Explanipedia

Wb5, a novel biomarker for monitoring efficacy and success of mass drug administration programs for Wuchereria bancrofti elimination Open

Rachel E Pietrow, Catherine M. Bjerum, Benjamin G. Koudou, Taniawati Supali, Philip J. Budge , et al. · 2025

The success of mass drug administration at reducing the prevalence of lymphatic filariasis in endemic areas has led to an increased need for highly sensitive and specific diagnostic assays. To be useful in post-elimination surveillance in …

Adherence to Hygiene Protocols and Doxycycline Therapy in Ameliorating Lymphatic Filariasis Morbidity in an Endemic Area Post-Interruption of Disease Transmission in Ghana Open

Linda Batsa Debrah, Ute Klarmann‐Schulz, Jubin Osei-Mensah, Janina M. Kuehlwein, Yusif Mubarik , et al. · 2024

Filarial lymphedema (LE) remains a significant global problem despite the progress made toward elimination of lymphatic filariasis (LF). In Ghana, the main approach to LF is preventive chemotherapy, but this has minimal impact on individua…

A novel antigen biomarker for detection of high-level of Loa loa microfilaremia Open

Sarah E. Greene, Yuefang Huang, Kerstin Fischer, Bruce A. Rosa, John Martin , et al. · 2024

Background Loiasis is a disease caused by the nematode Loa loa . Serious adverse events sometimes occur in people with heavy L . loa microfilaremia after ivermectin treatment. In regions of Central Africa where loiasis is endemic, this sig…

LEDoxy-SL: A Placebo-Controlled, Double-Blind, Randomized, 24-Month Trial of Six Weeks of Daily Doxycycline Plus Hygiene-Based Essential Care for Reducing Progression of Filarial Lymphedema in Sri Lanka Open

Thishan C. Yahathugoda, Nirmitha Lalindi De Silva, J. Eugene Ruben, Sharmini Gunawardena, Mirani V. Weerasooriya , et al. · 2024

Morbidity management of filarial lymphedema remains a challenge even during the post-lymphatic filariasis elimination era in Sri Lanka despite provision of the predominantly hygiene-based WHO Essential Package of Care. Because prior studie…

Efficacy and Feasibility of Short-Stretch Compression Therapy for Filarial Lymphedema in Sri Lanka Open

Jaimee M. Hall, Nirmitha Lalindi De Silva, J. Eugene Ruben, Sandani S. Thilakarathne, Thishan C. Yahathugoda , et al. · 2024

The WHO-recommended essential package of care (EPC) for filarial limb lymphedema consists of daily limb washing, entry lesion management, limb protection, exercises, and elevation. Decongestive therapy (DT) with compression bandaging by tr…

Moxidectin Plus Albendazole for Lymphatic Filariasis: An Open Label, Observer-Blinded, Randomized Controlled Trial Open

Benjamin G. Koudou, Catherine M. Bjerum, Allassane Foungoye Ouattara, Pascal Toki Gabo, Charles W. Goss , et al. · 2024

Longitudinal study of cross-reactive antigenemia in individuals with high Loa loa microfilarial density reveals promising biomarkers for distinguishing lymphatic filariasis from loiasis Open

Linda Djune-Yemeli, Marla I. Hertz, Hugues C. Nana-Djeunga, Amy Rush, Petra Erdmann-Gilmore , et al. · 2023

Background and methods Circulating Loa loa antigens are often detected in individuals with heavy L. loa infections by diagnostic tests for lymphatic filariasis (LF) caused by Wuchereria bancrofti . This is a major challenge to LF mapping a…

Implementation and Outcomes of a Pilot Collaborative Surgical Hydrocele Training in Côte d’Ivoire Open

Kevin Montes, Georgina Angoa, Catherine M. Bjerum, Adama Guira, Olivier Kouadio , et al. · 2023

Lymphatic filariasis (LF) is a neglected tropical disease that can cause hydrocele and its associated stigma, loss of economic productivity, and depression. Hydrocele surgery is an essential part of LF morbidity management but can be diffi…

Identification of biomarker candidates for filarial parasite infections by analysis of extracellular vesicles Open

D. A. Yates, Lucía Sánchez Di Maggio, Bruce A. Rosa, Robert W. Sprung, Petra Erdmann-Gilmore , et al. · 2023

Background Improved diagnostic tools are needed for detecting active filarial infections in humans. Tests are available that detect adult W. bancrofti circulating filarial antigen, but there are no sensitive and specific biomarker tests fo…

