Philip Meuleman
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View article: In Vivo Determinants of Hepatitis C Virus Adaptation and Escape From Neutralizing Antibody AR5A
In Vivo Determinants of Hepatitis C Virus Adaptation and Escape From Neutralizing Antibody AR5A Open
We show that L665S is an AR5A escape mutation in vivo, supporting the use of cost-effective vaccine escape studies in vitro. We also identify novel in vivo adaptive mutations and characterize their mechanism of action, thus facilitating in…
View article: IFN-β production promotes metabolic rewiring and protection against oxidative stress in hepatitis delta virus-infected hepatocyte cultures
IFN-β production promotes metabolic rewiring and protection against oxidative stress in hepatitis delta virus-infected hepatocyte cultures Open
View article: Higher Hepatitis E Seroprevalence in Workers in the Pig Sector in Flanders, Belgium: Results From a Seroprevalence Case‐Control Study
Higher Hepatitis E Seroprevalence in Workers in the Pig Sector in Flanders, Belgium: Results From a Seroprevalence Case‐Control Study Open
Introduction Autochthonous hepatitis E virus (HEV) infection in industrialised countries is a zoonosis. Pigs are recognised as the principal reservoir. Consequently, workers in the pig sector may be a high‐risk occupational group for HEV i…
View article: A novel in vitro system for simultaneous infections with hepatitis B, C, D and E viruses
A novel in vitro system for simultaneous infections with hepatitis B, C, D and E viruses Open
View article: Broadly neutralizing antibodies isolated from HEV convalescents confer protective effects in human liver-chimeric mice
Broadly neutralizing antibodies isolated from HEV convalescents confer protective effects in human liver-chimeric mice Open
Hepatitis E virus (HEV) causes 3.3 million symptomatic cases and 44,000 deaths per year. Chronic infections can arise in immunocompromised individuals, and pregnant women may suffer from fulminant disease as a consequence of HEV infection.…
View article: A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death
A critical role for HNF4α in polymicrobial sepsis-associated metabolic reprogramming and death Open
In sepsis, limited food intake and increased energy expenditure induce a starvation response, which is compromised by a quick decline in the expression of hepatic PPARα, a transcription factor essential in intracellular catabolism of free …
View article: High-throughput single-cell screening of viable hybridomas and patient-derived antibody-secreting cells using punchable microwells
High-throughput single-cell screening of viable hybridomas and patient-derived antibody-secreting cells using punchable microwells Open
Monoclonal antibodies (mAbs) hold significant potential as therapeutic agents and are invaluable tools in biomedical research. However, the lack of efficient high-throughput screening methods for single antibody-secreting cells (ASCs) has …
View article: TIM1, un récepteur de la phosphatidylsérine essentiel pour l’infection par le virus de l’hépatite E
TIM1, un récepteur de la phosphatidylsérine essentiel pour l’infection par le virus de l’hépatite E Open
International audience
View article: Phosphatidylinositol 4-Kinase III Alpha Governs Cytoskeletal Organization for Invasiveness of Liver Cancer Cells
Phosphatidylinositol 4-Kinase III Alpha Governs Cytoskeletal Organization for Invasiveness of Liver Cancer Cells Open
PI4KIIIα regulates cytoskeleton organization via PIK3C2γ/Akt2/paxillin-cofilin to favor migration and invasion of liver cancer cells. These findings provide mechanistic insight into the contribution of PI4KIIIα and HCV to the progression o…
View article: Virus–Host Protein Interaction Network of the Hepatitis E Virus ORF2-4 by Mammalian Two-Hybrid Assays
Virus–Host Protein Interaction Network of the Hepatitis E Virus ORF2-4 by Mammalian Two-Hybrid Assays Open
Throughout their life cycle, viruses interact with cellular host factors, thereby influencing propagation, host range, cell tropism and pathogenesis. The hepatitis E virus (HEV) is an underestimated RNA virus in which knowledge of the viru…
View article: Corrigendum to “Comparison of HAV and HCV infections in vivo and in vitro reveals distinct patterns of innate immune evasion and activation” [J Hepatol (2023) 645–656]
Corrigendum to “Comparison of HAV and HCV infections in vivo and in vitro reveals distinct patterns of innate immune evasion and activation” [J Hepatol (2023) 645–656] Open
Comparison of HAV and HCV infections in vivo and in vitro reveals distinct patterns of innate immune evasion and activationJournal of HepatologyVol. 79Issue 3PreviewHepatitis A virus (HAV) infections are considered not to trigger innate im…
View article: The phosphatidylserine receptor TIM1 promotes infection of enveloped hepatitis E virus
The phosphatidylserine receptor TIM1 promotes infection of enveloped hepatitis E virus Open
View article: Phosphatidylinositol 4-kinase III alpha governs cytoskeletal organization for invasiveness of liver cancer cells
Phosphatidylinositol 4-kinase III alpha governs cytoskeletal organization for invasiveness of liver cancer cells Open
Background and Aims High expression of phosphatidylinositol 4-kinase III alpha (PI4KIIIα) correlates with poor survival rates in patients with hepatocellular carcinoma (HCC). In addition, Hepatitis C virus (HCV) infections activate PI4KIII…
View article: Comparison of HAV and HCV infections in vivo and in vitro reveals distinct patterns of innate immune evasion and activation
Comparison of HAV and HCV infections in vivo and in vitro reveals distinct patterns of innate immune evasion and activation Open
View article: A human monoclonal antibody against HBsAg for the prevention and treatment of chronic HBV and HDV infection
A human monoclonal antibody against HBsAg for the prevention and treatment of chronic HBV and HDV infection Open
View article: Comparison of HAV and HCV infections<i>in vivo</i>and<i>in vitro</i>reveals distinct patterns of innate immune evasion and activation
