Ryan P. McNamara
YOU?
Author Swipe
View article: Sustained Humoral Activation through self-amplifying mRNA Vaccination Enhances Longitudinal Antibody Function in a Phase III Trial
Sustained Humoral Activation through self-amplifying mRNA Vaccination Enhances Longitudinal Antibody Function in a Phase III Trial Open
Summary Sustained and functional antibody responses to respiratory pathogens through vaccination is critical for global public health. The development and deployment of mRNA vaccines during the coronavirus disease 2019 (COVID19) pandemic w…
View article: Simian Immunodeficiency Virus-Derived Extracellular Vesicles Induce a Chronic Inflammatory Phenotype in Healthy Astrocytes Unresolved by Anti-Retroviral Therapy
Simian Immunodeficiency Virus-Derived Extracellular Vesicles Induce a Chronic Inflammatory Phenotype in Healthy Astrocytes Unresolved by Anti-Retroviral Therapy Open
Background/Objectives: Extracellular vesicles (EVs) are key mediators of intercellular communication and are implicated in the neuropathogenesis of HIV-associated brain injury (HABI). However, their direct effects on glial cells, particula…
View article: Simian Immunodeficiency Virus-Derived Extracellular Vesicles Induce a Chronic Inflammatory Phenotype in Healthy Astrocytes Unresolved by Anti-Retroviral Therapy
Simian Immunodeficiency Virus-Derived Extracellular Vesicles Induce a Chronic Inflammatory Phenotype in Healthy Astrocytes Unresolved by Anti-Retroviral Therapy Open
Background/Objectives: Extracellular vesicles (EVs) are key mediators of intercellular communication and are implicated in the neuropathogenesis of HIV-associated brain injury (HABI). However, their direct effects on glial cells, particula…
View article: Rational Design of Multiclade Coronavirus Spike Immunodominant Domain Nanoparticles to Elicit Broad Antibody Responses
Rational Design of Multiclade Coronavirus Spike Immunodominant Domain Nanoparticles to Elicit Broad Antibody Responses Open
Four seasonal endemic human coronaviruses (EhCoVs), HKU1-CoV, OC43-CoV, 229E-CoV, and NL63-CoV, are culprits of mild upper respiratory and periodic severe diseases in vulnerable populations. Despite their prevalence, understanding EhCoVs’ …
View article: Distinct antibody-based signatures and functionality distinguish latent and active pediatric tuberculosis
Distinct antibody-based signatures and functionality distinguish latent and active pediatric tuberculosis Open
Background Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is among the leading causes of death from an infectious agent among children worldwide. Children represent a particularly vulnerable population due to the greater ch…
View article: Adenovectored RSV prefusion glycoprotein + soluble glycoprotein combination immunization establishes persistent opsonophagocytic antibody response through IgG3
Adenovectored RSV prefusion glycoprotein + soluble glycoprotein combination immunization establishes persistent opsonophagocytic antibody response through IgG3 Open
Introduction Respiratory syncytial virus (RSV) causes significant lower-respiratory-tract disease in high-risk groups. A phase IIb trial showed that a combination vaccine of Ad26-vectored prefusion RSV F (Ad26.preF) plus soluble prefusion …
View article: Acute infectious mononucleosis generates persistent, functional EBNA-1 antibodies with high cross-reactivity to alpha-crystalline beta
Acute infectious mononucleosis generates persistent, functional EBNA-1 antibodies with high cross-reactivity to alpha-crystalline beta Open
We investigate the magnitude, specificity, and functional properties of Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA-1)-specific antibodies in young adults over the course of primary infection. EBNA-1-specific binding antibodies, as we…
View article: Preclinical development of a replication-competent vesicular stomatitis virus-based Lassa virus vaccine candidate advanced into human clinical trials
Preclinical development of a replication-competent vesicular stomatitis virus-based Lassa virus vaccine candidate advanced into human clinical trials Open
View article: Intra-Host Evolution Provides for the Continuous Emergence of SARS-CoV-2 Variants
Intra-Host Evolution Provides for the Continuous Emergence of SARS-CoV-2 Variants Open
