Philip S. Mehler
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View article: Using Bomb Calorimetry to Investigate Intestinal Energy Harvest in Anorexia Nervosa: Preliminary Findings on Stool Calorie Loss
Using Bomb Calorimetry to Investigate Intestinal Energy Harvest in Anorexia Nervosa: Preliminary Findings on Stool Calorie Loss Open
OBJECTIVE: Renourishment and weight restoration are critical first steps in anorexia nervosa (AN) treatment. The ability of the gastrointestinal tract to harvest and utilize energy from food is essential for successful weight restoration, …
View article: Whole Blood Thiamine Levels in Extreme Anorexia Nervosa: A Pilot Study
Whole Blood Thiamine Levels in Extreme Anorexia Nervosa: A Pilot Study Open
Objective Risk for thiamine deficiency in individuals with anorexia nervosa (AN) remains uncertain due to significant heterogeneity in limited studies and given that current treatment recommendations are based on expert opinion and researc…
View article: Greater Body Dissatisfaction at Admission Is Associated With Lower <scp>BMI</scp> at Discharge in Anorexia Nervosa: Predictive Validity of the Eating Pathology Symptoms Inventory
Greater Body Dissatisfaction at Admission Is Associated With Lower <span>BMI</span> at Discharge in Anorexia Nervosa: Predictive Validity of the Eating Pathology Symptoms Inventory Open
People with anorexia nervosa (AN) engage in dietary restriction and other weight loss behaviors that result in dangerously low body weight, leading to an increased risk for mortality and medical complications. Weight gain is one of the mos…
View article: Predictors of Successful Weight Restoration in the Treatment of Superior Mesenteric Artery Syndrome: A Systematic Review
Predictors of Successful Weight Restoration in the Treatment of Superior Mesenteric Artery Syndrome: A Systematic Review Open
Background/Objectives: Treatment for superior mesenteric artery (SMA) syndrome can include either weight restoration (conservative management) or surgical intervention, with the latter recommended when individuals fail conservative managem…
View article: Preliminary validation of developmental weight suppression in youth with transdiagnostic eating disorders
Preliminary validation of developmental weight suppression in youth with transdiagnostic eating disorders Open
Background Weight suppression (WS), traditionally defined as the difference between highest past and current weights at adult height, is a correlate and predictor of eating disorder (ED) psychopathology. However, for growing adolescents, i…
View article: Effects of Early Weight Trends on Residential Treatment Outcomes Among Adolescents With Anorexia Nervosa
Effects of Early Weight Trends on Residential Treatment Outcomes Among Adolescents With Anorexia Nervosa Open
Background Weight variability (WV), or daily‐to‐weekly fluctuations in weight, associates with increased eating pathology in adults with bulimia nervosa and greater weight gain across the developmental span in healthy controls, but few stu…
View article: The Eating Disorders Genetics Initiative 2 (EDGI2): study protocol
The Eating Disorders Genetics Initiative 2 (EDGI2): study protocol Open
View article: The Importance of Specialized Inpatient Medical Stabilization for Weight Restoration of Individuals with Extreme Eating Disorders
The Importance of Specialized Inpatient Medical Stabilization for Weight Restoration of Individuals with Extreme Eating Disorders Open
Inpatient care is a significant contributor to the health-care costs associated with the treatment of individuals with eating disorders (EDs). This study seeks to better understand the treatment outcomes of individuals with extreme EDs req…
View article: Eating Disorder Severity and Treatment Outcome Across Race/Ethnicity, Sexual Orientation, and Socioeconomic Status: Intersectional Inequities in a Clinical Sample
Eating Disorder Severity and Treatment Outcome Across Race/Ethnicity, Sexual Orientation, and Socioeconomic Status: Intersectional Inequities in a Clinical Sample Open
Background Marginalized populations experience increased eating disorder (ED) risk and encounter significant barriers to treatment. Intersectionality provides a framework for understanding how systemic oppression contributes to inequities …
View article: The Eating Disorders Genetics Initiative 2 (EDGI2): Study Protocol
The Eating Disorders Genetics Initiative 2 (EDGI2): Study Protocol Open
Background: The Eating Disorders Genetics Initiative 2 (EDGI2) is designed to explore the role of genes and environment in anorexia nervosa, bulimia nervosa, binge-eating disorder, and avoidant/restrictive food intake disorder (ARFID) with…