Comparison of HAV and HCV infections<i>in vivo</i>and<i>in vitro</i>reveals distinct patterns of innate immune evasion and activation Open
Objective Hepatitis A virus (HAV) infections are considered not to trigger an innate immune response in vivo , in contrast to hepatitis C virus (HCV). This lack of immune induction has been imputed to strong immune counteraction by HAV pro…
View article: Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice
Human hepatocyte PNPLA3-148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice Open
View article: Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy
Adeno‐associated virus serotype 2 capsid variants for improved liver‐directed gene therapy Open
Background and Aims: Current liver‐directed gene therapies look for adeno‐associated virus (AAV) vectors with improved efficacy. With this background, capsid engineering is explored. Whereas shuffled capsid library screenings have resulted…
View article: Novel prime-boost immune-based therapy inhibiting both hepatitis B and D virus infections
Novel prime-boost immune-based therapy inhibiting both hepatitis B and D virus infections Open
Objective Chronic HBV/HDV infections are a major cause of liver cancer. Current treatments can only rarely eliminate HBV and HDV. Our previously developed preS1-HDAg immunotherapy could induce neutralising antibodies to HBV in vivo and rai…
View article: A ribavirin-induced ORF2 single-nucleotide variant produces defective hepatitis E virus particles with immune decoy function
A ribavirin-induced ORF2 single-nucleotide variant produces defective hepatitis E virus particles with immune decoy function Open
Hepatitis E virus (HEV) is the causative agent of hepatitis E in humans and is the leading cause of enterically transmitted viral hepatitis worldwide. Ribavirin (RBV) is currently the only treatment option for many patients; however, cases…
View article: A Hepatitis C virus genotype 1b post-transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo
A Hepatitis C virus genotype 1b post-transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo Open
Hepatitis C virus (HCV) is highly diverse and grouped into eight genotypes (gts). Infectious cell culture models are limited to a few subtypes and isolates, hampering the development of prophylactic vaccines. A consensus gt1b genome (terme…
View article: A Hepatitis C virus genotype 1b post-transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo
A Hepatitis C virus genotype 1b post-transplant isolate with high replication efficiency in cell culture and its adaptation to infectious virus production in vitro and in vivo Open
Hepatitis C virus (HCV) is highly diverse and grouped into eight genotypes (gts). Infectious cell culture models are limited to a few subtypes, that do not include the highly prevalent gt1b, hampering the development of prophylactic vaccin…
View article: Viral Interference of Hepatitis C and E Virus Replication in Novel Experimental Co-Infection Systems
Viral Interference of Hepatitis C and E Virus Replication in Novel Experimental Co-Infection Systems Open
Background: Hepatitis C virus (HCV) constitutes a global health problem, while hepatitis E virus (HEV) is the major cause of acute viral hepatitis globally. HCV/HEV co-infections have been poorly characterized, as they are hampered by the …
View article: Study of Hepatitis E Virus-4 Infection in Human Liver-Chimeric, Immunodeficient, and Immunocompetent Mice
Study of Hepatitis E Virus-4 Infection in Human Liver-Chimeric, Immunodeficient, and Immunocompetent Mice Open
The hepatitis E virus (HEV) is responsible for 20 million infections worldwide per year. Although, HEV infection is mostly self-limiting, immunocompromised individuals may evolve toward chronicity. The lack of an efficient small animal mod…
View article: A Role for B Cells to Transmit Hepatitis C Virus Infection
A Role for B Cells to Transmit Hepatitis C Virus Infection Open
Hepatitis C virus (HCV) is highly variable and transmits through infected blood to establish a chronic liver infection in the majority of patients. Our knowledge on the infectivity of clinical HCV strains is hampered by the lack of in vitr…
View article: Human hepatocyte PNPLA3 148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice
Human hepatocyte PNPLA3 148M exacerbates rapid non-alcoholic fatty liver disease development in chimeric mice Open
Advanced non-alcoholic fatty liver disease (NAFLD) is a rapidly emerging global health problem associated with pre-disposing genetic polymorphisms, most strikingly an isoleucine to methionine substitution in patatin-like phospholipase doma…
View article: Human hepatocyte PNPLA3 148M exacerbates rapid non-alcoholic steatohepatitis development in chimeric mice
Human hepatocyte PNPLA3 148M exacerbates rapid non-alcoholic steatohepatitis development in chimeric mice Open
Advanced non-alcoholic fatty liver disease (NAFLD) is a rapidly emerging global health problem associated with pre-disposing genetic polymorphisms, most strikingly an isoleucine to methionine substitution in patatin-like phospholipase doma…
View article: Liver-expressed <i>Cd302</i> and <i>Cr1l</i> limit hepatitis C virus cross-species transmission to mice
Liver-expressed <i>Cd302</i> and <i>Cr1l</i> limit hepatitis C virus cross-species transmission to mice Open
Two transmembrane proteins cooperate to block infection of murine hepatocytes by human-tropic hepatitis C virus.
View article: A role for B cells to transmit hepatitis C virus infection
A role for B cells to transmit hepatitis C virus infection Open
Hepatitis C virus (HCV) is highly variable and transmits through infected blood to establish a chronic liver infection in the majority of patients. Our knowledge of the infectivity of clinical HCV strains is hampered by the lack of in vitr…
View article: Experimental Variables that Affect Human Hepatocyte AAV Transduction in Liver Chimeric Mice
Experimental Variables that Affect Human Hepatocyte AAV Transduction in Liver Chimeric Mice Open