Safety and tolerability of moxidectin and ivermectin combination treatments for lymphatic filariasis in Côte d’Ivoire: A randomized controlled superiority study Open

Catherine M. Bjerum, Benjamin G. Koudou, Allassane Ouattara, Daphne Lew, Charles W. Goss , et al. · 2023

Background Moxidectin is a macrocyclic lactone registered for the treatment of human onchocerciasis. The drug has a good safety profile, large volume of distribution and a long elimination half-life. This paper reports tolerability data fr…

Pharmacokinetics of Moxidectin combined with Albendazole or Albendazole plus Diethylcarbamazine for Bancroftian Filariasis Open

Yashpal S. Chhonker, Catherine M. Bjerum, Veenu Bala, Allassane Ouattara, Benjamin G. Koudou , et al. · 2023

Moxidectin (MOX) is a milbemycin endectocide recently approved by the U.S. FDA for the treatment of onchocerciasis in persons at least 12 years of age. MOX has been shown to have a good safety profile in recent clinical trials. The efficac…

Seroprevalence of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) antibodies among healthcare personnel in the Midwestern United States, September 2020–April 2021 Open

Rachel E. Bosserman, Christopher W Farnsworth, Caroline A. O’Neil, Candice Cass, Daniel Park , et al. · 2023

Objective: To determine the prevalence of severe acute respiratory coronavirus virus 2 (SARS-CoV-2) IgG nucleocapsid (N) antibodies among healthcare personnel (HCP) with no prior history of COVID-19 and to identify factors associated with …

Etiology of Persistent Microalbuminuria in Nigeria (P_MICRO study): protocol and study design Open

C. William Wester, Bryan E. Shepherd, Usman J. Wudil, Baba Maiyaki Musa, Donna J. Ingles , et al. · 2022

Background Microalbuminuria is an independent risk factor for cardiovascular and kidney disease and a predictor of end organ damage, both in the general population and in persons with HIV (PWH). Microalbuminuria is also an important risk f…

Characterization of a novel microfilarial antigen for diagnosis of Wuchereria bancrofti infections Open

Sarah E. Greene, Kerstin Fischer, Young‐Jun Choi, Kurt C. Curtis, Philip J. Budge , et al. · 2022

Background Lymphatic filariasis (LF) is a neglected tropical disease caused by the filarial nematodes Wuchereria bancrofti , Brugia malayi and Brugia timori . The Global Program to Eliminate LF uses mass drug administration (MDA) of anti-f…

Antibodies in healthcare personnel following severe acute respiratory syndrome coronavirus virus 2 (SARS-CoV-2) infection Open

Rachel E. Bosserman, Christopher W Farnsworth, Caroline A. O’Neil, Candice Cass, Daniel Park , et al. · 2022

In a prospective cohort of healthcare personnel (HCP), we measured severe acute respiratory syndrome coronavirus virus 2 (SARS-CoV-2) nucleocapsid IgG antibodies after SARS-CoV-2 infection. Among 79 HCP, 68 (86%) were seropositive 14–28 da…

Clinical and occupational risk factors for coronavirus disease 2019 (COVID-19) in healthcare personnel Open

Jennie H. Kwon, Philip J. Budge, Caroline A. O’Neil, Kate Peacock, Eva Aagaard , et al. · 2022

Objective: To identify characteristics associated with positive severe acute respiratory coronavirus virus 2 (SARS-CoV-2) polymerase chain reaction (PCR) tests in healthcare personnel. Design: Retrospective cohort study. Setting: A multiho…

Brugia malayi Glycoproteins Detected by the Filariasis Test Strip Antibody AD12.1 Open

Marla I. Hertz, Irene Hamlin, Amy Rush, Philip J. Budge · 2021

Background Rapid and accurate prevalence mapping of lymphatic filariasis (LF) is necessary to eliminate this disfiguring and disabling neglected tropical disease. Unfortunately, rapid tests such as the filariasis test strip (FTS) for Wuche…

Characterization of glycan determinants that mediate recognition of the major Wuchereria bancrofti circulating antigen by diagnostic antibodies Open

Marla I. Hertz, Amy Rush, Thomas B. Nutman, Gary J. Weil, Sasisekhar Bennuru , et al. · 2020