View article: Internal and External Forms of Blame and Disgust and Their Relationships to Suicidal Ideation Within Vulnerable Populations
Internal and External Forms of Blame and Disgust and Their Relationships to Suicidal Ideation Within Vulnerable Populations Open
View article: Zinc levels in severe eating disorders
Zinc levels in severe eating disorders Open
View article: The Eating Disorders Genetics Initiative 2 (EDGI2): Study Protocol
The Eating Disorders Genetics Initiative 2 (EDGI2): Study Protocol Open
Background: The Eating Disorders Genetics Initiative 2 (EDGI2) is designed to explore the role of genes and environment in anorexia nervosa, bulimia nervosa, binge-eating disorder, and avoidant/restrictive food intake disorder (ARFID) with…
View article: Virtual Versus In-Person Intensive Outpatient Treatment for Eating Disorders During the COVID-19 Pandemic in United States–Based Treatment Facilities: Naturalistic Study
Virtual Versus In-Person Intensive Outpatient Treatment for Eating Disorders During the COVID-19 Pandemic in United States–Based Treatment Facilities: Naturalistic Study Open
Background While virtual therapy has proven effective in treating eating disorders (EDs), little work has examined virtual therapy at higher levels of care, which are treatment options providing more support than weekly outpatient therapy …
View article: Does 24/7 care result in better outcomes for adults with eating disorders? A comparison of inpatient/residential care to partial hospitalization/intensive outpatient care for patients at low BMIs
Does 24/7 care result in better outcomes for adults with eating disorders? A comparison of inpatient/residential care to partial hospitalization/intensive outpatient care for patients at low BMIs Open
The current study suggests that patients with EDs at low BMIs gain more weight at a faster rate when participating in 24/7 care compared to non-24/7 care. Entering treatment at an appropriate level may result in shorter overall lengths of …
View article: Loss of Bone Density in Patients with Anorexia Nervosa Food That Alone Will Not Cure
Loss of Bone Density in Patients with Anorexia Nervosa Food That Alone Will Not Cure Open
Background: Anorexia Nervosa is a highly lethal illness that is also associated with many medical complications. Food restriction and weight loss define this illness. Most of its physical complications are reversible with weight restoratio…
View article: Predictors of treatment outcome in higher levels of care among a large sample of adolescents with heterogeneous eating disorders
Predictors of treatment outcome in higher levels of care among a large sample of adolescents with heterogeneous eating disorders Open
Background Despite widespread use of higher levels of care in treating eating disorders in adolescents, research supporting the use of these treatments remains limited by small sample sizes and a predominant focus on anorexia nervosa. Furt…
View article: Are Suicide-Specific Interventions Required to Reduce Suicidal Ideation? An Empirical Examination in a Clinical Sample of Eating-Disorder Participants
Are Suicide-Specific Interventions Required to Reduce Suicidal Ideation? An Empirical Examination in a Clinical Sample of Eating-Disorder Participants Open
In this research, we examined whether non-suicide-specific treatments effectively reduced suicidal ideation (SI) among a clinical sample of eating-disorder (ED) patients ( N = 3,447, of whom 50.9% presented with SI). All participants met c…
View article: Pelvic Floor Dysfunction in People with Eating Disorders and the Acute Effect of Different Interventions – A Retrospective Cohort Study
Pelvic Floor Dysfunction in People with Eating Disorders and the Acute Effect of Different Interventions – A Retrospective Cohort Study Open
Background: Studies suggest that there is an association between eating disorders and pelvic floor dysfunction (PFD), although the contribution of PFD toward symptomatology and interventions to improve these symptoms in the eating disorder…
View article: Scoping review of end-of-life care for persons with anorexia nervosa
Scoping review of end-of-life care for persons with anorexia nervosa Open
The debate around EOL care in AN needs consented, coherent terminology whose value base is reduced to a minimum and made transparent. While more empirical research into decision-making in AN and predictors of outcome might help reduce unce…
View article: “Terminal anorexia nervosa” may not be terminal: An empirical evaluation.
