Ian P. Hall
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View article: Long-acting hydrogel-based depot formulations of tirzepatide and semaglutide for the management of type 2 diabetes and weight
Long-acting hydrogel-based depot formulations of tirzepatide and semaglutide for the management of type 2 diabetes and weight Open
Several incretin hormone therapies have been clinically approved and have revolutionized the treatment of diabetes and obesity. Promising therapeutics include semaglutide (Ozempic and Wegovy), an agonist for glucagon-like peptide-1 (GLP-1)…
View article: Genomic Locus Tagged by Lung Function <scp>GWAS SNV</scp> rs12477314 (2q37.3) Acts as a Regulatory Region for a Systemic Inflammatory Phenotype
Genomic Locus Tagged by Lung Function <span>GWAS SNV</span> rs12477314 (2q37.3) Acts as a Regulatory Region for a Systemic Inflammatory Phenotype Open
SNV rs12477314 (C>T; 1000G MAF = 0.14), which maps to an intergenic region on 2q37.3, is a genome‐wide significant association signal for pulmonary function in genome‐wide association study meta‐analyses. Bioinformatic analysis revealed th…
View article: The role of the <i>ADRB2</i> Thr164Ile variant in lung function determination, plasma proteome variability and other phenotypes in UK Biobank
The role of the <i>ADRB2</i> Thr164Ile variant in lung function determination, plasma proteome variability and other phenotypes in UK Biobank Open
Introduction The effect of coding polymorphisms of the β 2 -adrenergic receptor gene ( ADRB2 ) on functional properties of the receptor is well established. We recently reported a genome-wide significant association between Thr164Ile and l…
View article: Epidemiological and phylogenetic analyses of public SARS-CoV-2 data from Malawi
Epidemiological and phylogenetic analyses of public SARS-CoV-2 data from Malawi Open
The COVID-19 pandemic has had varying impacts across different regions, necessitating localised data-driven responses. SARS-CoV-2 was first identified in a person in Wuhan, China, in December 2019 and spread globally within three months. W…
View article: Defining the Blood Cytokine Profile in Asthma to Understand Asthma Heterogeneity
Defining the Blood Cytokine Profile in Asthma to Understand Asthma Heterogeneity Open
Background Asthma is a heterogeneous disease characterized by overlapping clinical and inflammatory features. Objective This study aimed to provide insight into the systemic inflammatory profile in asthma, greater understanding of asthma e…
View article: Proteome-wide Mendelian randomization analyses to identify potential therapeutic targets for lung function and respiratory disease
Proteome-wide Mendelian randomization analyses to identify potential therapeutic targets for lung function and respiratory disease Open
RATIONALE Impaired lung function predicts mortality and is a diagnostic criterion for chronic obstructive pulmonary disease (COPD). Proteins are often the target of pharmacological interventions, therefore identifying causal links between …
View article: Genome-wide association study of Idiopathic Pulmonary Fibrosis susceptibility using clinically-curated European-ancestry datasets
Genome-wide association study of Idiopathic Pulmonary Fibrosis susceptibility using clinically-curated European-ancestry datasets Open
Background Idiopathic pulmonary fibrosis (IPF) is a rare, incurable lung disease with a median survival of 3-5 years after diagnosis. Treatment options are limited. Genetic association studies can identify new genes involved in disease tha…
View article: The role of the<i>ADRB2</i>Thr164Ile variant in lung function determination, plasma proteome variability and other phenotypes in UK Biobank
The role of the<i>ADRB2</i>Thr164Ile variant in lung function determination, plasma proteome variability and other phenotypes in UK Biobank Open
Introduction The effect of coding polymorphisms of the beta-2 adrenergic receptor gene ( ADRB2 ) on functional properties of the receptor is well-established. We recently reported a genome-wide significant association between Thr164Ile and…
View article: A systematic review to identify research gaps in studies modeling vaccination strategies against<i>Neisseria</i>infections
