMPAIRED TRANSACTIVATION OF MYELINATION GENE PROGRAMS Open
Schwannomas are common peripheral nerve sheath tumors that can cause severe morbidity due to their stereotypic intracranial and paraspinal locations. However, the molecular drivers responsible for a substantial subset remain unknown. Throu…
View article: Positive <scp>NKX3</scp>.1 as a diagnostic pitfall for prostate cancer in extramammary Paget's disease of genitourinary sites
Positive <span>NKX3</span>.1 as a diagnostic pitfall for prostate cancer in extramammary Paget's disease of genitourinary sites Open
Table S1. Antibodies used for immunohistochemistry. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be di…
View article: Supplementary Figure 2 from Temporal Dissection of Tumorigenesis in Primary Cancers
Supplementary Figure 2 from Temporal Dissection of Tumorigenesis in Primary Cancers Open
Supplementary Figure 2 from Temporal Dissection of Tumorigenesis in Primary Cancers
View article: Data from Temporal Dissection of Tumorigenesis in Primary Cancers
Data from Temporal Dissection of Tumorigenesis in Primary Cancers Open
Timely intervention for cancer requires knowledge of its earliest genetic aberrations. Sequencing of tumors and their metastases reveals numerous abnormalities occurring late in progression. A means to temporally order aberrations in a sin…
View article: Supplementary Table 2 from Temporal Dissection of Tumorigenesis in Primary Cancers
Supplementary Table 2 from Temporal Dissection of Tumorigenesis in Primary Cancers Open
Supplementary Table 2 from Temporal Dissection of Tumorigenesis in Primary Cancers
View article: Supplementary Figure Legends 1-4, Methods from Temporal Dissection of Tumorigenesis in Primary Cancers
Supplementary Figure Legends 1-4, Methods from Temporal Dissection of Tumorigenesis in Primary Cancers Open
Supplementary Figure Legends 1-4, Methods from Temporal Dissection of Tumorigenesis in Primary Cancers
View article: Supplementary Table 1 from Temporal Dissection of Tumorigenesis in Primary Cancers
Supplementary Table 1 from Temporal Dissection of Tumorigenesis in Primary Cancers Open
Supplementary Table 1 from Temporal Dissection of Tumorigenesis in Primary Cancers
View article: Supplementary Table 2 from Temporal Dissection of Tumorigenesis in Primary Cancers
Supplementary Table 2 from Temporal Dissection of Tumorigenesis in Primary Cancers Open
Supplementary Table 2 from Temporal Dissection of Tumorigenesis in Primary Cancers
View article: Data from Temporal Dissection of Tumorigenesis in Primary Cancers
Data from Temporal Dissection of Tumorigenesis in Primary Cancers Open
Timely intervention for cancer requires knowledge of its earliest genetic aberrations. Sequencing of tumors and their metastases reveals numerous abnormalities occurring late in progression. A means to temporally order aberrations in a sin…
View article: Supplementary Figure Legends 1-4, Methods from Temporal Dissection of Tumorigenesis in Primary Cancers
Supplementary Figure Legends 1-4, Methods from Temporal Dissection of Tumorigenesis in Primary Cancers Open
Supplementary Figure Legends 1-4, Methods from Temporal Dissection of Tumorigenesis in Primary Cancers
View article: Supplementary Figure 2 from Temporal Dissection of Tumorigenesis in Primary Cancers
Supplementary Figure 2 from Temporal Dissection of Tumorigenesis in Primary Cancers Open
Supplementary Figure 2 from Temporal Dissection of Tumorigenesis in Primary Cancers
View article: Supplementary Figure 4 from Temporal Dissection of Tumorigenesis in Primary Cancers
Supplementary Figure 4 from Temporal Dissection of Tumorigenesis in Primary Cancers Open
Supplementary Figure 4 from Temporal Dissection of Tumorigenesis in Primary Cancers
View article: Supplementary Figure 1 from Temporal Dissection of Tumorigenesis in Primary Cancers
