Philip Selby
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View article: Exploring Health Care Professionals' Engagement With a Precision Dosing Calculator and Supporting Clinical Information: Insights From an Eye-Tracking and Usability Study
Exploring Health Care Professionals' Engagement With a Precision Dosing Calculator and Supporting Clinical Information: Insights From an Eye-Tracking and Usability Study Open
Background: Pharmacokinetic-based dosing calculators for individualized drug dosing remain underutilized in clinical practice, often due to poor usability and a lack of user-centered design. Understanding how health care professionals inte…
View article: Determination of a vancomycin nephrotoxicity threshold and assessment of target attainment in hematology patients
Determination of a vancomycin nephrotoxicity threshold and assessment of target attainment in hematology patients Open
An area‐under‐the‐curve (AUC 24 )‐based approach is recommended to guide vancomycin therapeutic drug monitoring (TDM), yet trough concentrations are still commonly used despite associated risks. A definitive toxicity target is lacking, whi…
View article: Addressing the groundwater impacts of informal water markets – coupled human-natural systems modeling of policy options for Jordan
Addressing the groundwater impacts of informal water markets – coupled human-natural systems modeling of policy options for Jordan Open
Unreliable and unequal public water supply already affects around one billion urban residents around the world. In many cities, informal water markets have emerged to fill public supply gaps by delivering water via tanker trucks, depleting…
View article: Unexpected growth of an illegal water market
Unexpected growth of an illegal water market Open
Scarce and unreliable urban water supply in many countries has caused municipal users to rely on transfers from rural wells via unregulated markets. Assessments of this pervasive water re-allocation institution and its impacts on aquifers,…
View article: A Personalized Risk Model for Azacitidine Outcome in Myelodysplastic Syndrome and Other Myeloid Neoplasms Identified by Machine Learning Model Utilizing Real-World Data
A Personalized Risk Model for Azacitidine Outcome in Myelodysplastic Syndrome and Other Myeloid Neoplasms Identified by Machine Learning Model Utilizing Real-World Data Open
Azacitidine is an approved therapy for higher-risk myelodysplastic syndrome (MDS). However, only 30–40% patients respond to azacitidine, and the responses may take up to six cycles to become evident. Delayed responses and the myelosuppress…
View article: Population Pharmacokinetics of Ganciclovir in Allogeneic Hematopoietic Stem Cell Transplant Patients
Population Pharmacokinetics of Ganciclovir in Allogeneic Hematopoietic Stem Cell Transplant Patients Open
Treatment of cytomegalovirus (CMV) infection in allogeneic hematopoietic stem cell transplantation (alloHCT) patients with ganciclovir is complicated by toxicity and resistance. This study aimed to develop an intravenous ganciclovir popula…
View article: Optimizing antifungal prophylaxis in allogeneic stem cell transplantation: A cohort study of two different approaches
Optimizing antifungal prophylaxis in allogeneic stem cell transplantation: A cohort study of two different approaches Open
Background Limited consensus exists on the optimal use of antifungal agents to prevent invasive fungal infection in the early post allogeneic hematopoietic stem cell transplant (alloHCT) period, particularly when patients cannot tolerate o…
View article: A coupled human–natural system analysis of freshwater security under climate and population change
A coupled human–natural system analysis of freshwater security under climate and population change Open
Significance Jordan is facing an unfolding water crisis, exacerbated by climate change and conflict-induced refugee influxes. We present a freshwater security analysis for the country, enabled by an integrated systems model that combines s…