The design and development of a multicentric protocol to investigate the impact of adjunctive doxycycline on the management of peripheral lymphoedema caused by lymphatic filariasis and podoconiosis Open

John Horton, Ute Klarmann‐Schulz, Mariana Stephens, Philip J. Budge, Yaya Ibrahim Coulibaly , et al. · 2020

Brugia malayi galectin 2 is a tandem-repeat type galectin capable of binding mammalian polysaccharides Open

Marla I. Hertz, Philip M Glaessner, Amy Rush, Philip J. Budge · 2019

Portable infrared imaging for longitudinal limb volume monitoring in patients with lymphatic filariasis Open

Celia Zhou, Channa Yahathugoda, Lalindi De Silva, Upeksha Lakmini Rathnapala, Grant S. Owen , et al. · 2019

Limb volume measurements by 3DIS are accurate and reproducible, and this technique is feasible for use in patients' homes. We have developed practical suggestions for optimal outcomes with 3DIS. Duplicate measurements should be performed a…

The Longest Mile: Moving Malaria from Clinical Care to Elimination of Transmission Open

Philip J. Budge, Audrey R. Odom John · 2019

Finishing a task is generally more difficult than starting—the “longest mile is the last mile home.” This is particularly true in the battle against global infectious diseases. Smallpox remains the only human disease to have been completel…

Identification and characterization of Loa loa antigens responsible for cross-reactivity with rapid diagnostic tests for lymphatic filariasis Open

Marla I. Hertz, Hugues C. Nana-Djeunga, Joseph Kamgno, Abdel Jélil Njouendou, Valerine C. Chunda , et al. · 2018

Adverse events following single dose treatment of lymphatic filariasis: Observations from a review of the literature Open

Philip J. Budge, Carly Herbert, Britt Andersen, Gary J. Weil · 2018

Mild to moderate systemic AEs related to death of microfilariae are common following LF treatment. Post-treatment AEs are transient and rarely severe or serious. Comparison of AE rates from different community studies is difficult due to i…

Use of a Novel Portable Three-Dimensional Imaging System to Measure Limb Volume and Circumference in Patients with Filarial Lymphedema Open

Channa Yahathugoda, Michael Weiler, Ramakrishna U. Rao, Lalindi De Silva, J. Brandon Dixon , et al. · 2017

The World Health Organization’s Global Program to Eliminate Lymphatic Filariasis (LF) has reduced LF transmission worldwide, but millions remain affected by filarial lymphedema. Tools for clinically monitoring lymphedema in developing nati…

Transmission of<i>Balamuthia mandrillaris</i>by Organ Transplantation Open

Eileen C. Farnon, Kenneth E. Kokko, Philip J. Budge, Chukwuma Mbaeyi, Emily Lutterloh , et al. · 2016

Balamuthia can be transmitted through organ transplantation with an observed incubation time of 17-24 days. Clinicians should be aware of Balamuthia as a cause of encephalitis with high rate of fatality, and should notify public health dep…

Accuracy of Coverage Survey Recall following an Integrated Mass Drug Administration for Lymphatic Filariasis, Schistosomiasis, and Soil-Transmitted Helminthiasis Open

Philip J. Budge, Edmond Sognikin, Amanda Akosa, Els Mathieu, Michael S. Deming · 2016

In this population, coverage surveys provided remarkably consistent coverage estimates for up to one year following an integrated MDA. It is not clear if similar consistency will be seen in other settings, however, these data suggest that …

Molecular Epidemiology of Rhinovirus Detections in Young Children Open

Leigh M. Howard, Monika Johnson, Ana M. Gil, Marie R. Griffin, Kathryn M. Edwards , et al. · 2016

Background. Human rhinoviruses (HRVs) are frequently detected in children with acute respiratory illnesses (ARIs) but also in asymptomatic children. We compared features of ARI with HRV species (A, B, C) and determined genotypes associated…

Incidence and Risk Factors for Respiratory Syncytial Virus and Human Metapneumovirus Infections among Children in the Remote Highlands of Peru Open

Andrew Wu, Philip J. Budge, John V. Williams, Marie R. Griffin, Kathryn M. Edwards , et al. · 2015

In rural high altitude communities in Peru, childhood ARI due to RSV or MPV were common and associated with higher morbidity than ARI due to other viruses or with no viral detections. The risk factors identified in this study may be consid…

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