“Terminal anorexia nervosa” may not be terminal: An empirical evaluation. Open
Gaudiani et al. (2022) presented terminal anorexia nervosa (T-AN) as a potential new specifier to the anorexia nervosa (AN) diagnosis, with criteria including (a) AN diagnosis, (b) age > 30 years, (c) previously participated in high-qualit…
View article: Atypical antipsychotic use does not impact weight gain for individuals with extreme anorexia nervosa: a retrospective case–control study
Atypical antipsychotic use does not impact weight gain for individuals with extreme anorexia nervosa: a retrospective case–control study Open
View article: Can we predict the development of acute gastric dilatation in patients with anorexia nervosa?
Can we predict the development of acute gastric dilatation in patients with anorexia nervosa? Open
Background Acute gastric dilatation can develop in patients with anorexia nervosa who are being refed to achieve weight restoration. If unrecognized, this condition is associated with significant morbidity and mortality. Patients with acut…
View article: Characterising use of recovery record among a large, transdiagnostic sample of adults with eating disorders across higher levels of care
Characterising use of recovery record among a large, transdiagnostic sample of adults with eating disorders across higher levels of care Open
Objective Smartphone applications (i.e., apps) designed to target mental health symptoms have received increasing public and empirical attention, including in eating disorder|eating disorders (EDs) treatment. While some data have begun to …
View article: Vitamin D and hypophosphatemia in patients with anorexia nervosa and avoidant/restrictive food intake disorder: a case control study
Vitamin D and hypophosphatemia in patients with anorexia nervosa and avoidant/restrictive food intake disorder: a case control study Open
Background Refeeding hypophosphatemia (RH) is a common complication of nutritional restoration in malnourished individuals, yet clear risk stratification remains elusive. Individuals with anorexia nervosa (AN) and avoidant/restrictive food…
View article: Cardiac Tamponade in Anorexia Nervosa: An Argument for Conservative Management
Cardiac Tamponade in Anorexia Nervosa: An Argument for Conservative Management Open
Pericardial effusion is a commonly encountered cardiac complication of malnutrition.Pericardial effusion can rarely progress to cardiac tamponade, a condition of cardiovascular collapse that typically requires emergent surgical interventio…
View article: Vitamin D and Hypophosphatemia in Patients with Anorexia Nervosa and Avoidant/Restrictive Food Intake Disorder: A Case Control Study
Vitamin D and Hypophosphatemia in Patients with Anorexia Nervosa and Avoidant/Restrictive Food Intake Disorder: A Case Control Study Open
Background Refeeding hypophosphatemia (RH) is a common complication of nutritional restoration in malnourished individuals, yet clear risk stratification remains elusive. Individuals with anorexia nervosa (AN) and avoidant/restrictive food…
View article: Emergency room presentations of people with anorexia nervosa
Emergency room presentations of people with anorexia nervosa Open
View article: Pulmonary complications of eating disorders: a literature review
Pulmonary complications of eating disorders: a literature review Open
The medical complications of eating disorders (EDs) have been described in the literature; however, the pulmonary system has historically been described as relatively spared from the ravages of eating disorders and thus neglected in the li…
View article: A Multi-Disciplinary Approach to Managing End-Stage Renal Disease in Anorexia Nervosa: A Case Report
A Multi-Disciplinary Approach to Managing End-Stage Renal Disease in Anorexia Nervosa: A Case Report Open
Background: Renal dysfunction and electrolyte abnormalities are common complications of anorexia nervosa (AN), particularly in the binge-eating/purging type (AN-BP). Hypokalemic, or kaliopenic, nephropathy is an established clinical entity…