Philip Griebel
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View article: 483 DMI, gastrointestinal tract fermentation and permeability, and white blood cell responses in beef heifers provided post-ruminal yeast cell wall extract following feed restriction
483 DMI, gastrointestinal tract fermentation and permeability, and white blood cell responses in beef heifers provided post-ruminal yeast cell wall extract following feed restriction Open
The objectives of this study were to 1) evaluate gastrointestinal fermentation characteristics and permeability, and white blood cell concentrations as beef heifers recovered from a feed restriction (FR) challenge, and 2) determine whether…
View article: PSVIII-2 Effects of post-ruminal yeast cell wall extract on dry matter intake, gastrointestinal fermentation and permeability, and concentrations of white blood cell types in beef heifers exposed to feed restriction
PSVIII-2 Effects of post-ruminal yeast cell wall extract on dry matter intake, gastrointestinal fermentation and permeability, and concentrations of white blood cell types in beef heifers exposed to feed restriction Open
The objective of this study was to evaluate whether post-ruminal provision of a yeast cell wall extract (YCW) affected gastrointestinal fermentation characteristics and permeability, and white blood cell concentrations for heifers exposed …
View article: Oligodeoxynucleotides containing CpG motifs upregulate bactericidal activities of heterophils and enhance immunoprotection of neonatal broiler chickens against Salmonella Typhimurium septicemia
Oligodeoxynucleotides containing CpG motifs upregulate bactericidal activities of heterophils and enhance immunoprotection of neonatal broiler chickens against Salmonella Typhimurium septicemia Open
In the past, we demonstrated that oligodeoxynucleotides containing CpG motifs (CpG-ODN) mimicking bacterial DNA, stimulate the innate immune system of neonatal broiler chickens and protect them against Escherichia coli and Salmonella Typhi…
View article: Resting and activated bovine neutrophils and eosinophils differ in their responses to adrenergic agonists
Resting and activated bovine neutrophils and eosinophils differ in their responses to adrenergic agonists Open
Polymorphonuclear cells (PMN) provide a rapid response to infection and tissue damage and stress can modify these critical innate immune defences. The study of adrenergic receptor (AR) expression and function in bovine PMNs is limited but …
View article: No vaccine interference between bovine coronavirus and bovine herpesvirus-1 in a randomized trial when coadministrating two intranasal modified-live viral vaccines to neonatal calves
No vaccine interference between bovine coronavirus and bovine herpesvirus-1 in a randomized trial when coadministrating two intranasal modified-live viral vaccines to neonatal calves Open
OBJECTIVE Compare immune responses induced by 2 commercial intranasal (IN) modified-live viral (MLV) vaccines given individually or coadministered and evaluate prevention of infection and lung pathology following bovine herpesvirus-1 (BHV-…
View article: Plasma Cytokines and Birth Weight as Biomarkers of Vaccine-Induced Humoral Responses in Piglets
Plasma Cytokines and Birth Weight as Biomarkers of Vaccine-Induced Humoral Responses in Piglets Open
Failure to mount an effective immune response to vaccination leaves individuals at risk for infection and can compromise herd immunity. Vaccine unresponsiveness can range from poor responses “low responders” to a failure to seroconvert “no…
View article: Regionally Distinct Immune and Metabolic Transcriptional Responses in the Bovine Small Intestine and Draining Lymph Nodes During a Subclinical Mycobacterium avium subsp. paratuberculosis Infection
Regionally Distinct Immune and Metabolic Transcriptional Responses in the Bovine Small Intestine and Draining Lymph Nodes During a Subclinical Mycobacterium avium subsp. paratuberculosis Infection Open