A systematic review to identify research gaps in studies modeling vaccination strategies against<i>Neisseria</i>infections Open
The genus Neisseria includes two major human pathogens: N. meningitidis causing bacterial meningitis/septicemia and N. gonorrhoeae causing gonorrhoea. Mathematical models have been used to simulate their transmission and control strategies…
View article: Epithelial Interleukin‐1 Receptor‐Like‐1 Activation Is Contingent on Interleukin‐33 Isoforms and Asthma‐Related Receptor Variation
Epithelial Interleukin‐1 Receptor‐Like‐1 Activation Is Contingent on Interleukin‐33 Isoforms and Asthma‐Related Receptor Variation Open
Introduction The interleukin‐33/interleukin‐1 receptor‐like‐1 (IL‐33/IL1RL1) signalling pathway is implicated in asthma pathogenesis, with IL1RL1 nonsynonymous genetic polymorphisms associated with disease risk. We aimed to determine these…
View article: Interleukin‐1 receptor‐associated kinase 4 (IRAK4) is a critical regulator of inflammatory signalling through toll‐like receptors 4 and 7/8 in murine and human lungs
Interleukin‐1 receptor‐associated kinase 4 (IRAK4) is a critical regulator of inflammatory signalling through toll‐like receptors 4 and 7/8 in murine and human lungs Open
Background and Purpose Toll‐like receptors 4 (TLR4) and TLR7/TLR8 play an important role in mediating the inflammatory effects of bacterial and viral pathogens. Interleukin‐1 receptor‐associated kinase 4 (IRAK4) is an important regulator o…
View article: Epidemiological and phylogenetic analyses of public SARS-CoV-2 data from Malawi
Epidemiological and phylogenetic analyses of public SARS-CoV-2 data from Malawi Open
The novel Coronavirus SARS-CoV-2 was first identified in a person in Wuhan city, China in December 2019, and had spread to all continents in less than three months. While there were many similarities between the resulting COVID-19 pandemic…
View article: DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19
DYNamic Assessment of Multi‐Organ level dysfunction in patients recovering from COVID‐19: DYNAMO COVID‐19 Open
We evaluated the impacts of COVID‐19 on multi‐organ and metabolic function in patients following severe hospitalised infection compared to controls. Patients ( n = 21) without previous diabetes, cardiovascular or cerebrovascular disease we…
View article: IRAK4 is a critical regulator of inflammatory signalling through Toll like receptors (TLR) 4 and 7/8 in murine and human lungs
IRAK4 is a critical regulator of inflammatory signalling through Toll like receptors (TLR) 4 and 7/8 in murine and human lungs Open
Background and purpose: Toll like receptors (TLR) 4 and 7/8 play an important role in mediating the inflammatory effects of bacterial and viral pathogens. IRAK4 is an important regulator of TLR signalling, and hence is a potential therapeu…
View article: Free‐Breathing Functional Pulmonary Proton <scp>MRI</scp>: A Novel Approach Using Voxel‐Wise Lung Ventilation (<scp>VOLVE</scp>) Assessment in Healthy Volunteers and Patients With Chronic Obstructive Pulmonary Disease
Free‐Breathing Functional Pulmonary Proton <span>MRI</span>: A Novel Approach Using Voxel‐Wise Lung Ventilation (<span>VOLVE</span>) Assessment in Healthy Volunteers and Patients With Chronic Obstructive Pulmonary Disease Open
Background In respiratory medicine, there is a need for sensitive measures of regional lung function that can be performed using standard imaging technology, without the need for inhaled or intravenous contrast agents. Purpose To describe …
View article: Modelled impact of virtual fractional flow reserve in patients undergoing coronary angiography (VIRTU-4)
Modelled impact of virtual fractional flow reserve in patients undergoing coronary angiography (VIRTU-4) Open
Background The practical application of ‘virtual’ (computed) fractional flow reserve (vFFR) based on invasive coronary angiogram (ICA) images is unknown. The objective of this cohort study was to investigate the potential of vFFR to guide …
View article: Transcriptomics using lung resection material to advance our understanding of COPD and idiopathic pulmonary fibrosis pathogenesis
Transcriptomics using lung resection material to advance our understanding of COPD and idiopathic pulmonary fibrosis pathogenesis Open
