Explanipedia

Exploration of vanoxerine analogues as antibacterial agents Open

Alexander D. H. Kingdon, Holly V. Adcock, Eleni-Marina Kasimati, Philip G. E. Craven, Willem van Schaik , et al. · 2024

Azetidines Kill Multidrug-Resistant Mycobacterium tuberculosis without Detectable Resistance by Blocking Mycolate Assembly Open

Yixin Cui, Alice Lanne, Xudan Peng, Edward P. Browne, Apoorva Bhatt , et al. · 2024

Tuberculosis (TB) is the leading cause of global morbidity and mortality resulting from infectious disease, with over 10.6 million new cases and 1.4 million deaths in 2021. This global emergency is exacerbated by the emergence of multidrug…

Azetidines kill Mycobacterium tuberculosis without detectable resistance by blocking mycolate assembly Open

Alice Lanne, Yixin Cui, Edward P. Browne, Philip G. E. Craven, Nicholas J. Cundy , et al. · 2020

Tuberculosis (TB) is the leading cause of global morbidity and mortality resulting from infectious disease, with over 10 million new cases and 1.5 million deaths in 2019. This global emergency is exacerbated by the emergence of multi-drug-…

Novel nitrogen-containing heterocyclics with bactericidal activity against Mycobacterium tuberculosis Open

Alice Lanne, Yixin Cui, Mariwan Hama Salih, Philip G. E. Craven, Katie Dale , et al. · 2019

Tuberculosis (TB) is the leading cause of global morbidity and mortality caused by an infectious disease, with over 10 million new cases emerging in 2017. This global emergency is exacerbated by the emergence of multi-drug and extensively-…

2,7-Diazabicyclo[2.2.1]heptanes: novel asymmetric access and controlled bridge-opening Open

Gary R. Peczkowski, Philip G. E. Craven, Darren Stead, Nigel S. Simpkins · 2019

Organocatalysed asymmetric Michael additions of substituted triketopiperazines to enones afford products in high yield and enantiomeric ratio (er). Further modification delivers products possessing natural product (NP) scaffolds including …

CCDC 1880503: Experimental Crystal Structure Determination Open

Gary R. Peczkowski, Philip G. E. Craven, Darren Stead, Nigel S. Simpkins · 2019

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1880502: Experimental Crystal Structure Determination Open

Gary R. Peczkowski, Philip G. E. Craven, Darren Stead, Nigel S. Simpkins · 2019

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

Phosphino-Triazole Ligands for Palladium-Catalyzed Cross-Coupling Open

Yiming Zhao, Huy V. Nguyen, Louise Male, Philip G. E. Craven, Benjamin R. Buckley , et al. · 2018

Twelve 1,5-disubtituted and fourteen 5-substituted 1,2,3-triazole derivatives bearing diaryl or dialkyl phosphines at the 5-position were synthesized and used as ligands for palladium-catalyzed Suzuki-Miyaura cross-coupling reactions. Bulk…

Phosphino-Triazole Ligands for Palladium-Catalysed Cross-Coupling Open

Yiming Zhao, Huy V. Nguyen, Louise Male, Philip G. E. Craven, Benjamin R. Buckley , et al. · 2018

Twelve 1,5-disubtituted and fourteen 5-substituted 1,2,3-triazole derivatives bearing diaryl or dialkyl phosphines at the 5-position were synthesised and used as ligands for palladium-catalysed Suzuki-Miyaura cross-coupling reactions. Bulk…

CCDC 1577645: Experimental Crystal Structure Determination Open

A. Aimon, George Karageorgis, Jacob Masters, Mark Dow, Philip G. E. Craven , et al. · 2018

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

Synthesis and Demonstration of the Biological Relevance of sp3‐rich Scaffolds Distantly Related to Natural Product Frameworks Open

Daniel J. Foley, Philip G. E. Craven, P.M. Collins, Richard G. Doveston, A. Aimon , et al. · 2017

The productive exploration of chemical space is an enduring challenge in chemical biology and medicinal chemistry. Natural products are biologically relevant, and their frameworks have facilitated chemical tool and drug discovery. A “top‐d…

CCDC 1526777: Experimental Crystal Structure Determination Open

Daniel J. Foley, Philip G. E. Craven, Patrick M. Collins, Richard G. Doveston, A. Aimon , et al. · 2017

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1526778: Experimental Crystal Structure Determination Open

Daniel J. Foley, Philip G. E. Craven, Patrick M. Collins, Richard G. Doveston, A. Aimon , et al. · 2017

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1526780: Experimental Crystal Structure Determination Open

Daniel J. Foley, Philip G. E. Craven, Patrick M. Collins, Richard G. Doveston, A. Aimon , et al. · 2017

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1526779: Experimental Crystal Structure Determination Open

Daniel J. Foley, Philip G. E. Craven, Patrick M. Collins, Richard G. Doveston, A. Aimon , et al. · 2017

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1478959: Experimental Crystal Structure Determination Open

James D. Firth, Philip G. E. Craven, Matthew Lilburn, Axel Pahl, Stephen P. Marsden , et al. · 2016

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1478962: Experimental Crystal Structure Determination Open

James D. Firth, Philip G. E. Craven, Matthew Lilburn, Axel Pahl, Stephen P. Marsden , et al. · 2016

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1478960: Experimental Crystal Structure Determination Open

James D. Firth, Philip G. E. Craven, Matthew Lilburn, Axel Pahl, Stephen P. Marsden , et al. · 2016

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

A divergent synthetic approach to diverse molecular scaffolds: assessment of lead-likeness using LLAMA, an open-access computational tool Open

Ignacio Colomer, Christopher J. Empson, Philip G. E. Craven, Zachary Owen, Richard G. Doveston , et al. · 2016

LLAMA was used to assess the lead-likeness of scaffolds prepared via complementary cyclisations of hex-2-ene-1,6-diamine derivatives.

CCDC 1478963: Experimental Crystal Structure Determination Open

James D. Firth, Philip G. E. Craven, Matthew Lilburn, Axel Pahl, Stephen P. Marsden , et al. · 2016

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1478961: Experimental Crystal Structure Determination Open

James D. Firth, Philip G. E. Craven, Matthew Lilburn, Axel Pahl, Stephen P. Marsden , et al. · 2016

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1478957: Experimental Crystal Structure Determination Open

James D. Firth, Philip G. E. Craven, Matthew Lilburn, Axel Pahl, Stephen P. Marsden , et al. · 2016

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

A biosynthesis-inspired approach to over twenty diverse natural product-like scaffolds Open

James D. Firth, Philip G. E. Craven, Matthew Lilburn, Axel Pahl, Stephen P. Marsden , et al. · 2016

A synthetic approach to diverse natural product-like scaffolds was developed that was broadly inspired by diterpene biosynthesis.

CCDC 1478958: Experimental Crystal Structure Determination Open

James D. Firth, Philip G. E. Craven, Matthew Lilburn, Axel Pahl, Stephen P. Marsden , et al. · 2016

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

CCDC 1033179: Experimental Crystal Structure Determination Open

Philip G. E. Craven, A. Aimon, Mark Dow, Nicolas Fleury‐Brégeot, Rachel Guilleux , et al. · 2015

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …

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