Mycobacterium avium subsp. paratuberculosis (MAP) is the causative infectious agent of Johne’s disease (JD), an incurable granulomatous enteritis affecting domestic livestock and other ruminants around the world. Chronic MAP infections usu…
View article: Effect of maternal separation and transportation stress on the bovine upper respiratory tract microbiome and the immune response to resident opportunistic pathogens
Effect of maternal separation and transportation stress on the bovine upper respiratory tract microbiome and the immune response to resident opportunistic pathogens Open
Background The bovine upper respiratory tract (URT) microbiome includes opportunistic pathogens that cause respiratory disease and stress associated with maternal separation and transportation contributes to the severity of this respirator…
View article: EPIphany—A Platform for Analysis and Visualization of Peptide Immunoarray Data
EPIphany—A Platform for Analysis and Visualization of Peptide Immunoarray Data Open
Antibodies are critical effector molecules of the humoral immune system. Upon infection or vaccination, populations of antibodies are generated which bind to various regions of the invading pathogen or exogenous agent. Defining the reactiv…
View article: Innate and acquired immune responses of colostrum-fed neonatal Holstein calves following intranasal vaccination with two commercially available modified-live virus vaccines
Innate and acquired immune responses of colostrum-fed neonatal Holstein calves following intranasal vaccination with two commercially available modified-live virus vaccines Open
OBJECTIVE To compare immune responses induced by 2 commercially available vaccines with a bovine herpesvirus type 1 (BHV1) component following intranasal (IN) administration to colostrum-fed calves. ANIMALS 90 male Holstein calves (ages, 5…
View article: Effect of Maternal Separation and Transportation Stress on the Bovine Upper Respiratory Tract Microbiome and the Immune Response to Resident Opportunistic Pathogens
Effect of Maternal Separation and Transportation Stress on the Bovine Upper Respiratory Tract Microbiome and the Immune Response to Resident Opportunistic Pathogens Open
Background The bovine upper respiratory tract (URT) microbiome includes opportunistic pathogens that cause respiratory disease and stress associated with maternal separation and transportation contributes to the severity of this respirator…
View article: GIGA-AnimalGenomics-BLV/PCIP: PCIP-seq: simultaneous sequencing of integrated viral genomes and their insertion sites with long reads
GIGA-AnimalGenomics-BLV/PCIP: PCIP-seq: simultaneous sequencing of integrated viral genomes and their insertion sites with long reads Open
PCIP-seq: simultaneous sequencing of integrated viral genomes and their insertion sites with long reads Code Release v1.0.0 Authors: Maria Artesi; Vincent Hahaut; Basiel Cole; Laurens Lambrechts; Fereshteh Ashrafi; Ambroise Marçais; Olivie…
View article: Additional file 4 of PCIP-seq: simultaneous sequencing of integrated viral genomes and their insertion sites with long reads
Additional file 4 of PCIP-seq: simultaneous sequencing of integrated viral genomes and their insertion sites with long reads Open
Additional file 4: Dataset S3. PCIP-seq, ddPCR and validation oligos.
View article: Additional file 2 of PCIP-seq: simultaneous sequencing of integrated viral genomes and their insertion sites with long reads
Additional file 2 of PCIP-seq: simultaneous sequencing of integrated viral genomes and their insertion sites with long reads Open
Additional file 2: Dataset S1. HIV-1 integration sites identified in patients 02006 and 06042.
View article: Additional file 2 of Effect of maternal separation and transportation stress on the bovine upper respiratory tract microbiome and the immune response to resident opportunistic pathogens
Additional file 2 of Effect of maternal separation and transportation stress on the bovine upper respiratory tract microbiome and the immune response to resident opportunistic pathogens Open
Additional file 2. Bacterial species in URT and relationship between stress and microbial functions and stress and immune responses.
