Philip Hasbak
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View article: Evaluation of rest 82Rb positron emission tomography as an alternative to 99mTc-Based monitoring of cardiac function during chemotherapy
Evaluation of rest 82Rb positron emission tomography as an alternative to 99mTc-Based monitoring of cardiac function during chemotherapy Open
View article: Left ventricular ejection fraction reserve and its association with myocardial perfusion, coronary calcification, and strain in type 2 diabetes without overt cardiovascular disease
Left ventricular ejection fraction reserve and its association with myocardial perfusion, coronary calcification, and strain in type 2 diabetes without overt cardiovascular disease Open
View article: Left Ventricular Ejection Fraction Reserve and Its Association with Myocardial Perfusion, Coronary Calcification, and Strain in Type 2 Diabetes Without Overt Cardiovascular Disease
Left Ventricular Ejection Fraction Reserve and Its Association with Myocardial Perfusion, Coronary Calcification, and Strain in Type 2 Diabetes Without Overt Cardiovascular Disease Open
Background: Type 2 diabetes (T2D) is a major risk factor for cardiovascular disease (CVD), but the relationships between myocardial function, microvascular function, and atherosclerotic burden remain underexplored in asymptomatic individua…
View article: Sex differences in myocardial flow reserve among individuals with type 2 diabetes: insights from the DiaHeart study
Sex differences in myocardial flow reserve among individuals with type 2 diabetes: insights from the DiaHeart study Open
In individuals with type 2 diabetes without overt CVD, women exhibited lower MFR than men, primarily due to higher MBF at rest, suggesting sex-related differences. While MFR declined in both sexes, the sex difference was more pronounced in…
View article: Pulmonary blood volume as a marker of adenosine‐induced cardiac hyperemia: A Rubidium‐82 study
Pulmonary blood volume as a marker of adenosine‐induced cardiac hyperemia: A Rubidium‐82 study Open
Purpose To investigate the efficacy of pulmonary blood volume (PBV) as a marker of the cardiac hyperemic response to adenosine during myocardial perfusion imaging (MPI). Methods Forty healthy subjects underwent four consecutive Rubidium‐82…
View article: Positron Range Correction Helps Enhance the Image Quality of Cardiac<sup>82</sup>Rb PET/CT
Positron Range Correction Helps Enhance the Image Quality of Cardiac<sup>82</sup>Rb PET/CT Open
The image quality and quantitative accuracy of 82Rb myocardial perfusion imaging (MPI) using PET is challenged by the extensive positron range (PR) effects, with the PR of 82Rb being about 7 mm in soft tissues. This s…
View article: Coronary Microvascular Dysfunction Years After Cessation of Anabolic Androgenic Steroid Use
Coronary Microvascular Dysfunction Years After Cessation of Anabolic Androgenic Steroid Use Open
Importance Long-term use of anabolic androgenic steroids (AASs) is associated with a high risk of left ventricular hypertrophy, heart failure with reduced systolic function, and early sudden death, with the mechanism of progression being u…
View article: Detection of infective endocarditis with [64Cu]Cu-DOTATATE positron emission tomography/computed tomography: a case series
Detection of infective endocarditis with [64Cu]Cu-DOTATATE positron emission tomography/computed tomography: a case series Open
Background Infective endocarditis (IE) is a serious and fatal condition, with prosthetic valve endocarditis representing the worst prognosis. The recommended nuclear imaging modality 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomogr…
View article: Coronary microvascular dysfunction and left heart filling pressures in patients with type 2 diabetes
Coronary microvascular dysfunction and left heart filling pressures in patients with type 2 diabetes Open
Aims Patients with type 2 diabetes (T2D) have a high prevalence of diastolic dysfunction and heart failure with preserved ejection fraction (HFpEF), which in turn leads to an increased risk of hospitalization and death. However, the factor…
View article: Increased Subclinical Coronary Artery Pathology in Type 2 Diabetes With Albuminuria
Increased Subclinical Coronary Artery Pathology in Type 2 Diabetes With Albuminuria Open
Diabetes affects the kidneys, and the presence of albuminuria reflects widespread vascular damage and is a risk factor for cardiovascular disease (CVD). Still, the pathophysiological association between albuminuria and CVD remains incomple…
View article: Increased sub-clinical coronary artery pathology in type 2 diabetes with albuminuria.