Supplementary Figure 1 from Temporal Dissection of Tumorigenesis in Primary Cancers Open
Supplementary Figure 1 from Temporal Dissection of Tumorigenesis in Primary Cancers
View article: Supplementary Figure 3 from Temporal Dissection of Tumorigenesis in Primary Cancers
Supplementary Figure 3 from Temporal Dissection of Tumorigenesis in Primary Cancers Open
Supplementary Figure 3 from Temporal Dissection of Tumorigenesis in Primary Cancers
View article: Supplementary Figure 4 from Temporal Dissection of Tumorigenesis in Primary Cancers
Supplementary Figure 4 from Temporal Dissection of Tumorigenesis in Primary Cancers Open
Supplementary Figure 4 from Temporal Dissection of Tumorigenesis in Primary Cancers
View article: Supplementary Table 1 from Temporal Dissection of Tumorigenesis in Primary Cancers
Supplementary Table 1 from Temporal Dissection of Tumorigenesis in Primary Cancers Open
Supplementary Table 1 from Temporal Dissection of Tumorigenesis in Primary Cancers
View article: Supplementary Figure 1 from Temporal Dissection of Tumorigenesis in Primary Cancers
Supplementary Figure 1 from Temporal Dissection of Tumorigenesis in Primary Cancers Open
Supplementary Figure 1 from Temporal Dissection of Tumorigenesis in Primary Cancers
View article: Supplementary Figure 3 from Temporal Dissection of Tumorigenesis in Primary Cancers
Supplementary Figure 3 from Temporal Dissection of Tumorigenesis in Primary Cancers Open
Supplementary Figure 3 from Temporal Dissection of Tumorigenesis in Primary Cancers
View article: LAMP-enabled diagnosis of Kaposi’s sarcoma for sub-Saharan Africa
LAMP-enabled diagnosis of Kaposi’s sarcoma for sub-Saharan Africa Open
Kaposi’s sarcoma (KS) is an endothelial cancer caused by the Kaposi’s sarcoma-associated herpesvirus (KSHV) and is one of the most common cancers in sub-Saharan Africa. In limited-resource settings, traditional pathology infrastructure is …
View article: HPV51-associated Leiomyosarcoma
HPV51-associated Leiomyosarcoma Open
Inactivating mutations in tumor suppressor genes TP53 and RB1 are considered central drivers in leiomyosarcomas (LMSs). In high-risk human papillomavirus (HPV)-related tumors, a similar functional outcome is achieved through oncoproteins E…
View article: A rare case of axillary keratoacanthoma arising in hidradenitis suppurativa
A rare case of axillary keratoacanthoma arising in hidradenitis suppurativa Open
Keratoacanthoma (KA), a cutaneous, often spontaneously regressing tumor characteristically presenting as an umbilicated nodule with a central keratin plug, occurs most frequently in lightly pigmented individuals with sun damage. Here we re…
View article: Toxic epidermal necrolysis-like toxic erythema of chemotherapy: 2 illustrative cases
Toxic epidermal necrolysis-like toxic erythema of chemotherapy: 2 illustrative cases Open
View article: Evaluation of Crizotinib Treatment in a Patient With Unresectable <i>GOPC-ROS1</i> Fusion Agminated Spitz Nevi
Evaluation of Crizotinib Treatment in a Patient With Unresectable <i>GOPC-ROS1</i> Fusion Agminated Spitz Nevi Open
Given the response following crizotinib treatment observed in this case, the kinase fusion was believed to be functionally consequential in the patient's agminated Spitz nevi and likely the driver mutational event for growth of her nevi. T…
View article: Cutaneous Leishmaniasis Caused by an Unknown <i>Leishmania</i> Strain, Arizona, USA
Cutaneous Leishmaniasis Caused by an Unknown <i>Leishmania</i> Strain, Arizona, USA Open
We investigated an autochthonous case of cutaneous leishmaniasis caused by a genetically different Leishmania sp. in a patient in Arizona, USA. This parasite was classified into the subgenus Leishmania on the basis of multilocus DNA sequen…