Variants of concern (VOC) in SARS-CoV-2 refer to viruses whose viral genomes differ from the ancestor virus by ≥3 single-nucleotide variants (SNVs) and that show the potential for higher transmissibility and/or worse clinical progression. …
View article: Immune correlates of early clearance of Mycobacterium tuberculosis among tuberculosis household contacts in Indonesia
Immune correlates of early clearance of Mycobacterium tuberculosis among tuberculosis household contacts in Indonesia Open
Some individuals, even when heavily exposed to an infectious tuberculosis patient, do not develop a specific T-cell response as measured by interferon-gamma release assay (IGRA). This could be explained by an IFN-γ-independent adaptive imm…
View article: Estimating SARS-CoV-2 Exposure in Asymptomatic Hospitalized Children with Cancer in Western Kenya: An Analysis of Retrospective Serological Data
Estimating SARS-CoV-2 Exposure in Asymptomatic Hospitalized Children with Cancer in Western Kenya: An Analysis of Retrospective Serological Data Open
View article: Acute infectious mononucleosis generates persistent, functional EBNA-1 antibodies with high cross-reactivity to alpha crystalline beta
Acute infectious mononucleosis generates persistent, functional EBNA-1 antibodies with high cross-reactivity to alpha crystalline beta Open
Epstein-Barr Virus (EBV) infects over 95% of the world’s population and is the most common cause of infectious mononucleosis (IM). Epidemiologic studies have linked EBV with certain cancers or autoimmune conditions, including multiple scle…
View article: Humoral waning kinetics against SARS-CoV-2 is dictated by disease severity and vaccine platform
Humoral waning kinetics against SARS-CoV-2 is dictated by disease severity and vaccine platform Open
SARS-CoV-2 vaccine-acquired immunity provides robust cross-variant recognition, while infection-acquired immunity can be heterogenous, with disease severity often modulating post-recovery responses. We assessed antibody waning dynamics bet…
View article: Humoral correlates of protection against Mycobacterium tuberculosis following intravenous BCG vaccination in rhesus macaques
Humoral correlates of protection against Mycobacterium tuberculosis following intravenous BCG vaccination in rhesus macaques Open
View article: Monovalent XBB.1.5 mRNA Vaccine Recalls a More Durable and Coordinated Antibody Response to SARS-CoV-2 Spike than the Bivalent WT/BA.5 mRNA Vaccine
Monovalent XBB.1.5 mRNA Vaccine Recalls a More Durable and Coordinated Antibody Response to SARS-CoV-2 Spike than the Bivalent WT/BA.5 mRNA Vaccine Open
In the fall of 2023, the monovalent XBB.1.5 mRNA vaccine for COVID-19 became available. However, the comparative magnitude, durability, and functionality of antibody responses induced by the XBB.1.5 vaccine compared with the 2022-2023 biva…
View article: CD81 fusion alters SARS-CoV-2 Spike trafficking.
CD81 fusion alters SARS-CoV-2 Spike trafficking. Open
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic caused the biggest public health crises in recent history. Many expect future coronavirus introductions into the human population. Hence, it is essential to understa…
View article: Antibodies as key mediators of protection against Mycobacterium tuberculosis
Antibodies as key mediators of protection against Mycobacterium tuberculosis Open
Tuberculosis (TB) is caused by infection with the bacterial pathogen Mycobacterium tuberculosis (M.tb) in the respiratory tract. There was an estimated 10.6 million people newly diagnosed with TB, and there were approximately 1.3 million d…
View article: SARS-CoV-2 infection prior to vaccination amplifies Fc-mediated humoral profiles in an age-dependent manner
SARS-CoV-2 infection prior to vaccination amplifies Fc-mediated humoral profiles in an age-dependent manner Open
Immunity acquired by vaccination following infection, termed hybrid immunity, has been shown to confer enhanced protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by enhancing the breadth and potency of immune …
View article: CD81 fusion alters SARS-CoV-2 Spike trafficking
CD81 fusion alters SARS-CoV-2 Spike trafficking Open
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic caused the biggest public health crises in recent history. Many expect future coronavirus introductions into the human population. Hence, it is essential to understa…