Increased sub-clinical coronary artery pathology in type 2 diabetes with albuminuria. Open
Diabetes affects the kidneys, and presence of albuminuria reflects widespread vascular damage and is a risk factor for cardiovascular disease (CVD). Still, the pathophysiological association between albuminuria and CVD remains incompletely…
View article: Increased sub-clinical coronary artery pathology in type 2 diabetes with albuminuria.
Increased sub-clinical coronary artery pathology in type 2 diabetes with albuminuria. Open
Diabetes affects the kidneys, and presence of albuminuria reflects widespread vascular damage and is a risk factor for cardiovascular disease (CVD). Still, the pathophysiological association between albuminuria and CVD remains incompletely…
View article: Myocardial creep and cardiorespiratory motion correction improves diagnostic accuracy of Rubidium-82 cardiac positron emission tomography
Myocardial creep and cardiorespiratory motion correction improves diagnostic accuracy of Rubidium-82 cardiac positron emission tomography Open
3xMC has the potential to improve the diagnostic accuracy of myocardial MPI obtained from positron emission tomography. Therefore, its use should be considered both in clinical routine and large-scale multicenter studies.
View article: The effects of empagliflozin on measured glomerular filtration rate and estimated extracellular and plasma volumes in patients with type 2 diabetes
The effects of empagliflozin on measured glomerular filtration rate and estimated extracellular and plasma volumes in patients with type 2 diabetes Open
Aims To investigate the effects of empagliflozin on measured glomerular filtration rate (mGFR), estimated plasma volume (PV) and estimated extracellular volume (ECV) in a cohort of patients with type 2 diabetes (T2D) and high risk of cardi…
View article: Pulmonary blood volume assessment from a standard cardiac rubidium-82 imaging protocol: impact of adenosine-induced hyperemia
Pulmonary blood volume assessment from a standard cardiac rubidium-82 imaging protocol: impact of adenosine-induced hyperemia Open
View article: Fully Automated, Fast Motion Correction of Dynamic Whole-Body and Total-Body PET/CT Imaging Studies
Fully Automated, Fast Motion Correction of Dynamic Whole-Body and Total-Body PET/CT Imaging Studies Open
We introduce the Fast Algorithm for Motion Correction (FALCON) software, which allows correction of both rigid and nonlinear motion artifacts in dynamic whole-body (WB) images, irrespective of the PET/CT system or the tracer. Methods:
View article: [68Ga]Ga-NODAGA-E[(cRGDyK)]2 angiogenesis PET following myocardial infarction in an experimental rat model predicts cardiac functional parameters and development of heart failure
[68Ga]Ga-NODAGA-E[(cRGDyK)]2 angiogenesis PET following myocardial infarction in an experimental rat model predicts cardiac functional parameters and development of heart failure Open
View article: Quantification of myocardial blood flow using dynamic myocardial CT perfusion compared with 82Rb PET
Quantification of myocardial blood flow using dynamic myocardial CT perfusion compared with 82Rb PET Open
In healthy individuals, flow estimates obtained with dynamic myocardial CT perfusion during stress were, after conversion to MBF using the extraction of iodinated CT contrast agent, correlated with absolute MBF quantified with 82
View article: Wireless Single-Lead versus Standard 12-Lead ECG, for ST-Segment Deviation during Adenosine Cardiac Stress Scintigraphy
Wireless Single-Lead versus Standard 12-Lead ECG, for ST-Segment Deviation during Adenosine Cardiac Stress Scintigraphy Open
Wearable wireless electrocardiographic (ECG) monitoring is well-proven for arrythmia detection, but ischemia detection accuracy is not well-described. We aimed to assess the agreement of ST-segment deviation from single- versus 12-lead ECG…
View article: Detailed statistical analysis plan for the neurological complications in endoscopic versus open radial artery harvest (NEO) randomised clinical trial
Detailed statistical analysis plan for the neurological complications in endoscopic versus open radial artery harvest (NEO) randomised clinical trial Open
View article: Reduction of cardiac adipose tissue volume with short‐term empagliflozin treatment in patients with type 2 diabetes: A substudy from the <scp>SIMPLE</scp> randomized clinical trial
Reduction of cardiac adipose tissue volume with short‐term empagliflozin treatment in patients with type 2 diabetes: A substudy from the <span>SIMPLE</span> randomized clinical trial Open