Genes involved in cell death, inflammation and viral infection are common to both COPD and IPF. A link to rheumatic disease is unique to COPD, and IPF-specific analyses showed increases in gene expression of keratins, collagens, mucins and…
View article: Genome-wide SNP-sex interaction analysis of susceptibility to idiopathic pulmonary fibrosis
Genome-wide SNP-sex interaction analysis of susceptibility to idiopathic pulmonary fibrosis Open
Background Idiopathic pulmonary fibrosis (IPF) is a chronic lung condition that is more prevalent in males than females. The reasons for this are not fully understood, with differing environmental exposures due to historically sex-biased o…
View article: Characterization of non-coding regulatory RNA from Listeria monocytogenes
Characterization of non-coding regulatory RNA from Listeria monocytogenes Open
Non-coding (nc) RNAs enable rapid and adaptable control of gene expression. For example, micro (mi) RNAs, piwi-interacting (pi) RNAs, and small interfering (si) RNAs regulate gene expression post-transcriptionally by base pairing complemen…
View article: Association study of human leukocyte antigen variants and idiopathic pulmonary fibrosis
Association study of human leukocyte antigen variants and idiopathic pulmonary fibrosis Open
Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial pneumonia marked by progressive lung fibrosis and a poor prognosis. Recent studies have highlighted the potential role of infection in the pathogenesis of IPF, and …
View article: Asthma exacerbations and eosinophilia in the UK Biobank: a genome-wide association study
Asthma exacerbations and eosinophilia in the UK Biobank: a genome-wide association study Open
Background Asthma exacerbations reflect disease severity, affect morbidity and mortality, and may lead to declining lung function. Inflammatory endotypes ( e.g. T2-high (eosinophilic)) may play a key role in asthma exacerbations. We aimed …
View article: Genome-wide association study of preserved ratio impaired spirometry (PRISm)
Genome-wide association study of preserved ratio impaired spirometry (PRISm) Open
Background Preserved ratio impaired spirometry (PRISm) is defined as a forced expiratory volume in 1 s (FEV 1 ) <80% predicted and FEV 1 /forced vital capacity ≥0.70. PRISm is associated with respiratory symptoms and comorbidities. Our obj…
View article: Genome-wide association study of susceptibility to hospitalised respiratory infections
Genome-wide association study of susceptibility to hospitalised respiratory infections Open
Background: Globally, respiratory infections contribute to significant morbidity and mortality. However, genetic determinants of respiratory infections are understudied and remain poorly understood. Methods: We conducted a genome-wide asso…
View article: P189 Genetic differences between sexes in idiopathic pulmonary fibrosis: a genome-wide SNP-by-sex interaction analysis
P189 Genetic differences between sexes in idiopathic pulmonary fibrosis: a genome-wide SNP-by-sex interaction analysis Open
Introduction Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease, whereby scarring of the lungs occurs. IPF is a complex disease and is more prevalent in males than females, however it is not understood why this is. Genome-wide a…
View article: S19 Gas exchange imaging using dissolved-phase 129Xe MRI in post COVID cohorts
S19 Gas exchange imaging using dissolved-phase 129Xe MRI in post COVID cohorts Open
Introduction Hyperpolarised 129Xe MRI allows quantitative and regionally sensitive measurement of gas exchange. The objective of this work is to characterise longitudinal lung function abnormalities using hyperpolarised 129Xe MRI in patien…
View article: P191 Exploring the association between human leukocyte antigen (HLA) genetics and idiopathic pulmonary fibrosis
P191 Exploring the association between human leukocyte antigen (HLA) genetics and idiopathic pulmonary fibrosis Open
Introduction and Objective Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease characterised by progressive lung fibrosis. Recent studies support the role of infection in IPF development. The Human Leukocyte Antigen …