View article: Bovine Adenovirus-3 Tropism for Bovine Leukocyte Sub-Populations
Bovine Adenovirus-3 Tropism for Bovine Leukocyte Sub-Populations Open
A number of characteristics including lack of virulence and the ability to grow to high titers, have made bovine adenovirus-3 (BAdV-3) a vector of choice for further development as a vaccine-delivery vehicle for cattle. Despite the importa…
View article: A Bovine Enteric Mycobacterium Infection Model to Analyze Parenteral Vaccine-Induced Mucosal Immunity and Accelerate Vaccine Discovery
A Bovine Enteric Mycobacterium Infection Model to Analyze Parenteral Vaccine-Induced Mucosal Immunity and Accelerate Vaccine Discovery Open
Mycobacterial diseases of cattle are responsible for considerable production losses worldwide. In addition to their importance in animals, these infections offer a nuanced approach to understanding persistent mycobacterial infection in nat…
View article: An Improved Sequencing-Based Bioinformatics Pipeline to Track the Distribution and Clonal Architecture of Proviral Integration Sites
An Improved Sequencing-Based Bioinformatics Pipeline to Track the Distribution and Clonal Architecture of Proviral Integration Sites Open
The combined application of linear amplification-mediated PCR (LAM-PCR) protocols with next-generation sequencing (NGS) has had a large impact on our understanding of retroviral pathogenesis. Previously, considerable effort has been expend…
View article: Effects of lipopolysaccharide exposure in primary bovine ruminal epithelial cells
Effects of lipopolysaccharide exposure in primary bovine ruminal epithelial cells Open
The objective of this study was to investigate whether cultured ruminal epithelial cells (REC) responded to lipopolysaccharide (LPS) stimulation and determine whether LPS induced a proinflammatory response. Primary bovine REC were isolated…
View article: Kinome profiling of peripheral blood mononuclear cells collected prior to vaccination reveals biomarkers and potential mechanisms of vaccine unresponsiveness in pigs
Kinome profiling of peripheral blood mononuclear cells collected prior to vaccination reveals biomarkers and potential mechanisms of vaccine unresponsiveness in pigs Open
Inter-individual variance in host immune responses following vaccination can result in failure to develop protective immunity leaving individuals at risk for infection in addition to compromising herd immunity. While developing more effica…
View article: Regional Dichotomy in Enteric Mucosal Immune Responses to a Persistent Mycobacterium avium ssp. paratuberculosis Infection
Regional Dichotomy in Enteric Mucosal Immune Responses to a Persistent Mycobacterium avium ssp. paratuberculosis Infection Open
Chronic enteric Mycobacterium avium ssp. paratuberculosis (MAP) infections are endemic in ruminants globally resulting in significant production losses. The mucosal immune responses occurring at the site of infection, specifically in Peyer…
View article: 23 Differential microRNA expression in jejunal tissue and jejunal lymph nodes following naturally occurring Mycobacterium avium subspecies paratuberculosis infection in Holstein cows
23 Differential microRNA expression in jejunal tissue and jejunal lymph nodes following naturally occurring Mycobacterium avium subspecies paratuberculosis infection in Holstein cows Open
Mycobacterium avium subsp. Paratuberculosis (MAP) is the causal agent of Johne’s disease (JD), a chronic intestinal disease affecting ruminants worldwide. This study investigated miRNA expression in jejunal intestine (JE) and jejunal lymph…
View article: PSVI-14 Differentially expressed microRNAs with potential regulatory roles in ileum of Holstein cows with subclinical Johne’s disease
PSVI-14 Differentially expressed microRNAs with potential regulatory roles in ileum of Holstein cows with subclinical Johne’s disease Open
Paratuberculosis or Johne’s disease (JD), caused by Mycobacterium avium subsp. paratuberculosis (MAP), is a chronic inflammatory disorder of the intestinal tract of ruminants. The mechanisms of JD pathogenesis remain unclear but MAP can ca…
View article: PSVI-15 Transcriptome analysis of ileal lymph nodes identifies key microRNAs affecting disease progression in Holstein cows with subclinical Johne’s disease
PSVI-15 Transcriptome analysis of ileal lymph nodes identifies key microRNAs affecting disease progression in Holstein cows with subclinical Johne’s disease Open
Johne’s disease (JD) is a chronic enteric disease of ruminants caused by Mycobacterium avium subsp. Paratuberculosis (MAP) but immune and metabolic mechanisms affecting JD progression have not been clearly elucidated. MicroRNAs (miRNA) hav…
View article: A dendritic cell-targeted chimeric hepatitis B virus immunotherapeutic vaccine induces both cellular and humoral immune responses<i>in vivo</i>
A dendritic cell-targeted chimeric hepatitis B virus immunotherapeutic vaccine induces both cellular and humoral immune responses<i>in vivo</i> Open
Chimigen® HBV Immunotherapeutic Vaccine (C-HBV), a recombinant chimeric fusion protein comprising hepatitis B virus (HBV) S1 and S2 surface antigen fragments, Core antigen and a murine monoclonal antibody heavy chain fragment (Fc), was des…
View article: A Novel Animal Model for Regional Microbial Dysbiosis of the Pioneer Microbial Community
A Novel Animal Model for Regional Microbial Dysbiosis of the Pioneer Microbial Community Open
Pioneer microbiota colonizing the newborn gastrointestinal tract has long-lasting effects on host health. Restoration of the gut microbial community, following dysbiosis during the neonatal period, may be one strategy to prevent undesirabl…