Objective Ectopic accumulation of cardiac adipose tissue volume (CAT) has been associated with cardiac remodelling and cardiac dysfunction in type 2 diabetes and may be a future therapeutic target. In this substudy from the SIMPLE‐trial, w…
View article: Detailed statistical analysis plan for the Neurological complications in Endoscopic versus Open radial artery harvest (NEO) randomised clinical trial
Detailed statistical analysis plan for the Neurological complications in Endoscopic versus Open radial artery harvest (NEO) randomised clinical trial Open
IntroductionCoronary artery bypass grafting can be conducted using the radial artery as a bypass graft. However, it remains unclear, which harvesting method is superior, i.e. endoscopic or open radial artery, and which site for proximal an…
View article: Feasibility of positron range correction in 82-Rubidium cardiac PET/CT
Feasibility of positron range correction in 82-Rubidium cardiac PET/CT Open
View article: Myocardial perfusion reserve in patients with chronic hepatitis C before and after direct‐acting antiviral treatment—a pilot study
Myocardial perfusion reserve in patients with chronic hepatitis C before and after direct‐acting antiviral treatment—a pilot study Open
Introduction Patients with chronic hepatitis C (CHC) have an increased risk of atherosclerotic cardiovascular disease which may be due to inflammation and endothelial dysfunction caused by the chronic infection. In this prospective pilot s…
View article: Optimization of the left ventricle ejection fraction estimate obtained during cardiac adenosine stress 82Rubidium-PET scanning: impact of different reconstruction protocols
Optimization of the left ventricle ejection fraction estimate obtained during cardiac adenosine stress 82Rubidium-PET scanning: impact of different reconstruction protocols Open
View article: Feasibility of positron range correction in 82-Rubidium cardiac PET/CT
Feasibility of positron range correction in 82-Rubidium cardiac PET/CT Open
Background : Myocardial perfusion imaging (MPI) using positron emission tomography (PET) tracers is an essential tool in investigating diseases and treatment responses in cardiology. 82 Rubidium ( 82 Rb)-PET imaging is advantageous for MPI…
View article: Autonomic nervous system activity in primary Raynaud's phenomenon:Heart rate variability, plasma catecholamines and [<sup>123</sup>I]MIBG heart scintigraphy
Autonomic nervous system activity in primary Raynaud's phenomenon:Heart rate variability, plasma catecholamines and [<sup>123</sup>I]MIBG heart scintigraphy Open
Background and Aim: Primary Raynaud's phenomenon (pRP) is characterized by an exaggerated response to cold, resulting in the whitening typically of the fingers and toes. The patients are generally perceived as healthy individuals with a be…
View article: Image-derived and physiological markers to predict adequate adenosine-induced hyperemic response in Rubidium-82 myocardial perfusion imaging
Image-derived and physiological markers to predict adequate adenosine-induced hyperemic response in Rubidium-82 myocardial perfusion imaging Open
The image-derived and physiological markers all provide acceptable sensitivities and specificities when patients follow the caffeine pausation before MPI. However, their use warrants great care when caffeine consumption cannot be ruled out.
View article: Randomized Controlled Trial of the Hemodynamic Effects of Empagliflozin in Patients With Type 2 Diabetes at High Cardiovascular Risk: The SIMPLE Trial
Randomized Controlled Trial of the Hemodynamic Effects of Empagliflozin in Patients With Type 2 Diabetes at High Cardiovascular Risk: The SIMPLE Trial Open
Treatment with the sodium–glucose cotransporter 2 inhibitor (SGLT-2i) empagliflozin significantly reduces cardiovascular events in patients with type 2 diabetes (T2D); however, the mechanisms behind the reduction in cardiovascular (CV) eve…
View article: The Association Between Cardiovascular Autonomic Function and Changes in Kidney and Myocardial Function in Type 2 Diabetes and Healthy Controls
The Association Between Cardiovascular Autonomic Function and Changes in Kidney and Myocardial Function in Type 2 Diabetes and Healthy Controls Open
Background The mechanisms linking cardiovascular autonomic neuropathy, diabetic kidney disease and cardiovascular mortality in type 2 diabetes are widely unknown. We investigated the relationship between baseline cardiovascular autonomic f…