View article: Immune correlates of early clearance of<i>Mycobacterium tuberculosis</i>among tuberculosis household contacts in Indonesia
Immune correlates of early clearance of<i>Mycobacterium tuberculosis</i>among tuberculosis household contacts in Indonesia Open
Some individuals, even when heavily exposed to an infectious tuberculosis patient, do not develop a specific T-cell response as measured by interferon-gamma release assay (IGRA). This could be explained by an IFN-γ-independent adaptive imm…
View article: Compartment-specific antibody correlates of protection to SARS-CoV-2 Omicron in macaques
Compartment-specific antibody correlates of protection to SARS-CoV-2 Omicron in macaques Open
View article: Concurrent Administration of COVID-19 and Influenza Vaccines Enhances Spike-Specific Antibody Responses
Concurrent Administration of COVID-19 and Influenza Vaccines Enhances Spike-Specific Antibody Responses Open
Background The bivalent COVID-19 mRNA boosters became available in fall 2022 and were recommended alongside the seasonal influenza vaccine. However, the immunogenicity of concurrent vs separate administration of these vaccines remains uncl…
View article: Compartment-Specific Antibody Correlates of Protection to SARS-CoV-2 Omicron in Macaques
Compartment-Specific Antibody Correlates of Protection to SARS-CoV-2 Omicron in Macaques Open
Antibodies represent a primary mediator of protection against respiratory viruses such as SARS-CoV-2. Serum neutralizing antibodies (NAbs) are often considered a primary correlate of protection. However, detailed antibody profiles includin…
View article: Waning immunity and IgG4 responses following bivalent mRNA boosting
Waning immunity and IgG4 responses following bivalent mRNA boosting Open
Messenger RNA (mRNA) vaccines were highly effective against the ancestral SARS-CoV-2 strain, but the efficacy of bivalent mRNA boosters against XBB variants was substantially lower. Here, we show limited durability of neutralizing antibody…
View article: Humoral profiles of toddlers and young children following SARS-CoV-2 mRNA vaccination
Humoral profiles of toddlers and young children following SARS-CoV-2 mRNA vaccination Open
View article: Boosting with adjuvanted SCB-2019 elicits superior Fcγ-receptor engagement driven by IgG3 to SARS-CoV-2 spike
Boosting with adjuvanted SCB-2019 elicits superior Fcγ-receptor engagement driven by IgG3 to SARS-CoV-2 spike Open
View article: Understanding Fc function for rational vaccine design against pathogens
Understanding Fc function for rational vaccine design against pathogens Open
Antibodies represent the primary correlate of immunity following most clinically approved vaccines. However, their mechanisms of action vary from pathogen to pathogen, ranging from neutralization, to opsonophagocytosis, to cytotoxicity. An…
View article: 255. Borrelia-specific antibody profiling in joint fluid distinguishes antibiotic-refractory Lyme arthritis from antibiotic-responsive arthritis
255. Borrelia-specific antibody profiling in joint fluid distinguishes antibiotic-refractory Lyme arthritis from antibiotic-responsive arthritis Open
Background Lyme disease, caused by the spirochete Borrelia burgdorferi, is the most common vector-borne disease in the United States. It drives a multisystem disorder, of which Lyme arthritis is the most common feature of late disseminated…
View article: Distinct Functional Humoral Immune Responses Are Induced after Live Attenuated and Inactivated Seasonal Influenza Vaccination
Distinct Functional Humoral Immune Responses Are Induced after Live Attenuated and Inactivated Seasonal Influenza Vaccination Open
Influenza viruses infect 5–30% of the world’s population annually, resulting in millions of incidents of hospitalization and thousands of mortalities worldwide every year. Although annual vaccination has significantly reduced hospitalizati…
View article: 578 Anti-PD-1 therapy alters the generation and durability of de novo responses to vaccination in humans
578 Anti-PD-1 therapy alters the generation and durability of de novo responses to vaccination in humans Open
Background Although anti-PD-1 expands pre-existing tumor-specific T cell responses, preclinical models of infection and vaccination suggest that early PD-1 pathway blockade may preferentially expand effector cells at the expense of memory …