Philip Hanoian
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View article: Enhancing transcription–replication conflict targets ecDNA-positive cancers
Enhancing transcription–replication conflict targets ecDNA-positive cancers Open
Extrachromosomal DNA (ecDNA) presents a major challenge for cancer patients. ecDNA renders tumours treatment resistant by facilitating massive oncogene transcription and rapid genome evolution, contributing to poor patient survival 1–7 . A…
View article: Rampant transcription replication conflict creates therapeutic vulnerability in extrachromosomal DNA containing cancers
Rampant transcription replication conflict creates therapeutic vulnerability in extrachromosomal DNA containing cancers Open
Extrachromosomal DNA (ecDNA) presents a major challenge for precision medicine, contributing to poor survival for patients with oncogene-amplified tumours. EcDNA renders tumours resistant to targeted treatments by facilitating massive tran…
View article: RNA primer–primase complexes serve as the signal for polymerase recycling and Okazaki fragment initiation in T4 phage DNA replication
RNA primer–primase complexes serve as the signal for polymerase recycling and Okazaki fragment initiation in T4 phage DNA replication Open
Significance The lagging-strand polymerase sometimes begins the synthesis of a new Okazaki fragment prior to finishing the previous fragment, creating a gap between the Okazaki fragments. The mechanism and signal that initiate this behavio…